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Q7ZVY5 (CISY_DANRE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 85. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Citrate synthase, mitochondrial

EC=2.3.3.1
Alternative name(s):
Citrate (Si)-synthase
Gene names
Name:cs
ORF Names:zgc:55507
OrganismDanio rerio (Zebrafish) (Brachydanio rerio) [Reference proteome]
Taxonomic identifier7955 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Protein attributes

Sequence length468 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

Acetyl-CoA + H2O + oxaloacetate = citrate + CoA.

Pathway

Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 1/2.

Subunit structure

Homodimer By similarity.

Subcellular location

Mitochondrion matrix By similarity.

Miscellaneous

Citrate synthase is found in nearly all cells capable of oxidative metabolism.

Sequence similarities

Belongs to the citrate synthase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 3030Mitochondrion By similarity
Chain31 – 468438Citrate synthase, mitochondrial
PRO_0000253902

Sites

Active site3031 By similarity
Active site3491 By similarity
Active site4041 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q7ZVY5 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: 81F3D0260317065F

FASTA46851,751
        10         20         30         40         50         60 
MSFLSISRLA PRLLSSKNAA CVVVAARNAS ASTNLKDVLS DLVPKEQSRI KNFKQQYGKT 

        70         80         90        100        110        120 
SIGQITVDMV YGGMRGVKGL VYETSVLDPD EGIRFRGYSI PECQQLLPKA PGGEEPLPEG 

       130        140        150        160        170        180 
LFWLLVTGQV PTEEQVSWLS KEWAKRAALP SHVVTMLDNF PTNLHPMSQF SAAITALNSE 

       190        200        210        220        230        240 
SSFARAYSEG VNKAKYWEFV YEDSMDLIAK LPCVAAKIYR NLYREGSSIG AIDSNLDWSH 

       250        260        270        280        290        300 
NFTNMLGYTE PQFTELMRLY LTIHSDHEGG NVSAHTSHLV GSALSDPYLS FSAAMNGLAG 

       310        320        330        340        350        360 
PLHGLANQEV LVWLTALQKE LGGEVSDEKM RDYIWNTLKS GRVVPGYGHA VLRKTDPRYT 

       370        380        390        400        410        420 
CQREFALKHL PNDPMFKLVA QLYKIVPNVL LEQGKAKNPW PNVDAHSGVL LQYYGMTEMN 

       430        440        450        460 
YYTVLFGVSR ALGVLAQLVW SRALGFPLER PKSMSTDGLM ALVGAKSG 

« Hide

References

[1]NIH - Zebrafish Gene Collection (ZGC) project
Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: AB.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC045362 mRNA. Translation: AAH45362.1.
RefSeqNP_955892.1. NM_199598.1.
UniGeneDr.2432.

3D structure databases

ProteinModelPortalQ7ZVY5.
SMRQ7ZVY5. Positions 30-466.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEQ7ZVY5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID322339.
KEGGdre:322339.

Organism-specific databases

CTD1431.
ZFINZDB-GENE-030131-1058. cs.

Phylogenomic databases

eggNOGCOG0372.
HOGENOMHOG000130831.
HOVERGENHBG005336.
InParanoidQ7ZVY5.
KOK01647.
PhylomeDBQ7ZVY5.

Enzyme and pathway databases

UniPathwayUPA00223; UER00717.

Family and domain databases

Gene3D1.10.580.10. 1 hit.
InterProIPR016142. Citrate_synth-like_lrg_a-sub.
IPR002020. Citrate_synthase-like.
IPR016141. Citrate_synthase-like_core.
IPR019810. Citrate_synthase_AS.
IPR010109. Citrate_synthase_euk.
[Graphical view]
PANTHERPTHR11739. PTHR11739. 1 hit.
PfamPF00285. Citrate_synt. 1 hit.
[Graphical view]
PRINTSPR00143. CITRTSNTHASE.
SUPFAMSSF48256. SSF48256. 1 hit.
TIGRFAMsTIGR01793. cit_synth_euk. 1 hit.
PROSITEPS00480. CITRATE_SYNTHASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20807760.
PROQ7ZVY5.

Entry information

Entry nameCISY_DANRE
AccessionPrimary (citable) accession number: Q7ZVY5
Entry history
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: June 1, 2003
Last modified: May 14, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways