Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q7ZV14

- GPX8_DANRE

UniProt

Q7ZV14 - GPX8_DANRE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Probable glutathione peroxidase 8

Gene

gpx8

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

2 glutathione + H2O2 = glutathione disulfide + 2 H2O.

GO - Molecular functioni

  1. glutathione peroxidase activity Source: UniProtKB-EC

GO - Biological processi

  1. response to oxidative stress Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glutathione peroxidase 8 (EC:1.11.1.9)
Short name:
GPx-8
Short name:
GSHPx-8
Gene namesi
Name:gpx8
ORF Names:zgc:56280
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
ProteomesiUP000000437: Unplaced

Organism-specific databases

ZFINiZDB-GENE-040426-965. gpx8.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 210210Probable glutathione peroxidase 8PRO_0000317758Add
BLAST

Proteomic databases

PRIDEiQ7ZV14.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000011955.

Structurei

3D structure databases

ProteinModelPortaliQ7ZV14.
SMRiQ7ZV14. Positions 48-210.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei13 – 3523HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the glutathione peroxidase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0386.
HOGENOMiHOG000277054.
HOVERGENiHBG004333.
InParanoidiQ7ZV14.
KOiK00432.
PhylomeDBiQ7ZV14.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR013376. Glut_perox_Gpx7.
IPR000889. Glutathione_peroxidase.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PANTHERiPTHR11592. PTHR11592. 1 hit.
PfamiPF00255. GSHPx. 1 hit.
[Graphical view]
PIRSFiPIRSF000303. Glutathion_perox. 1 hit.
PRINTSiPR01011. GLUTPROXDASE.
SUPFAMiSSF52833. SSF52833. 1 hit.
TIGRFAMsiTIGR02540. gpx7. 1 hit.
PROSITEiPS00014. ER_TARGET. 1 hit.
PS51355. GLUTATHIONE_PEROXID_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7ZV14-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEALGGYPSK SSASRAGLFK VLLSVALCMG SLYLLQNKLS KSRKTKDFYS
60 70 80 90 100
YEVKDARGRT VSLEKYRGKV SLVVNVASGS ELTEQSYRAL QELHRELGTS
110 120 130 140 150
HFNVLAFPCS QYGDTESGTS REIEAFAKSN YGVTFPIFNK IKIMGSEAEP
160 170 180 190 200
AFRFLTDSVQ KIPRWNFWKF LVSPEGQVVR FWKPEEPVSD IRKEATTLVR
210
NIILKKRQEL
Length:210
Mass (Da):23,806
Last modified:June 1, 2003 - v1
Checksum:i3973B501C27B0DA8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC046044 mRNA. Translation: AAH46044.1.
RefSeqiNP_956516.1. NM_200222.1.
UniGeneiDr.107413.

Genome annotation databases

GeneIDi393191.
KEGGidre:393191.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC046044 mRNA. Translation: AAH46044.1 .
RefSeqi NP_956516.1. NM_200222.1.
UniGenei Dr.107413.

3D structure databases

ProteinModelPortali Q7ZV14.
SMRi Q7ZV14. Positions 48-210.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 7955.ENSDARP00000011955.

Proteomic databases

PRIDEi Q7ZV14.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 393191.
KEGGi dre:393191.

Organism-specific databases

CTDi 493869.
ZFINi ZDB-GENE-040426-965. gpx8.

Phylogenomic databases

eggNOGi COG0386.
HOGENOMi HOG000277054.
HOVERGENi HBG004333.
InParanoidi Q7ZV14.
KOi K00432.
PhylomeDBi Q7ZV14.

Miscellaneous databases

NextBioi 20814256.

Family and domain databases

Gene3Di 3.40.30.10. 1 hit.
InterProi IPR013376. Glut_perox_Gpx7.
IPR000889. Glutathione_peroxidase.
IPR012336. Thioredoxin-like_fold.
[Graphical view ]
PANTHERi PTHR11592. PTHR11592. 1 hit.
Pfami PF00255. GSHPx. 1 hit.
[Graphical view ]
PIRSFi PIRSF000303. Glutathion_perox. 1 hit.
PRINTSi PR01011. GLUTPROXDASE.
SUPFAMi SSF52833. SSF52833. 1 hit.
TIGRFAMsi TIGR02540. gpx7. 1 hit.
PROSITEi PS00014. ER_TARGET. 1 hit.
PS51355. GLUTATHIONE_PEROXID_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiGPX8_DANRE
AccessioniPrimary (citable) accession number: Q7ZV14
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: June 1, 2003
Last modified: October 1, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

Ser-80 is present instead of the conserved Cys/Sec which is expected to be the active site residue.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3