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Q7Z9M7 (GUN7_HYPJQ) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 39. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Endoglucanase-7

EC=3.2.1.4
Alternative name(s):
Cellulase-61B
Short name=Cel61B
Endo-1,4-beta-glucanase VII
Short name=EGVII
Endoglucanase VII
Endoglucanase-61B
Gene names
Name:cel61b
Synonyms:egl7
ORF Names:TRIREDRAFT_120961
OrganismHypocrea jecorina (strain QM6a) (Trichoderma reesei) [Complete proteome]
Taxonomic identifier431241 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesHypocreomycetidaeHypocrealesHypocreaceaeTrichoderma

Protein attributes

Sequence length249 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Has low levels of endoglucanase activity. May be involved in the degradation of cellulose or lignocellulose, chitin, or other polysaccharides.

Catalytic activity

Endohydrolysis of (1->4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans. Ref.3

Cofactor

Calcium Probable.

Subunit structure

Monomer. Ref.3

Subcellular location

Secreted Ref.3.

Induction

By cellulose, lactose and sophorose. Ref.1

Sequence similarities

Belongs to the glycosyl hydrolase 61 family.

Ontologies

Keywords
   Biological processCarbohydrate metabolism
Cellulose degradation
Polysaccharide degradation
   Cellular componentSecreted
   DomainSignal
   LigandCalcium
Metal-binding
   Molecular functionGlycosidase
Hydrolase
   PTMDisulfide bond
Glycoprotein
   Technical term3D-structure
Complete proteome
Gene Ontology (GO)
   Biological_processcellulose catabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functioncellulase activity

Inferred from electronic annotation. Source: UniProtKB-EC

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 Potential
Chain20 – 249230Endoglucanase-7
PRO_0000364090

Sites

Metal binding201Divalent metal cation
Metal binding1081Divalent metal cation
Metal binding1951Divalent metal cation

Amino acid modifications

Glycosylation251N-linked (GlcNAc...)
Disulfide bond78 ↔ 198
Disulfide bond120 ↔ 124

Experimental info

Sequence conflict1181V → A in EGR50392. Ref.2

Secondary structure

........................................... 249
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q7Z9M7 [UniParc].

Last modified September 5, 2012. Version 3.
Checksum: 1BC7F179D657E0EF

FASTA24926,828
        10         20         30         40         50         60 
MKSCAILAAL GCLAGSVLGH GQVQNFTING QYNQGFILDY YYQKQNTGHF PNVAGWYAED 

        70         80         90        100        110        120 
LDLGFISPDQ YTTPDIVCHK NAAPGAISAT AAAGSNIVFQ WGPGVWPHPY GPIVTYVVEC 

       130        140        150        160        170        180 
SGSCTTVNKN NLRWVKIQEA GINYNTQVWA QQDLINQGNK WTVKIPSSLR PGNYVFRHEL 

       190        200        210        220        230        240 
LAAHGASSAN GMQNYPQCVN IAVTGSGTKA LPAGTPATQL YKPTDPGILF NPYTTITSYT 


IPGPALWQG 

« Hide

References

« Hide 'large scale' references
[1]"Transcriptional regulation of biomass-degrading enzymes in the filamentous fungus Trichoderma reesei."
Foreman P.K., Brown D., Dankmeyer L., Dean R., Diener S., Dunn-Coleman N.S., Goedegebuur F., Houfek T.D., England G.J., Kelley A.S., Meerman H.J., Mitchell T., Mitchinson C., Olivares H.A., Teunissen P.J.M., Yao J., Ward M.
J. Biol. Chem. 278:31988-31997(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], INDUCTION.
Strain: QM6a.
[2]"Genome sequencing and analysis of the biomass-degrading fungus Trichoderma reesei (syn. Hypocrea jecorina)."
Martinez D., Berka R.M., Henrissat B., Saloheimo M., Arvas M., Baker S.E., Chapman J., Chertkov O., Coutinho P.M., Cullen D., Danchin E.G., Grigoriev I.V., Harris P., Jackson M., Kubicek C.P., Han C.S., Ho I., Larrondo L.F. expand/collapse author list , de Leon A.L., Magnuson J.K., Merino S., Misra M., Nelson B., Putnam N., Robbertse B., Salamov A.A., Schmoll M., Terry A., Thayer N., Westerholm-Parvinen A., Schoch C.L., Yao J., Barabote R., Nelson M.A., Detter C., Bruce D., Kuske C.R., Xie G., Richardson P., Rokhsar D.S., Lucas S.M., Rubin E.M., Dunn-Coleman N., Ward M., Brettin T.S.
Nat. Biotechnol. 26:553-560(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: QM6a.
[3]"The first structure of a glycoside hydrolase family 61 member, Cel61B from Hypocrea jecorina, at 1.6 A resolution."
Karkehabadi S., Hansson H., Kim S., Piens K., Mitchinson C., Sandgren M.
J. Mol. Biol. 383:144-154(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.6 ANGSTROMS) OF 20-249, SUBUNIT, CATALYTIC ACTIVITY, SUBCELLULAR LOCATION.
Strain: QM6a.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY281372 mRNA. Translation: AAP57753.1.
GL985060 Genomic DNA. Translation: EGR50392.1.
RefSeqXP_006963879.1. XM_006963817.1.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2VTCX-ray1.60A/B1-249[»]
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING51453.JGI120961.

Protein family/group databases

CAZyGH61. Glycoside Hydrolase Family 61.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiEGR50392; EGR50392; TRIREDRAFT_120961.
GeneID18483009.

Phylogenomic databases

OrthoDBEOG7GN2ZH.

Enzyme and pathway databases

BioCycMetaCyc:MONOMER-16506.

Family and domain databases

InterProIPR003961. Fibronectin_type3.
IPR005103. Glyco_hydro_61.
[Graphical view]
PfamPF03443. Glyco_hydro_61. 1 hit.
[Graphical view]
SMARTSM00060. FN3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceQ7Z9M7.

Entry information

Entry nameGUN7_HYPJQ
AccessionPrimary (citable) accession number: Q7Z9M7
Secondary accession number(s): G0RER9
Entry history
Integrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: September 5, 2012
Last modified: May 14, 2014
This is version 39 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries