SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q7ZA45

- GPD_LACTH

UniProt

Q7ZA45 - GPD_LACTH

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Glycerol-3-phosphate dehydrogenase [NAD(+)]

Gene
GPD
Organism
Lachancea thermotolerans (Yeast) (Kluyveromyces thermotolerans)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

sn-glycerol 3-phosphate + NAD+ = glycerone phosphate + NADH.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei159 – 1591NAD By similarity
Binding sitei182 – 1821NAD; via amide nitrogen By similarity
Binding sitei182 – 1821Substrate By similarity
Binding sitei215 – 2151NAD; via amide nitrogen By similarity
Active sitei275 – 2751Proton acceptor By similarity
Binding sitei340 – 3401NAD By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi71 – 766NAD By similarity

GO - Molecular functioni

  1. glycerol-3-phosphate dehydrogenase [NAD+] activity Source: UniProtKB-EC
  2. NAD binding Source: InterPro

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
  2. glycerol-3-phosphate catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Names & Taxonomyi

Protein namesi
Recommended name:
Glycerol-3-phosphate dehydrogenase [NAD(+)] (EC:1.1.1.8)
Gene namesi
Name:GPD
OrganismiLachancea thermotolerans (Yeast) (Kluyveromyces thermotolerans)
Taxonomic identifieri381046 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeLachancea

Subcellular locationi

GO - Cellular componenti

  1. glycerol-3-phosphate dehydrogenase complex Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 411411Glycerol-3-phosphate dehydrogenase [NAD(+)]PRO_0000138090Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ7ZA45.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni340 – 3412Substrate binding By similarity

Sequence similaritiesi

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR013328. DH_multihelical.
IPR006168. G3P_DH_NAD-dep.
IPR006109. G3P_DH_NAD-dep_C.
IPR017751. G3P_DH_NAD-dep_euk.
IPR011128. G3P_DH_NAD-dep_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11728. PTHR11728. 1 hit.
PfamiPF07479. NAD_Gly3P_dh_C. 1 hit.
PF01210. NAD_Gly3P_dh_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000114. Glycerol-3-P_dh. 1 hit.
PRINTSiPR00077. GPDHDRGNASE.
SUPFAMiSSF48179. SSF48179. 1 hit.
TIGRFAMsiTIGR03376. glycerol3P_DH. 1 hit.
PROSITEiPS00957. NAD_G3PDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7ZA45-1 [UniParc]FASTAAdd to Basket

« Hide

MFSISRITRT SSFTTQFRAL YRFKHSARKL QSIPFSIYKK MSAADRLNQT    50
HDILSESVQA VENPFKVTVI GSGNWGTTIS KVVAENAALR PHLFVKRVDM 100
WVFEETVDGQ KLTEIINTKH QNVKYLPNID LPENLVANPD LVSAVKDADI 150
LVFNIPHQFL PRIVSQLQGN IKKDARAISC LKGFDVSKDG VKLLSTYVTE 200
KLGITCGALS GANLAPEVAK ENWSETTVAY ELPKDFKGEG KDVDHAVLKA 250
LFHRPYFHVN VIDDVAGISV AGALKNVVAL GCGFVEGLGW GNNASAAIQR 300
VGLGEIIKFG QMFFPDSRVE TYYQESAGVA DLITTCSGGR NVRVATHMAK 350
TGKSAEECEK ELLNGQSAQV FTHVRRSTSG WPSAVRPMNS FCSRPFTRLS 400
TRTLLWTLCQ T 411
Length:411
Mass (Da):45,332
Last modified:October 1, 2003 - v1
Checksum:iA155FF3F16521A86
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY289713 Genomic DNA. Translation: AAP44104.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY289713 Genomic DNA. Translation: AAP44104.1 .

3D structure databases

ProteinModelPortali Q7ZA45.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProi IPR008927. 6-PGluconate_DH_C-like.
IPR013328. DH_multihelical.
IPR006168. G3P_DH_NAD-dep.
IPR006109. G3P_DH_NAD-dep_C.
IPR017751. G3P_DH_NAD-dep_euk.
IPR011128. G3P_DH_NAD-dep_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR11728. PTHR11728. 1 hit.
Pfami PF07479. NAD_Gly3P_dh_C. 1 hit.
PF01210. NAD_Gly3P_dh_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000114. Glycerol-3-P_dh. 1 hit.
PRINTSi PR00077. GPDHDRGNASE.
SUPFAMi SSF48179. SSF48179. 1 hit.
TIGRFAMsi TIGR03376. glycerol3P_DH. 1 hit.
PROSITEi PS00957. NAD_G3PDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Yeast orthologues associated with glycerol transport and metabolism."
    Neves L., Oliveira R., Lucas C.
    FEMS Yeast Res. 5:51-62(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: CBS 137.

Entry informationi

Entry nameiGPD_LACTH
AccessioniPrimary (citable) accession number: Q7ZA45
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: October 1, 2003
Last modified: October 16, 2013
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi