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Q7ZVE3 (TIGRB_DANRE) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Probable fructose-2,6-bisphosphatase TIGAR B
EC=3.1.3.46
Alternative name(s):
TP53-induced glycolysis and apoptosis regulator B
Gene names
Name:tigarb
ORF Names:si:ch211-240j22.3, zgc:56074
OrganismDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifier7955 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Cyprinidae › Danio

Protein attributes

Sequence length257 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Probable fructose-biphosphatase. Lowers cellular levels of fructose 2,6-bisphosphate. Protects cells against reactive oxygen species and against apoptosis induced by tp53 By similarity.

Catalytic activity

Beta-D-fructose 2,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate.

Sequence similarities

Belongs to the phosphoglycerate mutase family.

Caution

Not expected to have any kinase activity.

Ontologies

Keywords
   Molecular functionHydrolase
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Molecular functionfructose-2,6-bisphosphate 2-phosphatase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 257257Probable fructose-2,6-bisphosphatase TIGAR B
PRO_0000363068

Sites

Active site111Tele-phosphohistidine intermediate By similarity
Active site1831 By similarity

Experimental info

Sequence conflict441R → H in CAK04686. Ref.1
Sequence conflict1131S → A in CAK04686. Ref.1
Sequence conflict1341M → K in CAK04686. Ref.1
Sequence conflict1441L → F in AAH45897. Ref.2
Sequence conflict1541A → V in AAH45897. Ref.2
Sequence conflict1891I → V in CAK04686. Ref.1

Secondary structure

1 ............................. 257
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q7ZVE3 [UniParc].

Last modified February 10, 2009. Version 2.
Checksum: 93689C4A254F9209

FASTA25728,439
        10         20         30         40         50         60 
MLTFALTIVR HGETQYNRDK LLQGQGIDTP LSDTGHQQAA AAGRYLKDLH FTNVFVSNLQ 

        70         80         90        100        110        120 
RAIQTAEIIL GNNLHSSATE MILDPLLRER GFGVAEGRPK EHLKNMANAA GQSCRDYTPP 

       130        140        150        160        170        180 
GGETLEQVKT RFKMFLKSLF QRMLEEHGSA LSSAPSEADQ PVIAGLADDG AQNVPVHALM 

       190        200        210        220        230        240 
VSHGAFIRIS VRHLVEDLQC CLPAGLKMNQ VFSPCPNTGI SRFIFTIHRE ESVLRATRIQ 

       250 
GVFINRKDHL EEVKNSD

« Hide

References

[1]The Danio rerio sequencing project at the Sanger Institute
Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Tuebingen.
[2]NIH - Zebrafish Gene Collection (ZGC) project
Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CR751235 Genomic DNA. Translation: CAK04686.1.
BC045897 mRNA. Translation: AAH45897.1.
IPIIPI00505516.
RefSeqNP_956485.1. NM_200191.1.
UniGeneDr.79917.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3E9CX-ray2.00A/B1-257[»]
3E9DX-ray2.00A/B1-257[»]
3E9EX-ray2.10A/B1-257[»]
ProteinModelPortalQ7ZVE3.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSDART00000067392; ENSDARP00000067391; ENSDARG00000045858.
GeneID393160.
KEGGdre:393160.

Organism-specific databases

CTD393160.
ZFINZDB-GENE-040426-885. tigarb.

Phylogenomic databases

eggNOGfiNOG08071.
GeneTreeENSGT00390000013224.
HOGENOMHBG445749.
HOVERGENHBG108569.
InParanoidQ7ZVE3.
OrthoDBEOG40GCRZ.

Gene expression databases

ArrayExpressQ7ZVE3.
BgeeQ7ZVE3.

Family and domain databases

InterProIPR013078. His_Pase_superF_clade-1.
IPR001345. PG/BPGM_mutase_AS.
[Graphical view]
KOK14634.
PfamPF00300. His_Phos_1. 1 hit.
[Graphical view]
SMARTSM00855. PGAM. 1 hit.
[Graphical view]
PROSITEPS00175. PG_MUTASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTIGRB_DANRE
AccessionPrimary (citable) accession number: Q7ZVE3
Secondary accession number(s): Q1L8M5
Entry history
Integrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: February 10, 2009
Last modified: November 16, 2011
This is version 50 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

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