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Protein

S-adenosylmethionine synthase

Gene

mat1a

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the formation of S-adenosylmethionine from methionine and ATP.UniRule annotation

Catalytic activityi

ATP + L-methionine + H2O = phosphate + diphosphate + S-adenosyl-L-methionine.UniRule annotation

Cofactori

Protein has several cofactor binding sites:
  • K+UniRule annotationNote: Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.UniRule annotation
  • Mg2+UniRule annotationNote: Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.UniRule annotation

Pathwayi: S-adenosyl-L-methionine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes S-adenosyl-L-methionine from L-methionine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. S-adenosylmethionine synthase (mat2aa), S-adenosylmethionine synthase (mat2aa), S-adenosylmethionine synthase (mat2al), S-adenosylmethionine synthase (mat2ab), Methionine adenosyltransferase 2 subunit beta (mat2b), S-adenosylmethionine synthase (mat2ab), S-adenosylmethionine synthase (mat2ab), S-adenosylmethionine synthase (mat2aa), S-adenosylmethionine synthase (mat1a), S-adenosylmethionine synthase (mat2aa)
This subpathway is part of the pathway S-adenosyl-L-methionine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes S-adenosyl-L-methionine from L-methionine, the pathway S-adenosyl-L-methionine biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

TransferaseUniRule annotationImported

Keywords - Biological processi

One-carbon metabolismUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, MagnesiumUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding, PotassiumUniRule annotation

Enzyme and pathway databases

ReactomeiR-DRE-156581. Methylation.
R-DRE-1614635. Sulfur amino acid metabolism.
R-DRE-2408508. Metabolism of ingested SeMet, Sec, MeSec into H2Se.
UniPathwayiUPA00315; UER00080.

Names & Taxonomyi

Protein namesi
Recommended name:
S-adenosylmethionine synthaseUniRule annotation (EC:2.5.1.6UniRule annotation)
Gene namesi
Name:mat1aImported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 13

Organism-specific databases

ZFINiZDB-GENE-030131-6127. mat1a.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Expressioni

Gene expression databases

BgeeiENSDARG00000039605.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000057868.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini13 – 110S-AdoMet_synt_NInterPro annotationAdd BLAST98
Domaini125 – 245S-AdoMet_synt_MInterPro annotationAdd BLAST121
Domaini247 – 383S-AdoMet_synt_CInterPro annotationAdd BLAST137

Sequence similaritiesi

Belongs to the AdoMet synthase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG1506. Eukaryota.
COG0192. LUCA.
GeneTreeiENSGT00500000044811.
HOGENOMiHOG000245710.
HOVERGENiHBG001562.
KOiK00789.
OMAiVIHINPC.
OrthoDBiEOG091G08Z2.
TreeFamiTF300511.

Family and domain databases

HAMAPiMF_00086. S_AdoMet_synth1. 1 hit.
InterProiIPR022631. ADOMET_SYNTHASE_CS.
IPR022630. S-AdoMet_synt_C.
IPR022629. S-AdoMet_synt_central.
IPR022628. S-AdoMet_synt_N.
IPR002133. S-AdoMet_synthetase.
IPR022636. S-AdoMet_synthetase_sfam.
[Graphical view]
PANTHERiPTHR11964. PTHR11964. 1 hit.
PfamiPF02773. S-AdoMet_synt_C. 1 hit.
PF02772. S-AdoMet_synt_M. 1 hit.
PF00438. S-AdoMet_synt_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000497. MAT. 1 hit.
SUPFAMiSSF55973. SSF55973. 3 hits.
TIGRFAMsiTIGR01034. metK. 1 hit.
PROSITEiPS00376. ADOMET_SYNTHASE_1. 1 hit.
PS00377. ADOMET_SYNTHASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7ZW04-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEGLNDVHDD GSFMFTSESV GEGHPDKICD QISDAVLDAH LKQDPDAKVA
60 70 80 90 100
CETVCKTGMV LLCGEITSRA NVDYQKIVRD TIKHIGYDNS EKGFDYKTCN
110 120 130 140 150
VLVALEQQSP DIAQGVHVDR HEEDIGAGDQ GLMFGYATDE TEECMPLTIV
160 170 180 190 200
LAHKLNSKMA ELRRDGTIPW LRPDSKTQVT VHYKQENGAV IPLRVHTVVI
210 220 230 240 250
SVQHDDNISL EEQQRILKEK VIKAVVPARY LDDKTVYHLQ PSGRFVIGGP
260 270 280 290 300
QGDAGVTGRK IIVDTYGGWG AHGGGAFSGK DYTKVDRSAA YAARWVAKSL
310 320 330 340 350
VKSKLCRRVL VQVSYAIGVA HPLSISLFTY GSSEKTEKEL LHIVNKNFDL
360 370 380 390
RPGVIVRDLN LKRPFYQNTA CYGHFGRSEF PWEMAKTLKV
Length:390
Mass (Da):43,289
Last modified:June 1, 2003 - v1
Checksum:i253AC38E7639B437
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR932438 Genomic DNA. No translation available.
BC045343 mRNA. Translation: AAH45343.1.
BC164484 mRNA. Translation: AAI64484.1.
RefSeqiNP_956165.1. NM_199871.1.
UniGeneiDr.76807.

Genome annotation databases

EnsembliENSDART00000057869; ENSDARP00000057868; ENSDARG00000039605.
GeneIDi334195.
KEGGidre:334195.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR932438 Genomic DNA. No translation available.
BC045343 mRNA. Translation: AAH45343.1.
BC164484 mRNA. Translation: AAI64484.1.
RefSeqiNP_956165.1. NM_199871.1.
UniGeneiDr.76807.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000057868.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000057869; ENSDARP00000057868; ENSDARG00000039605.
GeneIDi334195.
KEGGidre:334195.

Organism-specific databases

CTDi4143.
ZFINiZDB-GENE-030131-6127. mat1a.

Phylogenomic databases

eggNOGiKOG1506. Eukaryota.
COG0192. LUCA.
GeneTreeiENSGT00500000044811.
HOGENOMiHOG000245710.
HOVERGENiHBG001562.
KOiK00789.
OMAiVIHINPC.
OrthoDBiEOG091G08Z2.
TreeFamiTF300511.

Enzyme and pathway databases

UniPathwayiUPA00315; UER00080.
ReactomeiR-DRE-156581. Methylation.
R-DRE-1614635. Sulfur amino acid metabolism.
R-DRE-2408508. Metabolism of ingested SeMet, Sec, MeSec into H2Se.

Gene expression databases

BgeeiENSDARG00000039605.

Family and domain databases

HAMAPiMF_00086. S_AdoMet_synth1. 1 hit.
InterProiIPR022631. ADOMET_SYNTHASE_CS.
IPR022630. S-AdoMet_synt_C.
IPR022629. S-AdoMet_synt_central.
IPR022628. S-AdoMet_synt_N.
IPR002133. S-AdoMet_synthetase.
IPR022636. S-AdoMet_synthetase_sfam.
[Graphical view]
PANTHERiPTHR11964. PTHR11964. 1 hit.
PfamiPF02773. S-AdoMet_synt_C. 1 hit.
PF02772. S-AdoMet_synt_M. 1 hit.
PF00438. S-AdoMet_synt_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000497. MAT. 1 hit.
SUPFAMiSSF55973. SSF55973. 3 hits.
TIGRFAMsiTIGR01034. metK. 1 hit.
PROSITEiPS00376. ADOMET_SYNTHASE_1. 1 hit.
PS00377. ADOMET_SYNTHASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ7ZW04_DANRE
AccessioniPrimary (citable) accession number: Q7ZW04
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2003
Last sequence update: June 1, 2003
Last modified: November 30, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.