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Protein

Toll-interacting protein

Gene

tollip

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Component of the signaling pathway of IL-1 and Toll-like receptors. Inhibits cell activation by microbial products. Connects the ubiquitin pathway to autophagy by functioning as a ubiquitin-ATG8 family adapter and thus mediating autophagic clearance of ubiquitin conjugates. The TOLLIP-dependent selective autophagy pathway plays an important role in clearance of cytotoxic polyQ proteins aggregates (By similarity).By similarity

GO - Biological processi

  1. autophagy Source: UniProtKB-KW
  2. inflammatory response Source: UniProtKB-KW
  3. innate immune response Source: UniProtKB-KW
  4. phosphorylation Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Autophagy, Immunity, Inflammatory response, Innate immunity

Names & Taxonomyi

Protein namesi
Recommended name:
Toll-interacting protein
Gene namesi
Name:tollip
ORF Names:zgc:76985
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
ProteomesiUP000000437: Unplaced

Organism-specific databases

ZFINiZDB-GENE-030131-8820. tollip.

Subcellular locationi

Cytoplasm Curated

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 276276Toll-interacting proteinPRO_0000384933Add
BLAST

Interactioni

Subunit structurei

Interacts with ATG8 family proteins (via AIM motifs), and ubiquitin (via CUE domain).By similarity

Protein-protein interaction databases

STRINGi7955.ENSDARP00000104363.

Structurei

3D structure databases

ProteinModelPortaliQ7ZV43.
SMRiQ7ZV43. Positions 233-275.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini40 – 13596C2Add
BLAST
Domaini231 – 27444CUEPROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi133 – 1364AIM1
Motifi151 – 1544AIM2

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi28 – 347Poly-Gln

Domaini

Both ATG8-interaction motifs (AIM1 and AIM2) are required for the association with ATG8 family proteins.By similarity

Sequence similaritiesi

Belongs to the tollip family.Curated
Contains 1 C2 domain.Curated
Contains 1 CUE domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG85357.
HOGENOMiHOG000293427.
InParanoidiQ7ZV43.
KOiK05402.
PhylomeDBiQ7ZV43.

Family and domain databases

Gene3Di2.60.40.150. 1 hit.
InterProiIPR000008. C2_dom.
IPR003892. CUE.
IPR009060. UBA-like.
[Graphical view]
PfamiPF00168. C2. 1 hit.
PF02845. CUE. 1 hit.
[Graphical view]
SMARTiSM00239. C2. 1 hit.
SM00546. CUE. 1 hit.
[Graphical view]
SUPFAMiSSF46934. SSF46934. 1 hit.
SSF49562. SSF49562. 1 hit.
PROSITEiPS51140. CUE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7ZV43-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATTISTQRG QVYIGELPQD FLRIMPTQQQ QQVQLDAQAA RQLQYGGSLG
60 70 80 90 100
TAGRLSITVV QAKLAKNYGM TRMDPYCRIR LGYAVYETPT AHNGAKNPRW
110 120 130 140 150
NKVIQCTVPP GVDSFYLEIF DERAFSMDDR IAWTHVTIPE NLREGTVVDE
160 170 180 190 200
WYSLSGRQGD DKEGMINLVM SFATIPAGMM MQPQPVVLMP TVYQQGVGYV
210 220 230 240 250
PIAGVPGMYN QGVVPMGMPA AAPVASQSAP CSEEDLKALQ DMFPNLDKEV
260 270
IRTVLEAQQG NKDAAINSLL QMAEEL
Length:276
Mass (Da):30,424
Last modified:June 1, 2003 - v1
Checksum:i1C61E5B737513D1E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti222 – 2221A → P in AAH66544 (Ref. 1) Curated
Sequence conflicti229 – 2291A → G in AAH66544 (Ref. 1) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC046009 mRNA. Translation: AAH46009.1.
BC066544 mRNA. Translation: AAH66544.1.
RefSeqiNP_996944.1. NM_207061.1.
UniGeneiDr.79855.

Genome annotation databases

GeneIDi336876.
KEGGidre:336876.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC046009 mRNA. Translation: AAH46009.1.
BC066544 mRNA. Translation: AAH66544.1.
RefSeqiNP_996944.1. NM_207061.1.
UniGeneiDr.79855.

3D structure databases

ProteinModelPortaliQ7ZV43.
SMRiQ7ZV43. Positions 233-275.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000104363.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi336876.
KEGGidre:336876.

Organism-specific databases

CTDi54472.
ZFINiZDB-GENE-030131-8820. tollip.

Phylogenomic databases

eggNOGiNOG85357.
HOGENOMiHOG000293427.
InParanoidiQ7ZV43.
KOiK05402.
PhylomeDBiQ7ZV43.

Miscellaneous databases

NextBioi20811951.
PROiQ7ZV43.

Family and domain databases

Gene3Di2.60.40.150. 1 hit.
InterProiIPR000008. C2_dom.
IPR003892. CUE.
IPR009060. UBA-like.
[Graphical view]
PfamiPF00168. C2. 1 hit.
PF02845. CUE. 1 hit.
[Graphical view]
SMARTiSM00239. C2. 1 hit.
SM00546. CUE. 1 hit.
[Graphical view]
SUPFAMiSSF46934. SSF46934. 1 hit.
SSF49562. SSF49562. 1 hit.
PROSITEiPS51140. CUE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.

Entry informationi

Entry nameiTOLIP_DANRE
AccessioniPrimary (citable) accession number: Q7ZV43
Secondary accession number(s): Q6NYL4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: June 1, 2003
Last modified: January 7, 2015
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.