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Protein

Serine/threonine-protein kinase Sgk1

Gene

sgk1

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Protein kinase that may play an important role in cellular stress response. May be involved in the regulation of processes such as cell survival, neuronal excitability and renal sodium excretion (By similarity).By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei129 – 1291ATPPROSITE-ProRule annotation
Active sitei224 – 2241Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi106 – 1149ATPPROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Apoptosis, Stress response

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-DRE-6804757. Regulation of TP53 Degradation.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase Sgk1 (EC:2.7.11.1)
Alternative name(s):
Serum/glucocorticoid-regulated kinase 1
Gene namesi
Name:sgk1
Synonyms:sgk
ORF Names:wu:fc20a09
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 23

Organism-specific databases

ZFINiZDB-GENE-030131-2860. sgk1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 433433Serine/threonine-protein kinase Sgk1PRO_0000380131Add
BLAST

Proteomic databases

PaxDbiQ7ZTW4.

Expressioni

Gene expression databases

BgeeiENSDARG00000025522.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000031762.

Structurei

3D structure databases

ProteinModelPortaliQ7ZTW4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini100 – 357258Protein kinasePROSITE-ProRule annotationAdd
BLAST
Domaini358 – 43376AGC-kinase C-terminalAdd
BLAST

Sequence similaritiesi

Contains 1 AGC-kinase C-terminal domain.Curated
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0598. Eukaryota.
ENOG410XNPH. LUCA.
GeneTreeiENSGT00820000126961.
HOGENOMiHOG000233033.
InParanoidiQ7ZTW4.
KOiK13302.
OMAiEVKEPCN.
OrthoDBiEOG091G06FF.
PhylomeDBiQ7ZTW4.
TreeFamiTF320906.

Family and domain databases

InterProiIPR000961. AGC-kinase_C.
IPR011009. Kinase-like_dom.
IPR017892. Pkinase_C.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
PF00433. Pkinase_C. 1 hit.
[Graphical view]
SMARTiSM00133. S_TK_X. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS51285. AGC_KINASE_CTER. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7ZTW4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTIQTETSVS APDLTYSKTR GLVANLSAFM KQRKMGLNDF IQKLSANSYA
60 70 80 90 100
CKHPEVQSIL NLTPPQDVEL MNSNPSPPPS PSQQINLGPS SNPTAKPSDF
110 120 130 140 150
DFLKVIGKGS FGKVLLARHR SDEKFYAVKV LQKKAILKKK EEKHIMSERN
160 170 180 190 200
VLLKNVKHPF LVGLHYSFQT TDKLYFVLDY INGGELFYHL QRERCFLEPR
210 220 230 240 250
ARFYAAEIAS ALGYLHSLNI VYRDLKPENI LLDSQGHIIL TDFGLCKENI
260 270 280 290 300
EPNGTTSTFC GTPEYLAPEV LHKQPYDRTV DWWCLGAVLY EMLYGLPPFY
310 320 330 340 350
SRNTAEMYDN ILNKPLQLKP NISNAARHLL EGLLQKDRTK RLGFTDDFTE
360 370 380 390 400
IKNHMFFSPI NWDDLNAKKL TPPFNPNVTG PNDLRHFDPE FTDEPVPNSI
410 420 430
GCSPDSALVT SSITEATEAF LGFSYAPAMD SYL
Length:433
Mass (Da):48,983
Last modified:June 1, 2003 - v1
Checksum:iF2AA4771E245FF56
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF512629 mRNA. Translation: ABO88209.1.
BC052134 mRNA. Translation: AAH52134.1.
BC067618 mRNA. Translation: AAH67618.1.
RefSeqiNP_954682.1. NM_199212.1.
UniGeneiDr.78523.

Genome annotation databases

EnsembliENSDART00000035031; ENSDARP00000031762; ENSDARG00000025522.
GeneIDi324140.
KEGGidre:324140.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF512629 mRNA. Translation: ABO88209.1.
BC052134 mRNA. Translation: AAH52134.1.
BC067618 mRNA. Translation: AAH67618.1.
RefSeqiNP_954682.1. NM_199212.1.
UniGeneiDr.78523.

3D structure databases

ProteinModelPortaliQ7ZTW4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000031762.

Proteomic databases

PaxDbiQ7ZTW4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000035031; ENSDARP00000031762; ENSDARG00000025522.
GeneIDi324140.
KEGGidre:324140.

Organism-specific databases

CTDi6446.
ZFINiZDB-GENE-030131-2860. sgk1.

Phylogenomic databases

eggNOGiKOG0598. Eukaryota.
ENOG410XNPH. LUCA.
GeneTreeiENSGT00820000126961.
HOGENOMiHOG000233033.
InParanoidiQ7ZTW4.
KOiK13302.
OMAiEVKEPCN.
OrthoDBiEOG091G06FF.
PhylomeDBiQ7ZTW4.
TreeFamiTF320906.

Enzyme and pathway databases

ReactomeiR-DRE-6804757. Regulation of TP53 Degradation.

Miscellaneous databases

PROiQ7ZTW4.

Gene expression databases

BgeeiENSDARG00000025522.

Family and domain databases

InterProiIPR000961. AGC-kinase_C.
IPR011009. Kinase-like_dom.
IPR017892. Pkinase_C.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
PF00433. Pkinase_C. 1 hit.
[Graphical view]
SMARTiSM00133. S_TK_X. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS51285. AGC_KINASE_CTER. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSGK1_DANRE
AccessioniPrimary (citable) accession number: Q7ZTW4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: June 1, 2003
Last modified: September 7, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.