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Protein

Actin, cytoplasmic 2

Gene

actbb

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.

Miscellaneous

In vertebrates 3 main groups of actin isoforms, alpha, beta and gamma have been identified. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins coexist in most cell types as components of the cytoskeleton and as mediators of internal cell motility.

GO - Molecular functioni

Keywordsi

LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-DRE-2029482. Regulation of actin dynamics for phagocytic cup formation.
R-DRE-3928662. EPHB-mediated forward signaling.
R-DRE-437239. Recycling pathway of L1.
R-DRE-4420097. VEGFA-VEGFR2 Pathway.
R-DRE-445095. Interaction between L1 and Ankyrins.
R-DRE-446353. Cell-extracellular matrix interactions.
R-DRE-5626467. RHO GTPases activate IQGAPs.
R-DRE-5663213. RHO GTPases Activate WASPs and WAVEs.
R-DRE-5663220. RHO GTPases Activate Formins.
R-DRE-5689603. UCH proteinases.
R-DRE-5696394. DNA Damage Recognition in GG-NER.
R-DRE-8856828. Clathrin-mediated endocytosis.

Names & Taxonomyi

Protein namesi
Recommended name:
Actin, cytoplasmic 2
Alternative name(s):
Beta-actin-2
Cleaved into the following chain:
Gene namesi
Name:actbb
Synonyms:bactin2
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 3

Organism-specific databases

ZFINiZDB-GENE-000329-3. actb2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003670881 – 375Actin, cytoplasmic 2Add BLAST375
Initiator methionineiRemoved; alternateBy similarity
ChainiPRO_00000007972 – 375Actin, cytoplasmic 2, N-terminally processedAdd BLAST374

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionine; in Actin, cytoplasmic 2; alternateBy similarity1
Modified residuei2N-acetylaspartate; in Actin, cytoplasmic 2, N-terminally processedBy similarity1
Modified residuei44Methionine (R)-sulfoxideBy similarity1
Modified residuei47Methionine (R)-sulfoxideBy similarity1
Modified residuei73Tele-methylhistidineBy similarity1

Post-translational modificationi

Oxidation of Met-44 and Met-47 by MICALs (mical1, mical2 or mical3) to form methionine sulfoxide promotes actin filament depolymerization. Mical1 and mical2 produce the (R)-S-oxide form. The (R)-S-oxide form is reverted by msrb1 and msrb2, which promote actin repolymerization (By similarity).By similarity

Keywords - PTMi

Acetylation, Methylation, Oxidation

Proteomic databases

PaxDbiQ7ZVF9.
PRIDEiQ7ZVF9.

Expressioni

Gene expression databases

BgeeiENSDARG00000037870.
ExpressionAtlasiQ7ZVF9. baseline.

Interactioni

Subunit structurei

Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to 4 others.

Protein-protein interaction databases

STRINGi7955.ENSDARP00000122263.

Structurei

3D structure databases

ProteinModelPortaliQ7ZVF9.
SMRiQ7ZVF9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the actin family.Curated

Phylogenomic databases

eggNOGiKOG0676. Eukaryota.
COG5277. LUCA.
GeneTreeiENSGT00760000118957.
HOVERGENiHBG003771.
InParanoidiQ7ZVF9.
KOiK05692.
OMAiANGIHET.
OrthoDBiEOG091G08LD.
TreeFamiTF354237.

Family and domain databases

InterProiView protein in InterPro
IPR004000. Actin.
IPR020902. Actin/actin-like_CS.
IPR004001. Actin_CS.
PANTHERiPTHR11937. PTHR11937. 1 hit.
PfamiView protein in Pfam
PF00022. Actin. 1 hit.
PRINTSiPR00190. ACTIN.
SMARTiView protein in SMART
SM00268. ACTIN. 1 hit.
PROSITEiView protein in PROSITE
PS00406. ACTINS_1. 1 hit.
PS00432. ACTINS_2. 1 hit.
PS01132. ACTINS_ACT_LIKE. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7ZVF9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDDEIAALVV DNGSGMCKAG FAGDDAPRAV FPSIVGRPRH QGVMVGMGQK
60 70 80 90 100
DSYVGDEAQS KRGILTLKYP IEHGIVTNWD DMEKIWHHTF YNELRVAPEE
110 120 130 140 150
HPVLLTEAPL NPKANREKMT QIMFETFNTP AMYVAIQAVL SLYASGRTTG
160 170 180 190 200
IVMDSGDGVT HTVPIYEGYA LPHAILRLDL AGRDLTDYLM KILTERGYSF
210 220 230 240 250
TTTAEREIVR DIKEKLCYVA LDFEQEMGTA ASSSSLEKSY ELPDGQVITI
260 270 280 290 300
GNERFRCPEA LFQPSFLGME SCGIHETTFN SIMKCDVDIR KDLYANTVLS
310 320 330 340 350
GGTTMYPGIA DRMQKEITSL APSTMKIKII APPERKYSVW IGGSILASLS
360 370
TFQQMWISKQ EYDESGPSIV HRKCF
Length:375
Mass (Da):41,753
Last modified:March 7, 2006 - v2
Checksum:i6DE990BC0FBD0D19
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti49Q → R in AAH67566 (Ref. 2) Curated1
Sequence conflicti254R → G in AAH67566 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF025305 mRNA. Translation: AAB97964.1.
BC045879 mRNA. Translation: AAH45879.1.
BC067566 mRNA. Translation: AAH67566.1.
RefSeqiNP_853632.3. NM_181601.4.
UniGeneiDr.152450.

Genome annotation databases

EnsembliENSDART00000055194; ENSDARP00000055193; ENSDARG00000037870.
ENSDART00000141737; ENSDARP00000122263; ENSDARG00000037870.
GeneIDi57935.
KEGGidre:57935.

Similar proteinsi

Entry informationi

Entry nameiACTB2_DANRE
AccessioniPrimary (citable) accession number: Q7ZVF9
Secondary accession number(s): O73815, P12714, Q6NWJ6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 16, 2004
Last sequence update: March 7, 2006
Last modified: November 22, 2017
This is version 119 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families