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Protein

Glycerol-3-phosphate dehydrogenase [NAD(+)]

Gene

GPD

Organism
Pichia angusta (Yeast) (Hansenula polymorpha)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

sn-glycerol 3-phosphate + NAD+ = glycerone phosphate + NADH.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei122 – 1221NADBy similarity
Binding sitei145 – 1451NAD; via amide nitrogenBy similarity
Binding sitei145 – 1451SubstrateBy similarity
Binding sitei178 – 1781NAD; via amide nitrogenBy similarity
Active sitei238 – 2381Proton acceptorBy similarity
Binding sitei303 – 3031NADBy similarity
Binding sitei332 – 3321NADBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi34 – 396NADBy similarity

GO - Molecular functioni

  1. glycerol-3-phosphate dehydrogenase [NAD+] activity Source: UniProtKB-EC
  2. NAD binding Source: InterPro

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
  2. glycerol-3-phosphate catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Names & Taxonomyi

Protein namesi
Recommended name:
Glycerol-3-phosphate dehydrogenase [NAD(+)] (EC:1.1.1.8)
Gene namesi
Name:GPD
OrganismiPichia angusta (Yeast) (Hansenula polymorpha)
Taxonomic identifieri870730 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesPichiaceaeOgataea

Subcellular locationi

GO - Cellular componenti

  1. glycerol-3-phosphate dehydrogenase complex Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 381381Glycerol-3-phosphate dehydrogenase [NAD(+)]PRO_0000138092Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ7ZA43.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni303 – 3042Substrate bindingBy similarity

Sequence similaritiesi

Phylogenomic databases

PhylomeDBiQ7ZA43.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR013328. 6PGD_dom_2.
IPR006168. G3P_DH_NAD-dep.
IPR006109. G3P_DH_NAD-dep_C.
IPR017751. G3P_DH_NAD-dep_euk.
IPR011128. G3P_DH_NAD-dep_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11728. PTHR11728. 1 hit.
PfamiPF07479. NAD_Gly3P_dh_C. 1 hit.
PF01210. NAD_Gly3P_dh_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000114. Glycerol-3-P_dh. 1 hit.
PRINTSiPR00077. GPDHDRGNASE.
SUPFAMiSSF48179. SSF48179. 1 hit.
TIGRFAMsiTIGR03376. glycerol3P_DH. 1 hit.
PROSITEiPS00957. NAD_G3PDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7ZA43-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTAMDRLDHV SNQLAAKRQK KNPEGKPFRI TVVGSGNWGS TIAKVVAENA
60 70 80 90 100
KELPEEFHQI VKMWVFEEEV DGRKLTEIIN TDHENVKYLP DVKLPDNIVA
110 120 130 140 150
IPDIVDACAD ADIIIFNIPH QFLPKILAQL KGKVNPKARA ISCLKGLEVT
160 170 180 190 200
KDGCKLLSNY ITEELGIYCG ALSGANLAPE VARQKWSETT VAYRIPQDFR
210 220 230 240 250
GEGKDVDQSV IRNLFHRPYF HVRVIDDVAG VSLSGALKNV IAMAAGFVEG
260 270 280 290 300
LGWGDNAKSA VMRIGLVEMI KFAHMFFEDC QSTTFTHESA GVADIITTCA
310 320 330 340 350
GGRNVRVGRY MAEHKVSGFE AEKVLLNGQS CQGLHTTREV YELLAAKNVI
360 370 380
DEFPLFKATY QIIYEGLPME KLPELLEASE D
Length:381
Mass (Da):42,205
Last modified:October 1, 2003 - v1
Checksum:iD1470A0A7B12D7C6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY289714 Genomic DNA. Translation: AAP44106.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY289714 Genomic DNA. Translation: AAP44106.1.

3D structure databases

ProteinModelPortaliQ7ZA43.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

PhylomeDBiQ7ZA43.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR013328. 6PGD_dom_2.
IPR006168. G3P_DH_NAD-dep.
IPR006109. G3P_DH_NAD-dep_C.
IPR017751. G3P_DH_NAD-dep_euk.
IPR011128. G3P_DH_NAD-dep_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11728. PTHR11728. 1 hit.
PfamiPF07479. NAD_Gly3P_dh_C. 1 hit.
PF01210. NAD_Gly3P_dh_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000114. Glycerol-3-P_dh. 1 hit.
PRINTSiPR00077. GPDHDRGNASE.
SUPFAMiSSF48179. SSF48179. 1 hit.
TIGRFAMsiTIGR03376. glycerol3P_DH. 1 hit.
PROSITEiPS00957. NAD_G3PDH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Yeast orthologues associated with glycerol transport and metabolism."
    Neves L., Oliveira R., Lucas C.
    FEMS Yeast Res. 5:51-62(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: IGc4129.

Entry informationi

Entry nameiGPD_PICAN
AccessioniPrimary (citable) accession number: Q7ZA43
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: October 1, 2003
Last modified: April 29, 2015
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.