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Protein
Submitted name:

Esr2a protein

Gene

esr2a

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi156 – 231Nuclear receptorPROSITE-ProRule annotationAdd BLAST76

GO - Molecular functioni

  • estrogen receptor activity Source: ZFIN
  • RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding Source: ZFIN
  • sequence-specific DNA binding Source: InterPro
  • steroid hormone binding Source: ZFIN
  • zinc ion binding Source: InterPro

GO - Biological processi

  • response to estrogen Source: ZFIN
  • transcription, DNA-templated Source: UniProtKB-UniRule

Keywordsi

Molecular functionDNA-bindingPROSITE-ProRule annotationSAAS annotation, ReceptorUniRule annotationSAAS annotationImported
Biological processTranscription, Transcription regulationUniRule annotationSAAS annotation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-DRE-1257604 PIP3 activates AKT signaling
R-DRE-383280 Nuclear Receptor transcription pathway
R-DRE-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-DRE-8939211 ESR-mediated signaling

Names & Taxonomyi

Protein namesi
Submitted name:
Esr2a proteinImported
Submitted name:
Estrogen receptor 2aImported
Submitted name:
Estrogen receptor beta2Imported
Gene namesi
Name:esr2aImported
Synonyms:erbeta2Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 20

Organism-specific databases

ZFINiZDB-GENE-030116-2 esr2a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusUniRule annotationSAAS annotation

Expressioni

Gene expression databases

BgeeiENSDARG00000016454

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000017514

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini156 – 231Nuclear receptorInterPro annotationAdd BLAST76
Domaini281 – 517NR LBDInterPro annotationAdd BLAST237

Sequence similaritiesi

Belongs to the nuclear hormone receptor family. NR3 subfamily.UniRule annotation

Keywords - Domaini

Zinc-fingerPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG3575 Eukaryota
ENOG410XRZC LUCA
GeneTreeiENSGT00760000118887
HOGENOMiHOG000233468
HOVERGENiHBG108344
KOiK08551
OrthoDBiEOG091G03V4
TreeFamiTF323751

Family and domain databases

Gene3Di3.30.50.10, 1 hit
InterProiView protein in InterPro
IPR028355 ER-beta/gamma
IPR021064 Estrogen_rcpt_beta_N
IPR035500 NHR_like_dom_sf
IPR000536 Nucl_hrmn_rcpt_lig-bd
IPR001723 Nuclear_hrmn_rcpt
IPR024178 Oest_rcpt/oest-rel_rcp
IPR001628 Znf_hrmn_rcpt
IPR013088 Znf_NHR/GATA
PfamiView protein in Pfam
PF12497 ERbeta_N, 1 hit
PF00104 Hormone_recep, 1 hit
PF00105 zf-C4, 1 hit
PIRSFiPIRSF500102 ER-b, 1 hit
PIRSF002527 ER-like_NR, 1 hit
PRINTSiPR00398 STRDHORMONER
PR00047 STROIDFINGER
SMARTiView protein in SMART
SM00430 HOLI, 1 hit
SM00399 ZnF_C4, 1 hit
SUPFAMiSSF48508 SSF48508, 1 hit
PROSITEiView protein in PROSITE
PS51843 NR_LBD, 1 hit
PS00031 NUCLEAR_REC_DBD_1, 1 hit
PS51030 NUCLEAR_REC_DBD_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q7ZU32-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEYPEGDSP LLQLQEVDSG RVGGHILSPI FNSSSPSLPV ENHPICIPSP
60 70 80 90 100
YTDLGHDFST LPFYSPALLG YSTSPLSDCS SVRQSLSPTL FWPPHSHVSS
110 120 130 140 150
LTLQQQSRLQ QNHATSGTWT EHTPHDHVEE ENSKPLVKRV ADTEETSVSL
160 170 180 190 200
RGKADMHYCA VCSDYASGYH YGVWSCEGCK AFFKRSIQGH NDYICPATNQ
210 220 230 240 250
CTIDKNRRKS CQACRLRKCY EVGMMKCGLR RDRSSYQQRG AQQKRLVRFS
260 270 280 290 300
GRMRMTGPRS QEIKSIPRPL SGNEVVRISL SPEELISRIM EAEPPEIYLM
310 320 330 340 350
KDMKKPFTEA NVMMSLTNLA DKELVHMISW AKKIPGFVEL SLFDQVHLLE
360 370 380 390 400
CCWLEVLMLG LMWRSVNHPG KLIFSPDLCL SRDESSCVQG LVEIFDMLLA
410 420 430 440 450
ATSRFRELKL QREEYVCLKA MILLNSNMCL GSSEGGEDLQ SRSKLLCLLD
460 470 480 490 500
SVTDALVWAI SKTGLSFQQR STRLAHLLML LSHIRHVSNK GMDHLHCMKM
510 520 530 540 550
KKMVPLYDLL LEMLDAHIMH SSRLSHSGPR APAAHKDNKS VQEAFPCSSQ

HGP
Length:553
Mass (Da):62,340
Last modified:June 1, 2003 - v1
Checksum:i1E7E78AB66AD7A53
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX255911 Genomic DNA No translation available.
BC044349 mRNA Translation: AAH44349.1
BC165404 mRNA Translation: AAI65404.1
AY307098 mRNA Translation: AAR03588.1
RefSeqiNP_851297.1, NM_180966.2
UniGeneiDr.80416

Genome annotation databases

EnsembliENSDART00000010643; ENSDARP00000017514; ENSDARG00000016454
ENSDART00000131069; ENSDARP00000110930; ENSDARG00000016454
GeneIDi317734
KEGGidre:317734

Similar proteinsi

Entry informationi

Entry nameiQ7ZU32_DANRE
AccessioniPrimary (citable) accession number: Q7ZU32
Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 2003
Last sequence update: June 1, 2003
Last modified: May 23, 2018
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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