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Q7ZTA0 (CRVP_AGKPI) Reviewed, UniProtKB/Swiss-Prot

Last modified January 22, 2014. Version 54. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cysteine-rich venom protein piscivorin
OrganismAgkistrodon piscivorus piscivorus (Eastern cottonmouth)
Taxonomic identifier8716 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaSerpentesColubroideaViperidaeCrotalinaeAgkistrodon

Protein attributes

Sequence length240 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Weakly blocks contraction of smooth muscle elicited by high potassium-induced depolarization, but does not block caffein-stimulated contraction. May target voltage-gated calcium channels on smooth muscle. Ref.1

Subcellular location

Secreted.

Tissue specificity

Expressed by the venom gland.

Sequence similarities

Belongs to the CRISP family.

Contains 1 SCP domain.

Contains 1 ShKT domain.

Mass spectrometry

Molecular mass is 24842.8±131.7 Da from positions 20 - 240. Determined by MALDI. Ref.1

Ontologies

Keywords
   Cellular componentSecreted
   DomainSignal
   Molecular functionCalcium channel impairing toxin
Ion channel impairing toxin
Neurotoxin
Toxin
   PTMDisulfide bond
   Technical termDirect protein sequencing
Gene Ontology (GO)
   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 Ref.1
Chain20 – 240221Cysteine-rich venom protein piscivorin
PRO_0000006274

Regions

Domain38 – 166129SCP
Domain202 – 23534ShKT

Amino acid modifications

Disulfide bond75 ↔ 153 By similarity
Disulfide bond92 ↔ 167 By similarity
Disulfide bond148 ↔ 164 By similarity
Disulfide bond186 ↔ 193 By similarity
Disulfide bond189 ↔ 198 By similarity
Disulfide bond202 ↔ 235 By similarity
Disulfide bond211 ↔ 229 By similarity
Disulfide bond220 ↔ 233 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q7ZTA0 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: B360237DEC9364DC

FASTA24026,682
        10         20         30         40         50         60 
MIAFIVLPIL AAVLQQSSGS VDFDSESPRK PEIQNQIVDL HNSLRRSVNP TASNMLKMEW 

        70         80         90        100        110        120 
YPEAAANAER WAYRCIESHS PRNSRVLGGI KCGENIYMSS IPIKWTEIIH AWHGENKNFK 

       130        140        150        160        170        180 
YGIGADPPNA VIGHFTQIVW YKSYLVGCAA AYCPSSEYSY FYVCQYCPAG NIIGKIATPY 

       190        200        210        220        230        240 
KSGPPCGDCP SACVNGLCTN PCTKEDKYTN CKSLVQQYGC QDKQMQSECS AICFCQNKII 

« Hide

References

[1]"Wide distribution of cysteine-rich secretory proteins in snake venoms: isolation and cloning of novel snake venom cysteine-rich secretory proteins."
Yamazaki Y., Hyodo F., Morita T.
Arch. Biochem. Biophys. 412:133-141(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 20-82; 92-117; 121-142; 176-201 AND 208-238, CHARACTERIZATION, FUNCTION, MASS SPECTROMETRY.
Tissue: Venom gland.

Web resources

Wikipedia

Piscivorin entry

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY181982 mRNA. Translation: AAO62994.1.

3D structure databases

ProteinModelPortalQ7ZTA0.
SMRQ7ZTA0. Positions 20-240.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG004184.

Family and domain databases

Gene3D3.40.33.10. 1 hit.
InterProIPR001283. Allrgn_V5/Tpx1.
IPR018244. Allrgn_V5/Tpx1_CS.
IPR014044. CAP_domain.
IPR013871. Cysteine_rich_secretory.
IPR003582. ShKT_dom.
IPR002413. V5_allergen.
[Graphical view]
PANTHERPTHR10334. PTHR10334. 1 hit.
PfamPF00188. CAP. 1 hit.
PF08562. Crisp. 1 hit.
[Graphical view]
PRINTSPR00838. V5ALLERGEN.
PR00837. V5TPXLIKE.
SMARTSM00198. SCP. 1 hit.
[Graphical view]
SUPFAMSSF55797. SSF55797. 1 hit.
PROSITEPS01009. CRISP_1. 1 hit.
PS01010. CRISP_2. 1 hit.
PS51670. SHKT. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCRVP_AGKPI
AccessionPrimary (citable) accession number: Q7ZTA0
Entry history
Integrated into UniProtKB/Swiss-Prot: March 29, 2004
Last sequence update: June 1, 2003
Last modified: January 22, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families