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Protein

KDEL motif-containing protein 1

Gene

kdelc1

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Protein family/group databases

CAZyiGT90. Glycosyltransferase Family 90.

Names & Taxonomyi

Protein namesi
Recommended name:
KDEL motif-containing protein 1
Gene namesi
Name:kdelc1
ORF Names:si:dkey-22a1.1, zgc:56065
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Unplaced

Organism-specific databases

ZFINiZDB-GENE-040426-878. kdelc1.

Subcellular locationi

  • Endoplasmic reticulum lumen PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000024716523 – 500KDEL motif-containing protein 1Add BLAST478

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi60N-linked (GlcNAc...)Sequence analysis1
Glycosylationi259N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ7ZVE6.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000042296.

Structurei

3D structure databases

ProteinModelPortaliQ7ZVE6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati23 – 128FilaminAdd BLAST106

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi497 – 500Prevents secretion from ERPROSITE-ProRule annotation4

Sequence similaritiesi

Belongs to the KDELC family.Curated
Contains 1 filamin repeat.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG2458. Eukaryota.
ENOG410XT5U. LUCA.
HOGENOMiHOG000286007.
HOVERGENiHBG081852.
InParanoidiQ7ZVE6.
PhylomeDBiQ7ZVE6.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR017868. Filamin/ABP280_repeat-like.
IPR001298. Filamin/ABP280_rpt.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR006598. LipoPS_modifying.
[Graphical view]
PfamiPF00630. Filamin. 1 hit.
PF05686. Glyco_transf_90. 1 hit.
[Graphical view]
SMARTiSM00672. CAP10. 1 hit.
SM00557. IG_FLMN. 1 hit.
[Graphical view]
SUPFAMiSSF81296. SSF81296. 1 hit.
PROSITEiPS00014. ER_TARGET. 1 hit.
PS50194. FILAMIN_REPEAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7ZVE6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRKLLLLLM SCIIFLTRRS KAAAAASASK TLVWGPGLET NAVLPARFFF
60 70 80 90 100
IQTVDTTGTN FTTSPGENTF EVKITSPTEP YARIWIQILD RNDGSFLVRY
110 120 130 140 150
RMYASYTDLH VEVLLKDKLV GKSPYVLRGA VYHESCDCPE PDGALWEKNM
160 170 180 190 200
HCPASFSQIE SDLSIFQSVD PDRNAHEIIQ RFGKSHSLCH YTIKNNQVYI
210 220 230 240 250
KTHGEHVGFR IFMDAFLLSL TRKVKLPDIE FFVNLGDWPL EKRRASQNPS
260 270 280 290 300
PVFSWCGSND TRDIVMPTYD LTESVLETMG RVSLDMMSVQ GHTGPVWEKK
310 320 330 340 350
INKGFWRGRD SRKERLELVK LARANTAMLD AALTNFFFFK HDESLYGPLV
360 370 380 390 400
KHVSFFDFFK YKYQINVDGT VAAYRLPYLL AGDSVVFKHD SIYYEHFYNE
410 420 430 440 450
LQPWVHYIPF RSDLSDLLEK IQWAKDHDEE AKKIALAGQQ FARTHLMGDS
460 470 480 490 500
VFCYYHKLFQ KYAELQVTKP KVRDGMELVE QPKDDLFPCY CARKKVRDEL
Length:500
Mass (Da):57,802
Last modified:June 1, 2003 - v1
Checksum:iAD1C93F7F5A8D23E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti26A → P in CAP71956 (PubMed:18296487).Curated1
Sequence conflicti69T → I in CAP71956 (PubMed:18296487).Curated1
Sequence conflicti71E → V in CAP71956 (PubMed:18296487).Curated1
Sequence conflicti167Q → K in CAP71956 (PubMed:18296487).Curated1
Sequence conflicti178I → V in CAP71956 (PubMed:18296487).Curated1
Sequence conflicti323R → K in CAI20990 (PubMed:23594743).Curated1
Sequence conflicti455Y → C in CAP71956 (PubMed:18296487).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU638807 mRNA. Translation: CAP71956.1.
BX322637 Genomic DNA. Translation: CAI20990.1.
BC045893 mRNA. Translation: AAH45893.1.
RefSeqiNP_957225.1. NM_200931.1.
UniGeneiDr.82452.

Genome annotation databases

GeneIDi393905.
KEGGidre:393905.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU638807 mRNA. Translation: CAP71956.1.
BX322637 Genomic DNA. Translation: CAI20990.1.
BC045893 mRNA. Translation: AAH45893.1.
RefSeqiNP_957225.1. NM_200931.1.
UniGeneiDr.82452.

3D structure databases

ProteinModelPortaliQ7ZVE6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000042296.

Protein family/group databases

CAZyiGT90. Glycosyltransferase Family 90.

Proteomic databases

PaxDbiQ7ZVE6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi393905.
KEGGidre:393905.

Organism-specific databases

CTDi79070.
ZFINiZDB-GENE-040426-878. kdelc1.

Phylogenomic databases

eggNOGiKOG2458. Eukaryota.
ENOG410XT5U. LUCA.
HOGENOMiHOG000286007.
HOVERGENiHBG081852.
InParanoidiQ7ZVE6.
PhylomeDBiQ7ZVE6.

Miscellaneous databases

PROiQ7ZVE6.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR017868. Filamin/ABP280_repeat-like.
IPR001298. Filamin/ABP280_rpt.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR006598. LipoPS_modifying.
[Graphical view]
PfamiPF00630. Filamin. 1 hit.
PF05686. Glyco_transf_90. 1 hit.
[Graphical view]
SMARTiSM00672. CAP10. 1 hit.
SM00557. IG_FLMN. 1 hit.
[Graphical view]
SUPFAMiSSF81296. SSF81296. 1 hit.
PROSITEiPS00014. ER_TARGET. 1 hit.
PS50194. FILAMIN_REPEAT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKDEL1_DANRE
AccessioniPrimary (citable) accession number: Q7ZVE6
Secondary accession number(s): B0CM11, Q5RI39
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: June 1, 2003
Last modified: October 5, 2016
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.