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Q7Z7N9 (T179B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Transmembrane protein 179B
Gene names
Name:TMEM179B
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length219 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Sequence similarities

Belongs to the TMEM179 family.

Ontologies

Keywords
   Cellular componentMembrane
   DomainTransmembrane
Transmembrane helix
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 219219Transmembrane protein 179B
PRO_0000328987

Regions

Transmembrane9 – 2921Helical; Potential
Transmembrane65 – 8521Helical; Potential
Transmembrane96 – 11621Helical; Potential
Transmembrane167 – 18721Helical; Potential

Amino acid modifications

Modified residue2061Phosphoserine Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q7Z7N9 [UniParc].

Last modified October 1, 2003. Version 1.
Checksum: 0D9EE5D760A0A10E

FASTA21923,550
        10         20         30         40         50         60 
MALSWLQRVE LALFAAAFLC GAVAAAAMTR TQGSFSGRCP LYGVATLNGS SLALSRPSAP 

        70         80         90        100        110        120 
SLCYFVAGAS GLLALYCLLL LLFWIYSSCI EDSHRGAIGL RIALAISAIA VFLVLVSACI 

       130        140        150        160        170        180 
LRFGTRSLCN SIISLNTTIS CSEAQKIPWT PPGTALQFYS NLHNAETSSW VNLVLWCVVL 

       190        200        210 
VLQVVQWKSE ATPYRPLERG DPEWSSETDA LVGSRLSHS 

« Hide

References

[1]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Ovary.
[3]"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-206, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Leukemic T-cell.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CH471076 Genomic DNA. Translation: EAW74098.1.
BC051355 mRNA. Translation: AAH51355.1.
CCDSCCDS8036.1.
RefSeqNP_955369.1. NM_199337.2.
UniGeneHs.381134.

3D structure databases

ProteinModelPortalQ7Z7N9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid131898. 2 interactions.
MINTMINT-7034562.

PTM databases

PhosphoSiteQ7Z7N9.

Polymorphism databases

DMDM74738902.

Proteomic databases

MaxQBQ7Z7N9.
PaxDbQ7Z7N9.
PRIDEQ7Z7N9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000333449; ENSP00000333697; ENSG00000185475.
GeneID374395.
KEGGhsa:374395.
UCSCuc001nvd.4. human.

Organism-specific databases

CTD374395.
GeneCardsGC11P062554.
HGNCHGNC:33744. TMEM179B.
HPAHPA016585.
neXtProtNX_Q7Z7N9.
PharmGKBPA162405996.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG41412.
HOGENOMHOG000154483.
HOVERGENHBG095581.
InParanoidQ7Z7N9.
OMALFWVYSS.
PhylomeDBQ7Z7N9.
TreeFamTF324841.

Gene expression databases

ArrayExpressQ7Z7N9.
BgeeQ7Z7N9.
CleanExHS_TMEM179B.
GenevestigatorQ7Z7N9.

Family and domain databases

ProtoNetSearch...

Other

ChiTaRSTMEM179B. human.
GenomeRNAi374395.
NextBio100178.
PROQ7Z7N9.

Entry information

Entry nameT179B_HUMAN
AccessionPrimary (citable) accession number: Q7Z7N9
Entry history
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: October 1, 2003
Last modified: July 9, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM