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Protein

Acylglycerol kinase, mitochondrial

Gene

agk

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Lipid kinase that can phosphorylate both monoacylglycerol and diacylglycerol to form lysophosphatidic acid (LPA) and phosphatidic acid (PA), respectively.By similarity

Catalytic activityi

ATP + acylglycerol = ADP + acyl-sn-glycerol 3-phosphate.
ATP + 1,2-diacyl-sn-glycerol = ADP + 1,2-diacyl-sn-glycerol 3-phosphate.

Cofactori

Mg2+By similarity

Pathwayi: glycerolipid metabolism

This protein is involved in the pathway glycerolipid metabolism, which is part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the pathway glycerolipid metabolism and in Lipid metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-DRE-1483206. Glycerophospholipid biosynthesis.
UniPathwayiUPA00230.

Names & Taxonomyi

Protein namesi
Recommended name:
Acylglycerol kinase, mitochondrial (EC:2.7.1.107, EC:2.7.1.94)
Alternative name(s):
Multiple substrate lipid kinase
Short name:
MuLK
Short name:
Multi-substrate lipid kinase
Gene namesi
Name:agk
Synonyms:mulk
ORF Names:si:ch211-238n5.3, zgc:55462
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 18

Organism-specific databases

ZFINiZDB-GENE-030131-6202. agk.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Membrane, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 34MitochondrionSequence analysisAdd BLAST34
ChainiPRO_000025238335 – 422Acylglycerol kinase, mitochondrialAdd BLAST388

Proteomic databases

PaxDbiQ7ZW00.

Expressioni

Gene expression databases

BgeeiENSDARG00000009837.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000011155.

Structurei

3D structure databases

ProteinModelPortaliQ7ZW00.
SMRiQ7ZW00.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini61 – 202DAGKcPROSITE-ProRule annotationAdd BLAST142

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG4435. Eukaryota.
COG1597. LUCA.
GeneTreeiENSGT00690000101761.
HOGENOMiHOG000252977.
HOVERGENiHBG080751.
InParanoidiQ7ZW00.
KOiK09881.
OMAiTKAAHFF.
OrthoDBiEOG091G06YD.
PhylomeDBiQ7ZW00.
TreeFamiTF320485.

Family and domain databases

Gene3Di3.40.50.10330. 1 hit.
InterProiView protein in InterPro
IPR017438. ATP-NAD_kinase_dom_1.
IPR001206. Diacylglycerol_kinase_cat_dom.
IPR016064. NAD/diacylglycerol_kinase.
PfamiView protein in Pfam
PF00781. DAGK_cat. 1 hit.
SMARTiView protein in SMART
SM00046. DAGKc. 1 hit.
SUPFAMiSSF111331. SSF111331. 2 hits.
PROSITEiView protein in PROSITE
PS50146. DAGK. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7ZW00-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARVVKVFRT LRNHWKKSTF AVCVLSYGGH WLYGNHCDSV LRREACIEAR
60 70 80 90 100
AFGQQLIGPQ EILKKATVIL NPAACKGKAN QLFEKNAAPI LHLAGVEVKI
110 120 130 140 150
VKTDYEGQAK KLMELMEQTD MLIIAGGDGT LQEVITGLLR RADEEIFSKT
160 170 180 190 200
PIGFIPLGSS NSLSQSLHLV SDNKVQHITS ATLSILKGET VPLDVLQIKG
210 220 230 240 250
EKEQPVFALL GLRWGAFRDV ATSISKYWYL GPLKTRAAHW FSSLKQWPQV
260 270 280 290 300
HVASLSYLAP VPRPPDLPDE IPQRPNLLYR IYRRLQNYWN PPLEEPPKEP
310 320 330 340 350
EPEQWESKDV STLELTVLTH NKNPVKRRVD DSMLISLDPE SLTAGQFITE
360 370 380 390 400
GTNKSVDPME PIENAVQIEA SAARLELPEE GAGFYDIDNQ EYEAMSVEVR
410 420
LLPRKLRFFC SAERREQLAE AQ
Length:422
Mass (Da):47,545
Last modified:October 17, 2006 - v2
Checksum:i856F387D221AC956
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti35N → K in AAH45347 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX470166 Genomic DNA. Translation: CAK04664.1.
BC045347 mRNA. Translation: AAH45347.1.
RefSeqiNP_956174.1. NM_199880.1.
UniGeneiDr.80681.

Genome annotation databases

EnsembliENSDART00000006109; ENSDARP00000011155; ENSDARG00000009837.
GeneIDi334270.
KEGGidre:334270.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiAGK_DANRE
AccessioniPrimary (citable) accession number: Q7ZW00
Secondary accession number(s): Q1LX48
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: October 17, 2006
Last modified: June 7, 2017
This is version 98 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways