Q7ZU32 (Q7ZU32_DANRE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Estrogen receptor 2a EMBL AAH44349.1

Submitted name:
Estrogen receptor beta2 EMBL AAR03588.1
Submitted name:
Uncharacterized protein Ensembl ENSDARP00000017514 Ensembl ENSDARP00000110930

Gene names

Name:	esr2a EMBL AAH44349.1 Ensembl ENSDARP00000017514 Ensembl ENSDARP00000110930 ZFIN ZDB-GENE-030116-2
Synonyms:	erbeta2 EMBL AAR03588.1

Organism

Danio rerio (Zebrafish) (Brachydanio rerio) [Reference proteome] EMBL AAH44349.1

Taxonomic identifier

7955 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Actinopterygii › Actinopteri › Neopterygii › Teleostei › Elopocephala › Clupeocephala › Otocephala › Ostariophysi › Otophysi › Cypriniphysi › Cypriniformes › Cyprinoidea › Cyprinidae › Danio

Protein attributes

Sequence length	553 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the nuclear hormone receptor family. RuleBase RU000377 Contains 1 nuclear receptor DNA-binding domain. SAAS SAAS000536

Ontologies

Keywords
Biological process	Transcription Transcription regulation SAAS SAAS000536 RuleBase RU004334
Cellular component	Nucleus SAAS SAAS000536 RuleBase RU004334
Domain	Zinc-finger SAAS SAAS000536 RuleBase RU004334
Ligand	DNA-binding SAAS SAAS000536 RuleBase RU004334 Metal-binding Zinc
Molecular function	Receptor RuleBase RU004334 EMBL AAH44349.1
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro steroid binding Inferred from electronic annotation. Source: InterPro steroid hormone receptor activity Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q7ZU32 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: 1E7E78AB66AD7A53	FASTA	553	62,340
	10 20 30 40 50 60 MSEYPEGDSP LLQLQEVDSG RVGGHILSPI FNSSSPSLPV ENHPICIPSP YTDLGHDFST 70 80 90 100 110 120 LPFYSPALLG YSTSPLSDCS SVRQSLSPTL FWPPHSHVSS LTLQQQSRLQ QNHATSGTWT 130 140 150 160 170 180 EHTPHDHVEE ENSKPLVKRV ADTEETSVSL RGKADMHYCA VCSDYASGYH YGVWSCEGCK 190 200 210 220 230 240 AFFKRSIQGH NDYICPATNQ CTIDKNRRKS CQACRLRKCY EVGMMKCGLR RDRSSYQQRG 250 260 270 280 290 300 AQQKRLVRFS GRMRMTGPRS QEIKSIPRPL SGNEVVRISL SPEELISRIM EAEPPEIYLM 310 320 330 340 350 360 KDMKKPFTEA NVMMSLTNLA DKELVHMISW AKKIPGFVEL SLFDQVHLLE CCWLEVLMLG 370 380 390 400 410 420 LMWRSVNHPG KLIFSPDLCL SRDESSCVQG LVEIFDMLLA ATSRFRELKL QREEYVCLKA 430 440 450 460 470 480 MILLNSNMCL GSSEGGEDLQ SRSKLLCLLD SVTDALVWAI SKTGLSFQQR STRLAHLLML 490 500 510 520 530 540 LSHIRHVSNK GMDHLHCMKM KKMVPLYDLL LEMLDAHIMH SSRLSHSGPR APAAHKDNKS 550 VQEAFPCSSQ HGP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	NIH - Zebrafish Gene Collection (ZGC) project Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: AB EMBL AAH44349.1. Tissue: Whole body EMBL AAH44349.1.
[2]	"Cloning and characterization of a novel truncated estrogen receptor alpha in zebrafish." Zeinstra L.M., Schuitemaker F., van der Burg B., Wang D., Bogerd J., van der Saag P.T. Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[3]	"The genomic sequence of Danio rerio." The Danio rerio Sequencing Project at the Sanger Institute Submitted (JUL-2010) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Tuebingen Ensembl ENSDARP00000017514 Ensembl ENSDARP00000110930.
[4]	Ensembl Submitted (FEB-2012) to UniProtKB Cited for: IDENTIFICATION. Strain: Tuebingen Ensembl ENSDARP00000017514 Ensembl ENSDARP00000110930.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX255911 Genomic DNA. No translation available. BC044349 mRNA. Translation: AAH44349.1. AY307098 mRNA. Translation: AAR03588.1.
IPI	IPI00490255.
RefSeq	NP_851297.1. NM_180966.2.
UniGene	Dr.80416.
3D structure databases
SMR	Q7ZU32. Positions 155-226, 280-519.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSDART00000010643; ENSDARP00000017514; ENSDARG00000016454. ENSDART00000131069; ENSDARP00000110930; ENSDARG00000016454.
GeneID	317734.
KEGG	dre:317734.
Organism-specific databases
CTD	317734.
ZFIN	ZDB-GENE-030116-2. esr2a.
Phylogenomic databases
eggNOG	NOG271979.
GeneTree	ENSGT00700000104072.
HOGENOM	HOG000233468.
HOVERGEN	HBG108344.
InParanoid	Q7ZU32.
KO	K08551.
OMA	LECCWLE.
OrthoDB	EOG41RPTT.
Family and domain databases
Gene3D	1.10.565.10. 2 hits. 3.30.50.10. 1 hit.
InterPro	IPR021064. Estrogen_rcpt_beta_N. IPR008946. Nucl_hormone_rcpt_ligand-bd. IPR000536. Nucl_hrmn_rcpt_lig-bd_core. IPR024178. Oest_rcpt/oest-rel_rcp. IPR001723. Str_hrmn_rcpt. IPR001628. Znf_hrmn_rcpt. IPR013088. Znf_NHR/GATA. [Graphical view]
Pfam	PF12497. ERbeta_N. 1 hit. PF00104. Hormone_recep. 1 hit. PF00105. zf-C4. 1 hit. [Graphical view]
PIRSF	PIRSF002527. ER-like_NR. 1 hit.
PRINTS	PR00398. STRDHORMONER. PR00047. STROIDFINGER.
SMART	SM00430. HOLI. 1 hit. SM00399. ZnF_C4. 1 hit. [Graphical view]
SUPFAM	SSF48508. Str_ncl_receptor. 1 hit.
PROSITE	PS00031. NUCLEAR_REC_DBD_1. 1 hit. PS51030. NUCLEAR_REC_DBD_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	20807163.

Entry information

Entry name

Q7ZU32_DANRE

Accession

Primary (citable) accession number: Q7ZU32

Entry history

Integrated into UniProtKB/TrEMBL:	June 1, 2003
Last sequence update:	June 1, 2003
Last modified:	May 29, 2013
This is version 83 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)