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Q7ZVB2

- A9A1A_DANRE

UniProt

Q7ZVB2 - A9A1A_DANRE

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Protein

Aldehyde dehydrogenase family 9 member A1-A

Gene
aldh9a1a, aldh9a1l
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

An aldehyde + NAD+ + H2O = a carboxylate + NADH.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei268 – 2681 Reviewed prediction
Active sitei302 – 3021 Reviewed prediction

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi246 – 2516NAD By similarity

GO - Molecular functioni

  1. aldehyde dehydrogenase (NAD) activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Names & Taxonomyi

Protein namesi
Recommended name:
Aldehyde dehydrogenase family 9 member A1-A (EC:1.2.1.3)
Gene namesi
Name:aldh9a1a
Synonyms:aldh9a1l
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
ProteomesiUP000000437: Chromosome 8

Organism-specific databases

ZFINiZDB-GENE-030131-1257. aldh9a1a.1.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 508508Aldehyde dehydrogenase family 9 member A1-APRO_0000300624Add
BLAST

Proteomic databases

PRIDEiQ7ZVB2.

Expressioni

Gene expression databases

BgeeiQ7ZVB2.

Interactioni

Subunit structurei

Homotetramer By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ7ZVB2.
SMRiQ7ZVB2. Positions 14-508.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1012.
GeneTreeiENSGT00720000108597.
HOGENOMiHOG000271505.
HOVERGENiHBG000097.
KOiK00149.
OMAiSIFEARW.
OrthoDBiEOG7327P4.
PhylomeDBiQ7ZVB2.
TreeFamiTF314257.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7ZVB2-1 [UniParc]FASTAAdd to Basket

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MAQQPLLSLP EFQSVSTGTL VVKEPLNFWG GARVKPRDTK NSEPVYEPAT    50
GRVLCDMIPC GEEEVDQAIK SAHSAYLKWS QLSGMERSRI MLEAARIIRE 100
RRNAIAKAEV ANNGKSITEA EVDIDVAWQC IEYYAGIAPT LSGQHIQLPG 150
GSFAYTRREP LGVCVGIGAW NYPFQIAAWK SAPALACGNA MVFKPSPMTP 200
VTAVMLAEIY KEAGVPDGLF NVVQGGAETG SLLCHHPMVA KVSFTGSVPT 250
GKKVMEMAAK SVKQVTLELG GKSPLIIFKD CELENAIKGA LMANFLTQGE 300
VCCNGTRVFV QREIMPKFLE EVVKRTKAIS VGDPLCEGTR MGALISKPHM 350
EKVLGFIKQA KEQGGKVLCG GERFVPNDPK LKDGYFVSPC VLDNCRDDMT 400
CVKEEIFGPV MSVLPFDTEE EVLQRANNTT FGLASGVFTR DIARAHRVAA 450
NLQAGTCYIN NYNVGPVEVP FGGYKMSGFG RENGTVTIEY YSQLKTVVVE 500
MGDVESLF 508
Length:508
Mass (Da):55,262
Last modified:June 1, 2003 - v1
Checksum:i5290ABC5F72553B2
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti61 – 611G → V in AAH66668. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC045932 mRNA. Translation: AAH45932.1.
BC066668 mRNA. Translation: AAH66668.1.
RefSeqiNP_958879.1. NM_201471.1.
XP_005166831.1. XM_005166774.1.
UniGeneiDr.104770.

Genome annotation databases

EnsembliENSDART00000100283; ENSDARP00000091056; ENSDARG00000069100.
ENSDART00000137838; ENSDARP00000118280; ENSDARG00000069100.
GeneIDi100005587.
KEGGidre:100005587.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC045932 mRNA. Translation: AAH45932.1 .
BC066668 mRNA. Translation: AAH66668.1 .
RefSeqi NP_958879.1. NM_201471.1.
XP_005166831.1. XM_005166774.1.
UniGenei Dr.104770.

3D structure databases

ProteinModelPortali Q7ZVB2.
SMRi Q7ZVB2. Positions 14-508.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q7ZVB2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSDART00000100283 ; ENSDARP00000091056 ; ENSDARG00000069100 .
ENSDART00000137838 ; ENSDARP00000118280 ; ENSDARG00000069100 .
GeneIDi 100005587.
KEGGi dre:100005587.

Organism-specific databases

CTDi 100005587.
ZFINi ZDB-GENE-030131-1257. aldh9a1a.1.

Phylogenomic databases

eggNOGi COG1012.
GeneTreei ENSGT00720000108597.
HOGENOMi HOG000271505.
HOVERGENi HBG000097.
KOi K00149.
OMAi SIFEARW.
OrthoDBi EOG7327P4.
PhylomeDBi Q7ZVB2.
TreeFami TF314257.

Miscellaneous databases

NextBioi 20786752.
PROi Q7ZVB2.

Gene expression databases

Bgeei Q7ZVB2.

Family and domain databases

Gene3Di 3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view ]
Pfami PF00171. Aldedh. 1 hit.
[Graphical view ]
SUPFAMi SSF53720. SSF53720. 1 hit.
PROSITEi PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Embryo.

Entry informationi

Entry nameiA9A1A_DANRE
AccessioniPrimary (citable) accession number: Q7ZVB2
Secondary accession number(s): Q6NYB3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: June 1, 2003
Last modified: June 11, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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