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Q7ZVJ4 (Q7ZVJ4_DANRE) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
L-lactate dehydrogenase RuleBase RU000496
EC=1.1.1.27 RuleBase RU000496
Gene names
Name:ldha EMBL AAH45838.1
OrganismDanio rerio (Zebrafish) (Brachydanio rerio) EMBL AAH45838.1
Taxonomic identifier7955 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Cyprinidae › Danio

Protein attributes

Sequence length333 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

(S)-lactate + NAD+ = pyruvate + NADH. RuleBase RU000496

Pathway

Fermentation; pyruvate fermentation to lactate; (S)-lactate from pyruvate: step 1/1. RuleBase RU000496

Sequence similarities

Belongs to the LDH/MDH superfamily. LDH family. RuleBase RU004149

Ontologies

Keywords
   Biological processGlycolysis RuleBase RU000496
   LigandNAD RuleBase RU000496
   Molecular functionOxidoreductase RuleBase RU000496
Gene Ontology (GO)
   Biological processglycolysis

Inferred from electronic annotation. Source: UniProtKB-KW

response to hypoxia

Inferred from direct assay. Source: ZFIN

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: InterPro

   Molecular functionL-lactate dehydrogenase activity

Inferred from electronic annotation. Source: EC

nucleotide binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequences

Sequence LengthMass (Da)Tools
Q7ZVJ4 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: 016EA21B1322AED9

FASTA33336,274
        10         20         30         40         50         60 
MASTKEKLIA HVSKEQPAGP TNKVTVVGVG MVGMAAAVSI LLKDLTDELA LVDVMEDKLK 

        70         80         90        100        110        120 
GEAMDLQHGS LFLKTHKIVA DKDYSVTANS KVVVVTAGAR QQEGESRLNL VQRNVNIFKF 

       130        140        150        160        170        180 
IIPNIIRYSP NCILLVVSNP VDILTYVAWK LSGLPRNRVI GSGTNLDSAR FRYLMGEKLG 

       190        200        210        220        230        240 
IHPSSCHGWV VGEHGDSSVP VWSGVNVAGV SLQALNPDLG TDKDKEDWKS VHKMVVDSAY 

       250        260        270        280        290        300 
EVIKLKGYTS WAIGMSVADL CESILKNMHK CHPVSTLVKG MHGVNEEVFL SVPCILGNNG 

       310        320        330 
LTDVVHMTLK PEEEKQLVKS AETLWGVQKE LTL

« Hide

References

[1]NIH - Zebrafish Gene Collection (ZGC) project
Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Whole body EMBL AAH45838.1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BC045838 mRNA. Translation: AAH45838.1.
IPIIPI00512269.
UniGeneDr.4212.

3D structure databases

HSSPHSSP built from PDB template 9LDT based on UniProtKB P00339.
ProteinModelPortalQ7ZVJ4.
SMRQ7ZVJ4. Positions 2-333.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ7ZVJ4.

Proteomic databases

PRIDEQ7ZVJ4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

ZFINZDB-GENE-991026-5. ldha.

Phylogenomic databases

eggNOGfiNOG04784.
HOVERGENHBG000462.
InParanoidQ7ZVJ4.

Gene expression databases

ArrayExpressQ7ZVJ4.
BgeeQ7ZVJ4.

Family and domain databases

HAMAPMF_00488. Lactate_dehydrog.
[Tree]
InterProIPR001557. L-lactate/malate_DH.
IPR011304. L-lactate_DH.
IPR018177. L-lactate_DH_AS.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
Gene3DG3DSA:3.90.110.10. lact_mal_DH. 1 hit.
G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PfamPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSPR00086. LLDHDRGNASE.
SUPFAMSSF56327. Lactate_DH/Glyco_hydro_4_C. 1 hit.
TIGRFAMsTIGR01771. L-LDH-NAD. 1 hit.
PROSITEPS00064. L_LDH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameQ7ZVJ4_DANRE
AccessionPrimary (citable) accession number: Q7ZVJ4
Entry history
Integrated into UniProtKB/TrEMBL: June 1, 2003
Last sequence update: June 1, 2003
Last modified: December 14, 2011
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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