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Q7ZA45

- GPD_LACTH

UniProt

Q7ZA45 - GPD_LACTH

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Protein

Glycerol-3-phosphate dehydrogenase [NAD(+)]

Gene

GPD

Organism
Lachancea thermotolerans (Yeast) (Kluyveromyces thermotolerans)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

sn-glycerol 3-phosphate + NAD+ = glycerone phosphate + NADH.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei159 – 1591NADBy similarity
Binding sitei182 – 1821NAD; via amide nitrogenBy similarity
Binding sitei182 – 1821SubstrateBy similarity
Binding sitei215 – 2151NAD; via amide nitrogenBy similarity
Active sitei275 – 2751Proton acceptorBy similarity
Binding sitei340 – 3401NADBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi71 – 766NADBy similarity

GO - Molecular functioni

  1. glycerol-3-phosphate dehydrogenase [NAD+] activity Source: UniProtKB-EC
  2. NAD binding Source: InterPro

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
  2. glycerol-3-phosphate catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Names & Taxonomyi

Protein namesi
Recommended name:
Glycerol-3-phosphate dehydrogenase [NAD(+)] (EC:1.1.1.8)
Gene namesi
Name:GPD
OrganismiLachancea thermotolerans (Yeast) (Kluyveromyces thermotolerans)
Taxonomic identifieri381046 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeLachancea

Subcellular locationi

GO - Cellular componenti

  1. glycerol-3-phosphate dehydrogenase complex Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 411411Glycerol-3-phosphate dehydrogenase [NAD(+)]PRO_0000138090Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ7ZA45.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni340 – 3412Substrate bindingBy similarity

Sequence similaritiesi

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR013328. DH_multihelical.
IPR006168. G3P_DH_NAD-dep.
IPR006109. G3P_DH_NAD-dep_C.
IPR017751. G3P_DH_NAD-dep_euk.
IPR011128. G3P_DH_NAD-dep_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11728. PTHR11728. 1 hit.
PfamiPF07479. NAD_Gly3P_dh_C. 1 hit.
PF01210. NAD_Gly3P_dh_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000114. Glycerol-3-P_dh. 1 hit.
PRINTSiPR00077. GPDHDRGNASE.
SUPFAMiSSF48179. SSF48179. 1 hit.
TIGRFAMsiTIGR03376. glycerol3P_DH. 1 hit.
PROSITEiPS00957. NAD_G3PDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7ZA45-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MFSISRITRT SSFTTQFRAL YRFKHSARKL QSIPFSIYKK MSAADRLNQT
60 70 80 90 100
HDILSESVQA VENPFKVTVI GSGNWGTTIS KVVAENAALR PHLFVKRVDM
110 120 130 140 150
WVFEETVDGQ KLTEIINTKH QNVKYLPNID LPENLVANPD LVSAVKDADI
160 170 180 190 200
LVFNIPHQFL PRIVSQLQGN IKKDARAISC LKGFDVSKDG VKLLSTYVTE
210 220 230 240 250
KLGITCGALS GANLAPEVAK ENWSETTVAY ELPKDFKGEG KDVDHAVLKA
260 270 280 290 300
LFHRPYFHVN VIDDVAGISV AGALKNVVAL GCGFVEGLGW GNNASAAIQR
310 320 330 340 350
VGLGEIIKFG QMFFPDSRVE TYYQESAGVA DLITTCSGGR NVRVATHMAK
360 370 380 390 400
TGKSAEECEK ELLNGQSAQV FTHVRRSTSG WPSAVRPMNS FCSRPFTRLS
410
TRTLLWTLCQ T
Length:411
Mass (Da):45,332
Last modified:October 1, 2003 - v1
Checksum:iA155FF3F16521A86
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY289713 Genomic DNA. Translation: AAP44104.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY289713 Genomic DNA. Translation: AAP44104.1 .

3D structure databases

ProteinModelPortali Q7ZA45.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProi IPR008927. 6-PGluconate_DH_C-like.
IPR013328. DH_multihelical.
IPR006168. G3P_DH_NAD-dep.
IPR006109. G3P_DH_NAD-dep_C.
IPR017751. G3P_DH_NAD-dep_euk.
IPR011128. G3P_DH_NAD-dep_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR11728. PTHR11728. 1 hit.
Pfami PF07479. NAD_Gly3P_dh_C. 1 hit.
PF01210. NAD_Gly3P_dh_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000114. Glycerol-3-P_dh. 1 hit.
PRINTSi PR00077. GPDHDRGNASE.
SUPFAMi SSF48179. SSF48179. 1 hit.
TIGRFAMsi TIGR03376. glycerol3P_DH. 1 hit.
PROSITEi PS00957. NAD_G3PDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Yeast orthologues associated with glycerol transport and metabolism."
    Neves L., Oliveira R., Lucas C.
    FEMS Yeast Res. 5:51-62(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: CBS 137.

Entry informationi

Entry nameiGPD_LACTH
AccessioniPrimary (citable) accession number: Q7ZA45
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: October 1, 2003
Last modified: October 1, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3