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Protein
Submitted name:

UPF1 regulator of nonsense transcripts homolog (Yeast)

Gene

upf1

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • chordate embryonic development Source: ZFIN
  • nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Source: ZFIN
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
UPF1 regulator of nonsense transcripts homolog (Yeast)Imported
Submitted name:
Upf1 regulator of nonsense transcripts homolog (Yeast)Imported
Gene namesi
Name:upf1Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Organism-specific databases

ZFINiZDB-GENE-040426-2836. upf1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000013006.

Structurei

3D structure databases

SMRiQ7ZVZ4. Positions 97-251, 274-888.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini100 – 251152UPF1-typeInterPro annotationAdd
BLAST

Phylogenomic databases

eggNOGiKOG1802. Eukaryota.
COG1112. LUCA.
HOGENOMiHOG000205990.
HOVERGENiHBG061556.
KOiK14326.
PhylomeDBiQ7ZVZ4.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR027417. P-loop_NTPase.
IPR018999. RNA-helicase_UPF1_UPF2-interct.
[Graphical view]
PfamiPF09416. UPF1_Zn_bind. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.

Sequencei

Sequence statusi: Complete.

Q7ZVZ4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVEAYGPSS QTLTFLDTEE AELLGADTQG SEFEFTDFTL PSQTQTQGQT
60 70 80 90 100
QSQLDNQVNG PDGVLPNGED AVGKTSQLLA ELNFEEDEED TYYTKVLPVH
110 120 130 140 150
ACSYCGIHDP ACVVYCNTSK KWFCNGRGNT SGSHIVNHLV RAKCKEVTLH
160 170 180 190 200
KDGPLGETVL ECYNCGCRNV FLLGFIPAKA DSVVVLLCRQ PCASQSSLKD
210 220 230 240 250
INWDSSQWQP LIQDRCFLSW LVKIPSEQEQ LRARQITAQQ INKLEELWKE
260 270 280 290 300
NPTATLEDLE KPGVDEEPQH VLLRYEDAYQ YQNIFGPLVK LEADYDKKLK
310 320 330 340 350
ESQTQDNITV RWDLGLNKKR IAYFTLPKTD SGDMRLMQGD EICLRYKGDM
360 370 380 390 400
APLWKGIGHV IKVPDNYGDE IAIELRSSAG APVEVPHNFQ VDFVWKSTSF
410 420 430 440 450
DRMQSALKTF AVDETSVSGY IYHKLLGHEV EDVIIKCQLP KRFTAQGLPD
460 470 480 490 500
LNHSQVYAVK TVLQRPLSLI QGPPGTGKTV TSATIVYHLA RQGNGPVLVC
510 520 530 540 550
APSNIAVDQL TEKIHQTGLK VVRLCAKSRE AIDSPVSFLA LHNQIRNMDS
560 570 580 590 600
MPELQKLQQL KDETGELSSS DEKRYRALKR TAERELLMNA DVICCTCVGA
610 620 630 640 650
GDPRLAKMQF RSILIDESTQ ATEPECMVPV VLGAKQLILV GDHCQLGPVV
660 670 680 690 700
MCKKAAKAGL SQSLFERLVV LGIRPIRLQV QYRMHPALSA FPSNIFYEGS
710 720 730 740 750
LQNGVTAADR LKKGFDFQWP QPDKPMFFYV TQGQEEIASS GTSYLNRTEA
760 770 780 790 800
ANVEKITTRL LKAGAKPDQI GIITPYEGQR SYLVQYMQFS GSLHTKLYQE
810 820 830 840 850
VEIASVDAFQ GREKDFIILS CVRANEHQGI GFLNDPRRLN VALTRARYGV
860 870 880 890 900
IIVGNPKALS KQPLWNHLLN YYKEQKVLVE GPLNNLRESL MQFSKPRKLV
910 920 930 940 950
NTINPGARFM STAMYDAREA MIPGSVYDRS STGRPSNMYF QTHDQVGMIG
960 970 980 990 1000
TGPNPMGSLN IPIPFNLVMP PMPPPGYLGQ VNGPAAGRGA PKGKTGGRGG
1010 1020 1030 1040 1050
RQRNRGTGNH GSGQPNMPNS QASQDLVSQP FSQGPLTQGY ITMSQPSQMS
1060 1070 1080 1090 1100
QPGLSQPELS QDSYLGDEFK SQMDVALSQD STYQGERAYQ HGGVTGLSQY
Length:1,100
Mass (Da):122,063
Last modified:June 1, 2003 - v1
Checksum:i3215FEBDDC63E3CB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC045353 mRNA. Translation: AAH45353.1.
FM986817 mRNA. Translation: CAX18770.1.
RefSeqiNP_998639.1. NM_213474.1.
UniGeneiDr.96025.

Genome annotation databases

GeneIDi406783.
KEGGidre:406783.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC045353 mRNA. Translation: AAH45353.1.
FM986817 mRNA. Translation: CAX18770.1.
RefSeqiNP_998639.1. NM_213474.1.
UniGeneiDr.96025.

3D structure databases

SMRiQ7ZVZ4. Positions 97-251, 274-888.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000013006.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi406783.
KEGGidre:406783.

Organism-specific databases

CTDi5976.
ZFINiZDB-GENE-040426-2836. upf1.

Phylogenomic databases

eggNOGiKOG1802. Eukaryota.
COG1112. LUCA.
HOGENOMiHOG000205990.
HOVERGENiHBG061556.
KOiK14326.
PhylomeDBiQ7ZVZ4.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR027417. P-loop_NTPase.
IPR018999. RNA-helicase_UPF1_UPF2-interct.
[Graphical view]
PfamiPF09416. UPF1_Zn_bind. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: ABImported.
    Tissue: Whole bodyImported.
  2. "Nonsense-mediated mRNA decay effectors are essential for zebrafish embryonic development and survival."
    Wittkopp N., Huntzinger E., Weiler C., Sauliere J., Schmidt S., Sonawane M., Izaurralde E.
    Mol. Cell. Biol. 29:3517-3528(2009)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: TUEImported.

Entry informationi

Entry nameiQ7ZVZ4_DANRE
AccessioniPrimary (citable) accession number: Q7ZVZ4
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2003
Last sequence update: June 1, 2003
Last modified: June 8, 2016
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.