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Q7ZVE6 (KDEL1_DANRE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
KDEL motif-containing protein 1
Gene names
Name:kdelc1
ORF Names:si:dkey-22a1.1, zgc:56065
OrganismDanio rerio (Zebrafish) (Brachydanio rerio) [Reference proteome]
Taxonomic identifier7955 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Protein attributes

Sequence length500 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Endoplasmic reticulum lumen By similarity.

Sequence similarities

Belongs to the KDELC family.

Contains 1 filamin repeat.

Ontologies

Keywords
   Cellular componentEndoplasmic reticulum
   DomainSignal
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentendoplasmic reticulum lumen

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2222 Potential
Chain23 – 500478KDEL motif-containing protein 1
PRO_0000247165

Regions

Repeat23 – 128106Filamin
Motif497 – 5004Prevents secretion from ER Potential

Amino acid modifications

Glycosylation601N-linked (GlcNAc...) Potential
Glycosylation2591N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict261A → P in CAP71956. Ref.1
Sequence conflict691T → I in CAP71956. Ref.1
Sequence conflict711E → V in CAP71956. Ref.1
Sequence conflict1671Q → K in CAP71956. Ref.1
Sequence conflict1781I → V in CAP71956. Ref.1
Sequence conflict3231R → K in CAI20990. Ref.2
Sequence conflict4551Y → C in CAP71956. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q7ZVE6 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: AD1C93F7F5A8D23E

FASTA50057,802
        10         20         30         40         50         60 
MLRKLLLLLM SCIIFLTRRS KAAAAASASK TLVWGPGLET NAVLPARFFF IQTVDTTGTN 

        70         80         90        100        110        120 
FTTSPGENTF EVKITSPTEP YARIWIQILD RNDGSFLVRY RMYASYTDLH VEVLLKDKLV 

       130        140        150        160        170        180 
GKSPYVLRGA VYHESCDCPE PDGALWEKNM HCPASFSQIE SDLSIFQSVD PDRNAHEIIQ 

       190        200        210        220        230        240 
RFGKSHSLCH YTIKNNQVYI KTHGEHVGFR IFMDAFLLSL TRKVKLPDIE FFVNLGDWPL 

       250        260        270        280        290        300 
EKRRASQNPS PVFSWCGSND TRDIVMPTYD LTESVLETMG RVSLDMMSVQ GHTGPVWEKK 

       310        320        330        340        350        360 
INKGFWRGRD SRKERLELVK LARANTAMLD AALTNFFFFK HDESLYGPLV KHVSFFDFFK 

       370        380        390        400        410        420 
YKYQINVDGT VAAYRLPYLL AGDSVVFKHD SIYYEHFYNE LQPWVHYIPF RSDLSDLLEK 

       430        440        450        460        470        480 
IQWAKDHDEE AKKIALAGQQ FARTHLMGDS VFCYYHKLFQ KYAELQVTKP KVRDGMELVE 

       490        500 
QPKDDLFPCY CARKKVRDEL 

« Hide

References

[1]"Large-scale screening for novel low-affinity extracellular protein interactions."
Bushell K.M., Soellner C., Schuster-Boeckler B., Bateman A., Wright G.J.
Genome Res. 18:622-630(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[2]"The zebrafish reference genome sequence and its relationship to the human genome."
Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J. expand/collapse author list , White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., Clee C., Oliver K., Clark R., Riddle C., Eliott D., Threadgold G., Harden G., Ware D., Mortimer B., Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.
Nature 496:498-503(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Tuebingen.
[3]NIH - Zebrafish Gene Collection (ZGC) project
Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: AB.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CU638807 mRNA. Translation: CAP71956.1.
BX322637 Genomic DNA. Translation: CAI20990.1.
BC045893 mRNA. Translation: AAH45893.1.
RefSeqNP_957225.1. NM_200931.1.
UniGeneDr.82452.

3D structure databases

ProteinModelPortalQ7ZVE6.
SMRQ7ZVE6. Positions 24-129.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

CAZyGT90. Glycosyltransferase Family 90.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID393905.
KEGGdre:393905.

Organism-specific databases

CTD79070.
ZFINZDB-GENE-040426-878. kdelc1.

Phylogenomic databases

eggNOGNOG248922.
HOGENOMHOG000286007.
HOVERGENHBG081852.
InParanoidQ7ZVE6.
PhylomeDBQ7ZVE6.

Family and domain databases

Gene3D2.60.40.10. 1 hit.
InterProIPR017868. Filamin/ABP280_repeat-like.
IPR001298. Filamin/ABP280_rpt.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR006598. LipoPS_modifying.
[Graphical view]
PfamPF00630. Filamin. 1 hit.
PF05686. Glyco_transf_90. 1 hit.
[Graphical view]
SMARTSM00672. CAP10. 1 hit.
SM00557. IG_FLMN. 1 hit.
[Graphical view]
SUPFAMSSF81296. SSF81296. 1 hit.
PROSITEPS00014. ER_TARGET. 1 hit.
PS50194. FILAMIN_REPEAT. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20814882.
PROQ7ZVE6.

Entry information

Entry nameKDEL1_DANRE
AccessionPrimary (citable) accession number: Q7ZVE6
Secondary accession number(s): B0CM11, Q5RI39
Entry history
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: June 1, 2003
Last modified: April 16, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families