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Q7ZV22

- MTAP_DANRE

UniProt

Q7ZV22 - MTAP_DANRE

Protein

S-methyl-5'-thioadenosine phosphorylase

Gene

mtap

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 80 (01 Oct 2014)
      Sequence version 2 (19 Jul 2005)
      Previous versions | rss
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    Functioni

    Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.UniRule annotation

    Catalytic activityi

    S-methyl-5'-thioadenosine + phosphate = adenine + S-methyl-5-thio-alpha-D-ribose 1-phosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei15 – 151PhosphateUniRule annotation
    Sitei175 – 1751Important for substrate specificityUniRule annotation
    Binding sitei193 – 1931Substrate; via amide nitrogenUniRule annotation
    Binding sitei194 – 1941PhosphateUniRule annotation
    Sitei230 – 2301Important for substrate specificityUniRule annotation

    GO - Molecular functioni

    1. phosphorylase activity Source: InterPro
    2. S-methyl-5-thioadenosine phosphorylase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. L-methionine biosynthetic process from methylthioadenosine Source: UniProtKB-HAMAP
    2. purine ribonucleoside salvage Source: UniProtKB-KW

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Biological processi

    Purine salvage

    Enzyme and pathway databases

    ReactomeiREACT_210544. Methionine salvage pathway.
    UniPathwayiUPA00904; UER00873.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    S-methyl-5'-thioadenosine phosphorylaseUniRule annotation (EC:2.4.2.28UniRule annotation)
    Alternative name(s):
    5'-methylthioadenosine phosphorylaseUniRule annotation
    Short name:
    MTA phosphorylaseUniRule annotation
    Short name:
    MTAPUniRule annotation
    Short name:
    MTAPaseUniRule annotation
    Gene namesi
    Name:mtap
    ORF Names:zgc:66012
    OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
    Taxonomic identifieri7955 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
    ProteomesiUP000000437: Chromosome 1

    Organism-specific databases

    ZFINiZDB-GENE-040426-1505. mtap.

    Subcellular locationi

    Cytoplasm UniRule annotation. Nucleus UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 280280S-methyl-5'-thioadenosine phosphorylasePRO_0000415114Add
    BLAST

    Expressioni

    Gene expression databases

    BgeeiQ7ZV22.

    Interactioni

    Subunit structurei

    Homotrimer.UniRule annotation

    Structurei

    3D structure databases

    ProteinModelPortaliQ7ZV22.
    SMRiQ7ZV22. Positions 7-278.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni57 – 582Phosphate bindingUniRule annotation
    Regioni90 – 912Phosphate bindingUniRule annotation
    Regioni217 – 2193Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0005.
    GeneTreeiENSGT00550000074874.
    HOGENOMiHOG000228986.
    HOVERGENiHBG002487.
    InParanoidiQ7ZV22.
    KOiK00772.
    OMAiCEAQLCY.
    OrthoDBiEOG771270.
    PhylomeDBiQ7ZV22.
    TreeFamiTF312883.

    Family and domain databases

    Gene3Di3.40.50.1580. 1 hit.
    HAMAPiMF_01963. MTAP.
    InterProiIPR010044. MTAP.
    IPR000845. Nucleoside_phosphorylase_d.
    IPR001369. PNP/MTAP.
    IPR018099. Purine_phosphorylase-2_CS.
    [Graphical view]
    PANTHERiPTHR11904. PTHR11904. 1 hit.
    PfamiPF01048. PNP_UDP_1. 1 hit.
    [Graphical view]
    SUPFAMiSSF53167. SSF53167. 1 hit.
    TIGRFAMsiTIGR01694. MTAP. 1 hit.
    PROSITEiPS01240. PNP_MTAP_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q7ZV22-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTSNSHVKIG IIGGSGLDDP DILEGRTERY VVTPYGKPSD ALILGKIKNV    50
    DCVLLARHGR QHTIMPTNVN YQANIWALKE EGCTHLLVTT ACGSLREDIQ 100
    PGDIVLIDQF IDRTTKRVQT FYDGQPTSPP GVCHIPMAEP FCSKTREVLL 150
    EVAQGLGVKC HTRGTMVTIE GPRFSSRAES LMFRQWGADV INMTTVPEVV 200
    LAKEAGLCYA SIAMATDYDC WKEHEEAVCV DNVLKTMKEN ANKASSILLT 250
    AIPQICQMDW DSTINAHKSM SQSSVMLPKH 280
    Length:280
    Mass (Da):30,847
    Last modified:July 19, 2005 - v2
    Checksum:iEBAB6A6FD5663B36
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX323448 Genomic DNA. No translation available.
    BC046035 mRNA. Translation: AAH46035.2.
    BC056545 mRNA. Translation: AAH56545.1.
    RefSeqiNP_956848.1. NM_200554.1.
    UniGeneiDr.84816.

    Genome annotation databases

    EnsembliENSDART00000054208; ENSDARP00000054207; ENSDARG00000037261.
    GeneIDi393526.
    KEGGidre:393526.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX323448 Genomic DNA. No translation available.
    BC046035 mRNA. Translation: AAH46035.2 .
    BC056545 mRNA. Translation: AAH56545.1 .
    RefSeqi NP_956848.1. NM_200554.1.
    UniGenei Dr.84816.

    3D structure databases

    ProteinModelPortali Q7ZV22.
    SMRi Q7ZV22. Positions 7-278.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSDART00000054208 ; ENSDARP00000054207 ; ENSDARG00000037261 .
    GeneIDi 393526.
    KEGGi dre:393526.

    Organism-specific databases

    CTDi 4507.
    ZFINi ZDB-GENE-040426-1505. mtap.

    Phylogenomic databases

    eggNOGi COG0005.
    GeneTreei ENSGT00550000074874.
    HOGENOMi HOG000228986.
    HOVERGENi HBG002487.
    InParanoidi Q7ZV22.
    KOi K00772.
    OMAi CEAQLCY.
    OrthoDBi EOG771270.
    PhylomeDBi Q7ZV22.
    TreeFami TF312883.

    Enzyme and pathway databases

    UniPathwayi UPA00904 ; UER00873 .
    Reactomei REACT_210544. Methionine salvage pathway.

    Miscellaneous databases

    NextBioi 20814549.
    PROi Q7ZV22.

    Gene expression databases

    Bgeei Q7ZV22.

    Family and domain databases

    Gene3Di 3.40.50.1580. 1 hit.
    HAMAPi MF_01963. MTAP.
    InterProi IPR010044. MTAP.
    IPR000845. Nucleoside_phosphorylase_d.
    IPR001369. PNP/MTAP.
    IPR018099. Purine_phosphorylase-2_CS.
    [Graphical view ]
    PANTHERi PTHR11904. PTHR11904. 1 hit.
    Pfami PF01048. PNP_UDP_1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53167. SSF53167. 1 hit.
    TIGRFAMsi TIGR01694. MTAP. 1 hit.
    PROSITEi PS01240. PNP_MTAP_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The zebrafish reference genome sequence and its relationship to the human genome."
      Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.
      , White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., Clee C., Oliver K., Clark R., Riddle C., Eliott D., Threadgold G., Harden G., Ware D., Mortimer B., Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.
      Nature 496:498-503(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Tuebingen.
    2. NIH - Zebrafish Gene Collection (ZGC) project
      Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Kidney.

    Entry informationi

    Entry nameiMTAP_DANRE
    AccessioniPrimary (citable) accession number: Q7ZV22
    Secondary accession number(s): Q6PHI0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 25, 2012
    Last sequence update: July 19, 2005
    Last modified: October 1, 2014
    This is version 80 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3