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Q7ZVB2 (A9A1A_DANRE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Aldehyde dehydrogenase family 9 member A1-A
EC=1.2.1.3
Gene names
Name:aldh9a1a
Synonyms:aldh9a1l
OrganismDanio rerio (Zebrafish) (Brachydanio rerio) [Reference proteome]
Taxonomic identifier7955 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Cyprinidae › Danio

Protein attributes

Sequence length508 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

An aldehyde + NAD+ + H2O = a carboxylate + NADH.

Subunit structure

Homotetramer By similarity.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the aldehyde dehydrogenase family.

Ontologies

Keywords
   Cellular componentCytoplasm
   LigandNAD
   Molecular functionOxidoreductase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionaldehyde dehydrogenase (NAD) activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 508508Aldehyde dehydrogenase family 9 member A1-A
PRO_0000300624

Regions

Nucleotide binding246 – 2516NAD By similarity

Sites

Active site2681 Potential
Active site3021 Potential

Experimental info

Sequence conflict611G → V in AAH66668. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q7ZVB2 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: 5290ABC5F72553B2

FASTA50855,262
        10         20         30         40         50         60 
MAQQPLLSLP EFQSVSTGTL VVKEPLNFWG GARVKPRDTK NSEPVYEPAT GRVLCDMIPC 

        70         80         90        100        110        120 
GEEEVDQAIK SAHSAYLKWS QLSGMERSRI MLEAARIIRE RRNAIAKAEV ANNGKSITEA 

       130        140        150        160        170        180 
EVDIDVAWQC IEYYAGIAPT LSGQHIQLPG GSFAYTRREP LGVCVGIGAW NYPFQIAAWK 

       190        200        210        220        230        240 
SAPALACGNA MVFKPSPMTP VTAVMLAEIY KEAGVPDGLF NVVQGGAETG SLLCHHPMVA 

       250        260        270        280        290        300 
KVSFTGSVPT GKKVMEMAAK SVKQVTLELG GKSPLIIFKD CELENAIKGA LMANFLTQGE 

       310        320        330        340        350        360 
VCCNGTRVFV QREIMPKFLE EVVKRTKAIS VGDPLCEGTR MGALISKPHM EKVLGFIKQA 

       370        380        390        400        410        420 
KEQGGKVLCG GERFVPNDPK LKDGYFVSPC VLDNCRDDMT CVKEEIFGPV MSVLPFDTEE 

       430        440        450        460        470        480 
EVLQRANNTT FGLASGVFTR DIARAHRVAA NLQAGTCYIN NYNVGPVEVP FGGYKMSGFG 

       490        500 
RENGTVTIEY YSQLKTVVVE MGDVESLF

« Hide

References

[1]NIH - Zebrafish Gene Collection (ZGC) project
Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Embryo.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BC045932 mRNA. Translation: AAH45932.1.
BC066668 mRNA. Translation: AAH66668.1.
IPIIPI00507539.
RefSeqNP_958879.1. NM_201471.1.
UniGeneDr.104770.

3D structure databases

HSSPHSSP built from PDB template 1A4S based on UniProtKB P56533.
ProteinModelPortalQ7ZVB2.
SMRQ7ZVB2. Positions 14-508.
ModBaseSearch...

Proteomic databases

PRIDEQ7ZVB2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSDART00000100283; ENSDARP00000091056; ENSDARG00000069100.
ENSDART00000137838; ENSDARP00000118280; ENSDARG00000069100.
GeneID100005587.
KEGGdre:100005587.

Organism-specific databases

CTD100005587.
ZFINZDB-GENE-030131-1257. aldh9a1a.1.

Phylogenomic databases

eggNOGCOG1012.
GeneTreeENSGT00560000077032.
HOGENOMHOG000271505.
HOVERGENHBG000097.
KOK00149.
OMAVKRTQKI.
OrthoDBEOG4THVSW.

Gene expression databases

ArrayExpressQ7ZVB2.
BgeeQ7ZVB2.

Family and domain databases

Gene3D3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view]
PfamPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMSSF53720. Aldehyde_DH/Histidinol_DH. 1 hit.
PROSITEPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20786752.

Entry information

Entry nameA9A1A_DANRE
AccessionPrimary (citable) accession number: Q7ZVB2
Secondary accession number(s): Q6NYB3
Entry history
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: June 1, 2003
Last modified: April 3, 2013
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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