Reviewed, UniProtKB/Swiss-Prot Q7ZV68 (VPS29_DANRE)

Names and origin

Protein names

Recommended name:
    Vacuolar protein sorting-associated protein 29
    EC=3.1.3.3
Alternative name(s):
    Vesicle protein sorting 29

Gene names

Name:	vps29
ORF Names:	zK83d9.2-001

Organism

Danio rerio (Zebrafish) (Brachydanio rerio)

Taxonomic identifier

7955 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Cyprinidae › Danio

Protein attributes

Sequence length	182 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Essential component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (igf2r and m6pr) from endosomes to the trans-Golgi network. Has low protein phosphatase activity By similarity.
Catalytic activity	O-phospho-L(or D)-serine + H2O = L(or D)-serine + phosphate.
Cofactor	Binds 2 zinc ions per subunit By similarity.
Subcellular location	Cytoplasm By similarity. Membrane; Peripheral membrane protein By similarity. Endosome membrane; Peripheral membrane protein By similarity.
Sequence similarities	Belongs to the VPS29 family.

Ontologies

Keywords
Biological process	Protein transport Transport
Cellular component	Cytoplasm Endosome Membrane
Ligand	Metal-binding Zinc
Molecular function	Hydrolase
Gene Ontology (GO)
Biological process	protein transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	endosome Inferred from electronic annotation. Source: UniProtKB-KW extrinsic to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	phosphoserine phosphatase activity Inferred from electronic annotation. Source: EC zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 182	182	Vacuolar protein sorting-associated protein 29		PRO_0000339651

Sequences

	Sequence		Length	Mass (Da)
	Q7ZV68-1 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: DF31C8F10ACE473B	FASTA	182	20,400
	10 20 30 40 50 60 MLVLVLGDLH IPHRCNTLPA KFKKLLVPGK IQHILCTGNL CTKESYDYLK TLAGDVHIVR 70 80 90 100 110 120 GDFDENLNYP EQKVVTVGQF KIGLIHGHQV IPWGDMASLA LLQRQLDVDI LISGHTHKFE 130 140 150 160 170 180 AFENENKFYI NPGSATGAYS ALESNITPSF VLMDIQASTV VTYVYQLIGD DVKVERIEYK KS

References

[1]	The Danio rerio sequencing project at the Sanger Institute Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Tuebingen.
[2]	NIH - Zebrafish Gene Collection (ZGC) project Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Embryo.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AL844518 Genomic DNA. Translation: CAE50610.1. BC045981 mRNA. Translation: AAH45981.1. BC071331 mRNA. Translation: AAH71331.1.
IPI	IPI00512841.
RefSeq	NP_956331.1.
UniGene	Dr.119761
3D structure databases
SMR	Q7ZV68. Positions 1-182.
ModBase	Search...
Protein-protein interaction databases
STRING	Q7ZV68.
Proteomic databases
PRIDE	Q7ZV68.
Genome annotation databases
Ensembl	ENSDART00000101246; ENSDARP00000092020; ENSDARG00000069521; Danio rerio. [Genome view]
GeneID	573437.
KEGG	dre:573437.
Organism-specific databases
CTD	573437.
ZFIN	ZDB-GENE-030131-8764. vps29.
Phylogenomic databases
HOGENOM	Q7ZV68.
HOVERGEN	Q7ZV68.
OMA	KFEAYEH.
Gene expression databases
ArrayExpress	Q7ZV68.
Bgee	Q7ZV68.
Family and domain databases
InterPro	IPR004843. M-pesterase. IPR000979. UPF0025. [Graphical view]
Pfam	PF00149. Metallophos. 1 hit. [Graphical view]
TIGRFAMs	TIGR00040. yfcE. 1 hit.
ProtoNet	Search...

Entry information

Entry name

VPS29_DANRE

Accession

Primary (citable) accession number: Q7ZV68

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 10, 2008
Last sequence update:	June 1, 2003
Last modified:	November 3, 2009
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Zebrafish annotation project