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Protein

Endoglucanase-7

Gene

cel61b

Organism
Hypocrea jecorina (strain QM6a) (Trichoderma reesei)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Has low levels of endoglucanase activity. May be involved in the degradation of cellulose or lignocellulose, chitin, or other polysaccharides.

Catalytic activityi

Endohydrolysis of (1->4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.1 Publication

Cofactori

Ca2+Curated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi20Divalent metal cation1
Metal bindingi108Divalent metal cation1
Metal bindingi195Divalent metal cation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Cellulose degradation, Polysaccharide degradation

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-16506.

Protein family/group databases

CAZyiAA9. Auxiliary Activities 9.

Names & Taxonomyi

Protein namesi
Recommended name:
Endoglucanase-7 (EC:3.2.1.4)
Alternative name(s):
Cellulase-61B
Short name:
Cel61B
Endo-1,4-beta-glucanase VII
Short name:
EGVII
Endoglucanase VII
Endoglucanase-61B
Gene namesi
Name:cel61b
Synonyms:egl7
ORF Names:TRIREDRAFT_120961
OrganismiHypocrea jecorina (strain QM6a) (Trichoderma reesei)
Taxonomic identifieri431241 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesHypocreomycetidaeHypocrealesHypocreaceaeTrichoderma
Proteomesi
  • UP000008984 Componenti: Unassembled WGS sequence

Organism-specific databases

EuPathDBiFungiDB:TRIREDRAFT_120961.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000036409020 – 249Endoglucanase-7Add BLAST230

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi25N-linked (GlcNAc...)1
Disulfide bondi78 ↔ 198
Disulfide bondi120 ↔ 124

Keywords - PTMi

Disulfide bond, Glycoprotein

Expressioni

Inductioni

By cellulose, lactose and sophorose.1 Publication

Interactioni

Subunit structurei

Monomer.1 Publication

Structurei

Secondary structure

1249
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi22 – 28Combined sources7
Beta strandi31 – 34Combined sources4
Helixi38 – 47Combined sources10
Helixi68 – 70Combined sources3
Helixi75 – 78Combined sources4
Beta strandi89 – 92Combined sources4
Beta strandi96 – 104Combined sources9
Beta strandi113 – 119Combined sources7
Helixi124 – 126Combined sources3
Helixi129 – 131Combined sources3
Beta strandi133 – 140Combined sources8
Turni144 – 147Combined sources4
Helixi150 – 156Combined sources7
Beta strandi159 – 164Combined sources6
Beta strandi171 – 182Combined sources12
Turni184 – 187Combined sources4
Beta strandi193 – 206Combined sources14
Helixi217 – 219Combined sources3
Turni226 – 228Combined sources3
Beta strandi232 – 234Combined sources3
Beta strandi242 – 244Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2VTCX-ray1.60A/B1-249[»]
SMRiQ7Z9M7.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ7Z9M7.

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 61 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

OrthoDBiEOG092C3ZEU.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR005103. Glyco_hydro_61.
IPR013783. Ig-like_fold.
[Graphical view]
PfamiPF03443. Glyco_hydro_61. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7Z9M7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKSCAILAAL GCLAGSVLGH GQVQNFTING QYNQGFILDY YYQKQNTGHF
60 70 80 90 100
PNVAGWYAED LDLGFISPDQ YTTPDIVCHK NAAPGAISAT AAAGSNIVFQ
110 120 130 140 150
WGPGVWPHPY GPIVTYVVEC SGSCTTVNKN NLRWVKIQEA GINYNTQVWA
160 170 180 190 200
QQDLINQGNK WTVKIPSSLR PGNYVFRHEL LAAHGASSAN GMQNYPQCVN
210 220 230 240
IAVTGSGTKA LPAGTPATQL YKPTDPGILF NPYTTITSYT IPGPALWQG
Length:249
Mass (Da):26,828
Last modified:September 5, 2012 - v3
Checksum:i1BC7F179D657E0EF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti118V → A in EGR50392 (PubMed:18454138).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY281372 mRNA. Translation: AAP57753.1.
GL985060 Genomic DNA. Translation: EGR50392.1.
RefSeqiXP_006963879.1. XM_006963817.1.

Genome annotation databases

GeneIDi18483009.
KEGGitre:TRIREDRAFT_120961.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY281372 mRNA. Translation: AAP57753.1.
GL985060 Genomic DNA. Translation: EGR50392.1.
RefSeqiXP_006963879.1. XM_006963817.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2VTCX-ray1.60A/B1-249[»]
SMRiQ7Z9M7.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

CAZyiAA9. Auxiliary Activities 9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi18483009.
KEGGitre:TRIREDRAFT_120961.

Organism-specific databases

EuPathDBiFungiDB:TRIREDRAFT_120961.

Phylogenomic databases

OrthoDBiEOG092C3ZEU.

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-16506.

Miscellaneous databases

EvolutionaryTraceiQ7Z9M7.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR005103. Glyco_hydro_61.
IPR013783. Ig-like_fold.
[Graphical view]
PfamiPF03443. Glyco_hydro_61. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGUN7_HYPJQ
AccessioniPrimary (citable) accession number: Q7Z9M7
Secondary accession number(s): G0RER9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: September 5, 2012
Last modified: November 30, 2016
This is version 50 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.