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Q7ZUS3

- Q7ZUS3_DANRE

UniProt

Q7ZUS3 - Q7ZUS3_DANRE

Protein
Submitted name:

GAD67

Gene

gad1b

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 79 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    GO - Molecular functioni

    1. carboxy-lyase activity Source: InterPro
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. carboxylic acid metabolic process Source: InterPro

    Keywords - Molecular functioni

    LyaseUniRule annotation

    Keywords - Ligandi

    Pyridoxal phosphateUniRule annotation

    Enzyme and pathway databases

    ReactomeiREACT_207458. GABA synthesis, release, reuptake and degradation.
    REACT_223869. GABA synthesis.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    GAD67Imported
    Submitted name:
    Glutamate decarboxylase 1Imported
    Submitted name:
    Uncharacterized proteinImported
    Gene namesi
    Name:gad1bImported
    Synonyms:gad1Imported, GAD67Imported
    OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
    Taxonomic identifieri7955 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
    ProteomesiUP000000437: Chromosome 6

    Organism-specific databases

    ZFINiZDB-GENE-030909-3. gad1b.

    Interactioni

    Protein-protein interaction databases

    STRINGi7955.ENSDARP00000024162.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the group II decarboxylase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0076.
    GeneTreeiENSGT00730000110441.
    HOGENOMiHOG000005382.
    HOVERGENiHBG004980.
    KOiK01580.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    InterProiIPR002129. PyrdxlP-dep_de-COase.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    IPR021115. Pyridoxal-P_BS.
    [Graphical view]
    PfamiPF00282. Pyridoxal_deC. 1 hit.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 1 hit.
    PROSITEiPS00392. DDC_GAD_HDC_YDC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q7ZUS3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MASSAPSSSA GDMDPNTANL RQPATTSDAW YGVAHGCTRK LGMKICGFLQ    50
    KNNSLDEKSR MVGSFKESAK NQMSCDNNER FTRDETDFSN LFARDLLPAK 100
    NGEEPTIQFL LEVVEILTNY VRKTFDRSTK VLDFHHPHQL LEGMEGFNLE 150
    LSDQPESLEQ ILVDCRDTLK YGVRTGHPRF FNQLSSGLDI IGLAGEWLTS 200
    TANTNMFTYE IAPVFVLMEQ LTLKKMREII GWPNGDGDAL FSPGGAISNM 250
    YSVMVARYKY FPEVKTKGMS AAPRLVLFTS EHSHYSIKKA GAVLGFGKEN 300
    VILLKTDERG RVIPADLEAK VIDAKQKGYV PLFVNATAGT TVYGAFDPIN 350
    DIADICEKYN LWLHVDGAWG GGLLMSRKHR HKLSGIERAN SVTWNPHKMM 400
    GVPLQCSAIL VREKGILQGC NSMCAGYLFQ PDKQYDVTYD TGDKAIQCGR 450
    HVDIFKFWLM WKAKGTIGFE QHIDRCLELS EYLYNKIKNR EGYEMVFEGQ 500
    PQHTNVCFWY IPPSLRGMPN GDERREKLHR VAPKIKAMMM ECGTTMVGYQ 550
    PQGDKVNFFR MVVSNHAVTK SDIDFLIDEI ERLGQDL 587
    Length:587
    Mass (Da):66,156
    Last modified:June 1, 2003 - v1
    Checksum:i1CF1FB099242491E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR384078 Genomic DNA. No translation available.
    BC047851 mRNA. Translation: AAH47851.1.
    AB183390 mRNA. Translation: BAD67441.1.
    RefSeqiNP_919400.1. NM_194419.1.
    XP_005172131.1. XM_005172074.1.
    UniGeneiDr.81985.

    Genome annotation databases

    EnsembliENSDART00000003008; ENSDARP00000024162; ENSDARG00000027419.
    GeneIDi378441.
    KEGGidre:378441.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR384078 Genomic DNA. No translation available.
    BC047851 mRNA. Translation: AAH47851.1 .
    AB183390 mRNA. Translation: BAD67441.1 .
    RefSeqi NP_919400.1. NM_194419.1.
    XP_005172131.1. XM_005172074.1.
    UniGenei Dr.81985.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 7955.ENSDARP00000024162.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSDART00000003008 ; ENSDARP00000024162 ; ENSDARG00000027419 .
    GeneIDi 378441.
    KEGGi dre:378441.

    Organism-specific databases

    CTDi 378441.
    ZFINi ZDB-GENE-030909-3. gad1b.

    Phylogenomic databases

    eggNOGi COG0076.
    GeneTreei ENSGT00730000110441.
    HOGENOMi HOG000005382.
    HOVERGENi HBG004980.
    KOi K01580.

    Enzyme and pathway databases

    Reactomei REACT_207458. GABA synthesis, release, reuptake and degradation.
    REACT_223869. GABA synthesis.

    Miscellaneous databases

    NextBioi 20813769.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    InterProi IPR002129. PyrdxlP-dep_de-COase.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    IPR021115. Pyridoxal-P_BS.
    [Graphical view ]
    Pfami PF00282. Pyridoxal_deC. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 1 hit.
    PROSITEi PS00392. DDC_GAD_HDC_YDC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Zebrafish Gene Collection (ZGC) project
      Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Whole bodyImported.
    2. "Distribution of prospective glutamatergic, glycinergic, and GABAergic neurons in embryonic and larval zebrafish."
      Higashijima S., Mandel G., Fetcho J.R.
      J. Comp. Neurol. 480:1-18(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
    3. Ensembl
      Submitted (FEB-2012) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: TuebingenImported.
    4. "The zebrafish reference genome sequence and its relationship to the human genome."
      Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.
      , White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., Clee C., Oliver K., Clark R., Riddle C., Eliott D., Threadgold G., Harden G., Ware D., Mortimer B., Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.
      Nature 496:498-503(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: TuebingenImported.

    Entry informationi

    Entry nameiQ7ZUS3_DANRE
    AccessioniPrimary (citable) accession number: Q7ZUS3
    Entry historyi
    Integrated into UniProtKB/TrEMBL: June 1, 2003
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 79 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3