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Protein

Actin, cytoplasmic 2

Gene

actbb

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-DRE-2029482. Regulation of actin dynamics for phagocytic cup formation.
R-DRE-3928662. EPHB-mediated forward signaling.
R-DRE-437239. Recycling pathway of L1.
R-DRE-4420097. VEGFA-VEGFR2 Pathway.
R-DRE-445095. Interaction between L1 and Ankyrins.
R-DRE-446353. Cell-extracellular matrix interactions.
R-DRE-5250924. B-WICH complex positively regulates rRNA expression.
R-DRE-5626467. RHO GTPases activate IQGAPs.
R-DRE-5663213. RHO GTPases Activate WASPs and WAVEs.
R-DRE-5696394. DNA Damage Recognition in GG-NER.

Names & Taxonomyi

Protein namesi
Recommended name:
Actin, cytoplasmic 2
Alternative name(s):
Beta-actin-2
Cleaved into the following chain:
Gene namesi
Name:actbb
Synonyms:bactin2
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 3

Organism-specific databases

ZFINiZDB-GENE-000329-3. actb2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 375375Actin, cytoplasmic 2PRO_0000367088Add
BLAST
Initiator methionineiRemoved; alternateBy similarity
Chaini2 – 375374Actin, cytoplasmic 2, N-terminally processedPRO_0000000797Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine; in Actin, cytoplasmic 2; alternateBy similarity
Modified residuei2 – 21N-acetylaspartate; in Actin, cytoplasmic 2, N-terminally processedBy similarity
Modified residuei44 – 441Methionine (R)-sulfoxideBy similarity
Modified residuei47 – 471Methionine (R)-sulfoxideBy similarity
Modified residuei73 – 731Tele-methylhistidineBy similarity

Post-translational modificationi

Oxidation of Met-44 and Met-47 by MICALs (mical1, mical2 or mical3) to form methionine sulfoxide promotes actin filament depolymerization. Mical1 and mical2 produce the (R)-S-oxide form. The (R)-S-oxide form is reverted by msrb1 and msrb2, which promote actin repolymerization (By similarity).By similarity

Keywords - PTMi

Acetylation, Methylation, Oxidation

Proteomic databases

PaxDbiQ7ZVF9.
PRIDEiQ7ZVF9.

Expressioni

Gene expression databases

BgeeiENSDARG00000037870.

Interactioni

Subunit structurei

Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to 4 others.

Protein-protein interaction databases

STRINGi7955.ENSDARP00000122263.

Structurei

3D structure databases

ProteinModelPortaliQ7ZVF9.
SMRiQ7ZVF9. Positions 2-375.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the actin family.Curated

Phylogenomic databases

eggNOGiKOG0676. Eukaryota.
COG5277. LUCA.
GeneTreeiENSGT00760000118957.
HOVERGENiHBG003771.
InParanoidiQ7ZVF9.
KOiK05692.
OMAiPFHTTAE.
OrthoDBiEOG091G08LD.
TreeFamiTF354237.

Family and domain databases

InterProiIPR004000. Actin.
IPR020902. Actin/actin-like_CS.
IPR004001. Actin_CS.
[Graphical view]
PANTHERiPTHR11937. PTHR11937. 1 hit.
PfamiPF00022. Actin. 1 hit.
[Graphical view]
PRINTSiPR00190. ACTIN.
SMARTiSM00268. ACTIN. 1 hit.
[Graphical view]
PROSITEiPS00406. ACTINS_1. 1 hit.
PS00432. ACTINS_2. 1 hit.
PS01132. ACTINS_ACT_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7ZVF9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDDEIAALVV DNGSGMCKAG FAGDDAPRAV FPSIVGRPRH QGVMVGMGQK
60 70 80 90 100
DSYVGDEAQS KRGILTLKYP IEHGIVTNWD DMEKIWHHTF YNELRVAPEE
110 120 130 140 150
HPVLLTEAPL NPKANREKMT QIMFETFNTP AMYVAIQAVL SLYASGRTTG
160 170 180 190 200
IVMDSGDGVT HTVPIYEGYA LPHAILRLDL AGRDLTDYLM KILTERGYSF
210 220 230 240 250
TTTAEREIVR DIKEKLCYVA LDFEQEMGTA ASSSSLEKSY ELPDGQVITI
260 270 280 290 300
GNERFRCPEA LFQPSFLGME SCGIHETTFN SIMKCDVDIR KDLYANTVLS
310 320 330 340 350
GGTTMYPGIA DRMQKEITSL APSTMKIKII APPERKYSVW IGGSILASLS
360 370
TFQQMWISKQ EYDESGPSIV HRKCF
Length:375
Mass (Da):41,753
Last modified:March 7, 2006 - v2
Checksum:i6DE990BC0FBD0D19
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti49 – 491Q → R in AAH67566 (Ref. 2) Curated
Sequence conflicti254 – 2541R → G in AAH67566 (Ref. 2) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF025305 mRNA. Translation: AAB97964.1.
BC045879 mRNA. Translation: AAH45879.1.
BC067566 mRNA. Translation: AAH67566.1.
RefSeqiNP_853632.3. NM_181601.4.
UniGeneiDr.152450.

Genome annotation databases

EnsembliENSDART00000055194; ENSDARP00000055193; ENSDARG00000037870.
ENSDART00000141737; ENSDARP00000122263; ENSDARG00000037870.
GeneIDi57935.
KEGGidre:57935.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF025305 mRNA. Translation: AAB97964.1.
BC045879 mRNA. Translation: AAH45879.1.
BC067566 mRNA. Translation: AAH67566.1.
RefSeqiNP_853632.3. NM_181601.4.
UniGeneiDr.152450.

3D structure databases

ProteinModelPortaliQ7ZVF9.
SMRiQ7ZVF9. Positions 2-375.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000122263.

Proteomic databases

PaxDbiQ7ZVF9.
PRIDEiQ7ZVF9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000055194; ENSDARP00000055193; ENSDARG00000037870.
ENSDART00000141737; ENSDARP00000122263; ENSDARG00000037870.
GeneIDi57935.
KEGGidre:57935.

Organism-specific databases

CTDi57935.
ZFINiZDB-GENE-000329-3. actb2.

Phylogenomic databases

eggNOGiKOG0676. Eukaryota.
COG5277. LUCA.
GeneTreeiENSGT00760000118957.
HOVERGENiHBG003771.
InParanoidiQ7ZVF9.
KOiK05692.
OMAiPFHTTAE.
OrthoDBiEOG091G08LD.
TreeFamiTF354237.

Enzyme and pathway databases

ReactomeiR-DRE-2029482. Regulation of actin dynamics for phagocytic cup formation.
R-DRE-3928662. EPHB-mediated forward signaling.
R-DRE-437239. Recycling pathway of L1.
R-DRE-4420097. VEGFA-VEGFR2 Pathway.
R-DRE-445095. Interaction between L1 and Ankyrins.
R-DRE-446353. Cell-extracellular matrix interactions.
R-DRE-5250924. B-WICH complex positively regulates rRNA expression.
R-DRE-5626467. RHO GTPases activate IQGAPs.
R-DRE-5663213. RHO GTPases Activate WASPs and WAVEs.
R-DRE-5696394. DNA Damage Recognition in GG-NER.

Miscellaneous databases

PROiQ7ZVF9.

Gene expression databases

BgeeiENSDARG00000037870.

Family and domain databases

InterProiIPR004000. Actin.
IPR020902. Actin/actin-like_CS.
IPR004001. Actin_CS.
[Graphical view]
PANTHERiPTHR11937. PTHR11937. 1 hit.
PfamiPF00022. Actin. 1 hit.
[Graphical view]
PRINTSiPR00190. ACTIN.
SMARTiSM00268. ACTIN. 1 hit.
[Graphical view]
PROSITEiPS00406. ACTINS_1. 1 hit.
PS00432. ACTINS_2. 1 hit.
PS01132. ACTINS_ACT_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiACTB2_DANRE
AccessioniPrimary (citable) accession number: Q7ZVF9
Secondary accession number(s): O73815, P12714, Q6NWJ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 16, 2004
Last sequence update: March 7, 2006
Last modified: September 7, 2016
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

In vertebrates 3 main groups of actin isoforms, alpha, beta and gamma have been identified. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins coexist in most cell types as components of the cytoskeleton and as mediators of internal cell motility.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.