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Protein
Submitted name:

Cct8 protein

Gene

cct8

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Molecular chaperone; assists the folding of proteins upon ATP hydrolysis.SAAS annotation

GO - Molecular functioni

GO - Biological processi

  • behavioral response to nicotine Source: ZFIN
  • protein folding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

ChaperoneUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-DRE-390471. Association of TriC/CCT with target proteins during biosynthesis.
R-DRE-6798695. Neutrophil degranulation.
R-DRE-6814122. Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding.

Names & Taxonomyi

Protein namesi
Submitted name:
Cct8 proteinImported
Submitted name:
Chaperonin containing TCP1, subunit 8 (Theta)Imported
Submitted name:
Uncharacterized proteinImported
Gene namesi
Name:cct8Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 10

Organism-specific databases

ZFINiZDB-GENE-040426-876. cct8.

Subcellular locationi

  • Cytoplasm SAAS annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

CytoplasmSAAS annotation

Expressioni

Gene expression databases

BgeeiENSDARG00000008243.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000003468.

Family & Domainsi

Sequence similaritiesi

Belongs to the TCP-1 chaperonin family.UniRule annotation

Phylogenomic databases

eggNOGiKOG0362. Eukaryota.
ENOG410XPXR. LUCA.
GeneTreeiENSGT00550000074783.
HOVERGENiHBG103107.
KOiK09500.
TreeFamiTF105699.

Family and domain databases

CDDicd03341. TCP1_theta. 1 hit.
Gene3Di1.10.560.10. 2 hits.
3.30.260.10. 2 hits.
3.50.7.10. 1 hit.
InterProiIPR012721. Chap_CCT_theta.
IPR017998. Chaperone_TCP-1.
IPR002194. Chaperonin_TCP-1_CS.
IPR002423. Cpn60/TCP-1.
IPR027409. GroEL-like_apical_dom.
IPR027413. GROEL-like_equatorial.
IPR027410. TCP-1-like_intermed.
[Graphical view]
PfamiPF00118. Cpn60_TCP1. 1 hit.
[Graphical view]
PRINTSiPR00304. TCOMPLEXTCP1.
SUPFAMiSSF52029. SSF52029. 1 hit.
TIGRFAMsiTIGR02346. chap_CCT_theta. 1 hit.
PROSITEiPS00750. TCP1_1. 1 hit.
PS00751. TCP1_2. 1 hit.
PS00995. TCP1_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7ZU96-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALHVPKAPG FAQMLKDGAK HYSGLEEAVF RNIQACKELA QTTRTAYGPN
60 70 80 90 100
GMNKMVINHL EKLFVTNDAA TILRELEVQH PAAKMIVMAS HMQEQEVGDG
110 120 130 140 150
TNFVLVFAGA LLELAEELLR MGLSVSEVIE GYEMACKKAL EILPDCVCSS
160 170 180 190 200
AKNLHDLEEA TAMIRSAVMS KQYGNEDFLA NLIAQACVSI FPESGSFNVD
210 220 230 240 250
NVRVCKILGC GLNSSTMLHG MVFKKEAEGD VTSVKDAKIA VFSCPFDCTV
260 270 280 290 300
TETKGTVLIK NADELMNFSK GEEDLMEAQV KAIADSGASV VVTGGKVADM
310 320 330 340 350
ALHYANKYKL MVVRLNSKWD LRRLCKTVGA TALPRLTSPT PEEMGRCDSV
360 370 380 390 400
YLSEVGDTQV VVFKHDKEDG AISTLVIRGS TDNLMDDIER AIDDGVNTFK
410 420 430 440 450
VLVRDARLCP GAGATEIELA KHITSYGESC PGLEQYAIKK YAEAFEALPR
460 470 480 490 500
ALAENSGVKG NELISKLYAT HHEGNKNSGF DIEGEGPAVR DMMEAGILDP
510 520 530 540
YLVKYWGIKL ATNAAITVLR VDQIIMAKPA GGPKAPQGKK DWDEDE
Length:546
Mass (Da):59,301
Last modified:June 1, 2003 - v1
Checksum:i069A55C212DAA114
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CT573197 Genomic DNA. No translation available.
BC050492 mRNA. Translation: AAH50492.1.
BC164659 mRNA. Translation: AAI64659.1.
RefSeqiNP_957356.1. NM_201062.1.
UniGeneiDr.75181.

Genome annotation databases

EnsembliENSDART00000009477; ENSDARP00000003468; ENSDARG00000008243.
GeneIDi394037.
KEGGidre:394037.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CT573197 Genomic DNA. No translation available.
BC050492 mRNA. Translation: AAH50492.1.
BC164659 mRNA. Translation: AAI64659.1.
RefSeqiNP_957356.1. NM_201062.1.
UniGeneiDr.75181.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000003468.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000009477; ENSDARP00000003468; ENSDARG00000008243.
GeneIDi394037.
KEGGidre:394037.

Organism-specific databases

CTDi10694.
ZFINiZDB-GENE-040426-876. cct8.

Phylogenomic databases

eggNOGiKOG0362. Eukaryota.
ENOG410XPXR. LUCA.
GeneTreeiENSGT00550000074783.
HOVERGENiHBG103107.
KOiK09500.
TreeFamiTF105699.

Enzyme and pathway databases

ReactomeiR-DRE-390471. Association of TriC/CCT with target proteins during biosynthesis.
R-DRE-6798695. Neutrophil degranulation.
R-DRE-6814122. Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding.

Gene expression databases

BgeeiENSDARG00000008243.

Family and domain databases

CDDicd03341. TCP1_theta. 1 hit.
Gene3Di1.10.560.10. 2 hits.
3.30.260.10. 2 hits.
3.50.7.10. 1 hit.
InterProiIPR012721. Chap_CCT_theta.
IPR017998. Chaperone_TCP-1.
IPR002194. Chaperonin_TCP-1_CS.
IPR002423. Cpn60/TCP-1.
IPR027409. GroEL-like_apical_dom.
IPR027413. GROEL-like_equatorial.
IPR027410. TCP-1-like_intermed.
[Graphical view]
PfamiPF00118. Cpn60_TCP1. 1 hit.
[Graphical view]
PRINTSiPR00304. TCOMPLEXTCP1.
SUPFAMiSSF52029. SSF52029. 1 hit.
TIGRFAMsiTIGR02346. chap_CCT_theta. 1 hit.
PROSITEiPS00750. TCP1_1. 1 hit.
PS00751. TCP1_2. 1 hit.
PS00995. TCP1_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ7ZU96_DANRE
AccessioniPrimary (citable) accession number: Q7ZU96
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2003
Last sequence update: June 1, 2003
Last modified: November 30, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.