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Q7ZA43

- GPD_PICAN

UniProt

Q7ZA43 - GPD_PICAN

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Protein

Glycerol-3-phosphate dehydrogenase [NAD(+)]

Gene
GPD
Organism
Pichia angusta (Yeast) (Hansenula polymorpha)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

sn-glycerol 3-phosphate + NAD+ = glycerone phosphate + NADH.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei122 – 1221NAD By similarity
Binding sitei145 – 1451NAD; via amide nitrogen By similarity
Binding sitei145 – 1451Substrate By similarity
Binding sitei178 – 1781NAD; via amide nitrogen By similarity
Active sitei238 – 2381Proton acceptor By similarity
Binding sitei303 – 3031NAD By similarity
Binding sitei332 – 3321NAD By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi34 – 396NAD By similarity

GO - Molecular functioni

  1. glycerol-3-phosphate dehydrogenase [NAD+] activity Source: UniProtKB-EC
  2. NAD binding Source: InterPro

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
  2. glycerol-3-phosphate catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Names & Taxonomyi

Protein namesi
Recommended name:
Glycerol-3-phosphate dehydrogenase [NAD(+)] (EC:1.1.1.8)
Gene namesi
Name:GPD
OrganismiPichia angusta (Yeast) (Hansenula polymorpha)
Taxonomic identifieri870730 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetales incertae sedisOgataea

Subcellular locationi

GO - Cellular componenti

  1. glycerol-3-phosphate dehydrogenase complex Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 381381Glycerol-3-phosphate dehydrogenase [NAD(+)]PRO_0000138092Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ7ZA43.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni303 – 3042Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

PhylomeDBiQ7ZA43.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR013328. DH_multihelical.
IPR006168. G3P_DH_NAD-dep.
IPR006109. G3P_DH_NAD-dep_C.
IPR017751. G3P_DH_NAD-dep_euk.
IPR011128. G3P_DH_NAD-dep_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11728. PTHR11728. 1 hit.
PfamiPF07479. NAD_Gly3P_dh_C. 1 hit.
PF01210. NAD_Gly3P_dh_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000114. Glycerol-3-P_dh. 1 hit.
PRINTSiPR00077. GPDHDRGNASE.
SUPFAMiSSF48179. SSF48179. 1 hit.
TIGRFAMsiTIGR03376. glycerol3P_DH. 1 hit.
PROSITEiPS00957. NAD_G3PDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7ZA43-1 [UniParc]FASTAAdd to Basket

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MTAMDRLDHV SNQLAAKRQK KNPEGKPFRI TVVGSGNWGS TIAKVVAENA    50
KELPEEFHQI VKMWVFEEEV DGRKLTEIIN TDHENVKYLP DVKLPDNIVA 100
IPDIVDACAD ADIIIFNIPH QFLPKILAQL KGKVNPKARA ISCLKGLEVT 150
KDGCKLLSNY ITEELGIYCG ALSGANLAPE VARQKWSETT VAYRIPQDFR 200
GEGKDVDQSV IRNLFHRPYF HVRVIDDVAG VSLSGALKNV IAMAAGFVEG 250
LGWGDNAKSA VMRIGLVEMI KFAHMFFEDC QSTTFTHESA GVADIITTCA 300
GGRNVRVGRY MAEHKVSGFE AEKVLLNGQS CQGLHTTREV YELLAAKNVI 350
DEFPLFKATY QIIYEGLPME KLPELLEASE D 381
Length:381
Mass (Da):42,205
Last modified:October 1, 2003 - v1
Checksum:iD1470A0A7B12D7C6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY289714 Genomic DNA. Translation: AAP44106.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY289714 Genomic DNA. Translation: AAP44106.1 .

3D structure databases

ProteinModelPortali Q7ZA43.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

PhylomeDBi Q7ZA43.

Family and domain databases

Gene3Di 1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProi IPR008927. 6-PGluconate_DH_C-like.
IPR013328. DH_multihelical.
IPR006168. G3P_DH_NAD-dep.
IPR006109. G3P_DH_NAD-dep_C.
IPR017751. G3P_DH_NAD-dep_euk.
IPR011128. G3P_DH_NAD-dep_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR11728. PTHR11728. 1 hit.
Pfami PF07479. NAD_Gly3P_dh_C. 1 hit.
PF01210. NAD_Gly3P_dh_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000114. Glycerol-3-P_dh. 1 hit.
PRINTSi PR00077. GPDHDRGNASE.
SUPFAMi SSF48179. SSF48179. 1 hit.
TIGRFAMsi TIGR03376. glycerol3P_DH. 1 hit.
PROSITEi PS00957. NAD_G3PDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Yeast orthologues associated with glycerol transport and metabolism."
    Neves L., Oliveira R., Lucas C.
    FEMS Yeast Res. 5:51-62(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: IGc4129.

Entry informationi

Entry nameiGPD_PICAN
AccessioniPrimary (citable) accession number: Q7ZA43
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: October 1, 2003
Last modified: July 9, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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