Q7Z7N9 (T179B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Transmembrane protein 179B

Gene names

Name:

TMEM179B

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	219 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Membrane; Multi-pass membrane protein Potential.
Sequence similarities	Belongs to the TMEM179 family.

Ontologies

Keywords
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 219	219	Transmembrane protein 179B		PRO_0000328987
Regions
	Transmembrane	9 – 29	21	Helical; Potential
	Transmembrane	65 – 85	21	Helical; Potential
	Transmembrane	96 – 116	21	Helical; Potential
	Transmembrane	167 – 187	21	Helical; Potential
Amino acid modifications
	Modified residue	206	1	Phosphoserine Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Q7Z7N9 [UniParc]. Last modified October 1, 2003. Version 1. Checksum: 0D9EE5D760A0A10E	FASTA	219	23,550
	10 20 30 40 50 60 MALSWLQRVE LALFAAAFLC GAVAAAAMTR TQGSFSGRCP LYGVATLNGS SLALSRPSAP 70 80 90 100 110 120 SLCYFVAGAS GLLALYCLLL LLFWIYSSCI EDSHRGAIGL RIALAISAIA VFLVLVSACI 130 140 150 160 170 180 LRFGTRSLCN SIISLNTTIS CSEAQKIPWT PPGTALQFYS NLHNAETSSW VNLVLWCVVL 190 200 210 VLQVVQWKSE ATPYRPLERG DPEWSSETDA LVGSRLSHS

References

[1]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Ovary.
[3]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-206, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CH471076 Genomic DNA. Translation: EAW74098.1. BC051355 mRNA. Translation: AAH51355.1.
IPI	IPI00334453.
RefSeq	NP_955369.1. NM_199337.2.
UniGene	Hs.381134.
3D structure databases
ProteinModelPortal	Q7Z7N9.
ModBase	Search...
Protein-protein interaction databases
MINT	MINT-7034562.
PTM databases
PhosphoSite	Q7Z7N9.
Polymorphism databases
DMDM	74738902.
Proteomic databases
PaxDb	Q7Z7N9.
PRIDE	Q7Z7N9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000333449; ENSP00000333697; ENSG00000185475.
GeneID	374395.
KEGG	hsa:374395.
UCSC	uc001nvd.4. human.
Organism-specific databases
CTD	374395.
GeneCards	GC11P062554.
HGNC	HGNC:33744. TMEM179B.
HPA	HPA016585.
neXtProt	NX_Q7Z7N9.
PharmGKB	PA162405996.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG41412.
HOGENOM	HOG000154483.
HOVERGEN	HBG095581.
InParanoid	Q7Z7N9.
OMA	WVYSSCI.
OrthoDB	EOG49ZXQH.
PhylomeDB	Q7Z7N9.
Gene expression databases
ArrayExpress	Q7Z7N9.
Bgee	Q7Z7N9.
CleanEx	HS_TMEM179B.
Genevestigator	Q7Z7N9.
Family and domain databases
ProtoNet	Search...
Other
ChiTaRS	TMEM179B. human.
GenomeRNAi	374395.
NextBio	100178.

Entry information

Entry name

T179B_HUMAN

Accession

Primary (citable) accession number: Q7Z7N9

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 8, 2008
Last sequence update:	October 1, 2003
Last modified:	April 3, 2013
This is version 65 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.