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Q7Z7N9

- T179B_HUMAN

UniProt

Q7Z7N9 - T179B_HUMAN

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Protein

Transmembrane protein 179B

Gene

TMEM179B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 179B
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:33744. TMEM179B.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162405996.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 219219Transmembrane protein 179BPRO_0000328987Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei206 – 2061Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ7Z7N9.
PaxDbiQ7Z7N9.
PRIDEiQ7Z7N9.

PTM databases

PhosphoSiteiQ7Z7N9.

Expressioni

Gene expression databases

BgeeiQ7Z7N9.
CleanExiHS_TMEM179B.
ExpressionAtlasiQ7Z7N9. baseline.
GenevestigatoriQ7Z7N9.

Organism-specific databases

HPAiHPA016585.

Interactioni

Protein-protein interaction databases

BioGridi131898. 6 interactions.
MINTiMINT-7034562.

Structurei

3D structure databases

ProteinModelPortaliQ7Z7N9.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei9 – 2921HelicalSequence AnalysisAdd
BLAST
Transmembranei65 – 8521HelicalSequence AnalysisAdd
BLAST
Transmembranei96 – 11621HelicalSequence AnalysisAdd
BLAST
Transmembranei167 – 18721HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the TMEM179 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG41412.
GeneTreeiENSGT00510000048151.
HOGENOMiHOG000154483.
HOVERGENiHBG095581.
InParanoidiQ7Z7N9.
OMAiLFWVYSS.
PhylomeDBiQ7Z7N9.
TreeFamiTF324841.

Family and domain databases

InterProiIPR029776. TMEM179B.
[Graphical view]
PANTHERiPTHR31056:SF1. PTHR31056:SF1. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7Z7N9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MALSWLQRVE LALFAAAFLC GAVAAAAMTR TQGSFSGRCP LYGVATLNGS
60 70 80 90 100
SLALSRPSAP SLCYFVAGAS GLLALYCLLL LLFWIYSSCI EDSHRGAIGL
110 120 130 140 150
RIALAISAIA VFLVLVSACI LRFGTRSLCN SIISLNTTIS CSEAQKIPWT
160 170 180 190 200
PPGTALQFYS NLHNAETSSW VNLVLWCVVL VLQVVQWKSE ATPYRPLERG
210
DPEWSSETDA LVGSRLSHS
Length:219
Mass (Da):23,550
Last modified:October 1, 2003 - v1
Checksum:i0D9EE5D760A0A10E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH471076 Genomic DNA. Translation: EAW74098.1.
BC051355 mRNA. Translation: AAH51355.1.
CCDSiCCDS8036.1.
RefSeqiNP_955369.1. NM_199337.2.
UniGeneiHs.381134.

Genome annotation databases

EnsembliENST00000333449; ENSP00000333697; ENSG00000185475.
GeneIDi374395.
KEGGihsa:374395.
UCSCiuc001nvd.4. human.

Polymorphism databases

DMDMi74738902.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH471076 Genomic DNA. Translation: EAW74098.1 .
BC051355 mRNA. Translation: AAH51355.1 .
CCDSi CCDS8036.1.
RefSeqi NP_955369.1. NM_199337.2.
UniGenei Hs.381134.

3D structure databases

ProteinModelPortali Q7Z7N9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 131898. 6 interactions.
MINTi MINT-7034562.

PTM databases

PhosphoSitei Q7Z7N9.

Polymorphism databases

DMDMi 74738902.

Proteomic databases

MaxQBi Q7Z7N9.
PaxDbi Q7Z7N9.
PRIDEi Q7Z7N9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000333449 ; ENSP00000333697 ; ENSG00000185475 .
GeneIDi 374395.
KEGGi hsa:374395.
UCSCi uc001nvd.4. human.

Organism-specific databases

CTDi 374395.
GeneCardsi GC11P062554.
HGNCi HGNC:33744. TMEM179B.
HPAi HPA016585.
neXtProti NX_Q7Z7N9.
PharmGKBi PA162405996.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG41412.
GeneTreei ENSGT00510000048151.
HOGENOMi HOG000154483.
HOVERGENi HBG095581.
InParanoidi Q7Z7N9.
OMAi LFWVYSS.
PhylomeDBi Q7Z7N9.
TreeFami TF324841.

Miscellaneous databases

ChiTaRSi TMEM179B. human.
GenomeRNAii 374395.
NextBioi 100178.
PROi Q7Z7N9.

Gene expression databases

Bgeei Q7Z7N9.
CleanExi HS_TMEM179B.
ExpressionAtlasi Q7Z7N9. baseline.
Genevestigatori Q7Z7N9.

Family and domain databases

InterProi IPR029776. TMEM179B.
[Graphical view ]
PANTHERi PTHR31056:SF1. PTHR31056:SF1. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Ovary.
  3. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-206, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.

Entry informationi

Entry nameiT179B_HUMAN
AccessioniPrimary (citable) accession number: Q7Z7N9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: October 1, 2003
Last modified: October 29, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3