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Q7ZV14

- GPX8_DANRE

UniProt

Q7ZV14 - GPX8_DANRE

Protein

Probable glutathione peroxidase 8

Gene

gpx8

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 86 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    2 glutathione + H2O2 = glutathione disulfide + 2 H2O.

    GO - Molecular functioni

    1. glutathione peroxidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. response to oxidative stress Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase, Peroxidase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable glutathione peroxidase 8 (EC:1.11.1.9)
    Short name:
    GPx-8
    Short name:
    GSHPx-8
    Gene namesi
    Name:gpx8
    ORF Names:zgc:56280
    OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
    Taxonomic identifieri7955 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
    ProteomesiUP000000437: Unplaced

    Organism-specific databases

    ZFINiZDB-GENE-040426-965. gpx8.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 210210Probable glutathione peroxidase 8PRO_0000317758Add
    BLAST

    Proteomic databases

    PRIDEiQ7ZV14.

    Interactioni

    Protein-protein interaction databases

    STRINGi7955.ENSDARP00000011955.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7ZV14.
    SMRiQ7ZV14. Positions 48-210.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei13 – 3523HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glutathione peroxidase family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0386.
    HOGENOMiHOG000277054.
    HOVERGENiHBG004333.
    InParanoidiQ7ZV14.
    KOiK00432.
    PhylomeDBiQ7ZV14.

    Family and domain databases

    Gene3Di3.40.30.10. 1 hit.
    InterProiIPR013376. Glut_perox_Gpx7.
    IPR000889. Glutathione_peroxidase.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view]
    PANTHERiPTHR11592. PTHR11592. 1 hit.
    PfamiPF00255. GSHPx. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000303. Glutathion_perox. 1 hit.
    PRINTSiPR01011. GLUTPROXDASE.
    SUPFAMiSSF52833. SSF52833. 1 hit.
    TIGRFAMsiTIGR02540. gpx7. 1 hit.
    PROSITEiPS00014. ER_TARGET. 1 hit.
    PS51355. GLUTATHIONE_PEROXID_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q7ZV14-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEALGGYPSK SSASRAGLFK VLLSVALCMG SLYLLQNKLS KSRKTKDFYS    50
    YEVKDARGRT VSLEKYRGKV SLVVNVASGS ELTEQSYRAL QELHRELGTS 100
    HFNVLAFPCS QYGDTESGTS REIEAFAKSN YGVTFPIFNK IKIMGSEAEP 150
    AFRFLTDSVQ KIPRWNFWKF LVSPEGQVVR FWKPEEPVSD IRKEATTLVR 200
    NIILKKRQEL 210
    Length:210
    Mass (Da):23,806
    Last modified:June 1, 2003 - v1
    Checksum:i3973B501C27B0DA8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC046044 mRNA. Translation: AAH46044.1.
    RefSeqiNP_956516.1. NM_200222.1.
    UniGeneiDr.107413.

    Genome annotation databases

    GeneIDi393191.
    KEGGidre:393191.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC046044 mRNA. Translation: AAH46044.1 .
    RefSeqi NP_956516.1. NM_200222.1.
    UniGenei Dr.107413.

    3D structure databases

    ProteinModelPortali Q7ZV14.
    SMRi Q7ZV14. Positions 48-210.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 7955.ENSDARP00000011955.

    Proteomic databases

    PRIDEi Q7ZV14.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 393191.
    KEGGi dre:393191.

    Organism-specific databases

    CTDi 493869.
    ZFINi ZDB-GENE-040426-965. gpx8.

    Phylogenomic databases

    eggNOGi COG0386.
    HOGENOMi HOG000277054.
    HOVERGENi HBG004333.
    InParanoidi Q7ZV14.
    KOi K00432.
    PhylomeDBi Q7ZV14.

    Miscellaneous databases

    NextBioi 20814256.

    Family and domain databases

    Gene3Di 3.40.30.10. 1 hit.
    InterProi IPR013376. Glut_perox_Gpx7.
    IPR000889. Glutathione_peroxidase.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view ]
    PANTHERi PTHR11592. PTHR11592. 1 hit.
    Pfami PF00255. GSHPx. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000303. Glutathion_perox. 1 hit.
    PRINTSi PR01011. GLUTPROXDASE.
    SUPFAMi SSF52833. SSF52833. 1 hit.
    TIGRFAMsi TIGR02540. gpx7. 1 hit.
    PROSITEi PS00014. ER_TARGET. 1 hit.
    PS51355. GLUTATHIONE_PEROXID_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Zebrafish Gene Collection (ZGC) project
      Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

    Entry informationi

    Entry nameiGPX8_DANRE
    AccessioniPrimary (citable) accession number: Q7ZV14
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 86 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Caution

    Ser-80 is present instead of the conserved Cys/Sec which is expected to be the active site residue.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3