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Q7ZV14 (GPX8_DANRE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 85. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable glutathione peroxidase 8

Short name=GPx-8
Short name=GSHPx-8
EC=1.11.1.9
Gene names
Name:gpx8
ORF Names:zgc:56280
OrganismDanio rerio (Zebrafish) (Brachydanio rerio) [Reference proteome]
Taxonomic identifier7955 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Protein attributes

Sequence length210 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

2 glutathione + H2O2 = glutathione disulfide + 2 H2O.

Subcellular location

Membrane; Single-pass membrane protein Potential.

Sequence similarities

Belongs to the glutathione peroxidase family.

Caution

Ser-80 is present instead of the conserved Cys/Sec which is expected to be the active site residue.

Ontologies

Keywords
   Cellular componentMembrane
   DomainTransmembrane
Transmembrane helix
   Molecular functionOxidoreductase
Peroxidase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processresponse to oxidative stress

Inferred from electronic annotation. Source: InterPro

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionglutathione peroxidase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 210210Probable glutathione peroxidase 8
PRO_0000317758

Regions

Transmembrane13 – 3523Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
Q7ZV14 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: 3973B501C27B0DA8

FASTA21023,806
        10         20         30         40         50         60 
MEALGGYPSK SSASRAGLFK VLLSVALCMG SLYLLQNKLS KSRKTKDFYS YEVKDARGRT 

        70         80         90        100        110        120 
VSLEKYRGKV SLVVNVASGS ELTEQSYRAL QELHRELGTS HFNVLAFPCS QYGDTESGTS 

       130        140        150        160        170        180 
REIEAFAKSN YGVTFPIFNK IKIMGSEAEP AFRFLTDSVQ KIPRWNFWKF LVSPEGQVVR 

       190        200        210 
FWKPEEPVSD IRKEATTLVR NIILKKRQEL 

« Hide

References

[1]NIH - Zebrafish Gene Collection (ZGC) project
Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC046044 mRNA. Translation: AAH46044.1.
RefSeqNP_956516.1. NM_200222.1.
UniGeneDr.107413.

3D structure databases

ProteinModelPortalQ7ZV14.
SMRQ7ZV14. Positions 48-210.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING7955.ENSDARP00000011955.

Proteomic databases

PRIDEQ7ZV14.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID393191.
KEGGdre:393191.

Organism-specific databases

CTD493869.
ZFINZDB-GENE-040426-965. gpx8.

Phylogenomic databases

eggNOGCOG0386.
HOGENOMHOG000277054.
HOVERGENHBG004333.
InParanoidQ7ZV14.
KOK00432.
PhylomeDBQ7ZV14.

Family and domain databases

Gene3D3.40.30.10. 1 hit.
InterProIPR013376. Glut_perox_Gpx7.
IPR000889. Glutathione_peroxidase.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PANTHERPTHR11592. PTHR11592. 1 hit.
PfamPF00255. GSHPx. 1 hit.
[Graphical view]
PIRSFPIRSF000303. Glutathion_perox. 1 hit.
PRINTSPR01011. GLUTPROXDASE.
SUPFAMSSF52833. SSF52833. 1 hit.
TIGRFAMsTIGR02540. gpx7. 1 hit.
PROSITEPS00014. ER_TARGET. 1 hit.
PS51355. GLUTATHIONE_PEROXID_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20814256.

Entry information

Entry nameGPX8_DANRE
AccessionPrimary (citable) accession number: Q7ZV14
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: June 1, 2003
Last modified: April 16, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families