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Q7ZW00

- AGK_DANRE

UniProt

Q7ZW00 - AGK_DANRE

Protein

Acylglycerol kinase, mitochondrial

Gene

agk

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 80 (01 Oct 2014)
      Sequence version 2 (17 Oct 2006)
      Previous versions | rss
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    Functioni

    Lipid kinase that can phosphorylate both monoacylglycerol and diacylglycerol to form lysophosphatidic acid (LPA) and phosphatidic acid (PA), respectively.By similarity

    Catalytic activityi

    ATP + acylglycerol = ADP + acyl-sn-glycerol 3-phosphate.
    ATP + 1,2-diacyl-sn-glycerol = ADP + 1,2-diacyl-sn-glycerol 3-phosphate.

    Cofactori

    Magnesium.By similarity

    Pathwayi

    GO - Molecular functioni

    1. acylglycerol kinase activity Source: UniProtKB-EC
    2. ATP binding Source: UniProtKB-KW
    3. diacylglycerol kinase activity Source: UniProtKB-EC
    4. NAD+ kinase activity Source: InterPro

    GO - Biological processi

    1. glycerolipid metabolic process Source: UniProtKB-UniPathway
    2. protein kinase C-activating G-protein coupled receptor signaling pathway Source: InterPro

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    UniPathwayiUPA00230.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Acylglycerol kinase, mitochondrial (EC:2.7.1.107, EC:2.7.1.94)
    Alternative name(s):
    Multiple substrate lipid kinase
    Short name:
    MuLK
    Short name:
    Multi-substrate lipid kinase
    Gene namesi
    Name:agk
    Synonyms:mulk
    ORF Names:si:ch211-238n5.3, zgc:55462
    OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
    Taxonomic identifieri7955 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
    ProteomesiUP000000437: Chromosome 18

    Organism-specific databases

    ZFINiZDB-GENE-030131-6202. agk.

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrial membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane, Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 3434MitochondrionSequence AnalysisAdd
    BLAST
    Chaini35 – 422388Acylglycerol kinase, mitochondrialPRO_0000252383Add
    BLAST

    Expressioni

    Gene expression databases

    BgeeiQ7ZW00.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7ZW00.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini61 – 202142DAGKcPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 DAGKc domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG1597.
    GeneTreeiENSGT00690000101761.
    HOGENOMiHOG000252977.
    HOVERGENiHBG080751.
    InParanoidiQ7ZW00.
    KOiK09881.
    OMAiTKAAHFF.
    OrthoDBiEOG7P2XS5.
    PhylomeDBiQ7ZW00.
    TreeFamiTF320485.

    Family and domain databases

    InterProiIPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR001206. Diacylglycerol_kinase_cat_dom.
    [Graphical view]
    PfamiPF00781. DAGK_cat. 1 hit.
    [Graphical view]
    SMARTiSM00046. DAGKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF111331. SSF111331. 2 hits.
    PROSITEiPS50146. DAGK. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q7ZW00-1 [UniParc]FASTAAdd to Basket

    « Hide

    MARVVKVFRT LRNHWKKSTF AVCVLSYGGH WLYGNHCDSV LRREACIEAR    50
    AFGQQLIGPQ EILKKATVIL NPAACKGKAN QLFEKNAAPI LHLAGVEVKI 100
    VKTDYEGQAK KLMELMEQTD MLIIAGGDGT LQEVITGLLR RADEEIFSKT 150
    PIGFIPLGSS NSLSQSLHLV SDNKVQHITS ATLSILKGET VPLDVLQIKG 200
    EKEQPVFALL GLRWGAFRDV ATSISKYWYL GPLKTRAAHW FSSLKQWPQV 250
    HVASLSYLAP VPRPPDLPDE IPQRPNLLYR IYRRLQNYWN PPLEEPPKEP 300
    EPEQWESKDV STLELTVLTH NKNPVKRRVD DSMLISLDPE SLTAGQFITE 350
    GTNKSVDPME PIENAVQIEA SAARLELPEE GAGFYDIDNQ EYEAMSVEVR 400
    LLPRKLRFFC SAERREQLAE AQ 422
    Length:422
    Mass (Da):47,545
    Last modified:October 17, 2006 - v2
    Checksum:i856F387D221AC956
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti35 – 351N → K in AAH45347. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX470166 Genomic DNA. Translation: CAK04664.1.
    BC045347 mRNA. Translation: AAH45347.1.
    RefSeqiNP_956174.1. NM_199880.1.
    UniGeneiDr.80681.

    Genome annotation databases

    EnsembliENSDART00000006109; ENSDARP00000011155; ENSDARG00000009837.
    GeneIDi334270.
    KEGGidre:334270.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX470166 Genomic DNA. Translation: CAK04664.1 .
    BC045347 mRNA. Translation: AAH45347.1 .
    RefSeqi NP_956174.1. NM_199880.1.
    UniGenei Dr.80681.

    3D structure databases

    ProteinModelPortali Q7ZW00.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSDART00000006109 ; ENSDARP00000011155 ; ENSDARG00000009837 .
    GeneIDi 334270.
    KEGGi dre:334270.

    Organism-specific databases

    CTDi 55750.
    ZFINi ZDB-GENE-030131-6202. agk.

    Phylogenomic databases

    eggNOGi COG1597.
    GeneTreei ENSGT00690000101761.
    HOGENOMi HOG000252977.
    HOVERGENi HBG080751.
    InParanoidi Q7ZW00.
    KOi K09881.
    OMAi TKAAHFF.
    OrthoDBi EOG7P2XS5.
    PhylomeDBi Q7ZW00.
    TreeFami TF320485.

    Enzyme and pathway databases

    UniPathwayi UPA00230 .

    Miscellaneous databases

    NextBioi 20810329.
    PROi Q7ZW00.

    Gene expression databases

    Bgeei Q7ZW00.

    Family and domain databases

    InterProi IPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR001206. Diacylglycerol_kinase_cat_dom.
    [Graphical view ]
    Pfami PF00781. DAGK_cat. 1 hit.
    [Graphical view ]
    SMARTi SM00046. DAGKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF111331. SSF111331. 2 hits.
    PROSITEi PS50146. DAGK. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The zebrafish reference genome sequence and its relationship to the human genome."
      Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.
      , White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., Clee C., Oliver K., Clark R., Riddle C., Eliott D., Threadgold G., Harden G., Ware D., Mortimer B., Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.
      Nature 496:498-503(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Tuebingen.
    2. NIH - Zebrafish Gene Collection (ZGC) project
      Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: AB.

    Entry informationi

    Entry nameiAGK_DANRE
    AccessioniPrimary (citable) accession number: Q7ZW00
    Secondary accession number(s): Q1LX48
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 17, 2006
    Last sequence update: October 17, 2006
    Last modified: October 1, 2014
    This is version 80 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3