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Q7ZU32

- Q7ZU32_DANRE

UniProt

Q7ZU32 - Q7ZU32_DANRE

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Protein
Submitted name:

Esr2a protein

Gene

esr2a

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. estrogen receptor activity Source: InterPro
  2. sequence-specific DNA binding Source: InterPro
  3. sequence-specific DNA binding transcription factor activity Source: InterPro
  4. steroid binding Source: InterPro
  5. zinc ion binding Source: InterPro

GO - Biological processi

  1. intracellular estrogen receptor signaling pathway Source: InterPro
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

ReceptorUniRule annotation

Keywords - Biological processi

Transcription, Transcription regulationUniRule annotation

Keywords - Ligandi

DNA-bindingUniRule annotationSAAS annotation, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Submitted name:
Esr2a proteinImported
Submitted name:
Estrogen receptor 2aImported
Submitted name:
Estrogen receptor beta2Imported
Submitted name:
Uncharacterized proteinImported
Gene namesi
Name:esr2aImported
Synonyms:erbeta2Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
ProteomesiUP000000437: Chromosome 20

Organism-specific databases

ZFINiZDB-GENE-030116-2. esr2a.

Subcellular locationi

Nucleus UniRule annotation

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

NucleusUniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the nuclear hormone receptor family.UniRule annotation
Belongs to the nuclear hormone receptor family. NR3 subfamily.UniRule annotation
Contains nuclear receptor DNA-binding domain.SAAS annotation

Keywords - Domaini

Zinc-fingerUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiNOG271979.
GeneTreeiENSGT00760000118887.
HOGENOMiHOG000233468.
HOVERGENiHBG108344.
KOiK08551.
OMAiLECCWLE.
TreeFamiTF323751.

Family and domain databases

Gene3Di1.10.565.10. 2 hits.
3.30.50.10. 1 hit.
InterProiIPR028355. ER-beta/gamma.
IPR021064. Estrogen_rcpt_beta_N.
IPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
IPR024178. Oest_rcpt/oest-rel_rcp.
IPR001723. Str_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF12497. ERbeta_N. 1 hit.
PF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PIRSFiPIRSF500102. ER-b. 1 hit.
PIRSF002527. ER-like_NR. 1 hit.
PRINTSiPR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7ZU32-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSEYPEGDSP LLQLQEVDSG RVGGHILSPI FNSSSPSLPV ENHPICIPSP
60 70 80 90 100
YTDLGHDFST LPFYSPALLG YSTSPLSDCS SVRQSLSPTL FWPPHSHVSS
110 120 130 140 150
LTLQQQSRLQ QNHATSGTWT EHTPHDHVEE ENSKPLVKRV ADTEETSVSL
160 170 180 190 200
RGKADMHYCA VCSDYASGYH YGVWSCEGCK AFFKRSIQGH NDYICPATNQ
210 220 230 240 250
CTIDKNRRKS CQACRLRKCY EVGMMKCGLR RDRSSYQQRG AQQKRLVRFS
260 270 280 290 300
GRMRMTGPRS QEIKSIPRPL SGNEVVRISL SPEELISRIM EAEPPEIYLM
310 320 330 340 350
KDMKKPFTEA NVMMSLTNLA DKELVHMISW AKKIPGFVEL SLFDQVHLLE
360 370 380 390 400
CCWLEVLMLG LMWRSVNHPG KLIFSPDLCL SRDESSCVQG LVEIFDMLLA
410 420 430 440 450
ATSRFRELKL QREEYVCLKA MILLNSNMCL GSSEGGEDLQ SRSKLLCLLD
460 470 480 490 500
SVTDALVWAI SKTGLSFQQR STRLAHLLML LSHIRHVSNK GMDHLHCMKM
510 520 530 540 550
KKMVPLYDLL LEMLDAHIMH SSRLSHSGPR APAAHKDNKS VQEAFPCSSQ

HGP
Length:553
Mass (Da):62,340
Last modified:June 1, 2003 - v1
Checksum:i1E7E78AB66AD7A53
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX255911 Genomic DNA. No translation available.
BC044349 mRNA. Translation: AAH44349.1.
BC165404 mRNA. Translation: AAI65404.1.
AY307098 mRNA. Translation: AAR03588.1.
RefSeqiNP_851297.1. NM_180966.2.
XP_005160545.1. XM_005160488.1.
UniGeneiDr.80416.

Genome annotation databases

EnsembliENSDART00000010643; ENSDARP00000017514; ENSDARG00000016454.
ENSDART00000131069; ENSDARP00000110930; ENSDARG00000016454.
GeneIDi317734.
KEGGidre:317734.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX255911 Genomic DNA. No translation available.
BC044349 mRNA. Translation: AAH44349.1 .
BC165404 mRNA. Translation: AAI65404.1 .
AY307098 mRNA. Translation: AAR03588.1 .
RefSeqi NP_851297.1. NM_180966.2.
XP_005160545.1. XM_005160488.1.
UniGenei Dr.80416.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSDART00000010643 ; ENSDARP00000017514 ; ENSDARG00000016454 .
ENSDART00000131069 ; ENSDARP00000110930 ; ENSDARG00000016454 .
GeneIDi 317734.
KEGGi dre:317734.

Organism-specific databases

CTDi 317734.
ZFINi ZDB-GENE-030116-2. esr2a.

Phylogenomic databases

eggNOGi NOG271979.
GeneTreei ENSGT00760000118887.
HOGENOMi HOG000233468.
HOVERGENi HBG108344.
KOi K08551.
OMAi LECCWLE.
TreeFami TF323751.

Miscellaneous databases

NextBioi 20807163.
PROi Q7ZU32.

Family and domain databases

Gene3Di 1.10.565.10. 2 hits.
3.30.50.10. 1 hit.
InterProi IPR028355. ER-beta/gamma.
IPR021064. Estrogen_rcpt_beta_N.
IPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
IPR024178. Oest_rcpt/oest-rel_rcp.
IPR001723. Str_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view ]
Pfami PF12497. ERbeta_N. 1 hit.
PF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view ]
PIRSFi PIRSF500102. ER-b. 1 hit.
PIRSF002527. ER-like_NR. 1 hit.
PRINTSi PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTi SM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view ]
SUPFAMi SSF48508. SSF48508. 1 hit.
PROSITEi PS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: ABImported.
    Tissue: Whole bodyImported.
  2. "Cloning and characterization of a novel truncated estrogen receptor alpha in zebrafish."
    Zeinstra L.M., Schuitemaker F., van der Burg B., Wang D., Bogerd J., van der Saag P.T.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  3. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: PCR rescueImported.
  4. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: TuebingenImported.
  5. "The zebrafish reference genome sequence and its relationship to the human genome."
    Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.
    , White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., Clee C., Oliver K., Clark R., Riddle C., Eliott D., Threadgold G., Harden G., Ware D., Mortimer B., Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.
    Nature 496:498-503(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TuebingenImported.

Entry informationi

Entry nameiQ7ZU32_DANRE
AccessioniPrimary (citable) accession number: Q7ZU32
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2003
Last sequence update: June 1, 2003
Last modified: October 29, 2014
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3