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Q7ZUS3

- Q7ZUS3_DANRE

UniProt

Q7ZUS3 - Q7ZUS3_DANRE

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Protein
Submitted name: GAD67
Gene
gad1b, gad1, GAD67
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed - Annotation score: 1 out of 5 - Experimental evidence at transcript leveli

Functioni

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

GO - Molecular functioni

  1. carboxy-lyase activity Source: InterPro
  2. pyridoxal phosphate binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. carboxylic acid metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotation

Enzyme and pathway databases

ReactomeiREACT_207458. GABA synthesis, release, reuptake and degradation.
REACT_223869. GABA synthesis.

Names & Taxonomyi

Protein namesi
Submitted name:
GAD67Imported
Submitted name:
Glutamate decarboxylase 1Imported
Submitted name:
Uncharacterized proteinImported
Gene namesi
Name:gad1bImported
Synonyms:gad1Imported, GAD67Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
ProteomesiUP000000437: Chromosome 6

Organism-specific databases

ZFINiZDB-GENE-030909-3. gad1b.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000024162.

Family & Domainsi

Sequence similaritiesi

Belongs to the group II decarboxylase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0076.
GeneTreeiENSGT00730000110441.
HOGENOMiHOG000005382.
HOVERGENiHBG004980.
KOiK01580.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
IPR021115. Pyridoxal-P_BS.
[Graphical view]
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
PROSITEiPS00392. DDC_GAD_HDC_YDC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7ZUS3-1 [UniParc]FASTAAdd to Basket

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MASSAPSSSA GDMDPNTANL RQPATTSDAW YGVAHGCTRK LGMKICGFLQ    50
KNNSLDEKSR MVGSFKESAK NQMSCDNNER FTRDETDFSN LFARDLLPAK 100
NGEEPTIQFL LEVVEILTNY VRKTFDRSTK VLDFHHPHQL LEGMEGFNLE 150
LSDQPESLEQ ILVDCRDTLK YGVRTGHPRF FNQLSSGLDI IGLAGEWLTS 200
TANTNMFTYE IAPVFVLMEQ LTLKKMREII GWPNGDGDAL FSPGGAISNM 250
YSVMVARYKY FPEVKTKGMS AAPRLVLFTS EHSHYSIKKA GAVLGFGKEN 300
VILLKTDERG RVIPADLEAK VIDAKQKGYV PLFVNATAGT TVYGAFDPIN 350
DIADICEKYN LWLHVDGAWG GGLLMSRKHR HKLSGIERAN SVTWNPHKMM 400
GVPLQCSAIL VREKGILQGC NSMCAGYLFQ PDKQYDVTYD TGDKAIQCGR 450
HVDIFKFWLM WKAKGTIGFE QHIDRCLELS EYLYNKIKNR EGYEMVFEGQ 500
PQHTNVCFWY IPPSLRGMPN GDERREKLHR VAPKIKAMMM ECGTTMVGYQ 550
PQGDKVNFFR MVVSNHAVTK SDIDFLIDEI ERLGQDL 587
Length:587
Mass (Da):66,156
Last modified:June 1, 2003 - v1
Checksum:i1CF1FB099242491E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR384078 Genomic DNA. No translation available.
BC047851 mRNA. Translation: AAH47851.1.
AB183390 mRNA. Translation: BAD67441.1.
RefSeqiNP_919400.1. NM_194419.1.
XP_005172131.1. XM_005172074.1.
UniGeneiDr.81985.

Genome annotation databases

EnsembliENSDART00000003008; ENSDARP00000024162; ENSDARG00000027419.
GeneIDi378441.
KEGGidre:378441.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR384078 Genomic DNA. No translation available.
BC047851 mRNA. Translation: AAH47851.1 .
AB183390 mRNA. Translation: BAD67441.1 .
RefSeqi NP_919400.1. NM_194419.1.
XP_005172131.1. XM_005172074.1.
UniGenei Dr.81985.

3D structure databases

ModBasei Search...

Protein-protein interaction databases

STRINGi 7955.ENSDARP00000024162.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSDART00000003008 ; ENSDARP00000024162 ; ENSDARG00000027419 .
GeneIDi 378441.
KEGGi dre:378441.

Organism-specific databases

CTDi 378441.
ZFINi ZDB-GENE-030909-3. gad1b.

Phylogenomic databases

eggNOGi COG0076.
GeneTreei ENSGT00730000110441.
HOGENOMi HOG000005382.
HOVERGENi HBG004980.
KOi K01580.

Enzyme and pathway databases

Reactomei REACT_207458. GABA synthesis, release, reuptake and degradation.
REACT_223869. GABA synthesis.

Miscellaneous databases

NextBioi 20813769.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProi IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
IPR021115. Pyridoxal-P_BS.
[Graphical view ]
Pfami PF00282. Pyridoxal_deC. 1 hit.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 1 hit.
PROSITEi PS00392. DDC_GAD_HDC_YDC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Whole bodyImported.
  2. "Distribution of prospective glutamatergic, glycinergic, and GABAergic neurons in embryonic and larval zebrafish."
    Higashijima S., Mandel G., Fetcho J.R.
    J. Comp. Neurol. 480:1-18(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  3. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: TuebingenImported.
  4. "The zebrafish reference genome sequence and its relationship to the human genome."
    Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.
    , White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., Clee C., Oliver K., Clark R., Riddle C., Eliott D., Threadgold G., Harden G., Ware D., Mortimer B., Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.
    Nature 496:498-503(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TuebingenImported.

Entry informationi

Entry nameiQ7ZUS3_DANRE
AccessioniPrimary (citable) accession number: Q7ZUS3
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2003
Last sequence update: June 1, 2003
Last modified: September 3, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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