Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Dihydroorotate dehydrogenase (fumarate)

Gene

URA1

Organism
Saccharomyces bayanus (Yeast) (Saccharomyces uvarum x Saccharomyces eubayanus)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the conversion of dihydroorotate to orotate with fumarate as the electron acceptor.By similarity

Catalytic activityi

(S)-dihydroorotate + fumarate = orotate + succinate.

Cofactori

FMNBy similarityNote: Binds 1 FMN per subunit.By similarity

Pathwayi: UMP biosynthesis via de novo pathway

This protein is involved in the pathway UMP biosynthesis via de novo pathway, which is part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the pathway UMP biosynthesis via de novo pathway and in Pyrimidine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei46SubstrateBy similarity1
Binding sitei130FMNBy similarity1
Binding sitei130SubstrateBy similarity1
Active sitei132NucleophileBy similarity1
Active sitei133NucleophileBy similarity1
Binding sitei167FMNBy similarity1
Binding sitei195FMN; via carbonyl oxygenBy similarity1
Binding sitei224FMN; via amide nitrogenBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi46 – 47FMNBy similarity2
Nucleotide bindingi252 – 253FMNBy similarity2
Nucleotide bindingi274 – 275FMNBy similarity2

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processPyrimidine biosynthesis
LigandFlavoprotein, FMN

Enzyme and pathway databases

UniPathwayiUPA00070

Names & Taxonomyi

Protein namesi
Recommended name:
Dihydroorotate dehydrogenase (fumarate) (EC:1.3.98.1)
Short name:
DHOD
Short name:
DHODase
Short name:
DHOdehase
Alternative name(s):
Dihydroorotate oxidase
Gene namesi
Name:URA1
OrganismiSaccharomyces bayanus (Yeast) (Saccharomyces uvarum x Saccharomyces eubayanus)
Taxonomic identifieri4931 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001485011 – 314Dihydroorotate dehydrogenase (fumarate)Add BLAST314

Proteomic databases

PRIDEiQ7Z894

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ7Z894
SMRiQ7Z894
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni70 – 74Substrate bindingBy similarity5
Regioni196 – 197Substrate bindingBy similarity2

Sequence similaritiesi

Family and domain databases

CDDicd04741 DHOD_1A_like, 1 hit
Gene3Di2.30.26.10, 2 hits
3.20.20.70, 3 hits
HAMAPiMF_00224 DHO_dh_type1, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR033886 DHOD_1A
IPR023359 Dihydro_DH_chainA_dom2
IPR005720 Dihydroorotate_DH
IPR024920 Dihydroorotate_DH_1
IPR012135 Dihydroorotate_DH_1_2
IPR001295 Dihydroorotate_DH_CS
PfamiView protein in Pfam
PF01180 DHO_dh, 1 hit
PIRSFiPIRSF000164 DHO_oxidase, 1 hit
TIGRFAMsiTIGR01037 pyrD_sub1_fam, 1 hit
PROSITEiView protein in PROSITE
PS00911 DHODEHASE_1, 1 hit
PS00912 DHODEHASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q7Z894-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTASLTTKFL DNTYENPFMN ASGVHCMTTP ELDELANSKA GAFITKSATT
60 70 80 90 100
LEREGNPKPR YISVPLGSIN SMGLPNEGVD YYLSHVLNRQ KKYPDAPAIF
110 120 130 140 150
FSVAGMSIDE NLGLLKKIQE SEFNGITELN LSCPNVPGKP QVAYDFDLTK
160 170 180 190 200
ETLEKVFAFF NKPLGIKLPP YFDFAHFDIM AKILNEFPLA YVNSINSVGN
210 220 230 240 250
GLFIDVEKES VVVKPKNGFG GIGGEYVKPT ALANVRAFYT RLRPEIKIIG
260 270 280 290 300
TGGIKSGKDA FEHLLCGASM LQIGTELQKE GVQIFERIER ELKDIMEAKG
310
YTSIDEFRGK LNSL
Length:314
Mass (Da):34,702
Last modified:October 1, 2003 - v1
Checksum:iDB479332CDEA49E7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY323900 Genomic DNA Translation: AAQ01777.1

Similar proteinsi

Entry informationi

Entry nameiPYRD_SACBA
AccessioniPrimary (citable) accession number: Q7Z894
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: October 1, 2003
Last modified: May 23, 2018
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health