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Q7ZVE6

- KDEL1_DANRE

UniProt

Q7ZVE6 - KDEL1_DANRE

Protein

KDEL motif-containing protein 1

Gene

kdelc1

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 66 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    Protein family/group databases

    CAZyiGT90. Glycosyltransferase Family 90.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    KDEL motif-containing protein 1
    Gene namesi
    Name:kdelc1
    ORF Names:si:dkey-22a1.1, zgc:56065
    OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
    Taxonomic identifieri7955 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
    ProteomesiUP000000437: Unplaced

    Organism-specific databases

    ZFINiZDB-GENE-040426-878. kdelc1.

    Subcellular locationi

    Endoplasmic reticulum lumen PROSITE-ProRule annotation

    GO - Cellular componenti

    1. endoplasmic reticulum lumen Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2222Sequence AnalysisAdd
    BLAST
    Chaini23 – 500478KDEL motif-containing protein 1PRO_0000247165Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi60 – 601N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi259 – 2591N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Structurei

    3D structure databases

    ProteinModelPortaliQ7ZVE6.
    SMRiQ7ZVE6. Positions 24-129.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati23 – 128106FilaminAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi497 – 5004Prevents secretion from ERPROSITE-ProRule annotation

    Sequence similaritiesi

    Belongs to the KDELC family.Curated
    Contains 1 filamin repeat.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG248922.
    HOGENOMiHOG000286007.
    HOVERGENiHBG081852.
    InParanoidiQ7ZVE6.
    PhylomeDBiQ7ZVE6.

    Family and domain databases

    Gene3Di2.60.40.10. 1 hit.
    InterProiIPR017868. Filamin/ABP280_repeat-like.
    IPR001298. Filamin/ABP280_rpt.
    IPR013783. Ig-like_fold.
    IPR014756. Ig_E-set.
    IPR006598. LipoPS_modifying.
    [Graphical view]
    PfamiPF00630. Filamin. 1 hit.
    PF05686. Glyco_transf_90. 1 hit.
    [Graphical view]
    SMARTiSM00672. CAP10. 1 hit.
    SM00557. IG_FLMN. 1 hit.
    [Graphical view]
    SUPFAMiSSF81296. SSF81296. 1 hit.
    PROSITEiPS00014. ER_TARGET. 1 hit.
    PS50194. FILAMIN_REPEAT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q7ZVE6-1 [UniParc]FASTAAdd to Basket

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    MLRKLLLLLM SCIIFLTRRS KAAAAASASK TLVWGPGLET NAVLPARFFF    50
    IQTVDTTGTN FTTSPGENTF EVKITSPTEP YARIWIQILD RNDGSFLVRY 100
    RMYASYTDLH VEVLLKDKLV GKSPYVLRGA VYHESCDCPE PDGALWEKNM 150
    HCPASFSQIE SDLSIFQSVD PDRNAHEIIQ RFGKSHSLCH YTIKNNQVYI 200
    KTHGEHVGFR IFMDAFLLSL TRKVKLPDIE FFVNLGDWPL EKRRASQNPS 250
    PVFSWCGSND TRDIVMPTYD LTESVLETMG RVSLDMMSVQ GHTGPVWEKK 300
    INKGFWRGRD SRKERLELVK LARANTAMLD AALTNFFFFK HDESLYGPLV 350
    KHVSFFDFFK YKYQINVDGT VAAYRLPYLL AGDSVVFKHD SIYYEHFYNE 400
    LQPWVHYIPF RSDLSDLLEK IQWAKDHDEE AKKIALAGQQ FARTHLMGDS 450
    VFCYYHKLFQ KYAELQVTKP KVRDGMELVE QPKDDLFPCY CARKKVRDEL 500
    Length:500
    Mass (Da):57,802
    Last modified:June 1, 2003 - v1
    Checksum:iAD1C93F7F5A8D23E
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti26 – 261A → P in CAP71956. (PubMed:18296487)Curated
    Sequence conflicti69 – 691T → I in CAP71956. (PubMed:18296487)Curated
    Sequence conflicti71 – 711E → V in CAP71956. (PubMed:18296487)Curated
    Sequence conflicti167 – 1671Q → K in CAP71956. (PubMed:18296487)Curated
    Sequence conflicti178 – 1781I → V in CAP71956. (PubMed:18296487)Curated
    Sequence conflicti323 – 3231R → K in CAI20990. (PubMed:23594743)Curated
    Sequence conflicti455 – 4551Y → C in CAP71956. (PubMed:18296487)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU638807 mRNA. Translation: CAP71956.1.
    BX322637 Genomic DNA. Translation: CAI20990.1.
    BC045893 mRNA. Translation: AAH45893.1.
    RefSeqiNP_957225.1. NM_200931.1.
    UniGeneiDr.82452.

    Genome annotation databases

    GeneIDi393905.
    KEGGidre:393905.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU638807 mRNA. Translation: CAP71956.1 .
    BX322637 Genomic DNA. Translation: CAI20990.1 .
    BC045893 mRNA. Translation: AAH45893.1 .
    RefSeqi NP_957225.1. NM_200931.1.
    UniGenei Dr.82452.

    3D structure databases

    ProteinModelPortali Q7ZVE6.
    SMRi Q7ZVE6. Positions 24-129.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    CAZyi GT90. Glycosyltransferase Family 90.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 393905.
    KEGGi dre:393905.

    Organism-specific databases

    CTDi 79070.
    ZFINi ZDB-GENE-040426-878. kdelc1.

    Phylogenomic databases

    eggNOGi NOG248922.
    HOGENOMi HOG000286007.
    HOVERGENi HBG081852.
    InParanoidi Q7ZVE6.
    PhylomeDBi Q7ZVE6.

    Miscellaneous databases

    NextBioi 20814882.
    PROi Q7ZVE6.

    Family and domain databases

    Gene3Di 2.60.40.10. 1 hit.
    InterProi IPR017868. Filamin/ABP280_repeat-like.
    IPR001298. Filamin/ABP280_rpt.
    IPR013783. Ig-like_fold.
    IPR014756. Ig_E-set.
    IPR006598. LipoPS_modifying.
    [Graphical view ]
    Pfami PF00630. Filamin. 1 hit.
    PF05686. Glyco_transf_90. 1 hit.
    [Graphical view ]
    SMARTi SM00672. CAP10. 1 hit.
    SM00557. IG_FLMN. 1 hit.
    [Graphical view ]
    SUPFAMi SSF81296. SSF81296. 1 hit.
    PROSITEi PS00014. ER_TARGET. 1 hit.
    PS50194. FILAMIN_REPEAT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Large-scale screening for novel low-affinity extracellular protein interactions."
      Bushell K.M., Soellner C., Schuster-Boeckler B., Bateman A., Wright G.J.
      Genome Res. 18:622-630(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    2. "The zebrafish reference genome sequence and its relationship to the human genome."
      Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.
      , White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., Clee C., Oliver K., Clark R., Riddle C., Eliott D., Threadgold G., Harden G., Ware D., Mortimer B., Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.
      Nature 496:498-503(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Tuebingen.
    3. NIH - Zebrafish Gene Collection (ZGC) project
      Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: AB.

    Entry informationi

    Entry nameiKDEL1_DANRE
    AccessioniPrimary (citable) accession number: Q7ZVE6
    Secondary accession number(s): B0CM11, Q5RI39
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 25, 2006
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 66 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3