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Q7Z9H9

- FIG4_SCHPO

UniProt

Q7Z9H9 - FIG4_SCHPO

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Protein
Polyphosphoinositide phosphatase
Gene
SPAC1093.03
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) By similarity.

Catalytic activityi

1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 3-phosphate + phosphate.

Cofactori

Magnesium By similarity.

GO - Molecular functioni

  1. phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity Source: PomBase

GO - Biological processi

  1. cell morphogenesis involved in conjugation with cellular fusion Source: PomBase
  2. phosphatidylinositol dephosphorylation Source: PomBase
  3. phosphatidylinositol-3-phosphate biosynthetic process Source: GOC
  4. phosphatidylinositol-mediated signaling Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

ReactomeiREACT_188299. Synthesis of PIPs at the Golgi membrane.
REACT_188300. Synthesis of PIPs at the early endosome membrane.
REACT_188310. Synthesis of PIPs at the late endosome membrane.

Names & Taxonomyi

Protein namesi
Recommended name:
Polyphosphoinositide phosphatase (EC:3.1.3.-)
Alternative name(s):
Phosphatidylinositol 3,5-bisphosphate 5-phosphatase
Gene namesi
ORF Names:SPAC1093.03
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome I

Organism-specific databases

PomBaseiSPAC1093.03.

Subcellular locationi

Cytoplasm. Vacuole membrane; Peripheral membrane protein By similarity 1 Publication

GO - Cellular componenti

  1. cytosol Source: PomBase
  2. extrinsic component of membrane Source: PomBase
  3. fungal-type vacuole membrane Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 832832Polyphosphoinositide phosphatase
PRO_0000317231Add
BLAST

Proteomic databases

MaxQBiQ7Z9H9.

Interactioni

Subunit structurei

Component of the PI(3,5)P2 regulatory complex By similarity.

Protein-protein interaction databases

BioGridi280477. 37 interactions.
MINTiMINT-4700749.
STRINGi4896.SPAC1093.03-1.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini145 – 491347SAC
Add
BLAST

Sequence similaritiesi

Contains 1 SAC domain.

Phylogenomic databases

eggNOGiCOG5329.
HOGENOMiHOG000168063.
OrthoDBiEOG7DRJBN.

Family and domain databases

InterProiIPR002013. Syja_N.
[Graphical view]
PfamiPF02383. Syja_N. 1 hit.
[Graphical view]
PROSITEiPS50275. SAC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7Z9H9-1 [UniParc]FASTAAdd to Basket

« Hide

MPATNSDEPL VKFELYQLKK CYYIVSENAT ATIFRILKIT QSEDELSISI    50
EEAAKILFRQ KLQLYLEKLE NESADGKLIL VTKAYAILGL FRFTAGYYLY 100
LCTERKVVAV IGGHNVYHVD KTQFIELNPS RRHNTSVERK CMSSIEKVDL 150
ARTFYFSYSY DLSQTIQYGF THPIPQHQVR DMFVWNWNML RPILDSVGID 200
SPWCIPLIHG FVDQAKLSVY GKPIIVTLIA RRSRHFAGAR FLRRGIRDDG 250
YVANEVETEQ IVFDGSASSF PISSTTPGIP CYTSYVQHRG SIPLRWSQEF 300
SNITPKPPIG IDFHDPFYAS TALHFDRLFG HYGIPCIVLN LVKSSEKVKR 350
ESLLLDEFES AIQYLNQFLK DSQKIQYIAW DMSAASKKKV PVTKTLEQMA 400
SDIVKKTGFF CTADRFFPGT FQTGVVRTNC VDCLDRTNAA QFVIGKCVLA 450
AQLRALGVLD SPQLDYESDA VRLLAEMYHG HGDAIALQYG GSLLVNTLDT 500
YRKNNQWSST SRDLIESVKR FYSNSFVDFQ RQEAISLFLG NFTVHGKIVV 550
FGEKRLQALT EKFKNGQLVR RDYRYWWTPV YVNQELRCKN AYCDSIQRKG 600
IKFPANYFDN VYTPNSISSF SEVLLPNLIS TLNFAPLSLI PLLRKSFLPL 650
SYNGFGIEAP SLNPFIPRRN QPRDMFKTSA EEENEDEDED DDKFRRVSLY 700
KWLFNNEERP VHKFIRKRLH QIPVSNKVQP RDQKQPDFKI PNTDINVYKI 750
HFQYNNISGL ADNYTLLSKH DRAMYNNYAD YSPDKIKEIK EKELNTYNDY 800
FNSAISENPT LKSDRSEKVA FYSAWITDYK ST 832
Length:832
Mass (Da):96,035
Last modified:June 13, 2012 - v3
Checksum:i0F76CCC03DBFF43E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329670 Genomic DNA. Translation: CAB60248.4.
RefSeqiNP_001018284.3. NM_001020079.3.

Genome annotation databases

EnsemblFungiiSPAC1093.03.1; SPAC1093.03.1:pep; SPAC1093.03.
GeneIDi3361401.
KEGGispo:SPAC1093.03.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329670 Genomic DNA. Translation: CAB60248.4 .
RefSeqi NP_001018284.3. NM_001020079.3.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 280477. 37 interactions.
MINTi MINT-4700749.
STRINGi 4896.SPAC1093.03-1.

Proteomic databases

MaxQBi Q7Z9H9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SPAC1093.03.1 ; SPAC1093.03.1:pep ; SPAC1093.03 .
GeneIDi 3361401.
KEGGi spo:SPAC1093.03.

Organism-specific databases

PomBasei SPAC1093.03.

Phylogenomic databases

eggNOGi COG5329.
HOGENOMi HOG000168063.
OrthoDBi EOG7DRJBN.

Enzyme and pathway databases

Reactomei REACT_188299. Synthesis of PIPs at the Golgi membrane.
REACT_188300. Synthesis of PIPs at the early endosome membrane.
REACT_188310. Synthesis of PIPs at the late endosome membrane.

Miscellaneous databases

NextBioi 20811452.

Family and domain databases

InterProi IPR002013. Syja_N.
[Graphical view ]
Pfami PF02383. Syja_N. 1 hit.
[Graphical view ]
PROSITEi PS50275. SAC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. "Comparative functional genomics of the fission yeasts."
    Rhind N., Chen Z., Yassour M., Thompson D.A., Haas B.J., Habib N., Wapinski I., Roy S., Lin M.F., Heiman D.I., Young S.K., Furuya K., Guo Y., Pidoux A., Chen H.M., Robbertse B., Goldberg J.M., Aoki K.
    , Bayne E.H., Berlin A.M., Desjardins C.A., Dobbs E., Dukaj L., Fan L., FitzGerald M.G., French C., Gujja S., Hansen K., Keifenheim D., Levin J.Z., Mosher R.A., Mueller C.A., Pfiffner J., Priest M., Russ C., Smialowska A., Swoboda P., Sykes S.M., Vaughn M., Vengrova S., Yoder R., Zeng Q., Allshire R., Baulcombe D., Birren B.W., Brown W., Ekwall K., Kellis M., Leatherwood J., Levin H., Margalit H., Martienssen R., Nieduszynski C.A., Spatafora J.W., Friedman N., Dalgaard J.Z., Baumann P., Niki H., Regev A., Nusbaum C.
    Science 332:930-936(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVISION OF GENE MODEL.
  3. "ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
    Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
    Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiFIG4_SCHPO
AccessioniPrimary (citable) accession number: Q7Z9H9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: June 13, 2012
Last modified: September 3, 2014
This is version 62 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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