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Q7Z8E7

- GPD_COLGL

UniProt

Q7Z8E7 - GPD_COLGL

Protein

Glycerol-3-phosphate dehydrogenase [NAD(+)]

Gene
N/A
Organism
Colletotrichum gloeosporioides (Anthracnose fungus) (Glomerella cingulata)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 61 (01 Oct 2014)
      Sequence version 1 (01 Oct 2003)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    sn-glycerol 3-phosphate + NAD+ = glycerone phosphate + NADH.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei119 – 1191NADBy similarity
    Binding sitei142 – 1421NAD; via amide nitrogenBy similarity
    Binding sitei142 – 1421SubstrateBy similarity
    Binding sitei175 – 1751NAD; via amide nitrogenBy similarity
    Active sitei278 – 2781Proton acceptorBy similarity
    Binding sitei344 – 3441NADBy similarity
    Binding sitei373 – 3731NADBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi16 – 216NADBy similarity

    GO - Molecular functioni

    1. glycerol-3-phosphate dehydrogenase [NAD+] activity Source: UniProtKB-EC
    2. NAD binding Source: InterPro

    GO - Biological processi

    1. carbohydrate metabolic process Source: InterPro
    2. glycerol-3-phosphate catabolic process Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    NAD

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycerol-3-phosphate dehydrogenase [NAD(+)] (EC:1.1.1.8)
    OrganismiColletotrichum gloeosporioides (Anthracnose fungus) (Glomerella cingulata)
    Taxonomic identifieri474922 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesHypocreomycetidaeGlomerellalesGlomerellaceaemitosporic GlomerellaceaeColletotrichum

    Subcellular locationi

    GO - Cellular componenti

    1. glycerol-3-phosphate dehydrogenase complex Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 420420Glycerol-3-phosphate dehydrogenase [NAD(+)]PRO_0000138089Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ7Z8E7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni344 – 3452Substrate bindingBy similarity

    Sequence similaritiesi

    Family and domain databases

    Gene3Di1.10.1040.10. 1 hit.
    3.40.50.720. 2 hits.
    InterProiIPR008927. 6-PGluconate_DH_C-like.
    IPR013328. DH_multihelical.
    IPR006168. G3P_DH_NAD-dep.
    IPR006109. G3P_DH_NAD-dep_C.
    IPR011128. G3P_DH_NAD-dep_N.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PANTHERiPTHR11728. PTHR11728. 1 hit.
    PfamiPF07479. NAD_Gly3P_dh_C. 1 hit.
    PF01210. NAD_Gly3P_dh_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000114. Glycerol-3-P_dh. 1 hit.
    PRINTSiPR00077. GPDHDRGNASE.
    SUPFAMiSSF48179. SSF48179. 1 hit.
    PROSITEiPS00957. NAD_G3PDH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q7Z8E7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MASLGADKKH KVTVVGSGNW GSTICKIVAE NTKANPDLFE EAVHMWVFEE    50
    DVVIDKSSPY YDPAVGDAPQ KLTGVINKYH ENTKYLPGIK LPDNIIANPS 100
    LQDAVKDSTI LVFNLPHQFI GNVCKQLRGH IMPFARGISC IKGVNVSDDG 150
    ISLFSEWIGD GLGIYCGALS GANIASEIAA EKWSETTIAY DPPPMDNSRA 200
    PTPRSNSPAN GNGIAPLTPV EMQHKDARGR TSKTKLTPVP AEYPPLDHQI 250
    FKQLFHRPYF HVRMVSDVAG VSLGGALKNI VALAAGFVDG RGWGDNAKAA 300
    IMRVGLLEMV NFGKEFFGQT VHTGTFTEES AGVADLITSC SGGRNFRCAK 350
    MAVAEGLSVE EIEKRELNGQ LLQGTSTAKE VNSFLKARGL EKDYPLFTAV 400
    HGILEGRHSV DDIPSLVSDS 420
    Length:420
    Mass (Da):45,278
    Last modified:October 1, 2003 - v1
    Checksum:iECCB6A3D3D1DF128
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY331190 mRNA. Translation: AAP94992.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY331190 mRNA. Translation: AAP94992.1 .

    3D structure databases

    ProteinModelPortali Q7Z8E7.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 1.10.1040.10. 1 hit.
    3.40.50.720. 2 hits.
    InterProi IPR008927. 6-PGluconate_DH_C-like.
    IPR013328. DH_multihelical.
    IPR006168. G3P_DH_NAD-dep.
    IPR006109. G3P_DH_NAD-dep_C.
    IPR011128. G3P_DH_NAD-dep_N.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    PANTHERi PTHR11728. PTHR11728. 1 hit.
    Pfami PF07479. NAD_Gly3P_dh_C. 1 hit.
    PF01210. NAD_Gly3P_dh_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000114. Glycerol-3-P_dh. 1 hit.
    PRINTSi PR00077. GPDHDRGNASE.
    SUPFAMi SSF48179. SSF48179. 1 hit.
    PROSITEi PS00957. NAD_G3PDH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Targeted gene disruption of glycerol-3-phosphate dehydrogenase in Colletotrichum gloeosporioides reveals evidence that glycerol is a significant transferred nutrient from host plant to fungal pathogen."
      Wei Y., Shen W., Dauk M., Wang F., Selvaraj G., Zou J.
      J. Biol. Chem. 279:429-435(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiGPD_COLGL
    AccessioniPrimary (citable) accession number: Q7Z8E7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 10, 2006
    Last sequence update: October 1, 2003
    Last modified: October 1, 2014
    This is version 61 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3