Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

NAD-dependent protein deacetylase sirtuin-2

Gene

sirt2

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Probable NAD-dependent protein deacetylase.By similarity

Catalytic activityi

NAD+ + an acetylprotein = nicotinamide + O-acetyl-ADP-ribose + a protein.PROSITE-ProRule annotation

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei185 – 1851Proton acceptorPROSITE-ProRule annotation
Metal bindingi193 – 1931ZincPROSITE-ProRule annotation
Metal bindingi198 – 1981ZincPROSITE-ProRule annotation
Metal bindingi219 – 2191ZincPROSITE-ProRule annotation
Metal bindingi222 – 2221ZincPROSITE-ProRule annotation
Binding sitei321 – 3211NAD; via amide nitrogenBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi82 – 10221NADBy similarityAdd
BLAST
Nucleotide bindingi165 – 1684NADBy similarity
Nucleotide bindingi259 – 2613NADBy similarity
Nucleotide bindingi284 – 2863NADBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Metal-binding, NAD, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
NAD-dependent protein deacetylase sirtuin-2 (EC:3.5.1.-)
Alternative name(s):
Regulatory protein SIR2 homolog 2
SIR2-like protein 2
Gene namesi
Name:sirt2
ORF Names:zgc:77003
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Unplaced

Organism-specific databases

ZFINiZDB-GENE-030131-1028. sirt2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 379379NAD-dependent protein deacetylase sirtuin-2PRO_0000110262Add
BLAST

Proteomic databases

PaxDbiQ7ZVK3.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000003412.

Structurei

3D structure databases

ProteinModelPortaliQ7ZVK3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini63 – 337275Deacetylase sirtuin-typePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the sirtuin family. Class I subfamily.Curated
Contains 1 deacetylase sirtuin-type domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2682. Eukaryota.
COG0846. LUCA.
HOGENOMiHOG000085952.
HOVERGENiHBG057095.
InParanoidiQ7ZVK3.
KOiK11412.
PhylomeDBiQ7ZVK3.

Family and domain databases

Gene3Di3.30.1600.10. 2 hits.
3.40.50.1220. 3 hits.
InterProiIPR029035. DHS-like_NAD/FAD-binding_dom.
IPR003000. Sirtuin.
IPR026591. Sirtuin_cat_small_dom.
IPR017328. Sirtuin_class_I.
IPR026590. Ssirtuin_cat_dom.
[Graphical view]
PANTHERiPTHR11085. PTHR11085. 1 hit.
PfamiPF02146. SIR2. 1 hit.
[Graphical view]
PIRSFiPIRSF037938. SIR2_euk. 1 hit.
SUPFAMiSSF52467. SSF52467. 1 hit.
PROSITEiPS50305. SIRTUIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7ZVK3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEEVSKRVE EEADTPGLEG QSDDSSDEGD ASGDTEMDFL RSLFSRTLGL
60 70 80 90 100
SPGDKVLDEL TLDSVARYIL SGKCKNIICM VGAGISTSAG IPDFRSPGTG
110 120 130 140 150
LYANLQKYNL PYPEAIFQID YFKKHPEPFF ALARELYPGQ FKPTVYHYFI
160 170 180 190 200
KMLKDKGLLR RCYSQNIDTL ERVAGLEGED LIEAHGTFHT SHCVSFLCRK
210 220 230 240 250
EYSMDWMKNQ IFSEEIPKCD SCGSLVKPDI VFFGESLPSR FFTSMKADFP
260 270 280 290 300
QCDLLIIMGT SLQVQPFASL VSRVSNRCPR LLINMEKTGQ SEFGMGLFSF
310 320 330 340 350
GGGMDFDSDK AYRDVAHLST CDDGCMTLAE LLGWKKELEE MVKREHALID
360 370
SKDAKKTDKE ASQSSKSAVA EAEKTDKTE
Length:379
Mass (Da):42,315
Last modified:June 1, 2003 - v1
Checksum:i1FD8A103DA2EC325
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC045510 mRNA. Translation: AAH45510.1.
RefSeqiNP_955890.1. NM_199596.1.
UniGeneiDr.13057.

Genome annotation databases

GeneIDi322309.
KEGGidre:322309.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC045510 mRNA. Translation: AAH45510.1.
RefSeqiNP_955890.1. NM_199596.1.
UniGeneiDr.13057.

3D structure databases

ProteinModelPortaliQ7ZVK3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000003412.

Proteomic databases

PaxDbiQ7ZVK3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi322309.
KEGGidre:322309.

Organism-specific databases

CTDi22933.
ZFINiZDB-GENE-030131-1028. sirt2.

Phylogenomic databases

eggNOGiKOG2682. Eukaryota.
COG0846. LUCA.
HOGENOMiHOG000085952.
HOVERGENiHBG057095.
InParanoidiQ7ZVK3.
KOiK11412.
PhylomeDBiQ7ZVK3.

Miscellaneous databases

PROiQ7ZVK3.

Family and domain databases

Gene3Di3.30.1600.10. 2 hits.
3.40.50.1220. 3 hits.
InterProiIPR029035. DHS-like_NAD/FAD-binding_dom.
IPR003000. Sirtuin.
IPR026591. Sirtuin_cat_small_dom.
IPR017328. Sirtuin_class_I.
IPR026590. Ssirtuin_cat_dom.
[Graphical view]
PANTHERiPTHR11085. PTHR11085. 1 hit.
PfamiPF02146. SIR2. 1 hit.
[Graphical view]
PIRSFiPIRSF037938. SIR2_euk. 1 hit.
SUPFAMiSSF52467. SSF52467. 1 hit.
PROSITEiPS50305. SIRTUIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSIR2_DANRE
AccessioniPrimary (citable) accession number: Q7ZVK3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2003
Last sequence update: June 1, 2003
Last modified: June 8, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.