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Protein

S-methyl-5'-thioadenosine phosphorylase

Gene

mtap

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.UniRule annotation

Catalytic activityi

S-methyl-5'-thioadenosine + phosphate = adenine + S-methyl-5-thio-alpha-D-ribose 1-phosphate.UniRule annotation

Pathwayi: L-methionine biosynthesis via salvage pathway

This protein is involved in step 1 of the subpathway that synthesizes S-methyl-5-thio-alpha-D-ribose 1-phosphate from S-methyl-5'-thioadenosine (phosphorylase route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. S-methyl-5'-thioadenosine phosphorylase (mtap), S-methyl-5'-thioadenosine phosphorylase (mtap)
This subpathway is part of the pathway L-methionine biosynthesis via salvage pathway, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes S-methyl-5-thio-alpha-D-ribose 1-phosphate from S-methyl-5'-thioadenosine (phosphorylase route), the pathway L-methionine biosynthesis via salvage pathway and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei15PhosphateUniRule annotation1
Sitei175Important for substrate specificityUniRule annotation1
Binding sitei193Substrate; via amide nitrogenUniRule annotation1
Binding sitei194PhosphateUniRule annotation1
Sitei230Important for substrate specificityUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase
Biological processPurine salvage

Enzyme and pathway databases

ReactomeiR-DRE-1237112 Methionine salvage pathway
UniPathwayiUPA00904; UER00873

Names & Taxonomyi

Protein namesi
Recommended name:
S-methyl-5'-thioadenosine phosphorylaseUniRule annotation (EC:2.4.2.28UniRule annotation)
Alternative name(s):
5'-methylthioadenosine phosphorylaseUniRule annotation
Short name:
MTA phosphorylaseUniRule annotation
Short name:
MTAPUniRule annotation
Short name:
MTAPaseUniRule annotation
Gene namesi
Name:mtap
ORF Names:zgc:66012
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 1

Organism-specific databases

ZFINiZDB-GENE-040426-1505 mtap

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004151141 – 280S-methyl-5'-thioadenosine phosphorylaseAdd BLAST280

Proteomic databases

PaxDbiQ7ZV22

Expressioni

Gene expression databases

BgeeiENSDARG00000037261
ExpressionAtlasiQ7ZV22 baseline

Interactioni

Subunit structurei

Homotrimer.UniRule annotation

Protein-protein interaction databases

STRINGi7955.ENSDARP00000054207

Structurei

3D structure databases

ProteinModelPortaliQ7ZV22
SMRiQ7ZV22
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni57 – 58Phosphate bindingUniRule annotation2
Regioni90 – 91Phosphate bindingUniRule annotation2
Regioni217 – 219Substrate bindingUniRule annotation3

Sequence similaritiesi

Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.UniRule annotation

Phylogenomic databases

eggNOGiKOG3985 Eukaryota
COG0005 LUCA
GeneTreeiENSGT00550000074874
HOGENOMiHOG000228986
HOVERGENiHBG002487
InParanoidiQ7ZV22
KOiK00772
OMAiNLYRSWG
OrthoDBiEOG091G0CQI
PhylomeDBiQ7ZV22
TreeFamiTF312883

Family and domain databases

HAMAPiMF_01963 MTAP, 1 hit
InterProiView protein in InterPro
IPR010044 MTAP
IPR000845 Nucleoside_phosphorylase_d
IPR035994 Nucleoside_phosphorylase_sf
IPR018099 Purine_phosphorylase-2_CS
PANTHERiPTHR42679 PTHR42679, 1 hit
PfamiView protein in Pfam
PF01048 PNP_UDP_1, 1 hit
SUPFAMiSSF53167 SSF53167, 1 hit
TIGRFAMsiTIGR01694 MTAP, 1 hit
PROSITEiView protein in PROSITE
PS01240 PNP_MTAP_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q7ZV22-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSNSHVKIG IIGGSGLDDP DILEGRTERY VVTPYGKPSD ALILGKIKNV
60 70 80 90 100
DCVLLARHGR QHTIMPTNVN YQANIWALKE EGCTHLLVTT ACGSLREDIQ
110 120 130 140 150
PGDIVLIDQF IDRTTKRVQT FYDGQPTSPP GVCHIPMAEP FCSKTREVLL
160 170 180 190 200
EVAQGLGVKC HTRGTMVTIE GPRFSSRAES LMFRQWGADV INMTTVPEVV
210 220 230 240 250
LAKEAGLCYA SIAMATDYDC WKEHEEAVCV DNVLKTMKEN ANKASSILLT
260 270 280
AIPQICQMDW DSTINAHKSM SQSSVMLPKH
Length:280
Mass (Da):30,847
Last modified:July 19, 2005 - v2
Checksum:iEBAB6A6FD5663B36
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX323448 Genomic DNA No translation available.
BC046035 mRNA Translation: AAH46035.2
BC056545 mRNA Translation: AAH56545.1
RefSeqiNP_956848.1, NM_200554.1
UniGeneiDr.84816

Genome annotation databases

EnsembliENSDART00000054208; ENSDARP00000054207; ENSDARG00000037261
GeneIDi393526
KEGGidre:393526

Similar proteinsi

Entry informationi

Entry nameiMTAP_DANRE
AccessioniPrimary (citable) accession number: Q7ZV22
Secondary accession number(s): Q6PHI0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 25, 2012
Last sequence update: July 19, 2005
Last modified: May 23, 2018
This is version 102 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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