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Q7ZVE6

- KDEL1_DANRE

UniProt

Q7ZVE6 - KDEL1_DANRE

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Protein

KDEL motif-containing protein 1

Gene

kdelc1

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

Protein family/group databases

CAZyiGT90. Glycosyltransferase Family 90.

Names & Taxonomyi

Protein namesi
Recommended name:
KDEL motif-containing protein 1
Gene namesi
Name:kdelc1
ORF Names:si:dkey-22a1.1, zgc:56065
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
ProteomesiUP000000437: Unplaced

Organism-specific databases

ZFINiZDB-GENE-040426-878. kdelc1.

Subcellular locationi

Endoplasmic reticulum lumen PROSITE-ProRule annotation

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence AnalysisAdd
BLAST
Chaini23 – 500478KDEL motif-containing protein 1PRO_0000247165Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi60 – 601N-linked (GlcNAc...)Sequence Analysis
Glycosylationi259 – 2591N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliQ7ZVE6.
SMRiQ7ZVE6. Positions 24-129.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati23 – 128106FilaminAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi497 – 5004Prevents secretion from ERPROSITE-ProRule annotation

Sequence similaritiesi

Belongs to the KDELC family.Curated
Contains 1 filamin repeat.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG248922.
HOGENOMiHOG000286007.
HOVERGENiHBG081852.
InParanoidiQ7ZVE6.
PhylomeDBiQ7ZVE6.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR017868. Filamin/ABP280_repeat-like.
IPR001298. Filamin/ABP280_rpt.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR006598. LipoPS_modifying.
[Graphical view]
PfamiPF00630. Filamin. 1 hit.
PF05686. Glyco_transf_90. 1 hit.
[Graphical view]
SMARTiSM00672. CAP10. 1 hit.
SM00557. IG_FLMN. 1 hit.
[Graphical view]
SUPFAMiSSF81296. SSF81296. 1 hit.
PROSITEiPS00014. ER_TARGET. 1 hit.
PS50194. FILAMIN_REPEAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7ZVE6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLRKLLLLLM SCIIFLTRRS KAAAAASASK TLVWGPGLET NAVLPARFFF
60 70 80 90 100
IQTVDTTGTN FTTSPGENTF EVKITSPTEP YARIWIQILD RNDGSFLVRY
110 120 130 140 150
RMYASYTDLH VEVLLKDKLV GKSPYVLRGA VYHESCDCPE PDGALWEKNM
160 170 180 190 200
HCPASFSQIE SDLSIFQSVD PDRNAHEIIQ RFGKSHSLCH YTIKNNQVYI
210 220 230 240 250
KTHGEHVGFR IFMDAFLLSL TRKVKLPDIE FFVNLGDWPL EKRRASQNPS
260 270 280 290 300
PVFSWCGSND TRDIVMPTYD LTESVLETMG RVSLDMMSVQ GHTGPVWEKK
310 320 330 340 350
INKGFWRGRD SRKERLELVK LARANTAMLD AALTNFFFFK HDESLYGPLV
360 370 380 390 400
KHVSFFDFFK YKYQINVDGT VAAYRLPYLL AGDSVVFKHD SIYYEHFYNE
410 420 430 440 450
LQPWVHYIPF RSDLSDLLEK IQWAKDHDEE AKKIALAGQQ FARTHLMGDS
460 470 480 490 500
VFCYYHKLFQ KYAELQVTKP KVRDGMELVE QPKDDLFPCY CARKKVRDEL
Length:500
Mass (Da):57,802
Last modified:June 1, 2003 - v1
Checksum:iAD1C93F7F5A8D23E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti26 – 261A → P in CAP71956. (PubMed:18296487)Curated
Sequence conflicti69 – 691T → I in CAP71956. (PubMed:18296487)Curated
Sequence conflicti71 – 711E → V in CAP71956. (PubMed:18296487)Curated
Sequence conflicti167 – 1671Q → K in CAP71956. (PubMed:18296487)Curated
Sequence conflicti178 – 1781I → V in CAP71956. (PubMed:18296487)Curated
Sequence conflicti323 – 3231R → K in CAI20990. (PubMed:23594743)Curated
Sequence conflicti455 – 4551Y → C in CAP71956. (PubMed:18296487)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU638807 mRNA. Translation: CAP71956.1.
BX322637 Genomic DNA. Translation: CAI20990.1.
BC045893 mRNA. Translation: AAH45893.1.
RefSeqiNP_957225.1. NM_200931.1.
UniGeneiDr.82452.

Genome annotation databases

GeneIDi393905.
KEGGidre:393905.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU638807 mRNA. Translation: CAP71956.1 .
BX322637 Genomic DNA. Translation: CAI20990.1 .
BC045893 mRNA. Translation: AAH45893.1 .
RefSeqi NP_957225.1. NM_200931.1.
UniGenei Dr.82452.

3D structure databases

ProteinModelPortali Q7ZVE6.
SMRi Q7ZVE6. Positions 24-129.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

CAZyi GT90. Glycosyltransferase Family 90.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 393905.
KEGGi dre:393905.

Organism-specific databases

CTDi 79070.
ZFINi ZDB-GENE-040426-878. kdelc1.

Phylogenomic databases

eggNOGi NOG248922.
HOGENOMi HOG000286007.
HOVERGENi HBG081852.
InParanoidi Q7ZVE6.
PhylomeDBi Q7ZVE6.

Miscellaneous databases

NextBioi 20814882.
PROi Q7ZVE6.

Family and domain databases

Gene3Di 2.60.40.10. 1 hit.
InterProi IPR017868. Filamin/ABP280_repeat-like.
IPR001298. Filamin/ABP280_rpt.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR006598. LipoPS_modifying.
[Graphical view ]
Pfami PF00630. Filamin. 1 hit.
PF05686. Glyco_transf_90. 1 hit.
[Graphical view ]
SMARTi SM00672. CAP10. 1 hit.
SM00557. IG_FLMN. 1 hit.
[Graphical view ]
SUPFAMi SSF81296. SSF81296. 1 hit.
PROSITEi PS00014. ER_TARGET. 1 hit.
PS50194. FILAMIN_REPEAT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Large-scale screening for novel low-affinity extracellular protein interactions."
    Bushell K.M., Soellner C., Schuster-Boeckler B., Bateman A., Wright G.J.
    Genome Res. 18:622-630(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. "The zebrafish reference genome sequence and its relationship to the human genome."
    Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.
    , White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., Clee C., Oliver K., Clark R., Riddle C., Eliott D., Threadgold G., Harden G., Ware D., Mortimer B., Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.
    Nature 496:498-503(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Tuebingen.
  3. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: AB.

Entry informationi

Entry nameiKDEL1_DANRE
AccessioniPrimary (citable) accession number: Q7ZVE6
Secondary accession number(s): B0CM11, Q5RI39
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: June 1, 2003
Last modified: October 29, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3