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Protein

Aldehyde dehydrogenase family 9 member A1-A

Gene

aldh9a1a

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

An aldehyde + NAD+ + H2O = a carboxylate + NADH.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei268 – 2681Sequence Analysis
Active sitei302 – 3021Sequence Analysis

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi246 – 2516NADBy similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Enzyme and pathway databases

ReactomeiREACT_301104. Carnitine synthesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Aldehyde dehydrogenase family 9 member A1-A (EC:1.2.1.3)
Gene namesi
Name:aldh9a1a
Synonyms:aldh9a1l
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
ProteomesiUP000000437 Componenti: Chromosome 8

Organism-specific databases

ZFINiZDB-GENE-030131-1257. aldh9a1a.1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 508508Aldehyde dehydrogenase family 9 member A1-APRO_0000300624Add
BLAST

Proteomic databases

PRIDEiQ7ZVB2.

Expressioni

Gene expression databases

BgeeiQ7ZVB2.
ExpressionAtlasiQ7ZVB2. differential.

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

STRINGi7955.ENSDARP00000118280.

Structurei

3D structure databases

ProteinModelPortaliQ7ZVB2.
SMRiQ7ZVB2. Positions 14-508.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldehyde dehydrogenase family.Curated

Phylogenomic databases

eggNOGiCOG1012.
GeneTreeiENSGT00800000124121.
HOGENOMiHOG000271505.
HOVERGENiHBG000097.
InParanoidiQ7ZVB2.
KOiK00149.
OMAiKDGYYMR.
OrthoDBiEOG7327P4.
PhylomeDBiQ7ZVB2.
TreeFamiTF314257.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7ZVB2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQQPLLSLP EFQSVSTGTL VVKEPLNFWG GARVKPRDTK NSEPVYEPAT
60 70 80 90 100
GRVLCDMIPC GEEEVDQAIK SAHSAYLKWS QLSGMERSRI MLEAARIIRE
110 120 130 140 150
RRNAIAKAEV ANNGKSITEA EVDIDVAWQC IEYYAGIAPT LSGQHIQLPG
160 170 180 190 200
GSFAYTRREP LGVCVGIGAW NYPFQIAAWK SAPALACGNA MVFKPSPMTP
210 220 230 240 250
VTAVMLAEIY KEAGVPDGLF NVVQGGAETG SLLCHHPMVA KVSFTGSVPT
260 270 280 290 300
GKKVMEMAAK SVKQVTLELG GKSPLIIFKD CELENAIKGA LMANFLTQGE
310 320 330 340 350
VCCNGTRVFV QREIMPKFLE EVVKRTKAIS VGDPLCEGTR MGALISKPHM
360 370 380 390 400
EKVLGFIKQA KEQGGKVLCG GERFVPNDPK LKDGYFVSPC VLDNCRDDMT
410 420 430 440 450
CVKEEIFGPV MSVLPFDTEE EVLQRANNTT FGLASGVFTR DIARAHRVAA
460 470 480 490 500
NLQAGTCYIN NYNVGPVEVP FGGYKMSGFG RENGTVTIEY YSQLKTVVVE

MGDVESLF
Length:508
Mass (Da):55,262
Last modified:June 1, 2003 - v1
Checksum:i5290ABC5F72553B2
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti61 – 611G → V in AAH66668 (Ref. 1) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC045932 mRNA. Translation: AAH45932.1.
BC066668 mRNA. Translation: AAH66668.1.
RefSeqiNP_958879.1. NM_201471.1.
XP_005166831.1. XM_005166774.2.
UniGeneiDr.104770.

Genome annotation databases

EnsembliENSDART00000100283; ENSDARP00000091056; ENSDARG00000069100.
ENSDART00000137838; ENSDARP00000118280; ENSDARG00000069100.
GeneIDi100005587.
KEGGidre:100005587.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC045932 mRNA. Translation: AAH45932.1.
BC066668 mRNA. Translation: AAH66668.1.
RefSeqiNP_958879.1. NM_201471.1.
XP_005166831.1. XM_005166774.2.
UniGeneiDr.104770.

3D structure databases

ProteinModelPortaliQ7ZVB2.
SMRiQ7ZVB2. Positions 14-508.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000118280.

Proteomic databases

PRIDEiQ7ZVB2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000100283; ENSDARP00000091056; ENSDARG00000069100.
ENSDART00000137838; ENSDARP00000118280; ENSDARG00000069100.
GeneIDi100005587.
KEGGidre:100005587.

Organism-specific databases

CTDi100005587.
ZFINiZDB-GENE-030131-1257. aldh9a1a.1.

Phylogenomic databases

eggNOGiCOG1012.
GeneTreeiENSGT00800000124121.
HOGENOMiHOG000271505.
HOVERGENiHBG000097.
InParanoidiQ7ZVB2.
KOiK00149.
OMAiKDGYYMR.
OrthoDBiEOG7327P4.
PhylomeDBiQ7ZVB2.
TreeFamiTF314257.

Enzyme and pathway databases

ReactomeiREACT_301104. Carnitine synthesis.

Miscellaneous databases

NextBioi20786752.
PROiQ7ZVB2.

Gene expression databases

BgeeiQ7ZVB2.
ExpressionAtlasiQ7ZVB2. differential.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Embryo.

Entry informationi

Entry nameiA9A1A_DANRE
AccessioniPrimary (citable) accession number: Q7ZVB2
Secondary accession number(s): Q6NYB3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: June 1, 2003
Last modified: July 22, 2015
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.