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Protein

OTU domain-containing protein 6B

Gene

otud6b

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei155 – 1551By similarity
Active sitei158 – 1581NucleophileBy similarity
Active sitei277 – 2771By similarity

GO - Molecular functioni

  1. cysteine-type peptidase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Ubl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
OTU domain-containing protein 6B (EC:3.4.19.12)
Gene namesi
Name:otud6b
ORF Names:zgc:56305
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
ProteomesiUP000000437 Componenti: Unplaced

Organism-specific databases

ZFINiZDB-GENE-040426-974. otud6b.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 293293OTU domain-containing protein 6BPRO_0000076282Add
BLAST

Proteomic databases

PRIDEiQ7ZV00.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000029725.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini147 – 284138OTUPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni152 – 1587Cys-loopBy similarity
Regioni219 – 22911Variable-loopBy similarityAdd
BLAST
Regioni267 – 27711His-loopBy similarityAdd
BLAST

Sequence similaritiesi

Contains 1 OTU domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG5539.
HOGENOMiHOG000192906.
HOVERGENiHBG080227.
InParanoidiQ7ZV00.
KOiK18342.
PhylomeDBiQ7ZV00.

Family and domain databases

InterProiIPR003323. OTU.
[Graphical view]
PfamiPF02338. OTU. 1 hit.
[Graphical view]
PROSITEiPS50802. OTU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7ZV00-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEVETAEEQ LAKQHRKEKK DLQAKIQSMK NAVPKNDKKR RKQLTEDIAK
60 70 80 90 100
LEAELSQKHE NELKLQNTSS VEEVSDALDS MSVANHEEQS DPSKQSRTSK
110 120 130 140 150
AQKRRDKKAA LEKEREMRIA EAEVENLSGS RHQEGLKLRE KLVERHLQIK
160 170 180 190 200
EISSDGHCMY RAVEHQLTER GLALGLKELR DQTAQYMRSH ADDFMPFLTN
210 220 230 240 250
PNTGDMYTAE EFEKYCSDVA DTAAWGGQLE LKALSQVLQL PIEVIQADSP
260 270 280 290
CITIGEEYDK PKITLIYMRH AYGLGEHYNS VEPLKDLANE EEG
Length:293
Mass (Da):33,507
Last modified:June 1, 2003 - v1
Checksum:iD8BE7A4E2742F3AB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC046060 mRNA. Translation: AAH46060.1.
RefSeqiNP_956519.1. NM_200225.1.
UniGeneiDr.16650.

Genome annotation databases

GeneIDi393194.
KEGGidre:393194.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC046060 mRNA. Translation: AAH46060.1.
RefSeqiNP_956519.1. NM_200225.1.
UniGeneiDr.16650.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000029725.

Proteomic databases

PRIDEiQ7ZV00.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi393194.
KEGGidre:393194.

Organism-specific databases

CTDi51633.
ZFINiZDB-GENE-040426-974. otud6b.

Phylogenomic databases

eggNOGiCOG5539.
HOGENOMiHOG000192906.
HOVERGENiHBG080227.
InParanoidiQ7ZV00.
KOiK18342.
PhylomeDBiQ7ZV00.

Miscellaneous databases

NextBioi20814259.
PROiQ7ZV00.

Family and domain databases

InterProiIPR003323. OTU.
[Graphical view]
PfamiPF02338. OTU. 1 hit.
[Graphical view]
PROSITEiPS50802. OTU. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiOTU6B_DANRE
AccessioniPrimary (citable) accession number: Q7ZV00
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: June 1, 2003
Last modified: April 1, 2015
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.