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Q7ZVB2

- A9A1A_DANRE

UniProt

Q7ZVB2 - A9A1A_DANRE

Protein

Aldehyde dehydrogenase family 9 member A1-A

Gene

aldh9a1a

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 83 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    An aldehyde + NAD+ + H2O = a carboxylate + NADH.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei268 – 2681Sequence Analysis
    Active sitei302 – 3021Sequence Analysis

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi246 – 2516NADBy similarity

    GO - Molecular functioni

    1. aldehyde dehydrogenase (NAD) activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    NAD

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Aldehyde dehydrogenase family 9 member A1-A (EC:1.2.1.3)
    Gene namesi
    Name:aldh9a1a
    Synonyms:aldh9a1l
    OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
    Taxonomic identifieri7955 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
    ProteomesiUP000000437: Chromosome 8

    Organism-specific databases

    ZFINiZDB-GENE-030131-1257. aldh9a1a.1.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 508508Aldehyde dehydrogenase family 9 member A1-APRO_0000300624Add
    BLAST

    Proteomic databases

    PRIDEiQ7ZVB2.

    Expressioni

    Gene expression databases

    BgeeiQ7ZVB2.

    Interactioni

    Subunit structurei

    Homotetramer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ7ZVB2.
    SMRiQ7ZVB2. Positions 14-508.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the aldehyde dehydrogenase family.Curated

    Phylogenomic databases

    eggNOGiCOG1012.
    GeneTreeiENSGT00720000108597.
    HOGENOMiHOG000271505.
    HOVERGENiHBG000097.
    KOiK00149.
    OMAiSIFEARW.
    OrthoDBiEOG7327P4.
    PhylomeDBiQ7ZVB2.
    TreeFamiTF314257.

    Family and domain databases

    Gene3Di3.40.309.10. 1 hit.
    3.40.605.10. 1 hit.
    InterProiIPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR016160. Ald_DH_CS_CYS.
    IPR029510. Ald_DH_CS_GLU.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    [Graphical view]
    PfamiPF00171. Aldedh. 1 hit.
    [Graphical view]
    SUPFAMiSSF53720. SSF53720. 1 hit.
    PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
    PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q7ZVB2-1 [UniParc]FASTAAdd to Basket

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    MAQQPLLSLP EFQSVSTGTL VVKEPLNFWG GARVKPRDTK NSEPVYEPAT    50
    GRVLCDMIPC GEEEVDQAIK SAHSAYLKWS QLSGMERSRI MLEAARIIRE 100
    RRNAIAKAEV ANNGKSITEA EVDIDVAWQC IEYYAGIAPT LSGQHIQLPG 150
    GSFAYTRREP LGVCVGIGAW NYPFQIAAWK SAPALACGNA MVFKPSPMTP 200
    VTAVMLAEIY KEAGVPDGLF NVVQGGAETG SLLCHHPMVA KVSFTGSVPT 250
    GKKVMEMAAK SVKQVTLELG GKSPLIIFKD CELENAIKGA LMANFLTQGE 300
    VCCNGTRVFV QREIMPKFLE EVVKRTKAIS VGDPLCEGTR MGALISKPHM 350
    EKVLGFIKQA KEQGGKVLCG GERFVPNDPK LKDGYFVSPC VLDNCRDDMT 400
    CVKEEIFGPV MSVLPFDTEE EVLQRANNTT FGLASGVFTR DIARAHRVAA 450
    NLQAGTCYIN NYNVGPVEVP FGGYKMSGFG RENGTVTIEY YSQLKTVVVE 500
    MGDVESLF 508
    Length:508
    Mass (Da):55,262
    Last modified:June 1, 2003 - v1
    Checksum:i5290ABC5F72553B2
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti61 – 611G → V in AAH66668. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC045932 mRNA. Translation: AAH45932.1.
    BC066668 mRNA. Translation: AAH66668.1.
    RefSeqiNP_958879.1. NM_201471.1.
    XP_005166831.1. XM_005166774.1.
    UniGeneiDr.104770.

    Genome annotation databases

    EnsembliENSDART00000100283; ENSDARP00000091056; ENSDARG00000069100.
    ENSDART00000137838; ENSDARP00000118280; ENSDARG00000069100.
    GeneIDi100005587.
    KEGGidre:100005587.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC045932 mRNA. Translation: AAH45932.1 .
    BC066668 mRNA. Translation: AAH66668.1 .
    RefSeqi NP_958879.1. NM_201471.1.
    XP_005166831.1. XM_005166774.1.
    UniGenei Dr.104770.

    3D structure databases

    ProteinModelPortali Q7ZVB2.
    SMRi Q7ZVB2. Positions 14-508.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q7ZVB2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSDART00000100283 ; ENSDARP00000091056 ; ENSDARG00000069100 .
    ENSDART00000137838 ; ENSDARP00000118280 ; ENSDARG00000069100 .
    GeneIDi 100005587.
    KEGGi dre:100005587.

    Organism-specific databases

    CTDi 100005587.
    ZFINi ZDB-GENE-030131-1257. aldh9a1a.1.

    Phylogenomic databases

    eggNOGi COG1012.
    GeneTreei ENSGT00720000108597.
    HOGENOMi HOG000271505.
    HOVERGENi HBG000097.
    KOi K00149.
    OMAi SIFEARW.
    OrthoDBi EOG7327P4.
    PhylomeDBi Q7ZVB2.
    TreeFami TF314257.

    Miscellaneous databases

    NextBioi 20786752.
    PROi Q7ZVB2.

    Gene expression databases

    Bgeei Q7ZVB2.

    Family and domain databases

    Gene3Di 3.40.309.10. 1 hit.
    3.40.605.10. 1 hit.
    InterProi IPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR016160. Ald_DH_CS_CYS.
    IPR029510. Ald_DH_CS_GLU.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    [Graphical view ]
    Pfami PF00171. Aldedh. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53720. SSF53720. 1 hit.
    PROSITEi PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
    PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Zebrafish Gene Collection (ZGC) project
      Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Embryo.

    Entry informationi

    Entry nameiA9A1A_DANRE
    AccessioniPrimary (citable) accession number: Q7ZVB2
    Secondary accession number(s): Q6NYB3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 11, 2007
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 83 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3