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Q7Z9M7

- GUN7_HYPJQ

UniProt

Q7Z9M7 - GUN7_HYPJQ

Protein

Endoglucanase-7

Gene

cel61b

Organism
Hypocrea jecorina (strain QM6a) (Trichoderma reesei)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 41 (01 Oct 2014)
      Sequence version 3 (05 Sep 2012)
      Previous versions | rss
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    Functioni

    Has low levels of endoglucanase activity. May be involved in the degradation of cellulose or lignocellulose, chitin, or other polysaccharides.

    Catalytic activityi

    Endohydrolysis of (1->4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.1 Publication

    Cofactori

    Calcium.Curated

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi20 – 201Divalent metal cation
    Metal bindingi108 – 1081Divalent metal cation
    Metal bindingi195 – 1951Divalent metal cation

    GO - Molecular functioni

    1. cellulase activity Source: UniProtKB-EC
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. cellulose catabolic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Keywords - Biological processi

    Carbohydrate metabolism, Cellulose degradation, Polysaccharide degradation

    Keywords - Ligandi

    Calcium, Metal-binding

    Enzyme and pathway databases

    BioCyciMetaCyc:MONOMER-16506.

    Protein family/group databases

    CAZyiGH61. Glycoside Hydrolase Family 61.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Endoglucanase-7 (EC:3.2.1.4)
    Alternative name(s):
    Cellulase-61B
    Short name:
    Cel61B
    Endo-1,4-beta-glucanase VII
    Short name:
    EGVII
    Endoglucanase VII
    Endoglucanase-61B
    Gene namesi
    Name:cel61b
    Synonyms:egl7
    ORF Names:TRIREDRAFT_120961
    OrganismiHypocrea jecorina (strain QM6a) (Trichoderma reesei)
    Taxonomic identifieri431241 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesHypocreomycetidaeHypocrealesHypocreaceaeTrichoderma
    ProteomesiUP000008984: Unassembled WGS sequence

    Subcellular locationi

    Secreted 1 Publication

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919Sequence AnalysisAdd
    BLAST
    Chaini20 – 249230Endoglucanase-7PRO_0000364090Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi25 – 251N-linked (GlcNAc...)
    Disulfide bondi78 ↔ 198
    Disulfide bondi120 ↔ 124

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Expressioni

    Inductioni

    By cellulose, lactose and sophorose.1 Publication

    Interactioni

    Subunit structurei

    Monomer.1 Publication

    Protein-protein interaction databases

    STRINGi51453.JGI120961.

    Structurei

    Secondary structure

    1
    249
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi22 – 287
    Beta strandi31 – 344
    Helixi38 – 4710
    Helixi68 – 703
    Helixi75 – 784
    Beta strandi89 – 924
    Beta strandi96 – 1049
    Beta strandi113 – 1197
    Helixi124 – 1263
    Helixi129 – 1313
    Beta strandi133 – 1408
    Turni144 – 1474
    Helixi150 – 1567
    Beta strandi159 – 1646
    Beta strandi171 – 18212
    Turni184 – 1874
    Beta strandi193 – 20614
    Helixi217 – 2193
    Turni226 – 2283
    Beta strandi232 – 2343
    Beta strandi242 – 2443

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2VTCX-ray1.60A/B1-249[»]
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ7Z9M7.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 61 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    OrthoDBiEOG7GN2ZH.

    Family and domain databases

    InterProiIPR003961. Fibronectin_type3.
    IPR005103. Glyco_hydro_61.
    [Graphical view]
    PfamiPF03443. Glyco_hydro_61. 1 hit.
    [Graphical view]
    SMARTiSM00060. FN3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q7Z9M7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKSCAILAAL GCLAGSVLGH GQVQNFTING QYNQGFILDY YYQKQNTGHF    50
    PNVAGWYAED LDLGFISPDQ YTTPDIVCHK NAAPGAISAT AAAGSNIVFQ 100
    WGPGVWPHPY GPIVTYVVEC SGSCTTVNKN NLRWVKIQEA GINYNTQVWA 150
    QQDLINQGNK WTVKIPSSLR PGNYVFRHEL LAAHGASSAN GMQNYPQCVN 200
    IAVTGSGTKA LPAGTPATQL YKPTDPGILF NPYTTITSYT IPGPALWQG 249
    Length:249
    Mass (Da):26,828
    Last modified:September 5, 2012 - v3
    Checksum:i1BC7F179D657E0EF
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti118 – 1181V → A in EGR50392. (PubMed:18454138)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY281372 mRNA. Translation: AAP57753.1.
    GL985060 Genomic DNA. Translation: EGR50392.1.
    RefSeqiXP_006963879.1. XM_006963817.1.

    Genome annotation databases

    EnsemblFungiiEGR50392; EGR50392; TRIREDRAFT_120961.
    GeneIDi18483009.
    KEGGitre:TRIREDRAFT_120961.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY281372 mRNA. Translation: AAP57753.1 .
    GL985060 Genomic DNA. Translation: EGR50392.1 .
    RefSeqi XP_006963879.1. XM_006963817.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2VTC X-ray 1.60 A/B 1-249 [» ]
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 51453.JGI120961.

    Protein family/group databases

    CAZyi GH61. Glycoside Hydrolase Family 61.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii EGR50392 ; EGR50392 ; TRIREDRAFT_120961 .
    GeneIDi 18483009.
    KEGGi tre:TRIREDRAFT_120961.

    Phylogenomic databases

    OrthoDBi EOG7GN2ZH.

    Enzyme and pathway databases

    BioCyci MetaCyc:MONOMER-16506.

    Miscellaneous databases

    EvolutionaryTracei Q7Z9M7.

    Family and domain databases

    InterProi IPR003961. Fibronectin_type3.
    IPR005103. Glyco_hydro_61.
    [Graphical view ]
    Pfami PF03443. Glyco_hydro_61. 1 hit.
    [Graphical view ]
    SMARTi SM00060. FN3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], INDUCTION.
      Strain: QM6a.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: QM6a.
    3. "The first structure of a glycoside hydrolase family 61 member, Cel61B from Hypocrea jecorina, at 1.6 A resolution."
      Karkehabadi S., Hansson H., Kim S., Piens K., Mitchinson C., Sandgren M.
      J. Mol. Biol. 383:144-154(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.6 ANGSTROMS) OF 20-249, SUBUNIT, CATALYTIC ACTIVITY, SUBCELLULAR LOCATION.
      Strain: QM6a.

    Entry informationi

    Entry nameiGUN7_HYPJQ
    AccessioniPrimary (citable) accession number: Q7Z9M7
    Secondary accession number(s): G0RER9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 10, 2009
    Last sequence update: September 5, 2012
    Last modified: October 1, 2014
    This is version 41 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3