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Q7Z9M7

- GUN7_HYPJQ

UniProt

Q7Z9M7 - GUN7_HYPJQ

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Protein
Endoglucanase-7
Gene
cel61b, egl7, TRIREDRAFT_120961
Organism
Hypocrea jecorina (strain QM6a) (Trichoderma reesei)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Has low levels of endoglucanase activity. May be involved in the degradation of cellulose or lignocellulose, chitin, or other polysaccharides.

Catalytic activityi

Endohydrolysis of (1->4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.1 Publication

Cofactori

Calcium Inferred.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi20 – 201Divalent metal cation
Metal bindingi108 – 1081Divalent metal cation
Metal bindingi195 – 1951Divalent metal cation

GO - Molecular functioni

  1. cellulase activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

  1. cellulose catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Cellulose degradation, Polysaccharide degradation

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-16506.

Protein family/group databases

CAZyiGH61. Glycoside Hydrolase Family 61.

Names & Taxonomyi

Protein namesi
Recommended name:
Endoglucanase-7 (EC:3.2.1.4)
Alternative name(s):
Cellulase-61B
Short name:
Cel61B
Endo-1,4-beta-glucanase VII
Short name:
EGVII
Endoglucanase VII
Endoglucanase-61B
Gene namesi
Name:cel61b
Synonyms:egl7
ORF Names:TRIREDRAFT_120961
OrganismiHypocrea jecorina (strain QM6a) (Trichoderma reesei)
Taxonomic identifieri431241 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesHypocreomycetidaeHypocrealesHypocreaceaeTrichoderma
ProteomesiUP000008984: Unassembled WGS sequence

Subcellular locationi

Secreted 1 Publication

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919 Reviewed prediction
Add
BLAST
Chaini20 – 249230Endoglucanase-7
PRO_0000364090Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi25 – 251N-linked (GlcNAc...)
Disulfide bondi78 ↔ 198
Disulfide bondi120 ↔ 124

Keywords - PTMi

Disulfide bond, Glycoprotein

Expressioni

Inductioni

By cellulose, lactose and sophorose.1 Publication

Interactioni

Subunit structurei

Monomer.1 Publication

Protein-protein interaction databases

STRINGi51453.JGI120961.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi22 – 287
Beta strandi31 – 344
Helixi38 – 4710
Helixi68 – 703
Helixi75 – 784
Beta strandi89 – 924
Beta strandi96 – 1049
Beta strandi113 – 1197
Helixi124 – 1263
Helixi129 – 1313
Beta strandi133 – 1408
Turni144 – 1474
Helixi150 – 1567
Beta strandi159 – 1646
Beta strandi171 – 18212
Turni184 – 1874
Beta strandi193 – 20614
Helixi217 – 2193
Turni226 – 2283
Beta strandi232 – 2343
Beta strandi242 – 2443

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2VTCX-ray1.60A/B1-249[»]

Miscellaneous databases

EvolutionaryTraceiQ7Z9M7.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

OrthoDBiEOG7GN2ZH.

Family and domain databases

InterProiIPR003961. Fibronectin_type3.
IPR005103. Glyco_hydro_61.
[Graphical view]
PfamiPF03443. Glyco_hydro_61. 1 hit.
[Graphical view]
SMARTiSM00060. FN3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7Z9M7-1 [UniParc]FASTAAdd to Basket

« Hide

MKSCAILAAL GCLAGSVLGH GQVQNFTING QYNQGFILDY YYQKQNTGHF    50
PNVAGWYAED LDLGFISPDQ YTTPDIVCHK NAAPGAISAT AAAGSNIVFQ 100
WGPGVWPHPY GPIVTYVVEC SGSCTTVNKN NLRWVKIQEA GINYNTQVWA 150
QQDLINQGNK WTVKIPSSLR PGNYVFRHEL LAAHGASSAN GMQNYPQCVN 200
IAVTGSGTKA LPAGTPATQL YKPTDPGILF NPYTTITSYT IPGPALWQG 249
Length:249
Mass (Da):26,828
Last modified:September 5, 2012 - v3
Checksum:i1BC7F179D657E0EF
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti118 – 1181V → A in EGR50392. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY281372 mRNA. Translation: AAP57753.1.
GL985060 Genomic DNA. Translation: EGR50392.1.
RefSeqiXP_006963879.1. XM_006963817.1.

Genome annotation databases

EnsemblFungiiEGR50392; EGR50392; TRIREDRAFT_120961.
GeneIDi18483009.
KEGGitre:TRIREDRAFT_120961.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY281372 mRNA. Translation: AAP57753.1 .
GL985060 Genomic DNA. Translation: EGR50392.1 .
RefSeqi XP_006963879.1. XM_006963817.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2VTC X-ray 1.60 A/B 1-249 [» ]
ModBasei Search...

Protein-protein interaction databases

STRINGi 51453.JGI120961.

Protein family/group databases

CAZyi GH61. Glycoside Hydrolase Family 61.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii EGR50392 ; EGR50392 ; TRIREDRAFT_120961 .
GeneIDi 18483009.
KEGGi tre:TRIREDRAFT_120961.

Phylogenomic databases

OrthoDBi EOG7GN2ZH.

Enzyme and pathway databases

BioCyci MetaCyc:MONOMER-16506.

Miscellaneous databases

EvolutionaryTracei Q7Z9M7.

Family and domain databases

InterProi IPR003961. Fibronectin_type3.
IPR005103. Glyco_hydro_61.
[Graphical view ]
Pfami PF03443. Glyco_hydro_61. 1 hit.
[Graphical view ]
SMARTi SM00060. FN3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], INDUCTION.
    Strain: QM6a.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: QM6a.
  3. "The first structure of a glycoside hydrolase family 61 member, Cel61B from Hypocrea jecorina, at 1.6 A resolution."
    Karkehabadi S., Hansson H., Kim S., Piens K., Mitchinson C., Sandgren M.
    J. Mol. Biol. 383:144-154(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.6 ANGSTROMS) OF 20-249, SUBUNIT, CATALYTIC ACTIVITY, SUBCELLULAR LOCATION.
    Strain: QM6a.

Entry informationi

Entry nameiGUN7_HYPJQ
AccessioniPrimary (citable) accession number: Q7Z9M7
Secondary accession number(s): G0RER9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: September 5, 2012
Last modified: September 3, 2014
This is version 40 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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