Q7ZV43 (TOLIP_DANRE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Toll-interacting protein

Gene names

Name:	tollip
ORF Names:	zgc:76985

Organism

Danio rerio (Zebrafish) (Brachydanio rerio) [Reference proteome]

Taxonomic identifier

7955 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Actinopterygii › Actinopteri › Neopterygii › Teleostei › Elopocephala › Clupeocephala › Otocephala › Ostariophysi › Otophysi › Cypriniphysi › Cypriniformes › Cyprinoidea › Cyprinidae › Danio

Protein attributes

Sequence length	276 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Component of the signaling pathway of IL-1 and Toll-like receptors. Inhibits cell activation by microbial products By similarity.
Subcellular location	Cytoplasm Probable.
Sequence similarities	Belongs to the tollip family. Contains 1 C2 domain. Contains 1 CUE domain.

Ontologies

Keywords
Biological process	Immunity Inflammatory response Innate immunity
Cellular component	Cytoplasm
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	inflammatory response Inferred from electronic annotation. Source: UniProtKB-KW innate immune response Inferred from electronic annotation. Source: UniProtKB-KW phosphorylation Inferred from sequence or structural similarity. Source: UniProtKB
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 276	276	Toll-interacting protein		PRO_0000384933
Regions
	Domain	40 – 135	96	C2
	Domain	231 – 274	44	CUE
	Compositional bias	28 – 34	7	Poly-Gln
Experimental info
	Sequence conflict	222	1	A → P in AAH66544. Ref.1
	Sequence conflict	229	1	A → G in AAH66544. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q7ZV43 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: 1C61E5B737513D1E	FASTA	276	30,424
	10 20 30 40 50 60 MATTISTQRG QVYIGELPQD FLRIMPTQQQ QQVQLDAQAA RQLQYGGSLG TAGRLSITVV 70 80 90 100 110 120 QAKLAKNYGM TRMDPYCRIR LGYAVYETPT AHNGAKNPRW NKVIQCTVPP GVDSFYLEIF 130 140 150 160 170 180 DERAFSMDDR IAWTHVTIPE NLREGTVVDE WYSLSGRQGD DKEGMINLVM SFATIPAGMM 190 200 210 220 230 240 MQPQPVVLMP TVYQQGVGYV PIAGVPGMYN QGVVPMGMPA AAPVASQSAP CSEEDLKALQ 250 260 270 DMFPNLDKEV IRTVLEAQQG NKDAAINSLL QMAEEL

References

[1]	NIH - Zebrafish Gene Collection (ZGC) project Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Kidney.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC046009 mRNA. Translation: AAH46009.1. BC066544 mRNA. Translation: AAH66544.1.
IPI	IPI00483567.
RefSeq	NP_996944.1. NM_207061.1.
UniGene	Dr.79855.
3D structure databases
HSSP	HSSP built from PDB template 1WGL based on UniProtKB Q9H0E2.
ProteinModelPortal	Q7ZV43.
SMR	Q7ZV43. Positions 233-275.
ModBase	Search...
Protein-protein interaction databases
STRING	7955.ENSDARP00000104363.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	336876.
KEGG	dre:336876.
Organism-specific databases
CTD	54472.
ZFIN	ZDB-GENE-030131-8820. tollip.
Phylogenomic databases
eggNOG	NOG85357.
HOGENOM	HOG000293427.
InParanoid	Q6NYL4.
KO	K05402.
OrthoDB	EOG4PK28P.
Family and domain databases
InterPro	IPR000008. C2_Ca-dep. IPR008973. C2_Ca/lipid-bd_dom_CaLB. IPR003892. CUE. IPR009060. UBA-like. [Graphical view]
Pfam	PF00168. C2. 1 hit. PF02845. CUE. 1 hit. [Graphical view]
SMART	SM00239. C2. 1 hit. SM00546. CUE. 1 hit. [Graphical view]
SUPFAM	SSF49562. C2_CaLB. 1 hit. SSF46934. UBA_like. 1 hit.
PROSITE	PS50004. C2. False negative. PS51140. CUE. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	20811951.

Entry information

Entry name

TOLIP_DANRE

Accession

Primary (citable) accession number: Q7ZV43
Secondary accession number(s): Q6NYL4

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 22, 2009
Last sequence update:	June 1, 2003
Last modified:	April 3, 2013
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program