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Protein

Protein pelota homolog

Gene

pelo

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Required for normal chromosome segregation during cell division and genomic stability (By similarity). May function in recognizing stalled ribosomes and triggering endonucleolytic cleavage of the mRNA, a mechanism to release non-functional ribosomes and degrade damaged mRNAs. May have ribonuclease activity (Potential).By similarityCurated

Cofactori

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Endonuclease, Hydrolase, Nuclease

Keywords - Biological processi

Cell cycle, Cell division

Keywords - Ligandi

Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein pelota homolog (EC:3.1.-.-)
Gene namesi
Name:pelo
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 12

Organism-specific databases

ZFINiZDB-GENE-040426-1074. pelo.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002328381 – 385Protein pelota homologAdd BLAST385

Proteomic databases

PaxDbiQ7ZWC4.
PRIDEiQ7ZWC4.

Expressioni

Gene expression databases

BgeeiENSDARG00000055477.
ExpressionAtlasiQ7ZWC4. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000072295.

Structurei

3D structure databases

ProteinModelPortaliQ7ZWC4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The N-terminal domain has the RNA-binding Sm fold. It may harbor the endoribonuclease activity (Potential).Curated

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2869. Eukaryota.
COG1537. LUCA.
GeneTreeiENSGT00390000016326.
HOGENOMiHOG000184162.
HOVERGENiHBG053560.
InParanoidiQ7ZWC4.
KOiK06965.
OMAiAFYGKKH.
OrthoDBiEOG091G0AVP.
PhylomeDBiQ7ZWC4.
TreeFamiTF105733.

Family and domain databases

Gene3Di3.30.1330.30. 1 hit.
InterProiIPR005140. eRF1_1_Pelota.
IPR005141. eRF1_2.
IPR005142. eRF1_3.
IPR029064. L30e-like.
IPR004405. Transl-rel_pelota.
[Graphical view]
PANTHERiPTHR10853. PTHR10853. 1 hit.
PfamiPF03463. eRF1_1. 1 hit.
PF03464. eRF1_2. 1 hit.
PF03465. eRF1_3. 1 hit.
[Graphical view]
SMARTiSM01194. eRF1_1. 1 hit.
[Graphical view]
SUPFAMiSSF55315. SSF55315. 1 hit.
TIGRFAMsiTIGR00111. pelota. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7ZWC4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLVHKDIEK DNAGQVTLIP DEAEDMWHTY NLLQVGDSLR ASTIRKVQTE
60 70 80 90 100
SSTGSVGSSR VRTTLTLCVE TIDFDSQACQ LRVKGTNIQE NQYVKMGAYH
110 120 130 140 150
TIELELNRKF TLAKKVWDSV VLDRIEQACD PAQKADVAAV VMQEGLANLV
160 170 180 190 200
LVTPAMTLLR AKVEVTIPRK RKGSCTQHDK ALERFYEAVM QGILRHFNFD
210 220 230 240 250
VVKCILVASP GFVKDQFISY LFKEAVRQDC KLLLENRSKF MVVHSSSGHK
260 270 280 290 300
YSLKEVLCDP AVTARLSDTK AAGEVKALED FYKMLQQEPD RAFYGLAHVE
310 320 330 340 350
RASEALAIDI LLISDTLFRH QDVATRGRYV RLVDNVKENG GTVRIFSSLH
360 370 380
VSGEQLNQLS GVAAILRFPI ADVSEPEENS SSDED
Length:385
Mass (Da):43,081
Last modified:June 1, 2003 - v1
Checksum:iAA75F54A20B1157A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC049484 mRNA. Translation: AAH49484.1.
RefSeqiNP_957430.1. NM_201136.1.
UniGeneiDr.75205.

Genome annotation databases

EnsembliENSDART00000077829; ENSDARP00000072295; ENSDARG00000055477.
GeneIDi394111.
KEGGidre:394111.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC049484 mRNA. Translation: AAH49484.1.
RefSeqiNP_957430.1. NM_201136.1.
UniGeneiDr.75205.

3D structure databases

ProteinModelPortaliQ7ZWC4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000072295.

Proteomic databases

PaxDbiQ7ZWC4.
PRIDEiQ7ZWC4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000077829; ENSDARP00000072295; ENSDARG00000055477.
GeneIDi394111.
KEGGidre:394111.

Organism-specific databases

CTDi53918.
ZFINiZDB-GENE-040426-1074. pelo.

Phylogenomic databases

eggNOGiKOG2869. Eukaryota.
COG1537. LUCA.
GeneTreeiENSGT00390000016326.
HOGENOMiHOG000184162.
HOVERGENiHBG053560.
InParanoidiQ7ZWC4.
KOiK06965.
OMAiAFYGKKH.
OrthoDBiEOG091G0AVP.
PhylomeDBiQ7ZWC4.
TreeFamiTF105733.

Miscellaneous databases

PROiQ7ZWC4.

Gene expression databases

BgeeiENSDARG00000055477.
ExpressionAtlasiQ7ZWC4. baseline and differential.

Family and domain databases

Gene3Di3.30.1330.30. 1 hit.
InterProiIPR005140. eRF1_1_Pelota.
IPR005141. eRF1_2.
IPR005142. eRF1_3.
IPR029064. L30e-like.
IPR004405. Transl-rel_pelota.
[Graphical view]
PANTHERiPTHR10853. PTHR10853. 1 hit.
PfamiPF03463. eRF1_1. 1 hit.
PF03464. eRF1_2. 1 hit.
PF03465. eRF1_3. 1 hit.
[Graphical view]
SMARTiSM01194. eRF1_1. 1 hit.
[Graphical view]
SUPFAMiSSF55315. SSF55315. 1 hit.
TIGRFAMsiTIGR00111. pelota. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPELO_DANRE
AccessioniPrimary (citable) accession number: Q7ZWC4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: June 1, 2003
Last modified: November 30, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.