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Q7ZU32

- Q7ZU32_DANRE

UniProt

Q7ZU32 - Q7ZU32_DANRE

Protein
Submitted name:

Esr2a protein

Gene

esr2a

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 93 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. estrogen receptor activity Source: InterPro
    2. sequence-specific DNA binding Source: InterPro
    3. sequence-specific DNA binding transcription factor activity Source: InterPro
    4. steroid binding Source: InterPro
    5. zinc ion binding Source: InterPro

    GO - Biological processi

    1. intracellular estrogen receptor signaling pathway Source: InterPro
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    ReceptorUniRule annotationImported

    Keywords - Biological processi

    Transcription, Transcription regulationUniRule annotationSAAS annotation

    Keywords - Ligandi

    DNA-bindingUniRule annotationSAAS annotation, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Esr2a proteinImported
    Submitted name:
    Estrogen receptor 2aImported
    Submitted name:
    Estrogen receptor beta2Imported
    Submitted name:
    Uncharacterized proteinImported
    Gene namesi
    Name:esr2aImported
    Synonyms:erbeta2Imported
    OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
    Taxonomic identifieri7955 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
    ProteomesiUP000000437: Chromosome 20

    Organism-specific databases

    ZFINiZDB-GENE-030116-2. esr2a.

    Subcellular locationi

    Nucleus UniRule annotation

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    NucleusUniRule annotationSAAS annotation

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the nuclear hormone receptor family.UniRule annotation
    Belongs to the nuclear hormone receptor family. NR3 subfamily.UniRule annotation
    Contains nuclear receptor DNA-binding domain.SAAS annotation

    Keywords - Domaini

    Zinc-fingerUniRule annotationSAAS annotation

    Phylogenomic databases

    eggNOGiNOG271979.
    GeneTreeiENSGT00730000110346.
    HOGENOMiHOG000233468.
    HOVERGENiHBG108344.
    InParanoidiQ7ZU32.
    KOiK08551.
    OMAiLECCWLE.
    TreeFamiTF323751.

    Family and domain databases

    Gene3Di1.10.565.10. 2 hits.
    3.30.50.10. 1 hit.
    InterProiIPR028355. ER-beta/gamma.
    IPR021064. Estrogen_rcpt_beta_N.
    IPR008946. Nucl_hormone_rcpt_ligand-bd.
    IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
    IPR024178. Oest_rcpt/oest-rel_rcp.
    IPR001723. Str_hrmn_rcpt.
    IPR001628. Znf_hrmn_rcpt.
    IPR013088. Znf_NHR/GATA.
    [Graphical view]
    PfamiPF12497. ERbeta_N. 1 hit.
    PF00104. Hormone_recep. 1 hit.
    PF00105. zf-C4. 1 hit.
    [Graphical view]
    PIRSFiPIRSF500102. ER-b. 1 hit.
    PIRSF002527. ER-like_NR. 1 hit.
    PRINTSiPR00398. STRDHORMONER.
    PR00047. STROIDFINGER.
    SMARTiSM00430. HOLI. 1 hit.
    SM00399. ZnF_C4. 1 hit.
    [Graphical view]
    SUPFAMiSSF48508. SSF48508. 1 hit.
    PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
    PS51030. NUCLEAR_REC_DBD_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q7ZU32-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSEYPEGDSP LLQLQEVDSG RVGGHILSPI FNSSSPSLPV ENHPICIPSP    50
    YTDLGHDFST LPFYSPALLG YSTSPLSDCS SVRQSLSPTL FWPPHSHVSS 100
    LTLQQQSRLQ QNHATSGTWT EHTPHDHVEE ENSKPLVKRV ADTEETSVSL 150
    RGKADMHYCA VCSDYASGYH YGVWSCEGCK AFFKRSIQGH NDYICPATNQ 200
    CTIDKNRRKS CQACRLRKCY EVGMMKCGLR RDRSSYQQRG AQQKRLVRFS 250
    GRMRMTGPRS QEIKSIPRPL SGNEVVRISL SPEELISRIM EAEPPEIYLM 300
    KDMKKPFTEA NVMMSLTNLA DKELVHMISW AKKIPGFVEL SLFDQVHLLE 350
    CCWLEVLMLG LMWRSVNHPG KLIFSPDLCL SRDESSCVQG LVEIFDMLLA 400
    ATSRFRELKL QREEYVCLKA MILLNSNMCL GSSEGGEDLQ SRSKLLCLLD 450
    SVTDALVWAI SKTGLSFQQR STRLAHLLML LSHIRHVSNK GMDHLHCMKM 500
    KKMVPLYDLL LEMLDAHIMH SSRLSHSGPR APAAHKDNKS VQEAFPCSSQ 550
    HGP 553
    Length:553
    Mass (Da):62,340
    Last modified:June 1, 2003 - v1
    Checksum:i1E7E78AB66AD7A53
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX255911 Genomic DNA. No translation available.
    BC044349 mRNA. Translation: AAH44349.1.
    BC165404 mRNA. Translation: AAI65404.1.
    AY307098 mRNA. Translation: AAR03588.1.
    RefSeqiNP_851297.1. NM_180966.2.
    XP_005160545.1. XM_005160488.1.
    UniGeneiDr.80416.

    Genome annotation databases

    EnsembliENSDART00000010643; ENSDARP00000017514; ENSDARG00000016454.
    ENSDART00000131069; ENSDARP00000110930; ENSDARG00000016454.
    GeneIDi317734.
    KEGGidre:317734.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX255911 Genomic DNA. No translation available.
    BC044349 mRNA. Translation: AAH44349.1 .
    BC165404 mRNA. Translation: AAI65404.1 .
    AY307098 mRNA. Translation: AAR03588.1 .
    RefSeqi NP_851297.1. NM_180966.2.
    XP_005160545.1. XM_005160488.1.
    UniGenei Dr.80416.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSDART00000010643 ; ENSDARP00000017514 ; ENSDARG00000016454 .
    ENSDART00000131069 ; ENSDARP00000110930 ; ENSDARG00000016454 .
    GeneIDi 317734.
    KEGGi dre:317734.

    Organism-specific databases

    CTDi 317734.
    ZFINi ZDB-GENE-030116-2. esr2a.

    Phylogenomic databases

    eggNOGi NOG271979.
    GeneTreei ENSGT00730000110346.
    HOGENOMi HOG000233468.
    HOVERGENi HBG108344.
    InParanoidi Q7ZU32.
    KOi K08551.
    OMAi LECCWLE.
    TreeFami TF323751.

    Miscellaneous databases

    NextBioi 20807163.
    PROi Q7ZU32.

    Family and domain databases

    Gene3Di 1.10.565.10. 2 hits.
    3.30.50.10. 1 hit.
    InterProi IPR028355. ER-beta/gamma.
    IPR021064. Estrogen_rcpt_beta_N.
    IPR008946. Nucl_hormone_rcpt_ligand-bd.
    IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
    IPR024178. Oest_rcpt/oest-rel_rcp.
    IPR001723. Str_hrmn_rcpt.
    IPR001628. Znf_hrmn_rcpt.
    IPR013088. Znf_NHR/GATA.
    [Graphical view ]
    Pfami PF12497. ERbeta_N. 1 hit.
    PF00104. Hormone_recep. 1 hit.
    PF00105. zf-C4. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF500102. ER-b. 1 hit.
    PIRSF002527. ER-like_NR. 1 hit.
    PRINTSi PR00398. STRDHORMONER.
    PR00047. STROIDFINGER.
    SMARTi SM00430. HOLI. 1 hit.
    SM00399. ZnF_C4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48508. SSF48508. 1 hit.
    PROSITEi PS00031. NUCLEAR_REC_DBD_1. 1 hit.
    PS51030. NUCLEAR_REC_DBD_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Zebrafish Gene Collection (ZGC) project
      Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: ABImported.
      Tissue: Whole bodyImported.
    2. "Cloning and characterization of a novel truncated estrogen receptor alpha in zebrafish."
      Zeinstra L.M., Schuitemaker F., van der Burg B., Wang D., Bogerd J., van der Saag P.T.
      Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
    3. NIH - Zebrafish Gene Collection (ZGC) project
      Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: PCR rescueImported.
    4. Ensembl
      Submitted (FEB-2012) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: TuebingenImported.
    5. "The zebrafish reference genome sequence and its relationship to the human genome."
      Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.
      , White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., Clee C., Oliver K., Clark R., Riddle C., Eliott D., Threadgold G., Harden G., Ware D., Mortimer B., Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.
      Nature 496:498-503(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: TuebingenImported.

    Entry informationi

    Entry nameiQ7ZU32_DANRE
    AccessioniPrimary (citable) accession number: Q7ZU32
    Entry historyi
    Integrated into UniProtKB/TrEMBL: June 1, 2003
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 93 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3