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Protein

mRNA export factor

Gene

rae1

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Binds mRNA. May function in nucleocytoplasmic transport and in directly or indirectly attaching cytoplasmic mRNPs to the cytoskeleton (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-DRE-159236. Transport of Mature mRNA derived from an Intron-Containing Transcript.
R-DRE-170822. Regulation of Glucokinase by Glucokinase Regulatory Protein.
R-DRE-3108214. SUMOylation of DNA damage response and repair proteins.
R-DRE-3301854. Nuclear Pore Complex (NPC) Disassembly.
R-DRE-3371453. Regulation of HSF1-mediated heat shock response.
R-DRE-4570464. SUMOylation of RNA binding proteins.
R-DRE-5578749. Transcriptional regulation by small RNAs.

Names & Taxonomyi

Protein namesi
Recommended name:
mRNA export factor
Alternative name(s):
Rae1 protein homolog
mRNA-associated protein mrnp 41
Gene namesi
Name:rae1
Synonyms:mrnp41
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 6

Organism-specific databases

ZFINiZDB-GENE-040426-1029. rae1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 368368mRNA export factorPRO_0000312982Add
BLAST

Proteomic databases

PaxDbiQ7ZWF0.
PRIDEiQ7ZWF0.

Expressioni

Gene expression databases

BgeeiQ7ZWF0.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000015105.

Structurei

3D structure databases

ProteinModelPortaliQ7ZWF0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati37 – 7943WD 1Add
BLAST
Repeati84 – 11431WD 2Add
BLAST
Repeati125 – 15733WD 3Add
BLAST
Repeati168 – 20639WD 4Add
BLAST
Repeati215 – 25541WD 5Add
BLAST
Repeati271 – 30131WD 6Add
BLAST
Repeati310 – 34637WD 7Add
BLAST

Sequence similaritiesi

Belongs to the WD repeat rae1 family.Curated
Contains 7 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0647. Eukaryota.
ENOG410XQ1M. LUCA.
GeneTreeiENSGT00530000063440.
HOGENOMiHOG000208823.
HOVERGENiHBG002942.
InParanoidiQ7ZWF0.
KOiK14298.
OMAiKGHEYYN.
OrthoDBiEOG7H792F.
PhylomeDBiQ7ZWF0.
TreeFamiTF105481.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 2 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 4 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 3 hits.
PS50294. WD_REPEATS_REGION. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7ZWF0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLFGTNTGF GSGGTGVFGS TTTDSHNPMK DVEVTSPPDD SISCLAFSPP
60 70 80 90 100
TMPGNFLIGG SWANDVRCWE VQDNGQTVPK AQQMHTGPVL DVCWSDDGSK
110 120 130 140 150
VFTASCDKTA KMWDLNSNQA IQIAQHEGPI RTIHWIKAPN YSCIMTGSWD
160 170 180 190 200
KTLKFWDTRS PNPMMSLQMP ERCYCADVVY PMAVVATAER GLIVYQLENQ
210 220 230 240 250
PSEFRRIESP LKHQHRCVAI FKDKQSKPTG FALGSIEGRV AIHYINPPNP
260 270 280 290 300
AKDNFTFKCH RSNGTNTATP QDIYAVNAIS FHPVHGTLAT VGSDGRFSFW
310 320 330 340 350
DKDARTKLKT SEQLDQPITA CCFNHNGNIF AYASSYDWSK GHEYYNPQKK
360
NYIFLRNAAE ELKPRNKK
Length:368
Mass (Da):41,051
Last modified:January 15, 2008 - v2
Checksum:i0A9FAD27C9291BF7
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti40 – 401D → E in AAH49445 (Ref. 1) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC049445 mRNA. Translation: AAH49445.1.
BC065853 mRNA. Translation: AAH65853.1.
RefSeqiNP_957292.1. NM_200998.1.
UniGeneiDr.75426.

Genome annotation databases

EnsembliENSDART00000020333; ENSDARP00000015105; ENSDARG00000007196.
GeneIDi393973.
KEGGidre:393973.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC049445 mRNA. Translation: AAH49445.1.
BC065853 mRNA. Translation: AAH65853.1.
RefSeqiNP_957292.1. NM_200998.1.
UniGeneiDr.75426.

3D structure databases

ProteinModelPortaliQ7ZWF0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000015105.

Proteomic databases

PaxDbiQ7ZWF0.
PRIDEiQ7ZWF0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000020333; ENSDARP00000015105; ENSDARG00000007196.
GeneIDi393973.
KEGGidre:393973.

Organism-specific databases

CTDi8480.
ZFINiZDB-GENE-040426-1029. rae1.

Phylogenomic databases

eggNOGiKOG0647. Eukaryota.
ENOG410XQ1M. LUCA.
GeneTreeiENSGT00530000063440.
HOGENOMiHOG000208823.
HOVERGENiHBG002942.
InParanoidiQ7ZWF0.
KOiK14298.
OMAiKGHEYYN.
OrthoDBiEOG7H792F.
PhylomeDBiQ7ZWF0.
TreeFamiTF105481.

Enzyme and pathway databases

ReactomeiR-DRE-159236. Transport of Mature mRNA derived from an Intron-Containing Transcript.
R-DRE-170822. Regulation of Glucokinase by Glucokinase Regulatory Protein.
R-DRE-3108214. SUMOylation of DNA damage response and repair proteins.
R-DRE-3301854. Nuclear Pore Complex (NPC) Disassembly.
R-DRE-3371453. Regulation of HSF1-mediated heat shock response.
R-DRE-4570464. SUMOylation of RNA binding proteins.
R-DRE-5578749. Transcriptional regulation by small RNAs.

Miscellaneous databases

PROiQ7ZWF0.

Gene expression databases

BgeeiQ7ZWF0.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 2 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 4 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 3 hits.
PS50294. WD_REPEATS_REGION. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiRAE1L_DANRE
AccessioniPrimary (citable) accession number: Q7ZWF0
Secondary accession number(s): Q6P037
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: July 6, 2016
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.