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Protein

Mitochondrial chaperone BCS1

Gene

bcs1l

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Chaperone necessary for the assembly of mitochondrial respiratory chain complex III.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi230 – 237ATPSequence analysis8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial chaperone BCS1
Alternative name(s):
BCS1-like protein
Gene namesi
Name:bcs1l
ORF Names:zgc:56205
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 9

Organism-specific databases

ZFINiZDB-GENE-040426-938. bcs1l.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 15Mitochondrial intermembraneSequence analysisAdd BLAST15
Transmembranei16 – 32HelicalSequence analysisAdd BLAST17
Topological domaini33 – 420Mitochondrial matrixSequence analysisAdd BLAST388

GO - Cellular componenti

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000847741 – 420Mitochondrial chaperone BCS1Add BLAST420

Proteomic databases

PaxDbiQ7ZV60.
PRIDEiQ7ZV60.

Expressioni

Gene expression databases

BgeeiENSDARG00000012295.
ExpressionAtlasiQ7ZV60. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000015141.

Structurei

3D structure databases

ProteinModelPortaliQ7ZV60.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AAA ATPase family. BCS1 subfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0743. Eukaryota.
COG0465. LUCA.
GeneTreeiENSGT00390000005415.
HOGENOMiHOG000198799.
HOVERGENiHBG048759.
InParanoidiQ7ZV60.
KOiK08900.
OMAiWLLQWIT.
OrthoDBiEOG091G08O3.
PhylomeDBiQ7ZV60.
TreeFamiTF315009.

Family and domain databases

InterProiView protein in InterPro
IPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR003960. ATPase_AAA_CS.
IPR027243. BCS1.
IPR014851. BCS1_N.
IPR027417. P-loop_NTPase.
PANTHERiPTHR23070:SF69. PTHR23070:SF69. 1 hit.
PfamiView protein in Pfam
PF00004. AAA. 1 hit.
PF08740. BCS1_N. 1 hit.
SMARTiView protein in SMART
SM00382. AAA. 1 hit.
SM01024. BCS1_N. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiView protein in PROSITE
PS00674. AAA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7ZV60-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLSDFIGAL KDNPYFGAGF GLVGVGTALA VARKGAQVGM IFFRRHYMIT
60 70 80 90 100
LEVPSKDKSY HWLLSWITKH AKHTQHLSVE TSYMQHESGK VHTQFDFHPS
110 120 130 140 150
PGNHIIWYGR KWIRVERVRE KQMMDLHTGT PWESVTFTAL GRDRQTFFNI
160 170 180 190 200
LQEARELALK QEEGRTVMYT AMGAEWRPFG FPRRRRPLSS VVLESGVAER
210 220 230 240 250
IVDDVKEFIG NPKWYTDRGI PYRRGYLLYG PPGCGKSSFI TALAGELGYS
260 270 280 290 300
ICLMSLSDRS LSDDRLNHLL SVAPQQSIIL LEDVDAAFVS RELLPTENPL
310 320 330 340 350
AYQGMGRLTF SGLLNALDGV ASSEARIVFM TTNFIERLDP ALVRPGRVDL
360 370 380 390 400
KQYVGHCSHW QLTQMFRRFY PQESAAEADH FSEQALAAHT DLSAAQVQGH
410 420
FMLYKTDPAG AIKNIAEIKD
Length:420
Mass (Da):47,492
Last modified:April 13, 2004 - v2
Checksum:i855330AC4B747035
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti84M → T in AAH45990 (Ref. 2) Curated1
Sequence conflicti150I → V in AAH45990 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY394959 mRNA. Translation: AAQ94586.1.
BC045990 mRNA. Translation: AAH45990.1.
RefSeqiNP_957476.2. NM_201182.2.
UniGeneiDr.80335.

Genome annotation databases

EnsembliENSDART00000022246; ENSDARP00000015141; ENSDARG00000012295.
GeneIDi394157.
KEGGidre:394157.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiBCS1_DANRE
AccessioniPrimary (citable) accession number: Q7ZV60
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: April 13, 2004
Last modified: June 7, 2017
This is version 94 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families