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Protein
Submitted name:

Cct8 protein

Gene

cct8

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Molecular chaperone; assists the folding of proteins upon ATP hydrolysis.SAAS annotation

GO - Molecular functioni

GO - Biological processi

  • 'de novo' protein folding Source: GO_Central
  • behavioral response to nicotine Source: ZFIN
  • chaperone-mediated protein folding Source: GO_Central

Keywordsi

Molecular functionChaperoneUniRule annotation
LigandATP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-DRE-390471 Association of TriC/CCT with target proteins during biosynthesis
R-DRE-6798695 Neutrophil degranulation
R-DRE-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding

Names & Taxonomyi

Protein namesi
Submitted name:
Cct8 proteinImported
Submitted name:
Chaperonin-containing TCP1, subunit 8 (theta)Imported
Gene namesi
Name:cct8Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 10

Organism-specific databases

ZFINiZDB-GENE-040426-876 cct8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

CytoplasmSAAS annotation

Expressioni

Gene expression databases

BgeeiENSDARG00000008243

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000003468

Family & Domainsi

Sequence similaritiesi

Belongs to the TCP-1 chaperonin family.UniRule annotation

Phylogenomic databases

eggNOGiKOG0362 Eukaryota
ENOG410XPXR LUCA
GeneTreeiENSGT00550000074783
HOVERGENiHBG103107
KOiK09500
TreeFamiTF105699

Family and domain databases

CDDicd03341 TCP1_theta, 1 hit
Gene3Di1.10.560.10, 2 hits
3.30.260.10, 2 hits
3.50.7.10, 2 hits
InterProiView protein in InterPro
IPR012721 Chap_CCT_theta
IPR017998 Chaperone_TCP-1
IPR002194 Chaperonin_TCP-1_CS
IPR002423 Cpn60/TCP-1
IPR027409 GroEL-like_apical_dom_sf
IPR027413 GROEL-like_equatorial_sf
IPR027410 TCP-1-like_intermed_sf
PfamiView protein in Pfam
PF00118 Cpn60_TCP1, 1 hit
PRINTSiPR00304 TCOMPLEXTCP1
SUPFAMiSSF48592 SSF48592, 2 hits
SSF52029 SSF52029, 1 hit
SSF54849 SSF54849, 2 hits
TIGRFAMsiTIGR02346 chap_CCT_theta, 1 hit
PROSITEiView protein in PROSITE
PS00750 TCP1_1, 1 hit
PS00751 TCP1_2, 1 hit
PS00995 TCP1_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q7ZU96-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALHVPKAPG FAQMLKDGAK HYSGLEEAVF RNIQACKELA QTTRTAYGPN
60 70 80 90 100
GMNKMVINHL EKLFVTNDAA TILRELEVQH PAAKMIVMAS HMQEQEVGDG
110 120 130 140 150
TNFVLVFAGA LLELAEELLR MGLSVSEVIE GYEMACKKAL EILPDCVCSS
160 170 180 190 200
AKNLHDLEEA TAMIRSAVMS KQYGNEDFLA NLIAQACVSI FPESGSFNVD
210 220 230 240 250
NVRVCKILGC GLNSSTMLHG MVFKKEAEGD VTSVKDAKIA VFSCPFDCTV
260 270 280 290 300
TETKGTVLIK NADELMNFSK GEEDLMEAQV KAIADSGASV VVTGGKVADM
310 320 330 340 350
ALHYANKYKL MVVRLNSKWD LRRLCKTVGA TALPRLTSPT PEEMGRCDSV
360 370 380 390 400
YLSEVGDTQV VVFKHDKEDG AISTLVIRGS TDNLMDDIER AIDDGVNTFK
410 420 430 440 450
VLVRDARLCP GAGATEIELA KHITSYGESC PGLEQYAIKK YAEAFEALPR
460 470 480 490 500
ALAENSGVKG NELISKLYAT HHEGNKNSGF DIEGEGPAVR DMMEAGILDP
510 520 530 540
YLVKYWGIKL ATNAAITVLR VDQIIMAKPA GGPKAPQGKK DWDEDE
Length:546
Mass (Da):59,301
Last modified:June 1, 2003 - v1
Checksum:i069A55C212DAA114
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR925781 Genomic DNA No translation available.
BC050492 mRNA Translation: AAH50492.1
BC164659 mRNA Translation: AAI64659.1
RefSeqiNP_957356.1, NM_201062.1
UniGeneiDr.75181

Genome annotation databases

EnsembliENSDART00000009477; ENSDARP00000003468; ENSDARG00000008243
GeneIDi394037
KEGGidre:394037

Similar proteinsi

Entry informationi

Entry nameiQ7ZU96_DANRE
AccessioniPrimary (citable) accession number: Q7ZU96
Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 2003
Last sequence update: June 1, 2003
Last modified: June 20, 2018
This is version 130 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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