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Q7ZTA0

- CRVP_AGKPI

UniProt

Q7ZTA0 - CRVP_AGKPI

Protein

Cysteine-rich venom protein piscivorin

Gene
N/A
Organism
Agkistrodon piscivorus piscivorus (Eastern cottonmouth)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 55 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    Weakly blocks contraction of smooth muscle elicited by high potassium-induced depolarization, but does not block caffein-stimulated contraction. May target voltage-gated calcium channels on smooth muscle.1 Publication

    Keywords - Molecular functioni

    Calcium channel impairing toxin, Ion channel impairing toxin, Neurotoxin, Toxin

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cysteine-rich venom protein piscivorin
    OrganismiAgkistrodon piscivorus piscivorus (Eastern cottonmouth)
    Taxonomic identifieri8716 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaSerpentesColubroideaViperidaeCrotalinaeAgkistrodon

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 19191 PublicationAdd
    BLAST
    Chaini20 – 240221Cysteine-rich venom protein piscivorinPRO_0000006274Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi75 ↔ 153PROSITE-ProRule annotation
    Disulfide bondi92 ↔ 167PROSITE-ProRule annotation
    Disulfide bondi148 ↔ 164PROSITE-ProRule annotation
    Disulfide bondi186 ↔ 193PROSITE-ProRule annotation
    Disulfide bondi189 ↔ 198PROSITE-ProRule annotation
    Disulfide bondi202 ↔ 235PROSITE-ProRule annotation
    Disulfide bondi211 ↔ 229PROSITE-ProRule annotation
    Disulfide bondi220 ↔ 233PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond

    Expressioni

    Tissue specificityi

    Expressed by the venom gland.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7ZTA0.
    SMRiQ7ZTA0. Positions 20-240.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini38 – 166129SCPAdd
    BLAST
    Domaini202 – 23534ShKTPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the CRISP family.Curated
    Contains 1 SCP domain.Curated
    Contains 1 ShKT domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    HOVERGENiHBG004184.

    Family and domain databases

    Gene3Di3.40.33.10. 1 hit.
    InterProiIPR001283. Allrgn_V5/Tpx1.
    IPR018244. Allrgn_V5/Tpx1_CS.
    IPR014044. CAP_domain.
    IPR013871. Cysteine_rich_secretory.
    IPR003582. ShKT_dom.
    IPR002413. V5_allergen.
    [Graphical view]
    PANTHERiPTHR10334. PTHR10334. 1 hit.
    PfamiPF00188. CAP. 1 hit.
    PF08562. Crisp. 1 hit.
    [Graphical view]
    PRINTSiPR00838. V5ALLERGEN.
    PR00837. V5TPXLIKE.
    SMARTiSM00198. SCP. 1 hit.
    [Graphical view]
    SUPFAMiSSF55797. SSF55797. 1 hit.
    PROSITEiPS01009. CRISP_1. 1 hit.
    PS01010. CRISP_2. 1 hit.
    PS51670. SHKT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q7ZTA0-1 [UniParc]FASTAAdd to Basket

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    MIAFIVLPIL AAVLQQSSGS VDFDSESPRK PEIQNQIVDL HNSLRRSVNP    50
    TASNMLKMEW YPEAAANAER WAYRCIESHS PRNSRVLGGI KCGENIYMSS 100
    IPIKWTEIIH AWHGENKNFK YGIGADPPNA VIGHFTQIVW YKSYLVGCAA 150
    AYCPSSEYSY FYVCQYCPAG NIIGKIATPY KSGPPCGDCP SACVNGLCTN 200
    PCTKEDKYTN CKSLVQQYGC QDKQMQSECS AICFCQNKII 240
    Length:240
    Mass (Da):26,682
    Last modified:June 1, 2003 - v1
    Checksum:iB360237DEC9364DC
    GO

    Mass spectrometryi

    Molecular mass is 24842.8±131.7 Da from positions 20 - 240. Determined by MALDI. 1 Publication

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY181982 mRNA. Translation: AAO62994.1.

    Cross-referencesi

    Web resourcesi

    Wikipedia

    Piscivorin entry

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY181982 mRNA. Translation: AAO62994.1 .

    3D structure databases

    ProteinModelPortali Q7ZTA0.
    SMRi Q7ZTA0. Positions 20-240.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG004184.

    Family and domain databases

    Gene3Di 3.40.33.10. 1 hit.
    InterProi IPR001283. Allrgn_V5/Tpx1.
    IPR018244. Allrgn_V5/Tpx1_CS.
    IPR014044. CAP_domain.
    IPR013871. Cysteine_rich_secretory.
    IPR003582. ShKT_dom.
    IPR002413. V5_allergen.
    [Graphical view ]
    PANTHERi PTHR10334. PTHR10334. 1 hit.
    Pfami PF00188. CAP. 1 hit.
    PF08562. Crisp. 1 hit.
    [Graphical view ]
    PRINTSi PR00838. V5ALLERGEN.
    PR00837. V5TPXLIKE.
    SMARTi SM00198. SCP. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55797. SSF55797. 1 hit.
    PROSITEi PS01009. CRISP_1. 1 hit.
    PS01010. CRISP_2. 1 hit.
    PS51670. SHKT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Wide distribution of cysteine-rich secretory proteins in snake venoms: isolation and cloning of novel snake venom cysteine-rich secretory proteins."
      Yamazaki Y., Hyodo F., Morita T.
      Arch. Biochem. Biophys. 412:133-141(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 20-82; 92-117; 121-142; 176-201 AND 208-238, CHARACTERIZATION, FUNCTION, MASS SPECTROMETRY.
      Tissue: Venom gland.

    Entry informationi

    Entry nameiCRVP_AGKPI
    AccessioniPrimary (citable) accession number: Q7ZTA0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 29, 2004
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 55 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programAnimal Toxin Annotation Program
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Direct protein sequencing

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3