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Protein
Submitted name:

Esr2a protein

Gene

esr2a

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi156 – 231Nuclear receptorPROSITE-ProRule annotationAdd BLAST76

GO - Molecular functioni

  • estrogen receptor activity Source: ZFIN
  • RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding Source: ZFIN
  • sequence-specific DNA binding Source: InterPro
  • steroid hormone binding Source: ZFIN
  • zinc ion binding Source: InterPro

GO - Biological processi

  • response to estrogen Source: ZFIN
  • transcription, DNA-templated Source: UniProtKB-UniRule

Keywordsi

Molecular functionDNA-bindingPROSITE-ProRule annotationSAAS annotation, ReceptorUniRule annotationImported
Biological processTranscription, Transcription regulationUniRule annotationSAAS annotation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-DRE-383280. Nuclear Receptor transcription pathway.

Names & Taxonomyi

Protein namesi
Submitted name:
Esr2a proteinImported
Submitted name:
Estrogen receptor 2aImported
Submitted name:
Estrogen receptor beta2Imported
Gene namesi
Name:esr2aImported
Synonyms:erbeta2Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 20

Organism-specific databases

ZFINiZDB-GENE-030116-2. esr2a.

Subcellular locationi

  • Nucleus UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

NucleusUniRule annotationSAAS annotation

Expressioni

Gene expression databases

BgeeiENSDARG00000016454.
ExpressionAtlasiQ7ZU32. baseline.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000017514.

Structurei

3D structure databases

SMRiQ7ZU32.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini156 – 231Nuclear receptor DNA-bindingInterPro annotationAdd BLAST76

Sequence similaritiesi

Belongs to the nuclear hormone receptor family. NR3 subfamily.UniRule annotation

Keywords - Domaini

Zinc-fingerPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG3575. Eukaryota.
ENOG410XRZC. LUCA.
GeneTreeiENSGT00760000118887.
HOGENOMiHOG000233468.
HOVERGENiHBG108344.
KOiK08551.
OMAiVKCGSRR.
OrthoDBiEOG091G03V4.
TreeFamiTF323751.

Family and domain databases

Gene3Di3.30.50.10. 1 hit.
InterProiView protein in InterPro
IPR028355. ER-beta/gamma.
IPR021064. Estrogen_rcpt_beta_N.
IPR000536. Nucl_hrmn_rcpt_lig-bd.
IPR001723. Nuclear_hrmn_rcpt.
IPR024178. Oest_rcpt/oest-rel_rcp.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
PfamiView protein in Pfam
PF12497. ERbeta_N. 1 hit.
PF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
PIRSFiPIRSF500102. ER-b. 1 hit.
PIRSF002527. ER-like_NR. 1 hit.
PRINTSiPR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiView protein in SMART
SM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiView protein in PROSITE
PS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7ZU32-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEYPEGDSP LLQLQEVDSG RVGGHILSPI FNSSSPSLPV ENHPICIPSP
60 70 80 90 100
YTDLGHDFST LPFYSPALLG YSTSPLSDCS SVRQSLSPTL FWPPHSHVSS
110 120 130 140 150
LTLQQQSRLQ QNHATSGTWT EHTPHDHVEE ENSKPLVKRV ADTEETSVSL
160 170 180 190 200
RGKADMHYCA VCSDYASGYH YGVWSCEGCK AFFKRSIQGH NDYICPATNQ
210 220 230 240 250
CTIDKNRRKS CQACRLRKCY EVGMMKCGLR RDRSSYQQRG AQQKRLVRFS
260 270 280 290 300
GRMRMTGPRS QEIKSIPRPL SGNEVVRISL SPEELISRIM EAEPPEIYLM
310 320 330 340 350
KDMKKPFTEA NVMMSLTNLA DKELVHMISW AKKIPGFVEL SLFDQVHLLE
360 370 380 390 400
CCWLEVLMLG LMWRSVNHPG KLIFSPDLCL SRDESSCVQG LVEIFDMLLA
410 420 430 440 450
ATSRFRELKL QREEYVCLKA MILLNSNMCL GSSEGGEDLQ SRSKLLCLLD
460 470 480 490 500
SVTDALVWAI SKTGLSFQQR STRLAHLLML LSHIRHVSNK GMDHLHCMKM
510 520 530 540 550
KKMVPLYDLL LEMLDAHIMH SSRLSHSGPR APAAHKDNKS VQEAFPCSSQ

HGP
Length:553
Mass (Da):62,340
Last modified:June 1, 2003 - v1
Checksum:i1E7E78AB66AD7A53
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX255911 Genomic DNA. No translation available.
BC044349 mRNA. Translation: AAH44349.1.
BC165404 mRNA. Translation: AAI65404.1.
AY307098 mRNA. Translation: AAR03588.1.
RefSeqiNP_851297.1. NM_180966.2.
UniGeneiDr.80416.

Genome annotation databases

EnsembliENSDART00000010643; ENSDARP00000017514; ENSDARG00000016454.
ENSDART00000131069; ENSDARP00000110930; ENSDARG00000016454.
GeneIDi317734.
KEGGidre:317734.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiQ7ZU32_DANRE
AccessioniPrimary (citable) accession number: Q7ZU32
Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 2003
Last sequence update: June 1, 2003
Last modified: July 5, 2017
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported