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Q7ZVY5

- CISY_DANRE

UniProt

Q7ZVY5 - CISY_DANRE

Protein

Citrate synthase, mitochondrial

Gene

cs

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 86 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Acetyl-CoA + H2O + oxaloacetate = citrate + CoA.PROSITE-ProRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei303 – 3031PROSITE-ProRule annotation
    Active sitei349 – 3491PROSITE-ProRule annotation
    Active sitei404 – 4041PROSITE-ProRule annotation

    GO - Molecular functioni

    1. citrate (Si)-synthase activity Source: UniProtKB

    GO - Biological processi

    1. carbohydrate metabolic process Source: UniProtKB
    2. cellular carbohydrate metabolic process Source: InterPro
    3. response to activity Source: ZFIN
    4. tricarboxylic acid cycle Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Tricarboxylic acid cycle

    Enzyme and pathway databases

    UniPathwayiUPA00223; UER00717.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Citrate synthase, mitochondrial (EC:2.3.3.1)
    Alternative name(s):
    Citrate (Si)-synthase
    Gene namesi
    Name:cs
    ORF Names:zgc:55507
    OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
    Taxonomic identifieri7955 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
    ProteomesiUP000000437: Unplaced

    Organism-specific databases

    ZFINiZDB-GENE-030131-1058. cs.

    Subcellular locationi

    Mitochondrion matrix By similarity

    GO - Cellular componenti

    1. mitochondrial matrix Source: UniProtKB

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 3030MitochondrionBy similarityAdd
    BLAST
    Chaini31 – 468438Citrate synthase, mitochondrialPRO_0000253902Add
    BLAST

    Proteomic databases

    PRIDEiQ7ZVY5.

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ7ZVY5.
    SMRiQ7ZVY5. Positions 30-466.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the citrate synthase family.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG0372.
    HOGENOMiHOG000130831.
    HOVERGENiHBG005336.
    InParanoidiQ7ZVY5.
    KOiK01647.
    PhylomeDBiQ7ZVY5.

    Family and domain databases

    Gene3Di1.10.580.10. 1 hit.
    InterProiIPR016142. Citrate_synth-like_lrg_a-sub.
    IPR002020. Citrate_synthase-like.
    IPR016141. Citrate_synthase-like_core.
    IPR019810. Citrate_synthase_AS.
    IPR010109. Citrate_synthase_euk.
    [Graphical view]
    PANTHERiPTHR11739. PTHR11739. 1 hit.
    PfamiPF00285. Citrate_synt. 1 hit.
    [Graphical view]
    PRINTSiPR00143. CITRTSNTHASE.
    SUPFAMiSSF48256. SSF48256. 1 hit.
    TIGRFAMsiTIGR01793. cit_synth_euk. 1 hit.
    PROSITEiPS00480. CITRATE_SYNTHASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q7ZVY5-1 [UniParc]FASTAAdd to Basket

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    MSFLSISRLA PRLLSSKNAA CVVVAARNAS ASTNLKDVLS DLVPKEQSRI    50
    KNFKQQYGKT SIGQITVDMV YGGMRGVKGL VYETSVLDPD EGIRFRGYSI 100
    PECQQLLPKA PGGEEPLPEG LFWLLVTGQV PTEEQVSWLS KEWAKRAALP 150
    SHVVTMLDNF PTNLHPMSQF SAAITALNSE SSFARAYSEG VNKAKYWEFV 200
    YEDSMDLIAK LPCVAAKIYR NLYREGSSIG AIDSNLDWSH NFTNMLGYTE 250
    PQFTELMRLY LTIHSDHEGG NVSAHTSHLV GSALSDPYLS FSAAMNGLAG 300
    PLHGLANQEV LVWLTALQKE LGGEVSDEKM RDYIWNTLKS GRVVPGYGHA 350
    VLRKTDPRYT CQREFALKHL PNDPMFKLVA QLYKIVPNVL LEQGKAKNPW 400
    PNVDAHSGVL LQYYGMTEMN YYTVLFGVSR ALGVLAQLVW SRALGFPLER 450
    PKSMSTDGLM ALVGAKSG 468
    Length:468
    Mass (Da):51,751
    Last modified:June 1, 2003 - v1
    Checksum:i81F3D0260317065F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC045362 mRNA. Translation: AAH45362.1.
    RefSeqiNP_955892.1. NM_199598.1.
    UniGeneiDr.2432.

    Genome annotation databases

    GeneIDi322339.
    KEGGidre:322339.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC045362 mRNA. Translation: AAH45362.1 .
    RefSeqi NP_955892.1. NM_199598.1.
    UniGenei Dr.2432.

    3D structure databases

    ProteinModelPortali Q7ZVY5.
    SMRi Q7ZVY5. Positions 30-466.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q7ZVY5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 322339.
    KEGGi dre:322339.

    Organism-specific databases

    CTDi 1431.
    ZFINi ZDB-GENE-030131-1058. cs.

    Phylogenomic databases

    eggNOGi COG0372.
    HOGENOMi HOG000130831.
    HOVERGENi HBG005336.
    InParanoidi Q7ZVY5.
    KOi K01647.
    PhylomeDBi Q7ZVY5.

    Enzyme and pathway databases

    UniPathwayi UPA00223 ; UER00717 .

    Miscellaneous databases

    NextBioi 20807760.
    PROi Q7ZVY5.

    Family and domain databases

    Gene3Di 1.10.580.10. 1 hit.
    InterProi IPR016142. Citrate_synth-like_lrg_a-sub.
    IPR002020. Citrate_synthase-like.
    IPR016141. Citrate_synthase-like_core.
    IPR019810. Citrate_synthase_AS.
    IPR010109. Citrate_synthase_euk.
    [Graphical view ]
    PANTHERi PTHR11739. PTHR11739. 1 hit.
    Pfami PF00285. Citrate_synt. 1 hit.
    [Graphical view ]
    PRINTSi PR00143. CITRTSNTHASE.
    SUPFAMi SSF48256. SSF48256. 1 hit.
    TIGRFAMsi TIGR01793. cit_synth_euk. 1 hit.
    PROSITEi PS00480. CITRATE_SYNTHASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Zebrafish Gene Collection (ZGC) project
      Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: AB.

    Entry informationi

    Entry nameiCISY_DANRE
    AccessioniPrimary (citable) accession number: Q7ZVY5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 17, 2006
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 86 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Citrate synthase is found in nearly all cells capable of oxidative metabolism.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3