Reviewed, UniProtKB/Swiss-Prot Q7Z7S3 (TRXB_PNECA)

Names and origin

Protein names

Recommended name:
    Thioredoxin reductase
    EC=1.8.1.9

Gene names

Name:

TRR1

Organism

Pneumocystis carinii

Taxonomic identifier

4754 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Pneumocystidomycetes › Pneumocystidaceae › Pneumocystis

Protein attributes

Sequence length	325 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	Thioredoxin + NADP+ = thioredoxin disulfide + NADPH.
Cofactor	Binds 1 FAD per subunit By similarity.
Subunit structure	Homodimer By similarity.
Subcellular location	Cytoplasm By similarity.
Miscellaneous	The active site is a redox-active disulfide bond.
Sequence similarities	Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Domain	Redox-active center
Ligand	FAD Flavoprotein NADP
Molecular function	Oxidoreductase
PTM	Disulfide bond
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW removal of superoxide radicals Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	FAD binding Inferred from electronic annotation. Source: InterPro electron carrier activity Inferred from electronic annotation. Source: InterPro thioredoxin-disulfide reductase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 325	325	Thioredoxin reductase		PRO_0000166766
Regions
	Nucleotide binding	32 – 44	13	FAD By similarity
	Nucleotide binding	286 – 295	10	FAD By similarity
Amino acid modifications
	Disulfide bond	140 ↔ 143		Redox-active By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q7Z7S3-1 [UniParc]. Last modified October 1, 2003. Version 1. Checksum: 7363B063F8293730	FASTA	325	35,282
	10 20 30 40 50 60 MHSKVVIIGS GPSGHTAAIY LGRAELKPIL YEGMLANGIA PGGQLTTTTD VENYPGFPDG 70 80 90 100 110 120 ILGPSLMEAF RKQSEKYGAQ IITDTVSKLD LSKRPFKYCC ESNEEVFHTA DVVILATGAY 130 140 150 160 170 180 ARRLNIPGEE IYWQRGISAC AVCDGAAPIF RGKPLAVVGG GDSAAEESLF LTRYATKVYL 190 200 210 220 230 240 LVRRDKLRAS PIMAKRLLHH PKIEILWNTV ALESLGDNNL MNCVKIKNVK TQEVSELQVN 250 260 270 280 290 300 GLFYAIGHEP ATTLVRGQVE CDKDGYIITK NGGPETNIKG FFAAGDVQDK KWRQAVTSAG 310 320 SGCMAGLAAE RLLAEEEEMK NIEDS

References

[1]	"Characterization of thioredoxin reductase genes (trr1) from Pneumocystis carinii and Pneumocystis jiroveci." Kutty G.K., Huang S.N., Kovacs J.A. Gene 310:175-183(2003) [PubMed: 12801645] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF532987 mRNA. Translation: AAP72146.1. AF541944 Genomic DNA. Translation: AAP72148.1.
3D structure databases
HSSP	HSSP built from PDB template 1CL0 based on UniProtKB P09625.
ModBase	Search...
Enzyme and pathway databases
BRENDA	1.8.1.9. 3409.
Family and domain databases
InterPro	IPR013027. FAD_pyr_nucl-diS_OxRdtase. IPR008255. Pyr_nucl-diS_OxRdtase_2_AS. IPR001327. Pyr_OxRdtase_NAD_bd. IPR000103. Pyridine_nuc-diS_OxRdtase_2. IPR005982. Thioredox_Rdtase. [Graphical view]
Pfam	PF00070. Pyr_redox. 1 hit. PF07992. Pyr_redox_2. 1 hit. [Graphical view]
PRINTS	PR00368. FADPNR. PR00469. PNDRDTASEII.
ProDom	PD000139. FAD_pyr_redox. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR01292. TRX_reduct. 1 hit.
PROSITE	PS00573. PYRIDINE_REDOX_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TRXB_PNECA

Accession

Primary (citable) accession number: Q7Z7S3

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 9, 2004
Last sequence update:	October 1, 2003
Last modified:	June 16, 2009
This is version 30 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)