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Q7Z8L4 (PYRF_PENCA) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Orotidine 5'-phosphate decarboxylase

EC=4.1.1.23
Alternative name(s):
OMP decarboxylase
Short name=OMPDCase
Short name=OMPdecase
Uridine 5'-monophosphate synthase
Short name=UMP synthase
Gene names
Name:pyrG
OrganismPenicillium camembertii
Taxonomic identifier5075 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaePenicillium

Protein attributes

Sequence length276 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Orotidine 5'-phosphate = UMP + CO2.

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2.

Sequence similarities

Belongs to the OMP decarboxylase family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 276276Orotidine 5'-phosphate decarboxylase
PRO_0000134668

Regions

Region62 – 643Substrate binding By similarity
Region93 – 10210Substrate binding By similarity

Sites

Active site951Proton donor By similarity
Binding site401Substrate By similarity
Binding site2281Substrate By similarity
Binding site2461Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q7Z8L4 [UniParc].

Last modified October 1, 2003. Version 1.
Checksum: 3CC4BB8B1E17DAA5

FASTA27629,913
        10         20         30         40         50         60 
MSSKSQLTYS ARAQSHPNPL ARKLFQVAEE KKSNVTVSAD VTTTKELLDL ADRLGPYIAV 

        70         80         90        100        110        120 
IKTHIDILSD FSQETIDGLN ALAQKHNFLI FEDRKFIDIG NTVQKQYHNG TLRISEWAHI 

       130        140        150        160        170        180 
INCSVLPGEG IVQALAQTAQ ATDFPYGSER GLLILAEMTS KGSLATGSYT SASVDIARKY 

       190        200        210        220        230        240 
PSFVLGFVST RSLGEVESTE APAQGEDFVV FTTGVNLSSK GDKLGQQYQT PQSAIGRGAD 

       250        260        270 
FIISGRGIYA AADPVEAAKQ YQQQGWEAYL ARVGAQ 

« Hide

References

[1]"Penicillium camembertii pyrG gene for orotidine-5'-phosphate decarboxylase, complete cds."
Miyachi S., Suzuki K.
Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: U-150.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB100244 Genomic DNA. Translation: BAC79366.1.

3D structure databases

ProteinModelPortalQ7Z8L4.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00070; UER00120.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
InterProIPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMSSF51366. SSF51366. 1 hit.
TIGRFAMsTIGR01740. pyrF. 1 hit.
PROSITEPS00156. OMPDECASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePYRF_PENCA
AccessionPrimary (citable) accession number: Q7Z8L4
Entry history
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: October 1, 2003
Last modified: November 13, 2013
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways