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Q7Z8E7

- GPD_COLGL

UniProt

Q7Z8E7 - GPD_COLGL

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Protein

Glycerol-3-phosphate dehydrogenase [NAD(+)]

Gene
N/A
Organism
Colletotrichum gloeosporioides (Anthracnose fungus) (Glomerella cingulata)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

sn-glycerol 3-phosphate + NAD+ = glycerone phosphate + NADH.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei119 – 1191NADBy similarity
Binding sitei142 – 1421NAD; via amide nitrogenBy similarity
Binding sitei142 – 1421SubstrateBy similarity
Binding sitei175 – 1751NAD; via amide nitrogenBy similarity
Active sitei278 – 2781Proton acceptorBy similarity
Binding sitei344 – 3441NADBy similarity
Binding sitei373 – 3731NADBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi16 – 216NADBy similarity

GO - Molecular functioni

  1. glycerol-3-phosphate dehydrogenase [NAD+] activity Source: UniProtKB-EC
  2. NAD binding Source: InterPro

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
  2. glycerol-3-phosphate catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Names & Taxonomyi

Protein namesi
Recommended name:
Glycerol-3-phosphate dehydrogenase [NAD(+)] (EC:1.1.1.8)
OrganismiColletotrichum gloeosporioides (Anthracnose fungus) (Glomerella cingulata)
Taxonomic identifieri474922 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesHypocreomycetidaeGlomerellalesGlomerellaceaemitosporic GlomerellaceaeColletotrichum

Subcellular locationi

GO - Cellular componenti

  1. glycerol-3-phosphate dehydrogenase complex Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 420420Glycerol-3-phosphate dehydrogenase [NAD(+)]PRO_0000138089Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ7Z8E7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni344 – 3452Substrate bindingBy similarity

Sequence similaritiesi

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
3.40.50.720. 2 hits.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR013328. DH_multihelical.
IPR006168. G3P_DH_NAD-dep.
IPR006109. G3P_DH_NAD-dep_C.
IPR011128. G3P_DH_NAD-dep_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11728. PTHR11728. 1 hit.
PfamiPF07479. NAD_Gly3P_dh_C. 1 hit.
PF01210. NAD_Gly3P_dh_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000114. Glycerol-3-P_dh. 1 hit.
PRINTSiPR00077. GPDHDRGNASE.
SUPFAMiSSF48179. SSF48179. 1 hit.
PROSITEiPS00957. NAD_G3PDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7Z8E7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MASLGADKKH KVTVVGSGNW GSTICKIVAE NTKANPDLFE EAVHMWVFEE
60 70 80 90 100
DVVIDKSSPY YDPAVGDAPQ KLTGVINKYH ENTKYLPGIK LPDNIIANPS
110 120 130 140 150
LQDAVKDSTI LVFNLPHQFI GNVCKQLRGH IMPFARGISC IKGVNVSDDG
160 170 180 190 200
ISLFSEWIGD GLGIYCGALS GANIASEIAA EKWSETTIAY DPPPMDNSRA
210 220 230 240 250
PTPRSNSPAN GNGIAPLTPV EMQHKDARGR TSKTKLTPVP AEYPPLDHQI
260 270 280 290 300
FKQLFHRPYF HVRMVSDVAG VSLGGALKNI VALAAGFVDG RGWGDNAKAA
310 320 330 340 350
IMRVGLLEMV NFGKEFFGQT VHTGTFTEES AGVADLITSC SGGRNFRCAK
360 370 380 390 400
MAVAEGLSVE EIEKRELNGQ LLQGTSTAKE VNSFLKARGL EKDYPLFTAV
410 420
HGILEGRHSV DDIPSLVSDS
Length:420
Mass (Da):45,278
Last modified:October 1, 2003 - v1
Checksum:iECCB6A3D3D1DF128
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY331190 mRNA. Translation: AAP94992.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY331190 mRNA. Translation: AAP94992.1 .

3D structure databases

ProteinModelPortali Q7Z8E7.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 1.10.1040.10. 1 hit.
3.40.50.720. 2 hits.
InterProi IPR008927. 6-PGluconate_DH_C-like.
IPR013328. DH_multihelical.
IPR006168. G3P_DH_NAD-dep.
IPR006109. G3P_DH_NAD-dep_C.
IPR011128. G3P_DH_NAD-dep_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR11728. PTHR11728. 1 hit.
Pfami PF07479. NAD_Gly3P_dh_C. 1 hit.
PF01210. NAD_Gly3P_dh_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000114. Glycerol-3-P_dh. 1 hit.
PRINTSi PR00077. GPDHDRGNASE.
SUPFAMi SSF48179. SSF48179. 1 hit.
PROSITEi PS00957. NAD_G3PDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Targeted gene disruption of glycerol-3-phosphate dehydrogenase in Colletotrichum gloeosporioides reveals evidence that glycerol is a significant transferred nutrient from host plant to fungal pathogen."
    Wei Y., Shen W., Dauk M., Wang F., Selvaraj G., Zou J.
    J. Biol. Chem. 279:429-435(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiGPD_COLGL
AccessioniPrimary (citable) accession number: Q7Z8E7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: October 1, 2003
Last modified: October 1, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3