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Q7Z9H9 (FIG4_SCHPO) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Polyphosphoinositide phosphatase

EC=3.1.3.-
Alternative name(s):
Phosphatidylinositol 3,5-bisphosphate 5-phosphatase
Gene names
ORF Names:SPAC1093.03
OrganismSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) [Reference proteome]
Taxonomic identifier284812 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces

Protein attributes

Sequence length832 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) By similarity.

Catalytic activity

1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 3-phosphate + phosphate.

Cofactor

Magnesium By similarity.

Subunit structure

Component of the PI(3,5)P2 regulatory complex By similarity.

Subcellular location

Cytoplasm. Vacuole membrane; Peripheral membrane protein By similarity Ref.3.

Sequence similarities

Contains 1 SAC domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 832832Polyphosphoinositide phosphatase
PRO_0000317231

Regions

Domain145 – 491347SAC

Sequences

Sequence LengthMass (Da)Tools
Q7Z9H9 [UniParc].

Last modified June 13, 2012. Version 3.
Checksum: 0F76CCC03DBFF43E

FASTA83296,035
        10         20         30         40         50         60 
MPATNSDEPL VKFELYQLKK CYYIVSENAT ATIFRILKIT QSEDELSISI EEAAKILFRQ 

        70         80         90        100        110        120 
KLQLYLEKLE NESADGKLIL VTKAYAILGL FRFTAGYYLY LCTERKVVAV IGGHNVYHVD 

       130        140        150        160        170        180 
KTQFIELNPS RRHNTSVERK CMSSIEKVDL ARTFYFSYSY DLSQTIQYGF THPIPQHQVR 

       190        200        210        220        230        240 
DMFVWNWNML RPILDSVGID SPWCIPLIHG FVDQAKLSVY GKPIIVTLIA RRSRHFAGAR 

       250        260        270        280        290        300 
FLRRGIRDDG YVANEVETEQ IVFDGSASSF PISSTTPGIP CYTSYVQHRG SIPLRWSQEF 

       310        320        330        340        350        360 
SNITPKPPIG IDFHDPFYAS TALHFDRLFG HYGIPCIVLN LVKSSEKVKR ESLLLDEFES 

       370        380        390        400        410        420 
AIQYLNQFLK DSQKIQYIAW DMSAASKKKV PVTKTLEQMA SDIVKKTGFF CTADRFFPGT 

       430        440        450        460        470        480 
FQTGVVRTNC VDCLDRTNAA QFVIGKCVLA AQLRALGVLD SPQLDYESDA VRLLAEMYHG 

       490        500        510        520        530        540 
HGDAIALQYG GSLLVNTLDT YRKNNQWSST SRDLIESVKR FYSNSFVDFQ RQEAISLFLG 

       550        560        570        580        590        600 
NFTVHGKIVV FGEKRLQALT EKFKNGQLVR RDYRYWWTPV YVNQELRCKN AYCDSIQRKG 

       610        620        630        640        650        660 
IKFPANYFDN VYTPNSISSF SEVLLPNLIS TLNFAPLSLI PLLRKSFLPL SYNGFGIEAP 

       670        680        690        700        710        720 
SLNPFIPRRN QPRDMFKTSA EEENEDEDED DDKFRRVSLY KWLFNNEERP VHKFIRKRLH 

       730        740        750        760        770        780 
QIPVSNKVQP RDQKQPDFKI PNTDINVYKI HFQYNNISGL ADNYTLLSKH DRAMYNNYAD 

       790        800        810        820        830 
YSPDKIKEIK EKELNTYNDY FNSAISENPT LKSDRSEKVA FYSAWITDYK ST 

« Hide

References

« Hide 'large scale' references
[1]"The genome sequence of Schizosaccharomyces pombe."
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. expand/collapse author list , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 972 / ATCC 24843.
[2]"Comparative functional genomics of the fission yeasts."
Rhind N., Chen Z., Yassour M., Thompson D.A., Haas B.J., Habib N., Wapinski I., Roy S., Lin M.F., Heiman D.I., Young S.K., Furuya K., Guo Y., Pidoux A., Chen H.M., Robbertse B., Goldberg J.M., Aoki K. expand/collapse author list , Bayne E.H., Berlin A.M., Desjardins C.A., Dobbs E., Dukaj L., Fan L., FitzGerald M.G., French C., Gujja S., Hansen K., Keifenheim D., Levin J.Z., Mosher R.A., Mueller C.A., Pfiffner J., Priest M., Russ C., Smialowska A., Swoboda P., Sykes S.M., Vaughn M., Vengrova S., Yoder R., Zeng Q., Allshire R., Baulcombe D., Birren B.W., Brown W., Ekwall K., Kellis M., Leatherwood J., Levin H., Margalit H., Martienssen R., Nieduszynski C.A., Spatafora J.W., Friedman N., Dalgaard J.Z., Baumann P., Niki H., Regev A., Nusbaum C.
Science 332:930-936(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: REVISION OF GENE MODEL.
[3]"ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CU329670 Genomic DNA. Translation: CAB60248.4.
RefSeqNP_001018284.3. NM_001020079.3.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid280477. 37 interactions.
MINTMINT-4700749.
STRING4896.SPAC1093.03-1.

Proteomic databases

MaxQBQ7Z9H9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiSPAC1093.03.1; SPAC1093.03.1:pep; SPAC1093.03.
GeneID3361401.
KEGGspo:SPAC1093.03.

Organism-specific databases

PomBaseSPAC1093.03.

Phylogenomic databases

eggNOGCOG5329.
HOGENOMHOG000168063.
OrthoDBEOG7DRJBN.

Family and domain databases

InterProIPR002013. Syja_N.
[Graphical view]
PfamPF02383. Syja_N. 1 hit.
[Graphical view]
PROSITEPS50275. SAC. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20811452.

Entry information

Entry nameFIG4_SCHPO
AccessionPrimary (citable) accession number: Q7Z9H9
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: June 13, 2012
Last modified: May 14, 2014
This is version 61 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Schizosaccharomyces pombe

Schizosaccharomyces pombe: entries and gene names