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Protein

Ankyrin repeat domain-containing protein 1

Gene

ANKRD1

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May act as a nuclear transcription factor that negatively regulates the expression of cardiac genes.By similarity

GO - Molecular functioni

GO - Biological processi

  • cellular response to growth factor stimulus Source: AgBase
  • myoblast differentiation Source: AgBase
  • negative regulation of apoptotic process Source: AgBase
  • negative regulation of gene expression Source: AgBase
  • positive regulation of gene expression Source: AgBase
  • positive regulation of myoblast proliferation Source: AgBase
  • post-embryonic development Source: AgBase
  • regulation of cell cycle Source: AgBase
  • regulation of transcription by RNA polymerase II Source: GO_Central
  • skeletal muscle cell differentiation Source: GO_Central
  • skeletal muscle tissue development Source: AgBase
  • skeletal myofibril assembly Source: AgBase

Names & Taxonomyi

Protein namesi
Recommended name:
Ankyrin repeat domain-containing protein 1
Alternative name(s):
Cardiac ankyrin repeat protein
Gene namesi
Name:ANKRD1
Synonyms:CARP
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002404841 – 319Ankyrin repeat domain-containing protein 1Add BLAST319

Proteomic databases

PaxDbiQ7ZT11

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000010477

Structurei

3D structure databases

ProteinModelPortaliQ7ZT11
SMRiQ7ZT11
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati152 – 181ANK 1Add BLAST30
Repeati185 – 214ANK 2Add BLAST30
Repeati218 – 247ANK 3Add BLAST30
Repeati251 – 280ANK 4Add BLAST30
Repeati284 – 315ANK 5Add BLAST32

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi62 – 108Lys-richAdd BLAST47

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiKOG0504 Eukaryota
COG0666 LUCA
HOGENOMiHOG000236321
HOVERGENiHBG071561
InParanoidiQ7ZT11
KOiK21433
PhylomeDBiQ7ZT11

Family and domain databases

CDDicd00204 ANK, 1 hit
Gene3Di1.25.40.20, 2 hits
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
PfamiView protein in Pfam
PF12796 Ank_2, 2 hits
PRINTSiPR01415 ANKYRIN
SMARTiView protein in SMART
SM00248 ANK, 4 hits
SUPFAMiSSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 4 hits

Sequencei

Sequence statusi: Complete.

Q7ZT11-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMTMKVEELV TGKKTDDKES GSFLPEDFKT GEYEAAVKLE KQDDLRTASD
60 70 80 90 100
HLSTQVDMAH GKEKKREAEL KKKKLQERSK LESLEDLEKI IQLKKKKKCR
110 120 130 140 150
KVKAPLLKEP EPEVITGPVD IAMFFRAALE NKLPVIEKYL SDKGDPNVCN
160 170 180 190 200
EYKRTALHRA CSEGHLEVVK KLVEAGALLE LKDMLESTAL HWACRGGNLE
210 220 230 240 250
IVKFLLDKGI NRNARDKLRS TPLHVAVRTG QHDCAEHLIA CEADLNAKDR
260 270 280 290 300
EGDTPMHDAV RLNRYKMVRL LILYGADLTI KNVDGKTPMD LVLQWQNGTK
310
ELFNNLKNNS YKSAHLNKF
Length:319
Mass (Da):36,273
Last modified:June 1, 2003 - v1
Checksum:i7DE4B6B2AF6BB696
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB082934 mRNA Translation: BAC66488.1
AB082935 mRNA Translation: BAC66489.1
RefSeqiNP_989736.1, NM_204405.1
UniGeneiGga.5751

Genome annotation databases

GeneIDi378926
KEGGigga:378926

Similar proteinsi

Entry informationi

Entry nameiANKR1_CHICK
AccessioniPrimary (citable) accession number: Q7ZT11
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: June 1, 2003
Last modified: March 28, 2018
This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health