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Q7ZW24 (ALG11_DANRE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase

EC=2.4.1.131
Alternative name(s):
Asparagine-linked glycosylation protein 11 homolog
Glycolipid 2-alpha-mannosyltransferase
Gene names
Name:alg11
OrganismDanio rerio (Zebrafish) (Brachydanio rerio) [Reference proteome]
Taxonomic identifier7955 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Protein attributes

Sequence length500 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

2 GDP-alpha-D-mannose + D-Man-alpha-(1->3)-(D-Man-alpha-(1->6))-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol = 2 GDP + D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-(D-Man-alpha-(1->6))-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol.

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Sequence similarities

Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.

Sequence caution

The sequence AAH45321.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Cellular componentMembrane
   DomainTransmembrane
Transmembrane helix
   Molecular functionGlycosyltransferase
Transferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processbiosynthetic process

Inferred from electronic annotation. Source: InterPro

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionGDP-Man:Man3GlcNAc2-PP-Dol alpha-1,2-mannosyltransferase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 500500GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase
PRO_0000295619

Regions

Transmembrane21 – 4121Helical; Potential
Transmembrane226 – 24621Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
Q7ZW24 [UniParc].

Last modified July 24, 2007. Version 2.
Checksum: CF3A77A19CE21836

FASTA50056,623
        10         20         30         40         50         60 
MSAHDHFSLC LCDLIRLLWS LMLPCFYLSF LLTTILFLFI MGVRSWLQMK RKTRRVQDGR 

        70         80         90        100        110        120 
PAVAFFHPYC NAGGGGERVL WCALRALQNR YQDVSFVVYT GDQGVTAEEI LDGARRRFNI 

       130        140        150        160        170        180 
RLPRPVKFVF LKHRLLVEAK LYPHFTLLGQ SVGSIFLGWE ALTEFVPDLY IDSMGFAFTL 

       190        200        210        220        230        240 
PVFRYLGGCQ VGSYVHYPTI STDMLSVVRE RNPRFNNADY ISSNPVLSAI KVIYYCVFAL 

       250        260        270        280        290        300 
LYGLAGSCSD VIMVNSTWTL GHILALWRTP NRTSVVYPPC DVQAFLDVPI GEDNEEKEQK 

       310        320        330        340        350        360 
KCHSLVSVGQ FRPEKDHQLQ IRAFKKLLDR KEAEPAGREA VKLVLIGGCR NQEDEDRVLM 

       370        380        390        400        410        420 
LRGLCQELGI ADRVEFKLNI PFQELKKDLT DATIGLHTMW NEHFGIGIVE CMAAGTIILA 

       430        440        450        460        470        480 
HKSGGPKLDI VVPYDGGPTG FLADDEDNYA DAMERILSMS PATRLEMRRR ARLSVSRFSD 

       490        500 
QEFEGSFLSA MEPLMSTLRA 

« Hide

References

[1]NIH - Zebrafish Gene Collection (ZGC) project
Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: AB.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC045321 mRNA. Translation: AAH45321.1. Different initiation.
UniGeneDr.78139.

3D structure databases

ProteinModelPortalQ7ZW24.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING7955.ENSDARP00000049513.

Protein family/group databases

CAZyGT4. Glycosyltransferase Family 4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

ZFINZDB-GENE-030131-7282. alg11.

Phylogenomic databases

eggNOGCOG0438.
HOGENOMHOG000209670.
HOVERGENHBG057178.
InParanoidQ7ZW24.
PhylomeDBQ7ZW24.

Family and domain databases

InterProIPR001296. Glyco_trans_1.
[Graphical view]
PfamPF00534. Glycos_transf_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

PROQ7ZW24.

Entry information

Entry nameALG11_DANRE
AccessionPrimary (citable) accession number: Q7ZW24
Entry history
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: July 24, 2007
Last modified: April 16, 2014
This is version 60 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families