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Q7ZA45 (GPD_LACTH) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 58. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glycerol-3-phosphate dehydrogenase [NAD(+)]

EC=1.1.1.8
Gene names
Name:GPD
OrganismLachancea thermotolerans (Yeast) (Kluyveromyces thermotolerans)
Taxonomic identifier381046 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeLachancea

Protein attributes

Sequence length411 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

sn-glycerol 3-phosphate + NAD+ = glycerone phosphate + NADH.

Sequence similarities

Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 411411Glycerol-3-phosphate dehydrogenase [NAD(+)]
PRO_0000138090

Regions

Nucleotide binding71 – 766NAD By similarity
Region340 – 3412Substrate binding By similarity

Sites

Active site2751Proton acceptor By similarity
Binding site1591NAD By similarity
Binding site1821NAD; via amide nitrogen By similarity
Binding site1821Substrate By similarity
Binding site2151NAD; via amide nitrogen By similarity
Binding site3401NAD By similarity

Sequences

Sequence LengthMass (Da)Tools
Q7ZA45 [UniParc].

Last modified October 1, 2003. Version 1.
Checksum: A155FF3F16521A86

FASTA41145,332
        10         20         30         40         50         60 
MFSISRITRT SSFTTQFRAL YRFKHSARKL QSIPFSIYKK MSAADRLNQT HDILSESVQA 

        70         80         90        100        110        120 
VENPFKVTVI GSGNWGTTIS KVVAENAALR PHLFVKRVDM WVFEETVDGQ KLTEIINTKH 

       130        140        150        160        170        180 
QNVKYLPNID LPENLVANPD LVSAVKDADI LVFNIPHQFL PRIVSQLQGN IKKDARAISC 

       190        200        210        220        230        240 
LKGFDVSKDG VKLLSTYVTE KLGITCGALS GANLAPEVAK ENWSETTVAY ELPKDFKGEG 

       250        260        270        280        290        300 
KDVDHAVLKA LFHRPYFHVN VIDDVAGISV AGALKNVVAL GCGFVEGLGW GNNASAAIQR 

       310        320        330        340        350        360 
VGLGEIIKFG QMFFPDSRVE TYYQESAGVA DLITTCSGGR NVRVATHMAK TGKSAEECEK 

       370        380        390        400        410 
ELLNGQSAQV FTHVRRSTSG WPSAVRPMNS FCSRPFTRLS TRTLLWTLCQ T 

« Hide

References

[1]"Yeast orthologues associated with glycerol transport and metabolism."
Neves L., Oliveira R., Lucas C.
FEMS Yeast Res. 5:51-62(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: CBS 137.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY289713 Genomic DNA. Translation: AAP44104.1.

3D structure databases

ProteinModelPortalQ7ZA45.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProIPR008927. 6-PGluconate_DH_C-like.
IPR013328. DH_multihelical.
IPR006168. G3P_DH_NAD-dep.
IPR006109. G3P_DH_NAD-dep_C.
IPR017751. G3P_DH_NAD-dep_euk.
IPR011128. G3P_DH_NAD-dep_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERPTHR11728. PTHR11728. 1 hit.
PfamPF07479. NAD_Gly3P_dh_C. 1 hit.
PF01210. NAD_Gly3P_dh_N. 1 hit.
[Graphical view]
PIRSFPIRSF000114. Glycerol-3-P_dh. 1 hit.
PRINTSPR00077. GPDHDRGNASE.
SUPFAMSSF48179. SSF48179. 1 hit.
TIGRFAMsTIGR03376. glycerol3P_DH. 1 hit.
PROSITEPS00957. NAD_G3PDH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGPD_LACTH
AccessionPrimary (citable) accession number: Q7ZA45
Entry history
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: October 1, 2003
Last modified: October 16, 2013
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families