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Q7ZVY5

- CISY_DANRE

UniProt

Q7ZVY5 - CISY_DANRE

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Protein

Citrate synthase, mitochondrial

Gene

cs

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Acetyl-CoA + H2O + oxaloacetate = citrate + CoA.PROSITE-ProRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei303 – 3031PROSITE-ProRule annotation
Active sitei349 – 3491PROSITE-ProRule annotation
Active sitei404 – 4041PROSITE-ProRule annotation

GO - Molecular functioni

  1. citrate (Si)-synthase activity Source: UniProtKB

GO - Biological processi

  1. carbohydrate metabolic process Source: UniProtKB
  2. cellular carbohydrate metabolic process Source: InterPro
  3. response to activity Source: ZFIN
  4. tricarboxylic acid cycle Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Tricarboxylic acid cycle

Enzyme and pathway databases

UniPathwayiUPA00223; UER00717.

Names & Taxonomyi

Protein namesi
Recommended name:
Citrate synthase, mitochondrial (EC:2.3.3.1)
Alternative name(s):
Citrate (Si)-synthase
Gene namesi
Name:cs
ORF Names:zgc:55507
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
ProteomesiUP000000437: Unplaced

Organism-specific databases

ZFINiZDB-GENE-030131-1058. cs.

Subcellular locationi

Mitochondrion matrix By similarity

GO - Cellular componenti

  1. mitochondrial matrix Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 3030MitochondrionBy similarityAdd
BLAST
Chaini31 – 468438Citrate synthase, mitochondrialPRO_0000253902Add
BLAST

Proteomic databases

PRIDEiQ7ZVY5.

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ7ZVY5.
SMRiQ7ZVY5. Positions 30-466.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the citrate synthase family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0372.
HOGENOMiHOG000130831.
HOVERGENiHBG005336.
InParanoidiQ7ZVY5.
KOiK01647.
PhylomeDBiQ7ZVY5.

Family and domain databases

Gene3Di1.10.580.10. 1 hit.
InterProiIPR016142. Citrate_synth-like_lrg_a-sub.
IPR002020. Citrate_synthase-like.
IPR016141. Citrate_synthase-like_core.
IPR019810. Citrate_synthase_AS.
IPR010109. Citrate_synthase_euk.
[Graphical view]
PANTHERiPTHR11739. PTHR11739. 1 hit.
PfamiPF00285. Citrate_synt. 1 hit.
[Graphical view]
PRINTSiPR00143. CITRTSNTHASE.
SUPFAMiSSF48256. SSF48256. 1 hit.
TIGRFAMsiTIGR01793. cit_synth_euk. 1 hit.
PROSITEiPS00480. CITRATE_SYNTHASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7ZVY5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSFLSISRLA PRLLSSKNAA CVVVAARNAS ASTNLKDVLS DLVPKEQSRI
60 70 80 90 100
KNFKQQYGKT SIGQITVDMV YGGMRGVKGL VYETSVLDPD EGIRFRGYSI
110 120 130 140 150
PECQQLLPKA PGGEEPLPEG LFWLLVTGQV PTEEQVSWLS KEWAKRAALP
160 170 180 190 200
SHVVTMLDNF PTNLHPMSQF SAAITALNSE SSFARAYSEG VNKAKYWEFV
210 220 230 240 250
YEDSMDLIAK LPCVAAKIYR NLYREGSSIG AIDSNLDWSH NFTNMLGYTE
260 270 280 290 300
PQFTELMRLY LTIHSDHEGG NVSAHTSHLV GSALSDPYLS FSAAMNGLAG
310 320 330 340 350
PLHGLANQEV LVWLTALQKE LGGEVSDEKM RDYIWNTLKS GRVVPGYGHA
360 370 380 390 400
VLRKTDPRYT CQREFALKHL PNDPMFKLVA QLYKIVPNVL LEQGKAKNPW
410 420 430 440 450
PNVDAHSGVL LQYYGMTEMN YYTVLFGVSR ALGVLAQLVW SRALGFPLER
460
PKSMSTDGLM ALVGAKSG
Length:468
Mass (Da):51,751
Last modified:June 1, 2003 - v1
Checksum:i81F3D0260317065F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC045362 mRNA. Translation: AAH45362.1.
RefSeqiNP_955892.1. NM_199598.1.
UniGeneiDr.2432.

Genome annotation databases

GeneIDi322339.
KEGGidre:322339.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC045362 mRNA. Translation: AAH45362.1 .
RefSeqi NP_955892.1. NM_199598.1.
UniGenei Dr.2432.

3D structure databases

ProteinModelPortali Q7ZVY5.
SMRi Q7ZVY5. Positions 30-466.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q7ZVY5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 322339.
KEGGi dre:322339.

Organism-specific databases

CTDi 1431.
ZFINi ZDB-GENE-030131-1058. cs.

Phylogenomic databases

eggNOGi COG0372.
HOGENOMi HOG000130831.
HOVERGENi HBG005336.
InParanoidi Q7ZVY5.
KOi K01647.
PhylomeDBi Q7ZVY5.

Enzyme and pathway databases

UniPathwayi UPA00223 ; UER00717 .

Miscellaneous databases

NextBioi 20807760.
PROi Q7ZVY5.

Family and domain databases

Gene3Di 1.10.580.10. 1 hit.
InterProi IPR016142. Citrate_synth-like_lrg_a-sub.
IPR002020. Citrate_synthase-like.
IPR016141. Citrate_synthase-like_core.
IPR019810. Citrate_synthase_AS.
IPR010109. Citrate_synthase_euk.
[Graphical view ]
PANTHERi PTHR11739. PTHR11739. 1 hit.
Pfami PF00285. Citrate_synt. 1 hit.
[Graphical view ]
PRINTSi PR00143. CITRTSNTHASE.
SUPFAMi SSF48256. SSF48256. 1 hit.
TIGRFAMsi TIGR01793. cit_synth_euk. 1 hit.
PROSITEi PS00480. CITRATE_SYNTHASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: AB.

Entry informationi

Entry nameiCISY_DANRE
AccessioniPrimary (citable) accession number: Q7ZVY5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: June 1, 2003
Last modified: October 1, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Citrate synthase is found in nearly all cells capable of oxidative metabolism.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3