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Q7ZSY6

- MT2_DANRE

UniProt

Q7ZSY6 - MT2_DANRE

Protein

Metallothionein-2

Gene

mt2

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Metallothioneins have a high content of cysteine residues that bind various heavy metals.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi4 – 41Divalent metal cation; cluster B
    Metal bindingi6 – 61Divalent metal cation; cluster B
    Metal bindingi12 – 121Divalent metal cation; cluster B
    Metal bindingi14 – 141Divalent metal cation; cluster B
    Metal bindingi18 – 181Divalent metal cation; cluster B
    Metal bindingi20 – 201Divalent metal cation; cluster B
    Metal bindingi23 – 231Divalent metal cation; cluster B
    Metal bindingi25 – 251Divalent metal cation; cluster B
    Metal bindingi28 – 281Divalent metal cation; cluster B
    Metal bindingi32 – 321Divalent metal cation; cluster A
    Metal bindingi33 – 331Divalent metal cation; cluster A
    Metal bindingi35 – 351Divalent metal cation; cluster A
    Metal bindingi36 – 361Divalent metal cation; cluster A
    Metal bindingi40 – 401Divalent metal cation; cluster A
    Metal bindingi43 – 431Divalent metal cation; cluster A
    Metal bindingi47 – 471Divalent metal cation; cluster A
    Metal bindingi49 – 491Divalent metal cation; cluster A
    Metal bindingi54 – 541Divalent metal cation; cluster A
    Metal bindingi58 – 581Divalent metal cation; cluster A
    Metal bindingi59 – 591Divalent metal cation; cluster A

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. response to cadmium ion Source: ZFIN
    2. response to copper ion Source: ZFIN
    3. response to metal ion Source: ZFIN
    4. response to methylmercury Source: ZFIN
    5. response to zinc ion Source: ZFIN

    Keywords - Ligandi

    Metal-binding, Metal-thiolate cluster

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Metallothionein-2
    Short name:
    MT-2
    Gene namesi
    Name:mt2
    OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
    Taxonomic identifieri7955 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
    ProteomesiUP000000437: Chromosome 18

    Organism-specific databases

    ZFINiZDB-GENE-030131-4174. mt2.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 6060Metallothionein-2PRO_0000197269Add
    BLAST

    Proteomic databases

    PRIDEiQ7ZSY6.

    Expressioni

    Developmental stagei

    Expressed both maternally and zygotically. Expressed ubiquitously during early embryogenesis, but becomes localized to the tail region during segmentation. During early larval development, expressed in discrete areas including the pronephric region, retina and cerebellum.1 Publication

    Inductioni

    By zinc ions.1 Publication

    Gene expression databases

    BgeeiQ7ZSY6.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7ZSY6.
    SMRiQ7ZSY6. Positions 2-29, 31-60.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 2828BetaAdd
    BLAST
    Regioni29 – 6032AlphaAdd
    BLAST

    Domaini

    Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines.

    Sequence similaritiesi

    Phylogenomic databases

    GeneTreeiENSGT00730000112385.
    HOVERGENiHBG009063.
    InParanoidiQ7ZSY6.
    KOiK14739.
    OMAiNCAGSCK.
    OrthoDBiEOG7TBC98.

    Family and domain databases

    Gene3Di4.10.10.10. 1 hit.
    InterProiIPR017854. Metalthion_dom.
    IPR023587. Metalthion_dom_vert.
    IPR003019. Metalthion_sfam_euk.
    IPR000006. Metalthion_vert.
    IPR018064. Metalthion_vert_metal_BS.
    [Graphical view]
    PANTHERiPTHR23299. PTHR23299. 1 hit.
    PfamiPF00131. Metallothio. 1 hit.
    [Graphical view]
    PRINTSiPR00860. MTVERTEBRATE.
    SUPFAMiSSF57868. SSF57868. 1 hit.
    PROSITEiPS00203. METALLOTHIONEIN_VRT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q7ZSY6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDPCECAKTG TCNCGATCKC TNCQCTTCKK SCCSCCPSGC SKCASGCVCK   50
    GNSCGSSCCQ 60
    Length:60
    Mass (Da):5,976
    Last modified:June 1, 2003 - v1
    Checksum:iE5388E7C378BB700
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY305851 Genomic DNA. Translation: AAP73739.1.
    AY514790 mRNA. Translation: AAS00513.1.
    AY514791 Genomic DNA. Translation: AAS00514.1.
    BC049475 mRNA. Translation: AAH49475.1.
    BC051612 mRNA. Translation: AAH51612.1.
    RefSeqiNP_001124525.2. NM_001131053.2.
    UniGeneiDr.121290.

    Genome annotation databases

    EnsembliENSDART00000061007; ENSDARP00000061006; ENSDARG00000041623.
    GeneIDi100174951.
    KEGGidre:100174951.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY305851 Genomic DNA. Translation: AAP73739.1 .
    AY514790 mRNA. Translation: AAS00513.1 .
    AY514791 Genomic DNA. Translation: AAS00514.1 .
    BC049475 mRNA. Translation: AAH49475.1 .
    BC051612 mRNA. Translation: AAH51612.1 .
    RefSeqi NP_001124525.2. NM_001131053.2.
    UniGenei Dr.121290.

    3D structure databases

    ProteinModelPortali Q7ZSY6.
    SMRi Q7ZSY6. Positions 2-29, 31-60.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q7ZSY6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSDART00000061007 ; ENSDARP00000061006 ; ENSDARG00000041623 .
    GeneIDi 100174951.
    KEGGi dre:100174951.

    Organism-specific databases

    CTDi 17750.
    ZFINi ZDB-GENE-030131-4174. mt2.

    Phylogenomic databases

    GeneTreei ENSGT00730000112385.
    HOVERGENi HBG009063.
    InParanoidi Q7ZSY6.
    KOi K14739.
    OMAi NCAGSCK.
    OrthoDBi EOG7TBC98.

    Miscellaneous databases

    NextBioi 20795516.

    Gene expression databases

    Bgeei Q7ZSY6.

    Family and domain databases

    Gene3Di 4.10.10.10. 1 hit.
    InterProi IPR017854. Metalthion_dom.
    IPR023587. Metalthion_dom_vert.
    IPR003019. Metalthion_sfam_euk.
    IPR000006. Metalthion_vert.
    IPR018064. Metalthion_vert_metal_BS.
    [Graphical view ]
    PANTHERi PTHR23299. PTHR23299. 1 hit.
    Pfami PF00131. Metallothio. 1 hit.
    [Graphical view ]
    PRINTSi PR00860. MTVERTEBRATE.
    SUPFAMi SSF57868. SSF57868. 1 hit.
    PROSITEi PS00203. METALLOTHIONEIN_VRT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of zebrafish metallothionein gene promoter in a zebrafish caudal fin cell-line, SJD. 1."
      Yan C.H.M., Chan K.M.
      Mar. Environ. Res. 54:335-339(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Expression of metallothionein gene during embryonic and early larval development in zebrafish."
      Chen W.-Y., John J.A.C., Lin C.-H., Lin H.-F., Wu S.-C., Lin C.-H., Chang C.-Y.
      Aquat. Toxicol. 69:215-227(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], DEVELOPMENTAL STAGE, INDUCTION.
      Tissue: Brain.
    3. NIH - Zebrafish Gene Collection (ZGC) project
      Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: SJD.

    Entry informationi

    Entry nameiMT2_DANRE
    AccessioniPrimary (citable) accession number: Q7ZSY6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 23, 2004
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 73 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Metallothioneins
      Classification of metallothioneins and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3