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Protein

Metallothionein-2

Gene

mt2

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Metallothioneins have a high content of cysteine residues that bind various heavy metals.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi4Divalent metal cation; cluster B1
Metal bindingi6Divalent metal cation; cluster B1
Metal bindingi12Divalent metal cation; cluster B1
Metal bindingi14Divalent metal cation; cluster B1
Metal bindingi18Divalent metal cation; cluster B1
Metal bindingi20Divalent metal cation; cluster B1
Metal bindingi23Divalent metal cation; cluster B1
Metal bindingi25Divalent metal cation; cluster B1
Metal bindingi28Divalent metal cation; cluster B1
Metal bindingi32Divalent metal cation; cluster A1
Metal bindingi33Divalent metal cation; cluster A1
Metal bindingi35Divalent metal cation; cluster A1
Metal bindingi36Divalent metal cation; cluster A1
Metal bindingi40Divalent metal cation; cluster A1
Metal bindingi43Divalent metal cation; cluster A1
Metal bindingi47Divalent metal cation; cluster A1
Metal bindingi49Divalent metal cation; cluster A1
Metal bindingi54Divalent metal cation; cluster A1
Metal bindingi58Divalent metal cation; cluster A1
Metal bindingi59Divalent metal cation; cluster A1

GO - Molecular functioni

GO - Biological processi

  • angiogenesis Source: ZFIN
  • positive regulation of cell migration involved in sprouting angiogenesis Source: ZFIN
  • positive regulation of vascular endothelial growth factor production Source: ZFIN
  • response to cadmium ion Source: ZFIN
  • response to copper ion Source: ZFIN
  • response to metal ion Source: ZFIN
  • response to methylmercury Source: ZFIN
  • response to zinc ion Source: ZFIN
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Metal-thiolate cluster

Names & Taxonomyi

Protein namesi
Recommended name:
Metallothionein-2
Short name:
MT-2
Gene namesi
Name:mt2
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 18

Organism-specific databases

ZFINiZDB-GENE-030131-4174. mt2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001972691 – 60Metallothionein-2Add BLAST60

Proteomic databases

PaxDbiQ7ZSY6.
PRIDEiQ7ZSY6.

Expressioni

Developmental stagei

Expressed both maternally and zygotically. Expressed ubiquitously during early embryogenesis, but becomes localized to the tail region during segmentation. During early larval development, expressed in discrete areas including the pronephric region, retina and cerebellum.1 Publication

Inductioni

By zinc ions.1 Publication

Gene expression databases

BgeeiENSDARG00000041623.
ExpressionAtlasiQ7ZSY6. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000061006.

Structurei

3D structure databases

ProteinModelPortaliQ7ZSY6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 28BetaAdd BLAST28
Regioni29 – 60AlphaAdd BLAST32

Domaini

Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines.

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00730000112385.
HOVERGENiHBG009063.
InParanoidiQ7ZSY6.
KOiK14739.
OMAiACKCKEC.

Family and domain databases

Gene3Di4.10.10.10. 1 hit.
InterProiIPR003019. Metalthion.
IPR017854. Metalthion_dom.
IPR023587. Metalthion_dom_vert.
IPR000006. Metalthion_vert.
IPR018064. Metalthion_vert_metal_BS.
[Graphical view]
PANTHERiPTHR23299. PTHR23299. 1 hit.
PfamiPF00131. Metallothio. 1 hit.
[Graphical view]
PRINTSiPR00860. MTVERTEBRATE.
SUPFAMiSSF57868. SSF57868. 1 hit.
PROSITEiPS00203. METALLOTHIONEIN_VRT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7ZSY6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPCECAKTG TCNCGATCKC TNCQCTTCKK SCCSCCPSGC SKCASGCVCK
60
GNSCGSSCCQ
Length:60
Mass (Da):5,976
Last modified:June 1, 2003 - v1
Checksum:iE5388E7C378BB700
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY305851 Genomic DNA. Translation: AAP73739.1.
AY514790 mRNA. Translation: AAS00513.1.
AY514791 Genomic DNA. Translation: AAS00514.1.
BC049475 mRNA. Translation: AAH49475.1.
BC051612 mRNA. Translation: AAH51612.1.
RefSeqiNP_001124525.2. NM_001131053.2.
UniGeneiDr.121290.

Genome annotation databases

EnsembliENSDART00000061007; ENSDARP00000061006; ENSDARG00000041623.
GeneIDi100174951.
KEGGidre:100174951.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY305851 Genomic DNA. Translation: AAP73739.1.
AY514790 mRNA. Translation: AAS00513.1.
AY514791 Genomic DNA. Translation: AAS00514.1.
BC049475 mRNA. Translation: AAH49475.1.
BC051612 mRNA. Translation: AAH51612.1.
RefSeqiNP_001124525.2. NM_001131053.2.
UniGeneiDr.121290.

3D structure databases

ProteinModelPortaliQ7ZSY6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000061006.

Proteomic databases

PaxDbiQ7ZSY6.
PRIDEiQ7ZSY6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000061007; ENSDARP00000061006; ENSDARG00000041623.
GeneIDi100174951.
KEGGidre:100174951.

Organism-specific databases

CTDi17750.
ZFINiZDB-GENE-030131-4174. mt2.

Phylogenomic databases

GeneTreeiENSGT00730000112385.
HOVERGENiHBG009063.
InParanoidiQ7ZSY6.
KOiK14739.
OMAiACKCKEC.

Gene expression databases

BgeeiENSDARG00000041623.
ExpressionAtlasiQ7ZSY6. baseline and differential.

Family and domain databases

Gene3Di4.10.10.10. 1 hit.
InterProiIPR003019. Metalthion.
IPR017854. Metalthion_dom.
IPR023587. Metalthion_dom_vert.
IPR000006. Metalthion_vert.
IPR018064. Metalthion_vert_metal_BS.
[Graphical view]
PANTHERiPTHR23299. PTHR23299. 1 hit.
PfamiPF00131. Metallothio. 1 hit.
[Graphical view]
PRINTSiPR00860. MTVERTEBRATE.
SUPFAMiSSF57868. SSF57868. 1 hit.
PROSITEiPS00203. METALLOTHIONEIN_VRT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMT2_DANRE
AccessioniPrimary (citable) accession number: Q7ZSY6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: June 1, 2003
Last modified: November 30, 2016
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Metallothioneins
    Classification of metallothioneins and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.