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Protein

S-adenosylmethionine synthase

Gene

mat1a

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the formation of S-adenosylmethionine from methionine and ATP.UniRule annotation

Catalytic activityi

ATP + L-methionine + H2O = phosphate + diphosphate + S-adenosyl-L-methionine.UniRule annotation

Cofactori

Protein has several cofactor binding sites:
  • K+UniRule annotationNote: Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.UniRule annotation
  • Mg2+UniRule annotationNote: Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.UniRule annotation

Pathwayi: S-adenosyl-L-methionine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes S-adenosyl-L-methionine from L-methionine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. S-adenosylmethionine synthase (mat2aa), Methionine adenosyltransferase 2 subunit beta (mat2b), S-adenosylmethionine synthase (mat2aa), S-adenosylmethionine synthase (mat2al), S-adenosylmethionine synthase (mat2ab), Methionine adenosyltransferase 2 subunit beta (mat2b), S-adenosylmethionine synthase (mat2ab), S-adenosylmethionine synthase (mat2ab), S-adenosylmethionine synthase (mat1a), S-adenosylmethionine synthase (mat2aa), Methionine adenosyltransferase 2 subunit beta (mat2b), S-adenosylmethionine synthase (mat2aa)
This subpathway is part of the pathway S-adenosyl-L-methionine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes S-adenosyl-L-methionine from L-methionine, the pathway S-adenosyl-L-methionine biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferaseUniRule annotationImported
Biological processOne-carbon metabolismUniRule annotation
LigandATP-bindingUniRule annotation, MagnesiumUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding, PotassiumUniRule annotation

Enzyme and pathway databases

ReactomeiR-DRE-156581 Methylation
R-DRE-1614635 Sulfur amino acid metabolism
R-DRE-2408508 Metabolism of ingested SeMet, Sec, MeSec into H2Se
UniPathwayiUPA00315; UER00080

Names & Taxonomyi

Protein namesi
Recommended name:
S-adenosylmethionine synthaseUniRule annotation (EC:2.5.1.6UniRule annotation)
Gene namesi
Name:mat1aImported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi

Organism-specific databases

ZFINiZDB-GENE-030131-6127 mat1a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Expressioni

Gene expression databases

BgeeiENSDARG00000039605

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000057868

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini13 – 110S-AdoMet_synt_NInterPro annotationAdd BLAST98
Domaini125 – 245S-AdoMet_synt_MInterPro annotationAdd BLAST121
Domaini247 – 383S-AdoMet_synt_CInterPro annotationAdd BLAST137

Sequence similaritiesi

Belongs to the AdoMet synthase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG1506 Eukaryota
COG0192 LUCA
GeneTreeiENSGT00500000044811
HOGENOMiHOG000245710
HOVERGENiHBG001562
KOiK00789
OMAiSEFPWEI
OrthoDBiEOG091G08Z2
TreeFamiTF300511

Family and domain databases

HAMAPiMF_00086 S_AdoMet_synth1, 1 hit
InterProiView protein in InterPro
IPR022631 ADOMET_SYNTHASE_CS
IPR022630 S-AdoMet_synt_C
IPR022629 S-AdoMet_synt_central
IPR022628 S-AdoMet_synt_N
IPR002133 S-AdoMet_synthetase
IPR022636 S-AdoMet_synthetase_sfam
PANTHERiPTHR11964 PTHR11964, 1 hit
PfamiView protein in Pfam
PF02773 S-AdoMet_synt_C, 1 hit
PF02772 S-AdoMet_synt_M, 1 hit
PF00438 S-AdoMet_synt_N, 1 hit
PIRSFiPIRSF000497 MAT, 1 hit
SUPFAMiSSF55973 SSF55973, 3 hits
TIGRFAMsiTIGR01034 metK, 1 hit
PROSITEiView protein in PROSITE
PS00376 ADOMET_SYNTHASE_1, 1 hit
PS00377 ADOMET_SYNTHASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q7ZW04-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEGLNDVHDD GSFMFTSESV GEGHPDKICD QISDAVLDAH LKQDPDAKVA
60 70 80 90 100
CETVCKTGMV LLCGEITSRA NVDYQKIVRD TIKHIGYDNS EKGFDYKTCN
110 120 130 140 150
VLVALEQQSP DIAQGVHVDR HEEDIGAGDQ GLMFGYATDE TEECMPLTIV
160 170 180 190 200
LAHKLNSKMA ELRRDGTIPW LRPDSKTQVT VHYKQENGAV IPLRVHTVVI
210 220 230 240 250
SVQHDDNISL EEQQRILKEK VIKAVVPARY LDDKTVYHLQ PSGRFVIGGP
260 270 280 290 300
QGDAGVTGRK IIVDTYGGWG AHGGGAFSGK DYTKVDRSAA YAARWVAKSL
310 320 330 340 350
VKSKLCRRVL VQVSYAIGVA HPLSISLFTY GSSEKTEKEL LHIVNKNFDL
360 370 380 390
RPGVIVRDLN LKRPFYQNTA CYGHFGRSEF PWEMAKTLKV
Length:390
Mass (Da):43,289
Last modified:June 1, 2003 - v1
Checksum:i253AC38E7639B437
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR932438 Genomic DNA No translation available.
BC045343 mRNA Translation: AAH45343.1
BC164484 mRNA Translation: AAI64484.1
RefSeqiNP_956165.1, NM_199871.1
UniGeneiDr.76807

Genome annotation databases

EnsembliENSDART00000057869; ENSDARP00000057868; ENSDARG00000039605
GeneIDi334195
KEGGidre:334195

Similar proteinsi

Entry informationi

Entry nameiQ7ZW04_DANRE
AccessioniPrimary (citable) accession number: Q7ZW04
Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 2003
Last sequence update: June 1, 2003
Last modified: May 23, 2018
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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