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Protein

Probable glutathione peroxidase 8

Gene

gpx8

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

2 glutathione + H2O2 = glutathione disulfide + 2 H2O.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glutathione peroxidase 8 (EC:1.11.1.9)
Short name:
GPx-8
Short name:
GSHPx-8
Gene namesi
Name:gpx8
ORF Names:zgc:56280
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
ProteomesiUP000000437 Componenti: Unplaced

Organism-specific databases

ZFINiZDB-GENE-040426-965. gpx8.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei13 – 3523HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 210210Probable glutathione peroxidase 8PRO_0000317758Add
BLAST

Proteomic databases

PRIDEiQ7ZV14.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000011955.

Structurei

3D structure databases

ProteinModelPortaliQ7ZV14.
SMRiQ7ZV14. Positions 48-210.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glutathione peroxidase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0386.
HOGENOMiHOG000277054.
HOVERGENiHBG004333.
InParanoidiQ7ZV14.
KOiK00432.
PhylomeDBiQ7ZV14.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR013376. Glut_perox_Gpx7.
IPR000889. Glutathione_peroxidase.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PANTHERiPTHR11592. PTHR11592. 1 hit.
PfamiPF00255. GSHPx. 1 hit.
[Graphical view]
PRINTSiPR01011. GLUTPROXDASE.
SUPFAMiSSF52833. SSF52833. 1 hit.
TIGRFAMsiTIGR02540. gpx7. 1 hit.
PROSITEiPS00014. ER_TARGET. 1 hit.
PS51355. GLUTATHIONE_PEROXID_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7ZV14-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEALGGYPSK SSASRAGLFK VLLSVALCMG SLYLLQNKLS KSRKTKDFYS
60 70 80 90 100
YEVKDARGRT VSLEKYRGKV SLVVNVASGS ELTEQSYRAL QELHRELGTS
110 120 130 140 150
HFNVLAFPCS QYGDTESGTS REIEAFAKSN YGVTFPIFNK IKIMGSEAEP
160 170 180 190 200
AFRFLTDSVQ KIPRWNFWKF LVSPEGQVVR FWKPEEPVSD IRKEATTLVR
210
NIILKKRQEL
Length:210
Mass (Da):23,806
Last modified:June 1, 2003 - v1
Checksum:i3973B501C27B0DA8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC046044 mRNA. Translation: AAH46044.1.
RefSeqiNP_956516.1. NM_200222.1.
UniGeneiDr.107413.

Genome annotation databases

GeneIDi393191.
KEGGidre:393191.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC046044 mRNA. Translation: AAH46044.1.
RefSeqiNP_956516.1. NM_200222.1.
UniGeneiDr.107413.

3D structure databases

ProteinModelPortaliQ7ZV14.
SMRiQ7ZV14. Positions 48-210.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000011955.

Proteomic databases

PRIDEiQ7ZV14.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi393191.
KEGGidre:393191.

Organism-specific databases

CTDi493869.
ZFINiZDB-GENE-040426-965. gpx8.

Phylogenomic databases

eggNOGiCOG0386.
HOGENOMiHOG000277054.
HOVERGENiHBG004333.
InParanoidiQ7ZV14.
KOiK00432.
PhylomeDBiQ7ZV14.

Miscellaneous databases

NextBioi20814256.
PROiQ7ZV14.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR013376. Glut_perox_Gpx7.
IPR000889. Glutathione_peroxidase.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PANTHERiPTHR11592. PTHR11592. 1 hit.
PfamiPF00255. GSHPx. 1 hit.
[Graphical view]
PRINTSiPR01011. GLUTPROXDASE.
SUPFAMiSSF52833. SSF52833. 1 hit.
TIGRFAMsiTIGR02540. gpx7. 1 hit.
PROSITEiPS00014. ER_TARGET. 1 hit.
PS51355. GLUTATHIONE_PEROXID_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiGPX8_DANRE
AccessioniPrimary (citable) accession number: Q7ZV14
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: June 1, 2003
Last modified: April 29, 2015
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

Ser-80 is present instead of the conserved Cys/Sec which is expected to be the active site residue.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.