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Q7ZV00

- OTU6B_DANRE

UniProt

Q7ZV00 - OTU6B_DANRE

Protein

OTU domain-containing protein 6B

Gene

otud6b

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 54 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei155 – 1551By similarity
    Active sitei158 – 1581NucleophileBy similarity
    Active sitei277 – 2771By similarity

    GO - Molecular functioni

    1. cysteine-type peptidase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol protease

    Keywords - Biological processi

    Ubl conjugation pathway

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    OTU domain-containing protein 6B (EC:3.4.19.12)
    Gene namesi
    Name:otud6b
    ORF Names:zgc:56305
    OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
    Taxonomic identifieri7955 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
    ProteomesiUP000000437: Unplaced

    Organism-specific databases

    ZFINiZDB-GENE-040426-974. otud6b.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 293293OTU domain-containing protein 6BPRO_0000076282Add
    BLAST

    Proteomic databases

    PRIDEiQ7ZV00.

    Interactioni

    Protein-protein interaction databases

    STRINGi7955.ENSDARP00000029725.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7ZV00.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini147 – 284138OTUPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni152 – 1587Cys-loopBy similarity
    Regioni219 – 22911Variable-loopBy similarityAdd
    BLAST
    Regioni267 – 27711His-loopBy similarityAdd
    BLAST

    Sequence similaritiesi

    Contains 1 OTU domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG5539.
    HOGENOMiHOG000192906.
    HOVERGENiHBG080227.
    KOiK18342.
    PhylomeDBiQ7ZV00.

    Family and domain databases

    InterProiIPR003323. OTU.
    [Graphical view]
    PfamiPF02338. OTU. 1 hit.
    [Graphical view]
    PROSITEiPS50802. OTU. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q7ZV00-1 [UniParc]FASTAAdd to Basket

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    MEEVETAEEQ LAKQHRKEKK DLQAKIQSMK NAVPKNDKKR RKQLTEDIAK    50
    LEAELSQKHE NELKLQNTSS VEEVSDALDS MSVANHEEQS DPSKQSRTSK 100
    AQKRRDKKAA LEKEREMRIA EAEVENLSGS RHQEGLKLRE KLVERHLQIK 150
    EISSDGHCMY RAVEHQLTER GLALGLKELR DQTAQYMRSH ADDFMPFLTN 200
    PNTGDMYTAE EFEKYCSDVA DTAAWGGQLE LKALSQVLQL PIEVIQADSP 250
    CITIGEEYDK PKITLIYMRH AYGLGEHYNS VEPLKDLANE EEG 293
    Length:293
    Mass (Da):33,507
    Last modified:June 1, 2003 - v1
    Checksum:iD8BE7A4E2742F3AB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC046060 mRNA. Translation: AAH46060.1.
    RefSeqiNP_956519.1. NM_200225.1.
    UniGeneiDr.16650.

    Genome annotation databases

    GeneIDi393194.
    KEGGidre:393194.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC046060 mRNA. Translation: AAH46060.1 .
    RefSeqi NP_956519.1. NM_200225.1.
    UniGenei Dr.16650.

    3D structure databases

    ProteinModelPortali Q7ZV00.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 7955.ENSDARP00000029725.

    Proteomic databases

    PRIDEi Q7ZV00.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 393194.
    KEGGi dre:393194.

    Organism-specific databases

    CTDi 51633.
    ZFINi ZDB-GENE-040426-974. otud6b.

    Phylogenomic databases

    eggNOGi COG5539.
    HOGENOMi HOG000192906.
    HOVERGENi HBG080227.
    KOi K18342.
    PhylomeDBi Q7ZV00.

    Miscellaneous databases

    NextBioi 20814259.
    PROi Q7ZV00.

    Family and domain databases

    InterProi IPR003323. OTU.
    [Graphical view ]
    Pfami PF02338. OTU. 1 hit.
    [Graphical view ]
    PROSITEi PS50802. OTU. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Zebrafish Gene Collection (ZGC) project
      Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

    Entry informationi

    Entry nameiOTU6B_DANRE
    AccessioniPrimary (citable) accession number: Q7ZV00
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 24, 2006
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 54 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3