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Q7ZV43 (TOLIP_DANRE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Toll-interacting protein
Gene names
Name:tollip
ORF Names:zgc:76985
OrganismDanio rerio (Zebrafish) (Brachydanio rerio) [Reference proteome]
Taxonomic identifier7955 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Protein attributes

Sequence length276 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Component of the signaling pathway of IL-1 and Toll-like receptors. Inhibits cell activation by microbial products By similarity.

Subcellular location

Cytoplasm Probable.

Sequence similarities

Belongs to the tollip family.

Contains 1 C2 domain.

Contains 1 CUE domain.

Ontologies

Keywords
   Biological processImmunity
Inflammatory response
Innate immunity
   Cellular componentCytoplasm
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processinflammatory response

Inferred from electronic annotation. Source: UniProtKB-KW

innate immune response

Inferred from electronic annotation. Source: UniProtKB-KW

phosphorylation

Inferred from sequence or structural similarity. Source: UniProtKB

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 276276Toll-interacting protein
PRO_0000384933

Regions

Domain40 – 13596C2
Domain231 – 27444CUE
Compositional bias28 – 347Poly-Gln

Experimental info

Sequence conflict2221A → P in AAH66544. Ref.1
Sequence conflict2291A → G in AAH66544. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q7ZV43 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: 1C61E5B737513D1E

FASTA27630,424
        10         20         30         40         50         60 
MATTISTQRG QVYIGELPQD FLRIMPTQQQ QQVQLDAQAA RQLQYGGSLG TAGRLSITVV 

        70         80         90        100        110        120 
QAKLAKNYGM TRMDPYCRIR LGYAVYETPT AHNGAKNPRW NKVIQCTVPP GVDSFYLEIF 

       130        140        150        160        170        180 
DERAFSMDDR IAWTHVTIPE NLREGTVVDE WYSLSGRQGD DKEGMINLVM SFATIPAGMM 

       190        200        210        220        230        240 
MQPQPVVLMP TVYQQGVGYV PIAGVPGMYN QGVVPMGMPA AAPVASQSAP CSEEDLKALQ 

       250        260        270 
DMFPNLDKEV IRTVLEAQQG NKDAAINSLL QMAEEL 

« Hide

References

[1]NIH - Zebrafish Gene Collection (ZGC) project
Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Kidney.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC046009 mRNA. Translation: AAH46009.1.
BC066544 mRNA. Translation: AAH66544.1.
RefSeqNP_996944.1. NM_207061.1.
UniGeneDr.79855.

3D structure databases

ProteinModelPortalQ7ZV43.
SMRQ7ZV43. Positions 233-275.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING7955.ENSDARP00000104363.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID336876.
KEGGdre:336876.

Organism-specific databases

CTD54472.
ZFINZDB-GENE-030131-8820. tollip.

Phylogenomic databases

eggNOGNOG85357.
HOGENOMHOG000293427.
InParanoidQ6NYL4.
KOK05402.
PhylomeDBQ7ZV43.

Family and domain databases

Gene3D2.60.40.150. 1 hit.
InterProIPR000008. C2_dom.
IPR003892. CUE.
IPR009060. UBA-like.
[Graphical view]
PfamPF00168. C2. 1 hit.
PF02845. CUE. 1 hit.
[Graphical view]
SMARTSM00239. C2. 1 hit.
SM00546. CUE. 1 hit.
[Graphical view]
SUPFAMSSF46934. SSF46934. 1 hit.
SSF49562. SSF49562. 1 hit.
PROSITEPS51140. CUE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20811951.
PROQ7ZV43.

Entry information

Entry nameTOLIP_DANRE
AccessionPrimary (citable) accession number: Q7ZV43
Secondary accession number(s): Q6NYL4
Entry history
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: June 1, 2003
Last modified: April 16, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families