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Protein

Acidic leucine-rich nuclear phosphoprotein 32 family member A

Gene

anp32a

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Implicated in a number of cellular processes, including proliferation, differentiation, caspase-dependent and caspase-independent apoptosis, suppression of transformation (tumor suppressor), inhibition of protein phosphatase 2A, regulation of mRNA trafficking and stability, and inhibition of acetyltransferases as part of the INHAT (inhibitor of histone acetyltransferases) complex.By similarity

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-DRE-450520. HuR (ELAVL1) binds and stabilizes mRNA.

Names & Taxonomyi

Protein namesi
Recommended name:
Acidic leucine-rich nuclear phosphoprotein 32 family member A
Gene namesi
Name:anp32a
ORF Names:zgc:55516
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 7

Organism-specific databases

ZFINiZDB-GENE-030131-7850. anp32a.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 254254Acidic leucine-rich nuclear phosphoprotein 32 family member APRO_0000240185Add
BLAST

Post-translational modificationi

Phosphorylated on serine residues.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ7ZUP0.
PRIDEiQ7ZUP0.

Expressioni

Gene expression databases

BgeeiENSDARG00000006487.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000097644.

Structurei

3D structure databases

ProteinModelPortaliQ7ZUP0.
SMRiQ7ZUP0. Positions 1-161.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati16 – 4025LRR 1Add
BLAST
Repeati43 – 6422LRR 2Add
BLAST
Repeati65 – 8723LRR 3Add
BLAST
Repeati89 – 11022LRR 4Add
BLAST
Domaini123 – 16139LRRCTAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi151 – 251101Glu-richAdd
BLAST

Sequence similaritiesi

Belongs to the ANP32 family.Curated
Contains 4 LRR (leucine-rich) repeats.Curated
Contains 1 LRRCT domain.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiKOG2739. Eukaryota.
ENOG4111HZT. LUCA.
GeneTreeiENSGT00560000077130.
HOGENOMiHOG000007361.
HOVERGENiHBG053102.
InParanoidiQ7ZUP0.
KOiK18646.
PhylomeDBiQ7ZUP0.
TreeFamiTF317206.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003603. U2A'_phosphoprotein32A_C.
[Graphical view]
SMARTiSM00446. LRRcap. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7ZUP0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDMKKRIHLE LRNRTPSDVK ELVLDNCRSN EGKIEGLTDE FEELEFLSTI
60 70 80 90 100
NVGLTSVTNL PKLNKLKKLE LSDNRISGGL EVLAGKCPNL THLNLSGNKI
110 120 130 140 150
KDLSTIEPLK KLESLKSLDL FNCEVTNLND YRENVFKLLP QLTYLDGYDK
160 170 180 190 200
EDKEAPDSDA EAYVEGLDDE DDEEDEGEEE DYDEDAAPGE EDEEEGEEDD
210 220 230 240 250
EEEGEEEEEE DISGEEEEEE ELNDGEVDDE EDFEEERGLK RKRELDEEGE

EDDD
Length:254
Mass (Da):29,091
Last modified:June 1, 2003 - v1
Checksum:iB4F94468072DC6BA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC048047 mRNA. Translation: AAH48047.1.
BC071357 mRNA. Translation: AAH71357.1.
RefSeqiNP_956280.1. NM_199986.1.
UniGeneiDr.20261.

Genome annotation databases

EnsembliENSDART00000008785; ENSDARP00000022360; ENSDARG00000006487.
GeneIDi335907.
KEGGidre:335907.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC048047 mRNA. Translation: AAH48047.1.
BC071357 mRNA. Translation: AAH71357.1.
RefSeqiNP_956280.1. NM_199986.1.
UniGeneiDr.20261.

3D structure databases

ProteinModelPortaliQ7ZUP0.
SMRiQ7ZUP0. Positions 1-161.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000097644.

Proteomic databases

PaxDbiQ7ZUP0.
PRIDEiQ7ZUP0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000008785; ENSDARP00000022360; ENSDARG00000006487.
GeneIDi335907.
KEGGidre:335907.

Organism-specific databases

CTDi8125.
ZFINiZDB-GENE-030131-7850. anp32a.

Phylogenomic databases

eggNOGiKOG2739. Eukaryota.
ENOG4111HZT. LUCA.
GeneTreeiENSGT00560000077130.
HOGENOMiHOG000007361.
HOVERGENiHBG053102.
InParanoidiQ7ZUP0.
KOiK18646.
PhylomeDBiQ7ZUP0.
TreeFamiTF317206.

Enzyme and pathway databases

ReactomeiR-DRE-450520. HuR (ELAVL1) binds and stabilizes mRNA.

Miscellaneous databases

PROiQ7ZUP0.

Gene expression databases

BgeeiENSDARG00000006487.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003603. U2A'_phosphoprotein32A_C.
[Graphical view]
SMARTiSM00446. LRRcap. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAN32A_DANRE
AccessioniPrimary (citable) accession number: Q7ZUP0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: June 1, 2003
Last modified: September 7, 2016
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.