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Q7ZTA0

- CRVP_AGKPI

UniProt

Q7ZTA0 - CRVP_AGKPI

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Protein
Cysteine-rich venom protein piscivorin
Gene
N/A
Organism
Agkistrodon piscivorus piscivorus (Eastern cottonmouth)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Weakly blocks contraction of smooth muscle elicited by high potassium-induced depolarization, but does not block caffein-stimulated contraction. May target voltage-gated calcium channels on smooth muscle.1 Publication

Keywords - Molecular functioni

Calcium channel impairing toxin, Ion channel impairing toxin, Neurotoxin, Toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Cysteine-rich venom protein piscivorin
OrganismiAgkistrodon piscivorus piscivorus (Eastern cottonmouth)
Taxonomic identifieri8716 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaSerpentesColubroideaViperidaeCrotalinaeAgkistrodon

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 19191 Publication
Add
BLAST
Chaini20 – 240221Cysteine-rich venom protein piscivorin
PRO_0000006274Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi75 ↔ 153 By similarity
Disulfide bondi92 ↔ 167 By similarity
Disulfide bondi148 ↔ 164 By similarity
Disulfide bondi186 ↔ 193 By similarity
Disulfide bondi189 ↔ 198 By similarity
Disulfide bondi202 ↔ 235 By similarity
Disulfide bondi211 ↔ 229 By similarity
Disulfide bondi220 ↔ 233 By similarity

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.

Structurei

3D structure databases

ProteinModelPortaliQ7ZTA0.
SMRiQ7ZTA0. Positions 20-240.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini38 – 166129SCP
Add
BLAST
Domaini202 – 23534ShKT
Add
BLAST

Sequence similaritiesi

Belongs to the CRISP family.
Contains 1 SCP domain.
Contains 1 ShKT domain.

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG004184.

Family and domain databases

Gene3Di3.40.33.10. 1 hit.
InterProiIPR001283. Allrgn_V5/Tpx1.
IPR018244. Allrgn_V5/Tpx1_CS.
IPR014044. CAP_domain.
IPR013871. Cysteine_rich_secretory.
IPR003582. ShKT_dom.
IPR002413. V5_allergen.
[Graphical view]
PANTHERiPTHR10334. PTHR10334. 1 hit.
PfamiPF00188. CAP. 1 hit.
PF08562. Crisp. 1 hit.
[Graphical view]
PRINTSiPR00838. V5ALLERGEN.
PR00837. V5TPXLIKE.
SMARTiSM00198. SCP. 1 hit.
[Graphical view]
SUPFAMiSSF55797. SSF55797. 1 hit.
PROSITEiPS01009. CRISP_1. 1 hit.
PS01010. CRISP_2. 1 hit.
PS51670. SHKT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7ZTA0-1 [UniParc]FASTAAdd to Basket

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MIAFIVLPIL AAVLQQSSGS VDFDSESPRK PEIQNQIVDL HNSLRRSVNP    50
TASNMLKMEW YPEAAANAER WAYRCIESHS PRNSRVLGGI KCGENIYMSS 100
IPIKWTEIIH AWHGENKNFK YGIGADPPNA VIGHFTQIVW YKSYLVGCAA 150
AYCPSSEYSY FYVCQYCPAG NIIGKIATPY KSGPPCGDCP SACVNGLCTN 200
PCTKEDKYTN CKSLVQQYGC QDKQMQSECS AICFCQNKII 240
Length:240
Mass (Da):26,682
Last modified:June 1, 2003 - v1
Checksum:iB360237DEC9364DC
GO

Mass spectrometryi

Molecular mass is 24842.8±131.7 Da from positions 20 - 240. Determined by MALDI. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY181982 mRNA. Translation: AAO62994.1.

Cross-referencesi

Web resourcesi

Wikipedia

Piscivorin entry

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY181982 mRNA. Translation: AAO62994.1 .

3D structure databases

ProteinModelPortali Q7ZTA0.
SMRi Q7ZTA0. Positions 20-240.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG004184.

Family and domain databases

Gene3Di 3.40.33.10. 1 hit.
InterProi IPR001283. Allrgn_V5/Tpx1.
IPR018244. Allrgn_V5/Tpx1_CS.
IPR014044. CAP_domain.
IPR013871. Cysteine_rich_secretory.
IPR003582. ShKT_dom.
IPR002413. V5_allergen.
[Graphical view ]
PANTHERi PTHR10334. PTHR10334. 1 hit.
Pfami PF00188. CAP. 1 hit.
PF08562. Crisp. 1 hit.
[Graphical view ]
PRINTSi PR00838. V5ALLERGEN.
PR00837. V5TPXLIKE.
SMARTi SM00198. SCP. 1 hit.
[Graphical view ]
SUPFAMi SSF55797. SSF55797. 1 hit.
PROSITEi PS01009. CRISP_1. 1 hit.
PS01010. CRISP_2. 1 hit.
PS51670. SHKT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Wide distribution of cysteine-rich secretory proteins in snake venoms: isolation and cloning of novel snake venom cysteine-rich secretory proteins."
    Yamazaki Y., Hyodo F., Morita T.
    Arch. Biochem. Biophys. 412:133-141(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 20-82; 92-117; 121-142; 176-201 AND 208-238, CHARACTERIZATION, FUNCTION, MASS SPECTROMETRY.
    Tissue: Venom gland.

Entry informationi

Entry nameiCRVP_AGKPI
AccessioniPrimary (citable) accession number: Q7ZTA0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2004
Last sequence update: June 1, 2003
Last modified: January 22, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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