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Protein

Hexokinase

Gene

hk1

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + D-hexose = ADP + D-hexose 6-phosphate.UniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. fructokinase activity Source: GO_Central
  3. glucokinase activity Source: GO_Central
  4. mannokinase activity Source: GO_Central

GO - Biological processi

  1. carbohydrate phosphorylation Source: GOC
  2. cellular glucose homeostasis Source: GO_Central
  3. glucose 6-phosphate metabolic process Source: GOC
  4. glycolytic process Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotationSAAS annotation, Transferase

Keywords - Biological processi

GlycolysisUniRule annotationSAAS annotation

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
HexokinaseUniRule annotation (EC:2.7.1.1UniRule annotation)
Gene namesi
Name:hk1Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Organism-specific databases

ZFINiZDB-GENE-040426-2848. hk1.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: GO_Central
Complete GO annotation...

PTM / Processingi

Proteomic databases

PRIDEiQ7ZUM3.

Structurei

3D structure databases

ProteinModelPortaliQ7ZUM3.
SMRiQ7ZUM3. Positions 16-914.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the hexokinase family.UniRule annotation

Phylogenomic databases

HOVERGENiHBG005020.
KOiK00844.
PhylomeDBiQ7ZUM3.

Family and domain databases

InterProiIPR001312. Hexokinase.
IPR022673. Hexokinase_C.
IPR019807. Hexokinase_CS.
IPR022672. Hexokinase_N.
[Graphical view]
PANTHERiPTHR19443. PTHR19443. 1 hit.
PfamiPF00349. Hexokinase_1. 2 hits.
PF03727. Hexokinase_2. 2 hits.
[Graphical view]
PRINTSiPR00475. HEXOKINASE.
PROSITEiPS00378. HEXOKINASES. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7ZUM3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIAAQLLAYY FTELKDDQVK KIDKYLYAMR FSDETLRDIM ARFRREMENG
60 70 80 90 100
LARDTNPTAT AKMLPTFVRS IPDGSEKGDF IALDLGGSNF RILRVKVSHE
110 120 130 140 150
KKQTVQMESQ IYETPEDIIH GSRSRLFDHV AECLGDFMEK QKIKDKKLPV
160 170 180 190 200
GFTFSFPCSQ SKLDEAVLLT WTKRFKVNGV EGMDVVKLLN KAIKKRGDYE
210 220 230 240 250
ADIMAVVNDT VGTMMTCGFD DQRCEVGIII GTGTNACYME ELRHMDMVEG
260 270 280 290 300
DEGRMCINTE WGAFGDDGTL EDIRTEFDRE IDRGSLNPGK QLFEKMVSGM
310 320 330 340 350
YMGELVRLIL VKMAKEGLLF EGRITPELLT KGKIETKHVS AIEKSKEGLT
360 370 380 390 400
KAKEILTRLG VEPSEDDCIA VQHVCAIVSF RSANLIAATL GAILTRLKDN
410 420 430 440 450
KNTPRLRTTV GIDGSLYKMH PQYARRLHKT VRRLVPESDV RFLLSESGSG
460 470 480 490 500
KGAALVTAWA YRLADQERQI AETLEEFRLT KDQLLEVKKR MRTEIQNGLS
510 520 530 540 550
KSTQNTATVK MLPTYVRSTP DGSENGDFLA LDLGGTNFRV LLVKIRSGKR
560 570 580 590 600
RTVEMHNKIY AIPIEVMQGT GEELFDHIVY CISDFLDYMG MKNARLPLGF
610 620 630 640 650
TFSFPCRQTS LDAGLLVNWT KGFKATDCEG EDVVGLLREG IKRREEFDLD
660 670 680 690 700
VVAIVNDTVG TMMTCAYEEP TCEVGLIAGT GSNACYMEEM RNIETVSGEE
710 720 730 740 750
GRMCVNMEWG AFGDNGCLDD IRTKYDDAVD DLSLNAGKQK YEKMCSGMYL
760 770 780 790 800
GEIVRNILID LTKRGFLFRG QISETLKTRG IFETKFLSQI ESDRLALLQV
810 820 830 840 850
RSILQHLGLD STCDDSIIVK EVCGAVSRRA AQLCGAGMAA VVDKIRENRG
860 870 880 890 900
LDHLDITVGV DGTLYKLHPH FSRIMHQTVK ELAPKCNVTF LLSEDGSGKG
910
AALITAVGCR LRQQEQKS
Length:918
Mass (Da):102,828
Last modified:June 1, 2003 - v1
Checksum:i09E759B881F5DFAA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC048065 mRNA. Translation: AAH48065.1.
RefSeqiNP_998417.1. NM_213252.1.
UniGeneiDr.9278.

Genome annotation databases

GeneIDi406791.
KEGGidre:406791.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC048065 mRNA. Translation: AAH48065.1.
RefSeqiNP_998417.1. NM_213252.1.
UniGeneiDr.9278.

3D structure databases

ProteinModelPortaliQ7ZUM3.
SMRiQ7ZUM3. Positions 16-914.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ7ZUM3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi406791.
KEGGidre:406791.

Organism-specific databases

CTDi3098.
ZFINiZDB-GENE-040426-2848. hk1.

Phylogenomic databases

HOVERGENiHBG005020.
KOiK00844.
PhylomeDBiQ7ZUM3.

Miscellaneous databases

NextBioi20818302.

Family and domain databases

InterProiIPR001312. Hexokinase.
IPR022673. Hexokinase_C.
IPR019807. Hexokinase_CS.
IPR022672. Hexokinase_N.
[Graphical view]
PANTHERiPTHR19443. PTHR19443. 1 hit.
PfamiPF00349. Hexokinase_1. 2 hits.
PF03727. Hexokinase_2. 2 hits.
[Graphical view]
PRINTSiPR00475. HEXOKINASE.
PROSITEiPS00378. HEXOKINASES. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: ABImported.
    Tissue: Whole bodyImported.

Entry informationi

Entry nameiQ7ZUM3_DANRE
AccessioniPrimary (citable) accession number: Q7ZUM3
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2003
Last sequence update: June 1, 2003
Last modified: April 29, 2015
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.