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Protein
Submitted name:

Esr2a protein

Gene

esr2a

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

ReceptorUniRule annotationImported

Keywords - Biological processi

Transcription, Transcription regulationUniRule annotationSAAS annotation

Keywords - Ligandi

DNA-bindingUniRule annotationSAAS annotation, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_278581. Nuclear Receptor transcription pathway.

Names & Taxonomyi

Protein namesi
Submitted name:
Esr2a proteinImported
Submitted name:
Estrogen receptor 2aImported
Submitted name:
Estrogen receptor beta2Imported
Submitted name:
Uncharacterized proteinImported
Gene namesi
Name:esr2aImported
Synonyms:erbeta2Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
ProteomesiUP000000437 Componenti: Chromosome 20

Organism-specific databases

ZFINiZDB-GENE-030116-2. esr2a.

Subcellular locationi

  • Nucleus UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

NucleusUniRule annotationSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000017514.

Family & Domainsi

Sequence similaritiesi

Belongs to the nuclear hormone receptor family. NR3 subfamily.UniRule annotation
Contains nuclear receptor DNA-binding domain.SAAS annotation

Keywords - Domaini

Zinc-fingerUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiNOG271979.
GeneTreeiENSGT00760000118887.
HOGENOMiHOG000233468.
HOVERGENiHBG108344.
KOiK08551.
OMAiLECCWLE.
TreeFamiTF323751.

Family and domain databases

Gene3Di1.10.565.10. 2 hits.
3.30.50.10. 1 hit.
InterProiIPR028355. ER-beta/gamma.
IPR021064. Estrogen_rcpt_beta_N.
IPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
IPR024178. Oest_rcpt/oest-rel_rcp.
IPR001723. Str_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF12497. ERbeta_N. 1 hit.
PF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PIRSFiPIRSF500102. ER-b. 1 hit.
PIRSF002527. ER-like_NR. 1 hit.
PRINTSiPR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7ZU32-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEYPEGDSP LLQLQEVDSG RVGGHILSPI FNSSSPSLPV ENHPICIPSP
60 70 80 90 100
YTDLGHDFST LPFYSPALLG YSTSPLSDCS SVRQSLSPTL FWPPHSHVSS
110 120 130 140 150
LTLQQQSRLQ QNHATSGTWT EHTPHDHVEE ENSKPLVKRV ADTEETSVSL
160 170 180 190 200
RGKADMHYCA VCSDYASGYH YGVWSCEGCK AFFKRSIQGH NDYICPATNQ
210 220 230 240 250
CTIDKNRRKS CQACRLRKCY EVGMMKCGLR RDRSSYQQRG AQQKRLVRFS
260 270 280 290 300
GRMRMTGPRS QEIKSIPRPL SGNEVVRISL SPEELISRIM EAEPPEIYLM
310 320 330 340 350
KDMKKPFTEA NVMMSLTNLA DKELVHMISW AKKIPGFVEL SLFDQVHLLE
360 370 380 390 400
CCWLEVLMLG LMWRSVNHPG KLIFSPDLCL SRDESSCVQG LVEIFDMLLA
410 420 430 440 450
ATSRFRELKL QREEYVCLKA MILLNSNMCL GSSEGGEDLQ SRSKLLCLLD
460 470 480 490 500
SVTDALVWAI SKTGLSFQQR STRLAHLLML LSHIRHVSNK GMDHLHCMKM
510 520 530 540 550
KKMVPLYDLL LEMLDAHIMH SSRLSHSGPR APAAHKDNKS VQEAFPCSSQ

HGP
Length:553
Mass (Da):62,340
Last modified:June 1, 2003 - v1
Checksum:i1E7E78AB66AD7A53
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX255911 Genomic DNA. No translation available.
BC044349 mRNA. Translation: AAH44349.1.
BC165404 mRNA. Translation: AAI65404.1.
AY307098 mRNA. Translation: AAR03588.1.
RefSeqiNP_851297.1. NM_180966.2.
XP_005160545.1. XM_005160488.2.
XP_009292911.1. XM_009294636.1.
UniGeneiDr.80416.

Genome annotation databases

EnsembliENSDART00000010643; ENSDARP00000017514; ENSDARG00000016454.
ENSDART00000131069; ENSDARP00000110930; ENSDARG00000016454.
GeneIDi317734.
KEGGidre:317734.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX255911 Genomic DNA. No translation available.
BC044349 mRNA. Translation: AAH44349.1.
BC165404 mRNA. Translation: AAI65404.1.
AY307098 mRNA. Translation: AAR03588.1.
RefSeqiNP_851297.1. NM_180966.2.
XP_005160545.1. XM_005160488.2.
XP_009292911.1. XM_009294636.1.
UniGeneiDr.80416.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000017514.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000010643; ENSDARP00000017514; ENSDARG00000016454.
ENSDART00000131069; ENSDARP00000110930; ENSDARG00000016454.
GeneIDi317734.
KEGGidre:317734.

Organism-specific databases

CTDi317734.
ZFINiZDB-GENE-030116-2. esr2a.

Phylogenomic databases

eggNOGiNOG271979.
GeneTreeiENSGT00760000118887.
HOGENOMiHOG000233468.
HOVERGENiHBG108344.
KOiK08551.
OMAiLECCWLE.
TreeFamiTF323751.

Enzyme and pathway databases

ReactomeiREACT_278581. Nuclear Receptor transcription pathway.

Miscellaneous databases

NextBioi20807163.
PROiQ7ZU32.

Family and domain databases

Gene3Di1.10.565.10. 2 hits.
3.30.50.10. 1 hit.
InterProiIPR028355. ER-beta/gamma.
IPR021064. Estrogen_rcpt_beta_N.
IPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
IPR024178. Oest_rcpt/oest-rel_rcp.
IPR001723. Str_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF12497. ERbeta_N. 1 hit.
PF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PIRSFiPIRSF500102. ER-b. 1 hit.
PIRSF002527. ER-like_NR. 1 hit.
PRINTSiPR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: ABImported.
    Tissue: Whole bodyImported.
  2. "Cloning and characterization of a novel truncated estrogen receptor alpha in zebrafish."
    Zeinstra L.M., Schuitemaker F., van der Burg B., Wang D., Bogerd J., van der Saag P.T.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  3. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: PCR rescueImported.
  4. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: TuebingenImported.
  5. "The zebrafish reference genome sequence and its relationship to the human genome."
    Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.
    , White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., Clee C., Oliver K., Clark R., Riddle C., Eliott D., Threadgold G., Harden G., Ware D., Mortimer B., Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.
    Nature 496:498-503(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TuebingenImported.

Entry informationi

Entry nameiQ7ZU32_DANRE
AccessioniPrimary (citable) accession number: Q7ZU32
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2003
Last sequence update: June 1, 2003
Last modified: July 22, 2015
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.