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Protein

Spindle assembly abnormal protein 6 homolog

Gene

sass6

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Central scaffolding component of the centrioles ensuring their 9-fold symmetry (PubMed:21273447). Required for centrosome biogenesis and duplication: required both for mother-centriole-dependent centriole duplication and deuterosome-dependent centriole amplification in multiciliated cells (By similarity).By similarity1 Publication

GO - Biological processi

  • centriole replication Source: UniProtKB
  • centrosome duplication Source: ZFIN
  • embryonic cleavage Source: ZFIN
  • mitotic spindle organization Source: ZFIN
  • nuclear division Source: ZFIN
  • spermatogenesis Source: ZFIN

Keywordsi

Biological processCell cycle

Names & Taxonomyi

Protein namesi
Recommended name:
Spindle assembly abnormal protein 6 homolog
Gene namesi
Name:sass6
Synonyms:sas6
ORF Names:zgc:55668
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Unplaced

Organism-specific databases

ZFINiZDB-GENE-040426-2784 sass6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001899751 – 627Spindle assembly abnormal protein 6 homologAdd BLAST627

Proteomic databases

PaxDbiQ7ZVT3

Interactioni

Subunit structurei

Nine homodimers form a cartwheel structure with an internal diameter of 23 nM and radial spokes connecting to the microtubule triplets.1 Publication

Protein-protein interaction databases

STRINGi7955.ENSDARP00000075634

Structurei

Secondary structure

1627
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi2 – 15Combined sources14
Beta strandi17 – 19Combined sources3
Beta strandi22 – 33Combined sources12
Beta strandi36 – 40Combined sources5
Beta strandi43 – 50Combined sources8
Beta strandi53 – 62Combined sources10
Helixi64 – 74Combined sources11
Helixi80 – 82Combined sources3
Helixi83 – 97Combined sources15
Beta strandi100 – 102Combined sources3
Beta strandi104 – 110Combined sources7
Beta strandi115 – 117Combined sources3
Beta strandi121 – 127Combined sources7
Beta strandi134 – 143Combined sources10
Helixi146 – 153Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2Y3VX-ray1.92A/B/C/D1-156[»]
2Y3WX-ray1.98A/B/C1-179[»]
ProteinModelPortaliQ7ZVT3
SMRiQ7ZVT3
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ7ZVT3

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini39 – 91PISAAdd BLAST53

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili153 – 473Sequence analysisAdd BLAST321

Domaini

The 35 nM long coiled-coil domain mediates homodimerization while the globular N-terminus links the dimers at an angle of 40 degrees to form the inner ring.1 Publication

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IF03 Eukaryota
ENOG410XQWJ LUCA
HOGENOMiHOG000124668
HOVERGENiHBG079167
InParanoidiQ7ZVT3
KOiK16487
PhylomeDBiQ7ZVT3

Family and domain databases

Gene3Di2.170.210.20, 1 hit
InterProiView protein in InterPro
IPR032396 SAS-6_N
IPR038558 SAS-6_N_sf
PfamiView protein in Pfam
PF16531 SAS-6_N, 1 hit

Sequencei

Sequence statusi: Complete.

Q7ZVT3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTELLFNKRL QVLVKSKDTD ERRSVIRVSI ELQLPSSPVH RKDLVVRLTD
60 70 80 90 100
DTDLYFLYNL IISEEDFQSL KVQQGLLIDF TSFPQKFIDL LEQCICEQDK
110 120 130 140 150
ESPRFLLQLS SSSSAFDHSP SNLNIVETNA FKHLTHLSLK LLPGSDTDIK
160 170 180 190 200
KYLASCLSSV KEEKQQLQQK LRKTEEDLTR QLNYAQQTLS EKSRELDKLR
210 220 230 240 250
SEWTSQTTSL SSRHMQDLTA EREKALETQS RLQQQNEQLR QELESSHHRS
260 270 280 290 300
TQQLQTKVSE LETANRELID KKYKSDSTIR DLKAKLTSLE EECQRSKQQV
310 320 330 340 350
LSLRRENSAL DSECHEKERL LNQLQTRVAV LEQEIKDKDQ LVLRTKEVLE
360 370 380 390 400
ATQQQKNSVE GNAESKQLQI SKLESTVKSL SEELIKANGI IKKLQADLKA
410 420 430 440 450
LLGKIKVKNS VTVPQEKILQ ETSDKLQRQQ RELQDTQQRL SLKEEEAAKL
460 470 480 490 500
KEQLEATVQK LDESREVLKT NENVITWLNK QLNENQLSRK QETVAMFETP
510 520 530 540 550
AAALRSAAVP HNMAFPITST INSKYPLALS CVSSGSRSVL TSSNGPKVQF
560 570 580 590 600
NPMSVKPSAA EVSPAAFSQP ANKENSEPVG LDSKYFERRD DSIPLRGLLP
610 620
SMHLNREVPK PLNTAAAKAT PSAFFPG
Length:627
Mass (Da):71,315
Last modified:June 1, 2003 - v1
Checksum:i068636706A28E4E7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC045420 mRNA Translation: AAH45420.1
RefSeqiNP_998603.1, NM_213438.1
UniGeneiDr.77479

Genome annotation databases

GeneIDi406747
KEGGidre:406747

Similar proteinsi

Entry informationi

Entry nameiSAS6_DANRE
AccessioniPrimary (citable) accession number: Q7ZVT3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: June 1, 2003
Last modified: March 28, 2018
This is version 76 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health