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Q7ZWE9

- KCY_DANRE

UniProt

Q7ZWE9 - KCY_DANRE

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Protein

UMP-CMP kinase

Gene
cmpk, cmpk1
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity By similarity.UniRule annotation

Catalytic activityi

ATP + (d)CMP = ADP + (d)CDP.UniRule annotation
ATP + UMP = ADP + UDP.UniRule annotation
ATP + nucleoside diphosphate = ADP + nucleoside triphosphate.UniRule annotation

Cofactori

Binds 1 magnesium ion per monomer By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei39 – 391NMP By similarity
Binding sitei100 – 1001CMP By similarity
Binding sitei134 – 1341ATP By similarity
Binding sitei140 – 1401NMP By similarity
Binding sitei151 – 1511NMP By similarity
Binding sitei179 – 1791ATP; via carbonyl oxygen By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi13 – 186ATP By similarity
Nucleotide bindingi61 – 633NMP By similarity
Nucleotide bindingi93 – 964NMP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. cytidylate kinase activity Source: UniProtKB-EC
  3. nucleoside diphosphate kinase activity Source: UniProtKB

GO - Biological processi

  1. nucleoside diphosphate phosphorylation Source: UniProtKB
  2. nucleoside triphosphate biosynthetic process Source: UniProtKB
  3. pyrimidine nucleotide biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Pyrimidine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
UMP-CMP kinase (EC:2.7.4.14)
Alternative name(s):
Deoxycytidylate kinase
Short name:
CK
Short name:
dCMP kinase
Nucleoside-diphosphate kinase (EC:2.7.4.6)
Uridine monophosphate/cytidine monophosphate kinase
Short name:
UMP/CMP kinase
Short name:
UMP/CMPK
Gene namesi
Name:cmpk
Synonyms:cmpk1
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
ProteomesiUP000000437: Unplaced

Organism-specific databases

ZFINiZDB-GENE-040426-2113. cmpk.

Subcellular locationi

Nucleus By similarity. Cytoplasm By similarity
Note: Predominantly nuclear By similarity.UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 196196UMP-CMP kinaseUniRule annotationPRO_0000292025Add
BLAST

Expressioni

Gene expression databases

BgeeiQ7ZWE9.

Interactioni

Subunit structurei

Monomer By similarity.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ7ZWE9.
SMRiQ7ZWE9. Positions 3-195.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni33 – 6331NMPbind By similarityAdd
BLAST
Regioni133 – 14311LID By similarityAdd
BLAST

Domaini

Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis By similarity.UniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0563.
HOVERGENiHBG108060.
InParanoidiQ7ZWE9.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00235. Adenylate_kinase_Adk.
MF_03172. Adenylate_kinase_UMP_CMP_kin.
InterProiIPR000850. Adenylat/UMP-CMP_kin.
IPR027417. P-loop_NTPase.
IPR006266. UMP_CMP_kinase.
[Graphical view]
PANTHERiPTHR23359. PTHR23359. 1 hit.
PRINTSiPR00094. ADENYLTKNASE.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR01359. UMP_CMP_kin_fam. 1 hit.
PROSITEiPS00113. ADENYLATE_KINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7ZWE9-1 [UniParc]FASTAAdd to Basket

« Hide

MKPQVVFVLG GPGAGKGTQC ARIVENYSYT HLSAGDLLRE ERSRTDSEFG    50
QLIDSYIKEG KIVPVQITIN LLRKAMEETM KADEKKFRFL IDGFPRNQDN 100
LQGWNTEMDG KADVKFVLFF DCSNEVCIDR CLERGKSSGR TDDNRESLEK 150
RIQTYLQSTR PIIELYEKQG KVQRIDASRS VDEVFADVKN ILEKDD 196
Length:196
Mass (Da):22,423
Last modified:June 26, 2007 - v2
Checksum:iC86279CB8E589811
GO

Sequence cautioni

The sequence AAH49446.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC049446 mRNA. Translation: AAH49446.1. Different initiation.
UniGeneiDr.24327.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC049446 mRNA. Translation: AAH49446.1 . Different initiation.
UniGenei Dr.24327.

3D structure databases

ProteinModelPortali Q7ZWE9.
SMRi Q7ZWE9. Positions 3-195.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

ZFINi ZDB-GENE-040426-2113. cmpk.

Phylogenomic databases

eggNOGi COG0563.
HOVERGENi HBG108060.
InParanoidi Q7ZWE9.

Miscellaneous databases

NextBioi 20817993.
PROi Q7ZWE9.

Gene expression databases

Bgeei Q7ZWE9.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
HAMAPi MF_00235. Adenylate_kinase_Adk.
MF_03172. Adenylate_kinase_UMP_CMP_kin.
InterProi IPR000850. Adenylat/UMP-CMP_kin.
IPR027417. P-loop_NTPase.
IPR006266. UMP_CMP_kinase.
[Graphical view ]
PANTHERi PTHR23359. PTHR23359. 1 hit.
PRINTSi PR00094. ADENYLTKNASE.
SUPFAMi SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR01359. UMP_CMP_kin_fam. 1 hit.
PROSITEi PS00113. ADENYLATE_KINASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiKCY_DANRE
AccessioniPrimary (citable) accession number: Q7ZWE9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: June 26, 2007
Last modified: April 16, 2014
This is version 74 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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