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Protein

mRNA export factor

Gene

rae1

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Plays a role in mitotic bipolar spindle formation. Binds mRNA. May function in nucleocytoplasmic transport and in directly or indirectly attaching cytoplasmic mRNPs to the cytoskeleton.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCell cycle, Cell division, Mitosis, Transport

Enzyme and pathway databases

ReactomeiR-DRE-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript
R-DRE-170822 Regulation of Glucokinase by Glucokinase Regulatory Protein
R-DRE-191859 snRNP Assembly
R-DRE-3108214 SUMOylation of DNA damage response and repair proteins
R-DRE-3301854 Nuclear Pore Complex (NPC) Disassembly
R-DRE-3371453 Regulation of HSF1-mediated heat shock response
R-DRE-4551638 SUMOylation of chromatin organization proteins
R-DRE-4570464 SUMOylation of RNA binding proteins
R-DRE-5578749 Transcriptional regulation by small RNAs

Names & Taxonomyi

Protein namesi
Recommended name:
mRNA export factor
Alternative name(s):
Rae1 protein homolog
mRNA-associated protein mrnp 41
Gene namesi
Name:rae1
Synonyms:mrnp41
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 6

Organism-specific databases

ZFINiZDB-GENE-040426-1029 rae1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003129821 – 368mRNA export factorAdd BLAST368

Proteomic databases

PaxDbiQ7ZWF0
PRIDEiQ7ZWF0

Expressioni

Gene expression databases

BgeeiENSDARG00000007196
ExpressionAtlasiQ7ZWF0 baseline

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000015105

Structurei

3D structure databases

ProteinModelPortaliQ7ZWF0
SMRiQ7ZWF0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati37 – 79WD 1Add BLAST43
Repeati84 – 114WD 2Add BLAST31
Repeati125 – 157WD 3Add BLAST33
Repeati168 – 206WD 4Add BLAST39
Repeati215 – 255WD 5Add BLAST41
Repeati271 – 301WD 6Add BLAST31
Repeati310 – 346WD 7Add BLAST37

Sequence similaritiesi

Belongs to the WD repeat rae1 family.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0647 Eukaryota
ENOG410XQ1M LUCA
GeneTreeiENSGT00530000063440
HOGENOMiHOG000208823
HOVERGENiHBG002942
InParanoidiQ7ZWF0
KOiK14298
OMAiKGHEYYN
OrthoDBiEOG091G09GO
PhylomeDBiQ7ZWF0
TreeFamiTF105481

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR020472 G-protein_beta_WD-40_rep
IPR037631 Gle2/RAE1
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PANTHERiPTHR10971:SF11 PTHR10971:SF11, 1 hit
PfamiView protein in Pfam
PF00400 WD40, 2 hits
PRINTSiPR00320 GPROTEINBRPT
SMARTiView protein in SMART
SM00320 WD40, 4 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 2 hits
PS50082 WD_REPEATS_2, 3 hits
PS50294 WD_REPEATS_REGION, 2 hits

Sequencei

Sequence statusi: Complete.

Q7ZWF0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLFGTNTGF GSGGTGVFGS TTTDSHNPMK DVEVTSPPDD SISCLAFSPP
60 70 80 90 100
TMPGNFLIGG SWANDVRCWE VQDNGQTVPK AQQMHTGPVL DVCWSDDGSK
110 120 130 140 150
VFTASCDKTA KMWDLNSNQA IQIAQHEGPI RTIHWIKAPN YSCIMTGSWD
160 170 180 190 200
KTLKFWDTRS PNPMMSLQMP ERCYCADVVY PMAVVATAER GLIVYQLENQ
210 220 230 240 250
PSEFRRIESP LKHQHRCVAI FKDKQSKPTG FALGSIEGRV AIHYINPPNP
260 270 280 290 300
AKDNFTFKCH RSNGTNTATP QDIYAVNAIS FHPVHGTLAT VGSDGRFSFW
310 320 330 340 350
DKDARTKLKT SEQLDQPITA CCFNHNGNIF AYASSYDWSK GHEYYNPQKK
360
NYIFLRNAAE ELKPRNKK
Length:368
Mass (Da):41,051
Last modified:January 15, 2008 - v2
Checksum:i0A9FAD27C9291BF7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti40D → E in AAH49445 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC049445 mRNA Translation: AAH49445.1
BC065853 mRNA Translation: AAH65853.1
RefSeqiNP_957292.1, NM_200998.1
UniGeneiDr.75426

Genome annotation databases

EnsembliENSDART00000020333; ENSDARP00000015105; ENSDARG00000007196
GeneIDi393973
KEGGidre:393973

Similar proteinsi

Entry informationi

Entry nameiRAE1L_DANRE
AccessioniPrimary (citable) accession number: Q7ZWF0
Secondary accession number(s): Q6P037
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: March 28, 2018
This is version 104 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health