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Q7ZSY6

- MT2_DANRE

UniProt

Q7ZSY6 - MT2_DANRE

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Protein
Metallothionein-2
Gene
mt2
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Metallothioneins have a high content of cysteine residues that bind various heavy metals By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi4 – 41Divalent metal cation; cluster B
Metal bindingi6 – 61Divalent metal cation; cluster B
Metal bindingi12 – 121Divalent metal cation; cluster B
Metal bindingi14 – 141Divalent metal cation; cluster B
Metal bindingi18 – 181Divalent metal cation; cluster B
Metal bindingi20 – 201Divalent metal cation; cluster B
Metal bindingi23 – 231Divalent metal cation; cluster B
Metal bindingi25 – 251Divalent metal cation; cluster B
Metal bindingi28 – 281Divalent metal cation; cluster B
Metal bindingi32 – 321Divalent metal cation; cluster A
Metal bindingi33 – 331Divalent metal cation; cluster A
Metal bindingi35 – 351Divalent metal cation; cluster A
Metal bindingi36 – 361Divalent metal cation; cluster A
Metal bindingi40 – 401Divalent metal cation; cluster A
Metal bindingi43 – 431Divalent metal cation; cluster A
Metal bindingi47 – 471Divalent metal cation; cluster A
Metal bindingi49 – 491Divalent metal cation; cluster A
Metal bindingi54 – 541Divalent metal cation; cluster A
Metal bindingi58 – 581Divalent metal cation; cluster A
Metal bindingi59 – 591Divalent metal cation; cluster A

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. response to cadmium ion Source: ZFIN
  2. response to copper ion Source: ZFIN
  3. response to metal ion Source: ZFIN
  4. response to methylmercury Source: ZFIN
  5. response to zinc ion Source: ZFIN
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Metal-thiolate cluster

Names & Taxonomyi

Protein namesi
Recommended name:
Metallothionein-2
Short name:
MT-2
Gene namesi
Name:mt2
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
ProteomesiUP000000437: Chromosome 18

Organism-specific databases

ZFINiZDB-GENE-030131-4174. mt2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 6060Metallothionein-2
PRO_0000197269Add
BLAST

Proteomic databases

PRIDEiQ7ZSY6.

Expressioni

Developmental stagei

Expressed both maternally and zygotically. Expressed ubiquitously during early embryogenesis, but becomes localized to the tail region during segmentation. During early larval development, expressed in discrete areas including the pronephric region, retina and cerebellum.1 Publication

Inductioni

By zinc ions.1 Publication

Gene expression databases

BgeeiQ7ZSY6.

Structurei

3D structure databases

ProteinModelPortaliQ7ZSY6.
SMRiQ7ZSY6. Positions 2-29, 31-60.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 2828Beta
Add
BLAST
Regioni29 – 6032Alpha
Add
BLAST

Domaini

Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines.

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00730000112385.
HOVERGENiHBG009063.
InParanoidiQ7ZSY6.
KOiK14739.
OMAiNCAGSCK.
OrthoDBiEOG7TBC98.

Family and domain databases

Gene3Di4.10.10.10. 1 hit.
InterProiIPR017854. Metalthion_dom.
IPR023587. Metalthion_dom_vert.
IPR003019. Metalthion_sfam_euk.
IPR000006. Metalthion_vert.
IPR018064. Metalthion_vert_metal_BS.
[Graphical view]
PANTHERiPTHR23299. PTHR23299. 1 hit.
PfamiPF00131. Metallothio. 1 hit.
[Graphical view]
PRINTSiPR00860. MTVERTEBRATE.
SUPFAMiSSF57868. SSF57868. 1 hit.
PROSITEiPS00203. METALLOTHIONEIN_VRT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7ZSY6-1 [UniParc]FASTAAdd to Basket

« Hide

MDPCECAKTG TCNCGATCKC TNCQCTTCKK SCCSCCPSGC SKCASGCVCK   50
GNSCGSSCCQ 60
Length:60
Mass (Da):5,976
Last modified:June 1, 2003 - v1
Checksum:iE5388E7C378BB700
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY305851 Genomic DNA. Translation: AAP73739.1.
AY514790 mRNA. Translation: AAS00513.1.
AY514791 Genomic DNA. Translation: AAS00514.1.
BC049475 mRNA. Translation: AAH49475.1.
BC051612 mRNA. Translation: AAH51612.1.
RefSeqiNP_001124525.2. NM_001131053.2.
UniGeneiDr.121290.

Genome annotation databases

EnsembliENSDART00000061007; ENSDARP00000061006; ENSDARG00000041623.
GeneIDi100174951.
KEGGidre:100174951.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY305851 Genomic DNA. Translation: AAP73739.1 .
AY514790 mRNA. Translation: AAS00513.1 .
AY514791 Genomic DNA. Translation: AAS00514.1 .
BC049475 mRNA. Translation: AAH49475.1 .
BC051612 mRNA. Translation: AAH51612.1 .
RefSeqi NP_001124525.2. NM_001131053.2.
UniGenei Dr.121290.

3D structure databases

ProteinModelPortali Q7ZSY6.
SMRi Q7ZSY6. Positions 2-29, 31-60.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q7ZSY6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSDART00000061007 ; ENSDARP00000061006 ; ENSDARG00000041623 .
GeneIDi 100174951.
KEGGi dre:100174951.

Organism-specific databases

CTDi 17750.
ZFINi ZDB-GENE-030131-4174. mt2.

Phylogenomic databases

GeneTreei ENSGT00730000112385.
HOVERGENi HBG009063.
InParanoidi Q7ZSY6.
KOi K14739.
OMAi NCAGSCK.
OrthoDBi EOG7TBC98.

Miscellaneous databases

NextBioi 20795516.

Gene expression databases

Bgeei Q7ZSY6.

Family and domain databases

Gene3Di 4.10.10.10. 1 hit.
InterProi IPR017854. Metalthion_dom.
IPR023587. Metalthion_dom_vert.
IPR003019. Metalthion_sfam_euk.
IPR000006. Metalthion_vert.
IPR018064. Metalthion_vert_metal_BS.
[Graphical view ]
PANTHERi PTHR23299. PTHR23299. 1 hit.
Pfami PF00131. Metallothio. 1 hit.
[Graphical view ]
PRINTSi PR00860. MTVERTEBRATE.
SUPFAMi SSF57868. SSF57868. 1 hit.
PROSITEi PS00203. METALLOTHIONEIN_VRT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of zebrafish metallothionein gene promoter in a zebrafish caudal fin cell-line, SJD. 1."
    Yan C.H.M., Chan K.M.
    Mar. Environ. Res. 54:335-339(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Expression of metallothionein gene during embryonic and early larval development in zebrafish."
    Chen W.-Y., John J.A.C., Lin C.-H., Lin H.-F., Wu S.-C., Lin C.-H., Chang C.-Y.
    Aquat. Toxicol. 69:215-227(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], DEVELOPMENTAL STAGE, INDUCTION.
    Tissue: Brain.
  3. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: SJD.

Entry informationi

Entry nameiMT2_DANRE
AccessioniPrimary (citable) accession number: Q7ZSY6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: June 1, 2003
Last modified: May 14, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Metallothioneins
    Classification of metallothioneins and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi