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Q7ZUM8

- UBP44_DANRE

UniProt

Q7ZUM8 - UBP44_DANRE

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Protein

Ubiquitin carboxyl-terminal hydrolase 44

Gene

usp44

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Deubiquitinase that plays a key role in the spindle assembly checkpoint by preventing premature anaphase onset. Acts by specifically mediating deubiquitination of cdc20, a negative regulator of the anaphase promoting complex/cyclosome (APC/C) (By similarity).By similarity

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei304 – 3041NucleophilePROSITE-ProRule annotation
Active sitei642 – 6421Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri24 – 8562UBP-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. ubiquitin-specific protease activity Source: UniProtKB
  2. ubiquitin thiolesterase activity Source: UniProtKB
  3. zinc ion binding Source: InterPro

GO - Biological processi

  1. central nervous system morphogenesis Source: ZFIN
  2. mitotic nuclear division Source: UniProtKB-KW
  3. negative regulation of mitotic anaphase-promoting complex activity Source: UniProtKB
  4. protein deubiquitination Source: UniProtKB
  5. regulation of spindle checkpoint Source: UniProtKB
  6. ubiquitin-dependent protein catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Cell cycle, Cell division, Mitosis, Ubl conjugation pathway

Keywords - Ligandi

Metal-binding, Zinc

Protein family/group databases

MEROPSiC19.073.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase 44 (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme 44
Ubiquitin thioesterase 44
Ubiquitin-specific-processing protease 44
Gene namesi
Name:usp44
ORF Names:zgc:55661
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
ProteomesiUP000000437: Unplaced

Organism-specific databases

ZFINiZDB-GENE-040426-774. usp44.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 695695Ubiquitin carboxyl-terminal hydrolase 44PRO_0000395812Add
BLAST

Proteomic databases

PRIDEiQ7ZUM8.

Structurei

3D structure databases

ProteinModelPortaliQ7ZUM8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini295 – 684390USPAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase C19 family. USP44 subfamily.Curated
Contains 1 UBP-type zinc finger.PROSITE-ProRule annotation
Contains 1 USP domain.Curated

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri24 – 8562UBP-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

HOGENOMiHOG000015084.
HOVERGENiHBG018027.
InParanoidiQ7ZUM8.
KOiK11834.
PhylomeDBiQ7ZUM8.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
IPR013083. Znf_RING/FYVE/PHD.
IPR001607. Znf_UBP.
[Graphical view]
PfamiPF00443. UCH. 1 hit.
PF02148. zf-UBP. 1 hit.
[Graphical view]
SMARTiSM00290. ZnF_UBP. 1 hit.
[Graphical view]
PROSITEiPS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
PS50271. ZF_UBP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7ZUM8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDRCKHVGRL RLAQDHSILN PQKWHCVDCN TTESVWACLS CSHVACGRYI
60 70 80 90 100
EEHALQHFKE QHHPLALEVN ELYVYCYLCD DYVLNDNATG DLKLLRSTLS
110 120 130 140 150
AIKSQCYEVT TRSGRTLRSS SANGDQLSPS TQELQLRDED RMFTALWHRR
160 170 180 190 200
RALIGRLFRL WFAQTERGKK RLEEERQQEE EEERKREARE RRRQLKRQLK
210 220 230 240 250
EELESAPPRK SHRIRRQSLK ATSVKPARAP AKSTKSVRRR SAPARVSTPT
260 270 280 290 300
PRTPRERTPQ QRPRPQAKAK RPQAPPSKTG DSPVKRRPTV TPGVTGLRNL
310 320 330 340 350
GNTCYMNSIL QVLSHLHVFR ECFLRLDLNQ ALELLASAVS RKLGLSAQRV
360 370 380 390 400
IQPKGLNQGS GLSGGASRSR NMELIQPKEP SSKHISLCHE LHTLFPVMWS
410 420 430 440 450
GKWALVSPFA MLHSVWQLIP AFRGYAQQDA QEFLCELLDK VQHELERTRT
460 470 480 490 500
LTPATVPANQ RRLIKQVLSV VNTIFHGQLL SQVRCLACDH RSNTIEPFWD
510 520 530 540 550
LSLEFPERYH SNSKDAAQVP CGLTEMLAKF TETEALEGAI YACDYCNNKR
560 570 580 590 600
RRFCSKQVVL TEAQKQLMVH KLPHVLRLHL KRFRWSGRNH REKIGVHVQF
610 620 630 640 650
EQELNMEPYC CKDSGNLPHP QHFLYQLSAV VMHHGKGFGS GHYTAFCYNT
660 670 680 690
EGGFWVHCND SKLSVCAVEE VCKAQAYILF YTQRNAQDKS KESDL
Length:695
Mass (Da):79,926
Last modified:June 1, 2003 - v1
Checksum:iCEAE12134C67ED9F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC048060 mRNA. Translation: AAH48060.1.
RefSeqiNP_956551.1. NM_200257.1.
UniGeneiDr.78996.

Genome annotation databases

GeneIDi393227.
KEGGidre:393227.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC048060 mRNA. Translation: AAH48060.1 .
RefSeqi NP_956551.1. NM_200257.1.
UniGenei Dr.78996.

3D structure databases

ProteinModelPortali Q7ZUM8.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi C19.073.

Proteomic databases

PRIDEi Q7ZUM8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 393227.
KEGGi dre:393227.

Organism-specific databases

CTDi 84101.
ZFINi ZDB-GENE-040426-774. usp44.

Phylogenomic databases

HOGENOMi HOG000015084.
HOVERGENi HBG018027.
InParanoidi Q7ZUM8.
KOi K11834.
PhylomeDBi Q7ZUM8.

Miscellaneous databases

NextBioi 20814291.
PROi Q7ZUM8.

Family and domain databases

Gene3Di 3.30.40.10. 1 hit.
InterProi IPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
IPR013083. Znf_RING/FYVE/PHD.
IPR001607. Znf_UBP.
[Graphical view ]
Pfami PF00443. UCH. 1 hit.
PF02148. zf-UBP. 1 hit.
[Graphical view ]
SMARTi SM00290. ZnF_UBP. 1 hit.
[Graphical view ]
PROSITEi PS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
PS50271. ZF_UBP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: AB.

Entry informationi

Entry nameiUBP44_DANRE
AccessioniPrimary (citable) accession number: Q7ZUM8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 13, 2010
Last sequence update: June 1, 2003
Last modified: October 29, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3