Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Aspartate aminotransferase

Gene

got1

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

AminotransferaseUniRule annotation, Transferase

Enzyme and pathway databases

ReactomeiR-DRE-70263. Gluconeogenesis.
R-DRE-70614. Amino acid synthesis and interconversion (transamination).

Names & Taxonomyi

Protein namesi
Recommended name:
Aspartate aminotransferaseUniRule annotation (EC:2.6.1.1UniRule annotation)
Gene namesi
Name:got1Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 13

Organism-specific databases

ZFINiZDB-GENE-040426-2003. got1.

Expressioni

Gene expression databases

BgeeiENSDARG00000039093.

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 402Aminotran_1_2InterPro annotationAdd BLAST374

Phylogenomic databases

GeneTreeiENSGT00390000014081.
HOGENOMiHOG000205084.
HOVERGENiHBG000951.
KOiK14454.
OMAiKYWDAEK.
OrthoDBiEOG091G06G3.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
InterProiIPR004839. Aminotransferase_I/II.
IPR000796. Asp_trans.
IPR004838. NHTrfase_class1_PyrdxlP-BS.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11879. PTHR11879. 1 hit.
PfamiPF00155. Aminotran_1_2. 1 hit.
[Graphical view]
PRINTSiPR00799. TRANSAMINASE.
SUPFAMiSSF53383. SSF53383. 1 hit.
PROSITEiPS00105. AA_TRANSFER_CLASS_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7ZUW8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSIFGEVPQA APVAVFKLTA DFREDQDQKK VNLGVGAYRT DECQPWVLPV
60 70 80 90 100
VRKVEKMIAD DHSLNHEYLP ILGLPEFRSS ASKIALGEDS PAIKENRVGA
110 120 130 140 150
VQCLGGTGAL KIGAEFLRRW YNGTDNTKTP VYVSAPTWEN HNAVFSNAGF
160 170 180 190 200
EDIRPYKYWD PVKRGLDLAG FLGDMESAPD HSIFVLHACA HNPTGTDPTQ
210 220 230 240 250
DQWKQIAEVM KRKNLFAFFD SAYQGFASGD LEKDAWAVRY FVSQGFELFC
260 270 280 290 300
AQSFSKNFGL YNERVGNLTV VAKDQDNVNR VLSQMEKIVR ITWSNPPSQG
310 320 330 340 350
ARLVAITLNT PELFAEWKAN VKTMADRVLL MRAQLKEKLK ALGTPGTWEH
360 370 380 390 400
ITEQIGMFSF TGLNPKQVEY MIKEKHIYLM ASGRINMCGL TSKNIDYVAE
410
SIHEAVTKVQ
Length:410
Mass (Da):45,982
Last modified:June 1, 2003 - v1
Checksum:i03949B6BF84D2383
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX005330 Genomic DNA. No translation available.
CU929568 Genomic DNA. No translation available.
BC047800 mRNA. Translation: AAH47800.1.
BC155112 mRNA. Translation: AAI55113.1.
BC164786 mRNA. Translation: AAI64786.1.
RefSeqiNP_998222.1. NM_213057.2.
XP_017214217.1. XM_017358728.1.
UniGeneiDr.75522.

Genome annotation databases

EnsembliENSDART00000167859; ENSDARP00000129948; ENSDARG00000039093.
GeneIDi406330.
KEGGidre:406330.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX005330 Genomic DNA. No translation available.
CU929568 Genomic DNA. No translation available.
BC047800 mRNA. Translation: AAH47800.1.
BC155112 mRNA. Translation: AAI55113.1.
BC164786 mRNA. Translation: AAI64786.1.
RefSeqiNP_998222.1. NM_213057.2.
XP_017214217.1. XM_017358728.1.
UniGeneiDr.75522.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000167859; ENSDARP00000129948; ENSDARG00000039093.
GeneIDi406330.
KEGGidre:406330.

Organism-specific databases

CTDi2805.
ZFINiZDB-GENE-040426-2003. got1.

Phylogenomic databases

GeneTreeiENSGT00390000014081.
HOGENOMiHOG000205084.
HOVERGENiHBG000951.
KOiK14454.
OMAiKYWDAEK.
OrthoDBiEOG091G06G3.

Enzyme and pathway databases

ReactomeiR-DRE-70263. Gluconeogenesis.
R-DRE-70614. Amino acid synthesis and interconversion (transamination).

Gene expression databases

BgeeiENSDARG00000039093.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
InterProiIPR004839. Aminotransferase_I/II.
IPR000796. Asp_trans.
IPR004838. NHTrfase_class1_PyrdxlP-BS.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11879. PTHR11879. 1 hit.
PfamiPF00155. Aminotran_1_2. 1 hit.
[Graphical view]
PRINTSiPR00799. TRANSAMINASE.
SUPFAMiSSF53383. SSF53383. 1 hit.
PROSITEiPS00105. AA_TRANSFER_CLASS_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ7ZUW8_DANRE
AccessioniPrimary (citable) accession number: Q7ZUW8
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2003
Last sequence update: June 1, 2003
Last modified: November 2, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Miscellaneous

In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.UniRule annotation

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.