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Q7ZV14

- GPX8_DANRE

UniProt

Q7ZV14 - GPX8_DANRE

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Protein
Probable glutathione peroxidase 8
Gene
gpx8, zgc:56280
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

2 glutathione + H2O2 = glutathione disulfide + 2 H2O.

GO - Molecular functioni

  1. glutathione peroxidase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. response to oxidative stress Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glutathione peroxidase 8 (EC:1.11.1.9)
Short name:
GPx-8
Short name:
GSHPx-8
Gene namesi
Name:gpx8
ORF Names:zgc:56280
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
ProteomesiUP000000437: Unplaced

Organism-specific databases

ZFINiZDB-GENE-040426-965. gpx8.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei13 – 3523Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 210210Probable glutathione peroxidase 8
PRO_0000317758Add
BLAST

Proteomic databases

PRIDEiQ7ZV14.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000011955.

Structurei

3D structure databases

ProteinModelPortaliQ7ZV14.
SMRiQ7ZV14. Positions 48-210.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0386.
HOGENOMiHOG000277054.
HOVERGENiHBG004333.
InParanoidiQ7ZV14.
KOiK00432.
PhylomeDBiQ7ZV14.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR013376. Glut_perox_Gpx7.
IPR000889. Glutathione_peroxidase.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PANTHERiPTHR11592. PTHR11592. 1 hit.
PfamiPF00255. GSHPx. 1 hit.
[Graphical view]
PIRSFiPIRSF000303. Glutathion_perox. 1 hit.
PRINTSiPR01011. GLUTPROXDASE.
SUPFAMiSSF52833. SSF52833. 1 hit.
TIGRFAMsiTIGR02540. gpx7. 1 hit.
PROSITEiPS00014. ER_TARGET. 1 hit.
PS51355. GLUTATHIONE_PEROXID_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7ZV14-1 [UniParc]FASTAAdd to Basket

« Hide

MEALGGYPSK SSASRAGLFK VLLSVALCMG SLYLLQNKLS KSRKTKDFYS    50
YEVKDARGRT VSLEKYRGKV SLVVNVASGS ELTEQSYRAL QELHRELGTS 100
HFNVLAFPCS QYGDTESGTS REIEAFAKSN YGVTFPIFNK IKIMGSEAEP 150
AFRFLTDSVQ KIPRWNFWKF LVSPEGQVVR FWKPEEPVSD IRKEATTLVR 200
NIILKKRQEL 210
Length:210
Mass (Da):23,806
Last modified:June 1, 2003 - v1
Checksum:i3973B501C27B0DA8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC046044 mRNA. Translation: AAH46044.1.
RefSeqiNP_956516.1. NM_200222.1.
UniGeneiDr.107413.

Genome annotation databases

GeneIDi393191.
KEGGidre:393191.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC046044 mRNA. Translation: AAH46044.1 .
RefSeqi NP_956516.1. NM_200222.1.
UniGenei Dr.107413.

3D structure databases

ProteinModelPortali Q7ZV14.
SMRi Q7ZV14. Positions 48-210.
ModBasei Search...

Protein-protein interaction databases

STRINGi 7955.ENSDARP00000011955.

Proteomic databases

PRIDEi Q7ZV14.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 393191.
KEGGi dre:393191.

Organism-specific databases

CTDi 493869.
ZFINi ZDB-GENE-040426-965. gpx8.

Phylogenomic databases

eggNOGi COG0386.
HOGENOMi HOG000277054.
HOVERGENi HBG004333.
InParanoidi Q7ZV14.
KOi K00432.
PhylomeDBi Q7ZV14.

Miscellaneous databases

NextBioi 20814256.

Family and domain databases

Gene3Di 3.40.30.10. 1 hit.
InterProi IPR013376. Glut_perox_Gpx7.
IPR000889. Glutathione_peroxidase.
IPR012336. Thioredoxin-like_fold.
[Graphical view ]
PANTHERi PTHR11592. PTHR11592. 1 hit.
Pfami PF00255. GSHPx. 1 hit.
[Graphical view ]
PIRSFi PIRSF000303. Glutathion_perox. 1 hit.
PRINTSi PR01011. GLUTPROXDASE.
SUPFAMi SSF52833. SSF52833. 1 hit.
TIGRFAMsi TIGR02540. gpx7. 1 hit.
PROSITEi PS00014. ER_TARGET. 1 hit.
PS51355. GLUTATHIONE_PEROXID_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiGPX8_DANRE
AccessioniPrimary (citable) accession number: Q7ZV14
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: June 1, 2003
Last modified: April 16, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

Ser-80 is present instead of the conserved Cys/Sec which is expected to be the active site residue.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi