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Protein
Submitted name:

Nuclear factor (Erythroid-derived 2)-like 2

Gene

nfe2l2a

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • DNA binding Source: ZFIN
  • protein heterodimerization activity Source: ZFIN
  • transcription factor activity, sequence-specific DNA binding Source: InterPro
  • transcription regulatory region sequence-specific DNA binding Source: ZFIN

GO - Biological processi

  • cellular response to oxidative stress Source: ZFIN
  • cellular response to prostaglandin stimulus Source: ZFIN
  • cellular response to xenobiotic stimulus Source: ZFIN
  • positive regulation of transcription, DNA-templated Source: ZFIN
  • regulation of transcription, DNA-templated Source: ZFIN
  • regulation of transcription from RNA polymerase II promoter Source: GO_Central
  • response to oxidative stress Source: ZFIN
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionDNA-bindingSAAS annotation
Biological processTranscription, Transcription regulationSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Nuclear factor (Erythroid-derived 2)-like 2Imported
Submitted name:
Nuclear factor, erythroid 2-like 2aImported
Gene namesi
Name:nfe2l2aImported
Synonyms:nfe2l2Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 9

Organism-specific databases

ZFINiZDB-GENE-030723-2. nfe2l2a.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Expressioni

Gene expression databases

BgeeiENSDARG00000042824.

Interactioni

GO - Molecular functioni

  • protein heterodimerization activity Source: ZFIN

Protein-protein interaction databases

STRINGi7955.ENSDARP00000062853.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini478 – 541BZIPInterPro annotationAdd BLAST64

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili44 – 75Sequence analysisAdd BLAST32
Coiled coili496 – 537Sequence analysisAdd BLAST42

Sequence similaritiesi

Belongs to the bZIP family.SAAS annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiENOG410ISV3. Eukaryota.
ENOG41100FB. LUCA.
GeneTreeiENSGT00890000139356.
HOVERGENiHBG052609.
OMAiALHIPFP.
OrthoDBiEOG091G02EB.
TreeFamiTF326681.

Family and domain databases

Gene3Di1.10.880.10. 1 hit.
InterProiView protein in InterPro
IPR004827. bZIP.
IPR004826. bZIP_Maf.
IPR029845. Nrf2.
IPR008917. TF_DNA-bd_sf.
PANTHERiPTHR24411:SF3. PTHR24411:SF3. 1 hit.
PfamiView protein in Pfam
PF03131. bZIP_Maf. 1 hit.
SMARTiView protein in SMART
SM00338. BRLZ. 1 hit.
SUPFAMiSSF47454. SSF47454. 1 hit.
PROSITEiView protein in PROSITE
PS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7ZVI2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMEIEMSKMQ PSQQDMDLID ILWRQDVDLG AGREVFDFSY RQKEVELRRR
60 70 80 90 100
REQEEQELQE RLQEQEKTLL AQLQLDEETG EFLPRSTPLT HTPEADGGGA
110 120 130 140 150
GEITQNGAFA EQEADPMSFD ECMQLLAETF PLTEPAESAP PCLNTSAPPS
160 170 180 190 200
TDLMMPADVP AFTQNPLLPG SLDQAWMELL SLPELQQCLN MQMQETLDMN
210 220 230 240 250
AFMKPSTEAP TQNYGQYLPG MDHLGSAQTE VCPPEFTNTY NGSFNTMVSP
260 270 280 290 300
NMNQLSLNVP DVGAEFGPEE FNELFYPEME VKVNNPPITS DGGNMVGDPP
310 320 330 340 350
VNPIDLQSFS PGDFSSGKPD PIVEFQDSDS GLSLDASPHM SSPGKSITQD
360 370 380 390 400
GSFGFSDSDS EEMEGSPGSM ESDYNEIFPL VYLNDGSQTP LSEKSSTEKQ
410 420 430 440 450
EMKLKNPKME PAEASGHSKP PFTKDKLKKR SEARLSRDEQ RAKALQIPFT
460 470 480 490 500
VDMIINLPVD DFNEMMSKHQ LNEAQLALVR DIRRRGKNKV AAQNCRKRKL
510 520 530 540 550
ENIVGLEYEL DSLKEEKERL MKEKSERSSN LKEMKQQLST LYQEVFGMLR
560 570 580
DENGKAFSPN EFSLQHTADG TVFLVPRLKK TLVKNI
Length:586
Mass (Da):65,789
Last modified:June 1, 2003 - v1
Checksum:iB8D121A86C41B054
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR848724 Genomic DNA. No translation available.
BC045852 mRNA. Translation: AAH45852.1.
UniGeneiDr.155361.

Genome annotation databases

EnsembliENSDART00000062854; ENSDARP00000062853; ENSDARG00000042824.

Similar proteinsi

Entry informationi

Entry nameiQ7ZVI2_DANRE
AccessioniPrimary (citable) accession number: Q7ZVI2
Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 2003
Last sequence update: June 1, 2003
Last modified: November 22, 2017
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported