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Q7ZV43

- TOLIP_DANRE

UniProt

Q7ZV43 - TOLIP_DANRE

Protein

Toll-interacting protein

Gene

tollip

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 68 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    Component of the signaling pathway of IL-1 and Toll-like receptors. Inhibits cell activation by microbial products. Connects the ubiquitin pathway to autophagy by functioning as a ubiquitin-ATG8 family adapter and thus mediating autophagic clearance of ubiquitin conjugates. The TOLLIP-dependent selective autophagy pathway plays an important role in clearance of cytotoxic polyQ proteins aggregates By similarity.By similarity

    GO - Biological processi

    1. inflammatory response Source: UniProtKB-KW
    2. innate immune response Source: UniProtKB-KW
    3. phosphorylation Source: UniProtKB

    Keywords - Biological processi

    Autophagy, Immunity, Inflammatory response, Innate immunity

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Toll-interacting protein
    Gene namesi
    Name:tollip
    ORF Names:zgc:76985
    OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
    Taxonomic identifieri7955 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
    ProteomesiUP000000437: Unplaced

    Organism-specific databases

    ZFINiZDB-GENE-030131-8820. tollip.

    Subcellular locationi

    Cytoplasm Curated

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 276276Toll-interacting proteinPRO_0000384933Add
    BLAST

    Interactioni

    Subunit structurei

    Interacts with ATG8 family proteins (via AIM motifs), and ubiquitin (via CUE domain).By similarity

    Protein-protein interaction databases

    STRINGi7955.ENSDARP00000104363.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7ZV43.
    SMRiQ7ZV43. Positions 233-275.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini40 – 13596C2Add
    BLAST
    Domaini231 – 27444CUEPROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi133 – 1364AIM1
    Motifi151 – 1544AIM2

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi28 – 347Poly-Gln

    Domaini

    Both ATG8-interaction motifs (AIM1 and AIM2) are required for the association with ATG8 family proteins.By similarity

    Sequence similaritiesi

    Belongs to the tollip family.Curated
    Contains 1 C2 domain.Curated
    Contains 1 CUE domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG85357.
    HOGENOMiHOG000293427.
    InParanoidiQ6NYL4.
    KOiK05402.
    PhylomeDBiQ7ZV43.

    Family and domain databases

    Gene3Di2.60.40.150. 1 hit.
    InterProiIPR000008. C2_dom.
    IPR003892. CUE.
    IPR009060. UBA-like.
    [Graphical view]
    PfamiPF00168. C2. 1 hit.
    PF02845. CUE. 1 hit.
    [Graphical view]
    SMARTiSM00239. C2. 1 hit.
    SM00546. CUE. 1 hit.
    [Graphical view]
    SUPFAMiSSF46934. SSF46934. 1 hit.
    SSF49562. SSF49562. 1 hit.
    PROSITEiPS51140. CUE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q7ZV43-1 [UniParc]FASTAAdd to Basket

    « Hide

    MATTISTQRG QVYIGELPQD FLRIMPTQQQ QQVQLDAQAA RQLQYGGSLG    50
    TAGRLSITVV QAKLAKNYGM TRMDPYCRIR LGYAVYETPT AHNGAKNPRW 100
    NKVIQCTVPP GVDSFYLEIF DERAFSMDDR IAWTHVTIPE NLREGTVVDE 150
    WYSLSGRQGD DKEGMINLVM SFATIPAGMM MQPQPVVLMP TVYQQGVGYV 200
    PIAGVPGMYN QGVVPMGMPA AAPVASQSAP CSEEDLKALQ DMFPNLDKEV 250
    IRTVLEAQQG NKDAAINSLL QMAEEL 276
    Length:276
    Mass (Da):30,424
    Last modified:June 1, 2003 - v1
    Checksum:i1C61E5B737513D1E
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti222 – 2221A → P in AAH66544. 1 PublicationCurated
    Sequence conflicti229 – 2291A → G in AAH66544. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC046009 mRNA. Translation: AAH46009.1.
    BC066544 mRNA. Translation: AAH66544.1.
    RefSeqiNP_996944.1. NM_207061.1.
    UniGeneiDr.79855.

    Genome annotation databases

    GeneIDi336876.
    KEGGidre:336876.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC046009 mRNA. Translation: AAH46009.1 .
    BC066544 mRNA. Translation: AAH66544.1 .
    RefSeqi NP_996944.1. NM_207061.1.
    UniGenei Dr.79855.

    3D structure databases

    ProteinModelPortali Q7ZV43.
    SMRi Q7ZV43. Positions 233-275.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 7955.ENSDARP00000104363.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 336876.
    KEGGi dre:336876.

    Organism-specific databases

    CTDi 54472.
    ZFINi ZDB-GENE-030131-8820. tollip.

    Phylogenomic databases

    eggNOGi NOG85357.
    HOGENOMi HOG000293427.
    InParanoidi Q6NYL4.
    KOi K05402.
    PhylomeDBi Q7ZV43.

    Miscellaneous databases

    NextBioi 20811951.
    PROi Q7ZV43.

    Family and domain databases

    Gene3Di 2.60.40.150. 1 hit.
    InterProi IPR000008. C2_dom.
    IPR003892. CUE.
    IPR009060. UBA-like.
    [Graphical view ]
    Pfami PF00168. C2. 1 hit.
    PF02845. CUE. 1 hit.
    [Graphical view ]
    SMARTi SM00239. C2. 1 hit.
    SM00546. CUE. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46934. SSF46934. 1 hit.
    SSF49562. SSF49562. 1 hit.
    PROSITEi PS51140. CUE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Zebrafish Gene Collection (ZGC) project
      Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Kidney.

    Entry informationi

    Entry nameiTOLIP_DANRE
    AccessioniPrimary (citable) accession number: Q7ZV43
    Secondary accession number(s): Q6NYL4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 22, 2009
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 68 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3