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Protein

Katanin p80 WD40 repeat-containing subunit B1

Gene

katnb1

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation.UniRule annotation

GO - Biological processi

  • brain development Source: ZFIN
  • cell division Source: UniProtKB-KW
  • microtubule severing Source: UniProtKB-HAMAP
  • midbrain development Source: ZFIN
  • mitotic nuclear division Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Names & Taxonomyi

Protein namesi
Recommended name:
Katanin p80 WD40 repeat-containing subunit B1UniRule annotation
Short name:
Katanin p80 subunit B1UniRule annotation
Alternative name(s):
p80 kataninUniRule annotation
Gene namesi
Name:katnb1
ORF Names:zgc:56071
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 7

Organism-specific databases

ZFINiZDB-GENE-040426-1954. katnb1.

Subcellular locationi

  • Cytoplasm UniRule annotation
  • Cytoplasmcytoskeletonmicrotubule organizing centercentrosome UniRule annotation
  • Cytoplasmcytoskeletonspindle pole UniRule annotation
  • Cytoplasmcytoskeleton UniRule annotation

  • Note: Predominantly cytoplasmic. Localized to the interphase centrosome and mitotic spindle poles.UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

Pathology & Biotechi

Disruption phenotypei

Results in a significant reduction in midbrain size. A wide spectrum of defects in gastrulation and formation of anterior structures are noticed, ranging from milder microcephaly to more severe anencephaly and early embryonic death.2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 694694Katanin p80 WD40 repeat-containing subunit B1PRO_0000051051Add
BLAST

Proteomic databases

PaxDbiQ7ZUV2.

Expressioni

Gene expression databases

BgeeiQ7ZUV2.

Interactioni

Subunit structurei

Interacts with katna1. This interaction enhances the microtubule binding and severing activity of katna1 and also targets this activity to the centrosome.UniRule annotation

Protein-protein interaction databases

STRINGi7955.ENSDARP00000024623.

Structurei

3D structure databases

ProteinModelPortaliQ7ZUV2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati18 – 5841WD 1Add
BLAST
Repeati61 – 10040WD 2Add
BLAST
Repeati103 – 14240WD 3Add
BLAST
Repeati145 – 18642WD 4Add
BLAST
Repeati188 – 22639WD 5Add
BLAST
Repeati229 – 26941WD 6Add
BLAST

Sequence similaritiesi

Belongs to the WD repeat KATNB1 family.UniRule annotation
Contains 6 WD repeats.UniRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0267. Eukaryota.
ENOG410XQAC. LUCA.
GeneTreeiENSGT00810000125363.
HOGENOMiHOG000008039.
HOVERGENiHBG052294.
InParanoidiQ7ZUV2.
KOiK18643.
OMAiAWKLQEF.
OrthoDBiEOG72ZCDG.
PhylomeDBiQ7ZUV2.
TreeFamiTF332359.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
HAMAPiMF_03022. Katanin_p80_B1.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR026962. Katanin_bsu1.
IPR028021. Katanin_C-terminal.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PANTHERiPTHR19845:SF0. PTHR19845:SF0. 1 hit.
PfamiPF13925. Katanin_con80. 1 hit.
PF00400. WD40. 6 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 6 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 3 hits.
PS50082. WD_REPEATS_2. 5 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7ZUV2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALTNTTITS WKLQEIVAHS SNVSSLVLGK SSGRLLATGG EDCRVNIWAV
60 70 80 90 100
SKPNCIMSLT GHTSAVGCIQ FNSSEERVVA GSLSGSLRLW DLEAAKILRT
110 120 130 140 150
LMGHKASISS LDFHPMGEYL ASGSVDSNIK LWDVRRKGCV FRYKGHTQAV
160 170 180 190 200
RCLAFSPDGK WLASASDDST VKLWDLIAGK MITEFTSHTS AVNVVQFHPN
210 220 230 240 250
EYLLASGSAD RTVKLWDLEK FNMIGSSEGE TGVVRSVLFN PDGSCLYSGS
260 270 280 290 300
ENTLRVYGWE PDRCFDVVHV GWGKVSDLAI SNNQMIAVSY SHTNVSWYVV
310 320 330 340 350
DLNRVKKSGS VIQGLIQDKP IPAPSSALGT TLRRNYERPT TSCTGQEMKQ
360 370 380 390 400
SSEADRRSPE GERRSPSSED EKEDKESSAE ITNPEDYKEI FQPRSVISRT
410 420 430 440 450
PPKTTEPFPA PLEHSFSESV LEKPGPVVKI VTPVIDRAGQ LKGPITSSTP
460 470 480 490 500
VQRVEPTVIA AAPRPVAVVT TSASSPSRPV VNTTKPKPST GIILSTRNEP
510 520 530 540 550
IGLNAGDFLS HARNAKASAM GDEEALAQIR KGHDTMCVML SSRSKNLDSV
560 570 580 590 600
RSVWASGDVK TSLDSAVSMN DLSIVVDVLN IINLKPSLWK LDLCTSILPQ
610 620 630 640 650
IEELLQSRYE SYVQTGCMSL KLILKRFWPL ISDTLNAPPS VGVDITREER
660 670 680 690
HQKCKACYKQ LKNLSNVVKN RAEQVGRHGS TFRELQLLMA PLDY
Length:694
Mass (Da):75,995
Last modified:June 1, 2003 - v1
Checksum:i4D7A9145EA300EB4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC047819 mRNA. Translation: AAH47819.1.
RefSeqiNP_998183.1. NM_213018.1.
XP_005166561.1. XM_005166504.2.
XP_005166562.1. XM_005166505.2.
UniGeneiDr.76809.

Genome annotation databases

EnsembliENSDART00000014632; ENSDARP00000024623; ENSDARG00000005456.
ENSDART00000169463; ENSDARP00000131168; ENSDARG00000005456.
GeneIDi406291.
KEGGidre:406291.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC047819 mRNA. Translation: AAH47819.1.
RefSeqiNP_998183.1. NM_213018.1.
XP_005166561.1. XM_005166504.2.
XP_005166562.1. XM_005166505.2.
UniGeneiDr.76809.

3D structure databases

ProteinModelPortaliQ7ZUV2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000024623.

Proteomic databases

PaxDbiQ7ZUV2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000014632; ENSDARP00000024623; ENSDARG00000005456.
ENSDART00000169463; ENSDARP00000131168; ENSDARG00000005456.
GeneIDi406291.
KEGGidre:406291.

Organism-specific databases

CTDi10300.
ZFINiZDB-GENE-040426-1954. katnb1.

Phylogenomic databases

eggNOGiKOG0267. Eukaryota.
ENOG410XQAC. LUCA.
GeneTreeiENSGT00810000125363.
HOGENOMiHOG000008039.
HOVERGENiHBG052294.
InParanoidiQ7ZUV2.
KOiK18643.
OMAiAWKLQEF.
OrthoDBiEOG72ZCDG.
PhylomeDBiQ7ZUV2.
TreeFamiTF332359.

Miscellaneous databases

PROiQ7ZUV2.

Gene expression databases

BgeeiQ7ZUV2.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
HAMAPiMF_03022. Katanin_p80_B1.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR026962. Katanin_bsu1.
IPR028021. Katanin_C-terminal.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PANTHERiPTHR19845:SF0. PTHR19845:SF0. 1 hit.
PfamiPF13925. Katanin_con80. 1 hit.
PF00400. WD40. 6 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 6 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 3 hits.
PS50082. WD_REPEATS_2. 5 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. Cited for: DISRUPTION PHENOTYPE.
  3. Cited for: DISRUPTION PHENOTYPE.

Entry informationi

Entry nameiKTNB1_DANRE
AccessioniPrimary (citable) accession number: Q7ZUV2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: June 1, 2003
Last modified: June 8, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.