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Protein

Hexokinase

Gene

hk2

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + D-hexose = ADP + D-hexose 6-phosphate.UniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. hexokinase activity Source: InterPro

GO - Biological processi

  1. glycolytic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotationSAAS annotation, Transferase

Keywords - Biological processi

GlycolysisUniRule annotationSAAS annotation

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
HexokinaseUniRule annotation (EC:2.7.1.1UniRule annotation)
Gene namesi
Name:hk2Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Organism-specific databases

ZFINiZDB-GENE-040426-2017. hk2.

PTM / Processingi

Proteomic databases

PRIDEiQ7ZVL7.

Structurei

3D structure databases

ProteinModelPortaliQ7ZVL7.
SMRiQ7ZVL7. Positions 17-916.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the hexokinase family.UniRule annotation
Contains 2 hexokinase type-1 domains.UniRule annotation
Contains 2 hexokinase type-2 domains.UniRule annotation

Phylogenomic databases

eggNOGiCOG5026.
HOVERGENiHBG005020.
KOiK00844.
PhylomeDBiQ7ZVL7.

Family and domain databases

InterProiIPR001312. Hexokinase.
IPR022673. Hexokinase_C.
IPR019807. Hexokinase_CS.
IPR022672. Hexokinase_N.
[Graphical view]
PANTHERiPTHR19443. PTHR19443. 1 hit.
PfamiPF00349. Hexokinase_1. 2 hits.
PF03727. Hexokinase_2. 2 hits.
[Graphical view]
PRINTSiPR00475. HEXOKINASE.
PROSITEiPS00378. HEXOKINASES. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7ZVL7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIATQLLAYY FTELHHDHVQ KVDKYLYHMR LSNENLMDVS KRFRKEMDKG
60 70 80 90 100
LGRDTNPTAA VKMLPTFVRS TPDGTETGDF LALDLGGTNF RVLLVKVSSN
110 120 130 140 150
GMQKVEMENQ IYAISENIMR GCGSELFDHI AECLANFLEK LGIKEKKLPL
160 170 180 190 200
GFTFSFPCQQ TKLDESFLVS WTKGFKASGV EGKDVVSLLR KAIRKRGDFD
210 220 230 240 250
IDIVAVINDT VGTMMTCGYD DHHCEIGLIV GTGTNACYME EMRHLELVDG
260 270 280 290 300
DEGRMCVNME WGAFGDDGAL DDLRTEFDRE IDAGSLNPGK QLFEKMISGM
310 320 330 340 350
YMGELVRLIL VKMAKDGLLF QGHTTPDLLT TGHFQTSFVS AIENRKDDEG
360 370 380 390 400
IVSAEQVLRG LGLDPTPEDC VATQRVCQIV STRAAHLCAA SLAAVLRQIR
410 420 430 440 450
DNKASDRLRT SIGVDGSVYK NHPEFARRLN KMVRSLVPDC DVRFLRSEDG
460 470 480 490 500
SGKGAAMVTA VAYRLAKQHA ERQRVLDTLR LGRDQLLEVK KRMEEEMKRG
510 520 530 540 550
LAKKTHNNAT VKMLPTFVRS TPDGTERGDF LALDLGGTNF RVLLVRVRGG
560 570 580 590 600
KRRNVEMNNK IYTIPQDITQ GTGEELFDHI VHCIADFLEY MGMKGASLPL
610 620 630 640 650
GFTFSFPCHQ DKLDQGILIK WTKGFKASGC EGEDVASLLK DAIHRCEEFD
660 670 680 690 700
LDVVAVVNDT VGTMMTCGYE DPQCEVGLIV GTGTNACYME EMSNVELVDG
710 720 730 740 750
DEGRMCVNME WGAFGDQGEL DDIWTEFDRA VDDQSTYPGR QRYEKMISGM
760 770 780 790 800
YLGEIVRNVL LHFTAKGLLF RGKLSERLKT RGIFETKFLS QIESDRLALR
810 820 830 840 850
QVRSILQHLG LTSSTCDDSI LVKEVCSVVS KRAAQLCGAG LAAVVDKIRL
860 870 880 890 900
NRGLNQLSIT VGVDGTLYKL HPHFATIMRE TLRDLAPNCE VSLVQSEDGS
910
GKGAALITAV ACRLRDAGK
Length:919
Mass (Da):102,163
Last modified:June 1, 2003 - v1
Checksum:iBC330D143D6A2891
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC045496 mRNA. Translation: AAH45496.1.
RefSeqiNP_998231.1. NM_213066.1.
UniGeneiDr.80401.

Genome annotation databases

GeneIDi406339.
KEGGidre:406339.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC045496 mRNA. Translation: AAH45496.1.
RefSeqiNP_998231.1. NM_213066.1.
UniGeneiDr.80401.

3D structure databases

ProteinModelPortaliQ7ZVL7.
SMRiQ7ZVL7. Positions 17-916.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ7ZVL7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi406339.
KEGGidre:406339.

Organism-specific databases

CTDi3099.
ZFINiZDB-GENE-040426-2017. hk2.

Phylogenomic databases

eggNOGiCOG5026.
HOVERGENiHBG005020.
KOiK00844.
PhylomeDBiQ7ZVL7.

Miscellaneous databases

NextBioi20817959.

Family and domain databases

InterProiIPR001312. Hexokinase.
IPR022673. Hexokinase_C.
IPR019807. Hexokinase_CS.
IPR022672. Hexokinase_N.
[Graphical view]
PANTHERiPTHR19443. PTHR19443. 1 hit.
PfamiPF00349. Hexokinase_1. 2 hits.
PF03727. Hexokinase_2. 2 hits.
[Graphical view]
PRINTSiPR00475. HEXOKINASE.
PROSITEiPS00378. HEXOKINASES. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: ABImported.
    Tissue: Whole bodyImported.

Entry informationi

Entry nameiQ7ZVL7_DANRE
AccessioniPrimary (citable) accession number: Q7ZVL7
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2003
Last sequence update: June 1, 2003
Last modified: April 1, 2015
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.