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Protein

Toll-interacting protein

Gene

tollip

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Component of the signaling pathway of IL-1 and Toll-like receptors. Inhibits cell activation by microbial products. Connects the ubiquitin pathway to autophagy by functioning as a ubiquitin-ATG8 family adapter and thus mediating autophagic clearance of ubiquitin conjugates. The TOLLIP-dependent selective autophagy pathway plays an important role in clearance of cytotoxic polyQ proteins aggregates (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processAutophagy, Immunity, Inflammatory response, Innate immunity

Names & Taxonomyi

Protein namesi
Recommended name:
Toll-interacting protein
Gene namesi
Name:tollip
ORF Names:zgc:76985
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Unplaced

Organism-specific databases

ZFINiZDB-GENE-030131-8820 tollip

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003849331 – 276Toll-interacting proteinAdd BLAST276

Proteomic databases

PaxDbiQ7ZV43

Interactioni

Subunit structurei

Interacts with ATG8 family proteins (via AIM motifs), and ubiquitin (via CUE domain).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000112313

Structurei

3D structure databases

ProteinModelPortaliQ7ZV43
SMRiQ7ZV43
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini40 – 135C2Add BLAST96
Domaini231 – 274CUEPROSITE-ProRule annotationAdd BLAST44

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi133 – 136AIM14
Motifi151 – 154AIM24

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi28 – 34Poly-Gln7

Domaini

Both ATG8-interaction motifs (AIM1 and AIM2) are required for the association with ATG8 family proteins.By similarity

Sequence similaritiesi

Belongs to the tollip family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IE45 Eukaryota
ENOG410XQPY LUCA
HOGENOMiHOG000293427
InParanoidiQ7ZV43
PhylomeDBiQ7ZV43

Family and domain databases

CDDicd04016 C2_Tollip, 1 hit
Gene3Di2.60.40.150, 1 hit
InterProiView protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR003892 CUE
IPR037301 Tollip_C2
IPR009060 UBA-like_sf
PfamiView protein in Pfam
PF00168 C2, 1 hit
PF02845 CUE, 1 hit
SMARTiView protein in SMART
SM00239 C2, 1 hit
SM00546 CUE, 1 hit
SUPFAMiSSF46934 SSF46934, 1 hit
PROSITEiView protein in PROSITE
PS51140 CUE, 1 hit

Sequencei

Sequence statusi: Complete.

Q7ZV43-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATTISTQRG QVYIGELPQD FLRIMPTQQQ QQVQLDAQAA RQLQYGGSLG
60 70 80 90 100
TAGRLSITVV QAKLAKNYGM TRMDPYCRIR LGYAVYETPT AHNGAKNPRW
110 120 130 140 150
NKVIQCTVPP GVDSFYLEIF DERAFSMDDR IAWTHVTIPE NLREGTVVDE
160 170 180 190 200
WYSLSGRQGD DKEGMINLVM SFATIPAGMM MQPQPVVLMP TVYQQGVGYV
210 220 230 240 250
PIAGVPGMYN QGVVPMGMPA AAPVASQSAP CSEEDLKALQ DMFPNLDKEV
260 270
IRTVLEAQQG NKDAAINSLL QMAEEL
Length:276
Mass (Da):30,424
Last modified:June 1, 2003 - v1
Checksum:i1C61E5B737513D1E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti222A → P in AAH66544 (Ref. 1) Curated1
Sequence conflicti229A → G in AAH66544 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC046009 mRNA Translation: AAH46009.1
BC066544 mRNA Translation: AAH66544.1
UniGeneiDr.79855

Similar proteinsi

Entry informationi

Entry nameiTOLIP_DANRE
AccessioniPrimary (citable) accession number: Q7ZV43
Secondary accession number(s): Q6NYL4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: June 1, 2003
Last modified: May 23, 2018
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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