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Q7Z9H9

- FIG4_SCHPO

UniProt

Q7Z9H9 - FIG4_SCHPO

Protein

Polyphosphoinositide phosphatase

Gene

SPAC1093.03

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 63 (01 Oct 2014)
      Sequence version 3 (13 Jun 2012)
      Previous versions | rss
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    Functioni

    The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2).By similarity

    Catalytic activityi

    1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 3-phosphate + phosphate.

    Cofactori

    Magnesium.By similarity

    GO - Molecular functioni

    1. phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity Source: PomBase

    GO - Biological processi

    1. cell morphogenesis involved in conjugation with cellular fusion Source: PomBase
    2. phosphatidylinositol-3-phosphate biosynthetic process Source: GOC
    3. phosphatidylinositol dephosphorylation Source: PomBase
    4. phosphatidylinositol-mediated signaling Source: PomBase

    Keywords - Molecular functioni

    Hydrolase

    Enzyme and pathway databases

    ReactomeiREACT_188299. Synthesis of PIPs at the Golgi membrane.
    REACT_188300. Synthesis of PIPs at the early endosome membrane.
    REACT_188310. Synthesis of PIPs at the late endosome membrane.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Polyphosphoinositide phosphatase (EC:3.1.3.-)
    Alternative name(s):
    Phosphatidylinositol 3,5-bisphosphate 5-phosphatase
    Gene namesi
    ORF Names:SPAC1093.03
    OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    Taxonomic identifieri284812 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
    ProteomesiUP000002485: Chromosome I

    Organism-specific databases

    PomBaseiSPAC1093.03.

    Subcellular locationi

    Cytoplasm 1 Publication. Vacuole membrane By similarity; Peripheral membrane protein By similarity

    GO - Cellular componenti

    1. cytosol Source: PomBase
    2. extrinsic component of membrane Source: PomBase
    3. fungal-type vacuole membrane Source: PomBase

    Keywords - Cellular componenti

    Cytoplasm, Membrane, Vacuole

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 832832Polyphosphoinositide phosphatasePRO_0000317231Add
    BLAST

    Proteomic databases

    MaxQBiQ7Z9H9.

    Interactioni

    Subunit structurei

    Component of the PI(3,5)P2 regulatory complex.By similarity

    Protein-protein interaction databases

    BioGridi280477. 37 interactions.
    MINTiMINT-4700749.
    STRINGi4896.SPAC1093.03-1.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini145 – 491347SACPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 SAC domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG5329.
    HOGENOMiHOG000168063.
    OrthoDBiEOG7DRJBN.

    Family and domain databases

    InterProiIPR002013. Syja_N.
    [Graphical view]
    PfamiPF02383. Syja_N. 1 hit.
    [Graphical view]
    PROSITEiPS50275. SAC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q7Z9H9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPATNSDEPL VKFELYQLKK CYYIVSENAT ATIFRILKIT QSEDELSISI    50
    EEAAKILFRQ KLQLYLEKLE NESADGKLIL VTKAYAILGL FRFTAGYYLY 100
    LCTERKVVAV IGGHNVYHVD KTQFIELNPS RRHNTSVERK CMSSIEKVDL 150
    ARTFYFSYSY DLSQTIQYGF THPIPQHQVR DMFVWNWNML RPILDSVGID 200
    SPWCIPLIHG FVDQAKLSVY GKPIIVTLIA RRSRHFAGAR FLRRGIRDDG 250
    YVANEVETEQ IVFDGSASSF PISSTTPGIP CYTSYVQHRG SIPLRWSQEF 300
    SNITPKPPIG IDFHDPFYAS TALHFDRLFG HYGIPCIVLN LVKSSEKVKR 350
    ESLLLDEFES AIQYLNQFLK DSQKIQYIAW DMSAASKKKV PVTKTLEQMA 400
    SDIVKKTGFF CTADRFFPGT FQTGVVRTNC VDCLDRTNAA QFVIGKCVLA 450
    AQLRALGVLD SPQLDYESDA VRLLAEMYHG HGDAIALQYG GSLLVNTLDT 500
    YRKNNQWSST SRDLIESVKR FYSNSFVDFQ RQEAISLFLG NFTVHGKIVV 550
    FGEKRLQALT EKFKNGQLVR RDYRYWWTPV YVNQELRCKN AYCDSIQRKG 600
    IKFPANYFDN VYTPNSISSF SEVLLPNLIS TLNFAPLSLI PLLRKSFLPL 650
    SYNGFGIEAP SLNPFIPRRN QPRDMFKTSA EEENEDEDED DDKFRRVSLY 700
    KWLFNNEERP VHKFIRKRLH QIPVSNKVQP RDQKQPDFKI PNTDINVYKI 750
    HFQYNNISGL ADNYTLLSKH DRAMYNNYAD YSPDKIKEIK EKELNTYNDY 800
    FNSAISENPT LKSDRSEKVA FYSAWITDYK ST 832
    Length:832
    Mass (Da):96,035
    Last modified:June 13, 2012 - v3
    Checksum:i0F76CCC03DBFF43E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329670 Genomic DNA. Translation: CAB60248.4.
    RefSeqiNP_001018284.3. NM_001020079.3.

    Genome annotation databases

    EnsemblFungiiSPAC1093.03.1; SPAC1093.03.1:pep; SPAC1093.03.
    GeneIDi3361401.
    KEGGispo:SPAC1093.03.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329670 Genomic DNA. Translation: CAB60248.4 .
    RefSeqi NP_001018284.3. NM_001020079.3.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 280477. 37 interactions.
    MINTi MINT-4700749.
    STRINGi 4896.SPAC1093.03-1.

    Proteomic databases

    MaxQBi Q7Z9H9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii SPAC1093.03.1 ; SPAC1093.03.1:pep ; SPAC1093.03 .
    GeneIDi 3361401.
    KEGGi spo:SPAC1093.03.

    Organism-specific databases

    PomBasei SPAC1093.03.

    Phylogenomic databases

    eggNOGi COG5329.
    HOGENOMi HOG000168063.
    OrthoDBi EOG7DRJBN.

    Enzyme and pathway databases

    Reactomei REACT_188299. Synthesis of PIPs at the Golgi membrane.
    REACT_188300. Synthesis of PIPs at the early endosome membrane.
    REACT_188310. Synthesis of PIPs at the late endosome membrane.

    Miscellaneous databases

    NextBioi 20811452.

    Family and domain databases

    InterProi IPR002013. Syja_N.
    [Graphical view ]
    Pfami PF02383. Syja_N. 1 hit.
    [Graphical view ]
    PROSITEi PS50275. SAC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Schizosaccharomyces pombe."
      Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
      , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
      Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 972 / ATCC 24843.
    2. "Comparative functional genomics of the fission yeasts."
      Rhind N., Chen Z., Yassour M., Thompson D.A., Haas B.J., Habib N., Wapinski I., Roy S., Lin M.F., Heiman D.I., Young S.K., Furuya K., Guo Y., Pidoux A., Chen H.M., Robbertse B., Goldberg J.M., Aoki K.
      , Bayne E.H., Berlin A.M., Desjardins C.A., Dobbs E., Dukaj L., Fan L., FitzGerald M.G., French C., Gujja S., Hansen K., Keifenheim D., Levin J.Z., Mosher R.A., Mueller C.A., Pfiffner J., Priest M., Russ C., Smialowska A., Swoboda P., Sykes S.M., Vaughn M., Vengrova S., Yoder R., Zeng Q., Allshire R., Baulcombe D., Birren B.W., Brown W., Ekwall K., Kellis M., Leatherwood J., Levin H., Margalit H., Martienssen R., Nieduszynski C.A., Spatafora J.W., Friedman N., Dalgaard J.Z., Baumann P., Niki H., Regev A., Nusbaum C.
      Science 332:930-936(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVISION OF GENE MODEL.
    3. "ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
      Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
      Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiFIG4_SCHPO
    AccessioniPrimary (citable) accession number: Q7Z9H9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: June 13, 2012
    Last modified: October 1, 2014
    This is version 63 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Schizosaccharomyces pombe
      Schizosaccharomyces pombe: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3