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Q7ZTA0

- CRVP_AGKPI

UniProt

Q7ZTA0 - CRVP_AGKPI

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Protein

Cysteine-rich venom protein piscivorin

Gene
N/A
Organism
Agkistrodon piscivorus piscivorus (Eastern cottonmouth)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Weakly blocks contraction of smooth muscle elicited by high potassium-induced depolarization, but does not block caffein-stimulated contraction. May target voltage-gated calcium channels on smooth muscle.1 Publication

Keywords - Molecular functioni

Calcium channel impairing toxin, Ion channel impairing toxin, Neurotoxin, Toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Cysteine-rich venom protein piscivorin
OrganismiAgkistrodon piscivorus piscivorus (Eastern cottonmouth)
Taxonomic identifieri8716 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaSerpentesColubroideaViperidaeCrotalinaeAgkistrodon

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 19191 PublicationAdd
BLAST
Chaini20 – 240221Cysteine-rich venom protein piscivorinPRO_0000006274Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi75 ↔ 153PROSITE-ProRule annotation
Disulfide bondi92 ↔ 167PROSITE-ProRule annotation
Disulfide bondi148 ↔ 164PROSITE-ProRule annotation
Disulfide bondi186 ↔ 193PROSITE-ProRule annotation
Disulfide bondi189 ↔ 198PROSITE-ProRule annotation
Disulfide bondi202 ↔ 235PROSITE-ProRule annotation
Disulfide bondi211 ↔ 229PROSITE-ProRule annotation
Disulfide bondi220 ↔ 233PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.

Structurei

3D structure databases

ProteinModelPortaliQ7ZTA0.
SMRiQ7ZTA0. Positions 20-240.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini38 – 166129SCPAdd
BLAST
Domaini202 – 23534ShKTPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the CRISP family.Curated
Contains 1 SCP domain.Curated
Contains 1 ShKT domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG004184.

Family and domain databases

Gene3Di3.40.33.10. 1 hit.
InterProiIPR001283. Allrgn_V5/Tpx1.
IPR018244. Allrgn_V5/Tpx1_CS.
IPR014044. CAP_domain.
IPR013871. Cysteine_rich_secretory.
IPR003582. ShKT_dom.
IPR002413. V5_allergen.
[Graphical view]
PANTHERiPTHR10334. PTHR10334. 1 hit.
PfamiPF00188. CAP. 1 hit.
PF08562. Crisp. 1 hit.
[Graphical view]
PRINTSiPR00838. V5ALLERGEN.
PR00837. V5TPXLIKE.
SMARTiSM00198. SCP. 1 hit.
[Graphical view]
SUPFAMiSSF55797. SSF55797. 1 hit.
PROSITEiPS01009. CRISP_1. 1 hit.
PS01010. CRISP_2. 1 hit.
PS51670. SHKT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7ZTA0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIAFIVLPIL AAVLQQSSGS VDFDSESPRK PEIQNQIVDL HNSLRRSVNP
60 70 80 90 100
TASNMLKMEW YPEAAANAER WAYRCIESHS PRNSRVLGGI KCGENIYMSS
110 120 130 140 150
IPIKWTEIIH AWHGENKNFK YGIGADPPNA VIGHFTQIVW YKSYLVGCAA
160 170 180 190 200
AYCPSSEYSY FYVCQYCPAG NIIGKIATPY KSGPPCGDCP SACVNGLCTN
210 220 230 240
PCTKEDKYTN CKSLVQQYGC QDKQMQSECS AICFCQNKII
Length:240
Mass (Da):26,682
Last modified:June 1, 2003 - v1
Checksum:iB360237DEC9364DC
GO

Mass spectrometryi

Molecular mass is 24842.8±131.7 Da from positions 20 - 240. Determined by MALDI. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY181982 mRNA. Translation: AAO62994.1.

Cross-referencesi

Web resourcesi

Wikipedia

Piscivorin entry

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY181982 mRNA. Translation: AAO62994.1 .

3D structure databases

ProteinModelPortali Q7ZTA0.
SMRi Q7ZTA0. Positions 20-240.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG004184.

Family and domain databases

Gene3Di 3.40.33.10. 1 hit.
InterProi IPR001283. Allrgn_V5/Tpx1.
IPR018244. Allrgn_V5/Tpx1_CS.
IPR014044. CAP_domain.
IPR013871. Cysteine_rich_secretory.
IPR003582. ShKT_dom.
IPR002413. V5_allergen.
[Graphical view ]
PANTHERi PTHR10334. PTHR10334. 1 hit.
Pfami PF00188. CAP. 1 hit.
PF08562. Crisp. 1 hit.
[Graphical view ]
PRINTSi PR00838. V5ALLERGEN.
PR00837. V5TPXLIKE.
SMARTi SM00198. SCP. 1 hit.
[Graphical view ]
SUPFAMi SSF55797. SSF55797. 1 hit.
PROSITEi PS01009. CRISP_1. 1 hit.
PS01010. CRISP_2. 1 hit.
PS51670. SHKT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Wide distribution of cysteine-rich secretory proteins in snake venoms: isolation and cloning of novel snake venom cysteine-rich secretory proteins."
    Yamazaki Y., Hyodo F., Morita T.
    Arch. Biochem. Biophys. 412:133-141(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 20-82; 92-117; 121-142; 176-201 AND 208-238, CHARACTERIZATION, FUNCTION, MASS SPECTROMETRY.
    Tissue: Venom gland.

Entry informationi

Entry nameiCRVP_AGKPI
AccessioniPrimary (citable) accession number: Q7ZTA0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2004
Last sequence update: June 1, 2003
Last modified: October 29, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3