Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Transmembrane protein 179B

Gene

TMEM179B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 179B
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:33744. TMEM179B.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei9 – 2921HelicalSequence AnalysisAdd
BLAST
Transmembranei65 – 8521HelicalSequence AnalysisAdd
BLAST
Transmembranei96 – 11621HelicalSequence AnalysisAdd
BLAST
Transmembranei167 – 18721HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162405996.

Polymorphism and mutation databases

BioMutaiTMEM179B.
DMDMi74738902.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 219219Transmembrane protein 179BPRO_0000328987Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei206 – 2061Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ7Z7N9.
PaxDbiQ7Z7N9.
PRIDEiQ7Z7N9.

PTM databases

PhosphoSiteiQ7Z7N9.

Expressioni

Gene expression databases

BgeeiQ7Z7N9.
CleanExiHS_TMEM179B.
ExpressionAtlasiQ7Z7N9. baseline.
GenevestigatoriQ7Z7N9.

Organism-specific databases

HPAiHPA016585.

Interactioni

Protein-protein interaction databases

BioGridi131898. 7 interactions.
MINTiMINT-7034562.

Structurei

3D structure databases

ProteinModelPortaliQ7Z7N9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TMEM179 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG41412.
GeneTreeiENSGT00510000048151.
HOGENOMiHOG000154483.
HOVERGENiHBG095581.
InParanoidiQ7Z7N9.
OMAiLFWVYSS.
PhylomeDBiQ7Z7N9.
TreeFamiTF324841.

Family and domain databases

InterProiIPR029776. TMEM179B.
[Graphical view]
PANTHERiPTHR31056:SF1. PTHR31056:SF1. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7Z7N9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALSWLQRVE LALFAAAFLC GAVAAAAMTR TQGSFSGRCP LYGVATLNGS
60 70 80 90 100
SLALSRPSAP SLCYFVAGAS GLLALYCLLL LLFWIYSSCI EDSHRGAIGL
110 120 130 140 150
RIALAISAIA VFLVLVSACI LRFGTRSLCN SIISLNTTIS CSEAQKIPWT
160 170 180 190 200
PPGTALQFYS NLHNAETSSW VNLVLWCVVL VLQVVQWKSE ATPYRPLERG
210
DPEWSSETDA LVGSRLSHS
Length:219
Mass (Da):23,550
Last modified:October 1, 2003 - v1
Checksum:i0D9EE5D760A0A10E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471076 Genomic DNA. Translation: EAW74098.1.
BC051355 mRNA. Translation: AAH51355.1.
CCDSiCCDS8036.1.
RefSeqiNP_955369.1. NM_199337.2.
UniGeneiHs.381134.

Genome annotation databases

EnsembliENST00000333449; ENSP00000333697; ENSG00000185475.
GeneIDi374395.
KEGGihsa:374395.
UCSCiuc001nvd.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471076 Genomic DNA. Translation: EAW74098.1.
BC051355 mRNA. Translation: AAH51355.1.
CCDSiCCDS8036.1.
RefSeqiNP_955369.1. NM_199337.2.
UniGeneiHs.381134.

3D structure databases

ProteinModelPortaliQ7Z7N9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi131898. 7 interactions.
MINTiMINT-7034562.

PTM databases

PhosphoSiteiQ7Z7N9.

Polymorphism and mutation databases

BioMutaiTMEM179B.
DMDMi74738902.

Proteomic databases

MaxQBiQ7Z7N9.
PaxDbiQ7Z7N9.
PRIDEiQ7Z7N9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000333449; ENSP00000333697; ENSG00000185475.
GeneIDi374395.
KEGGihsa:374395.
UCSCiuc001nvd.4. human.

Organism-specific databases

CTDi374395.
GeneCardsiGC11P062554.
HGNCiHGNC:33744. TMEM179B.
HPAiHPA016585.
neXtProtiNX_Q7Z7N9.
PharmGKBiPA162405996.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG41412.
GeneTreeiENSGT00510000048151.
HOGENOMiHOG000154483.
HOVERGENiHBG095581.
InParanoidiQ7Z7N9.
OMAiLFWVYSS.
PhylomeDBiQ7Z7N9.
TreeFamiTF324841.

Miscellaneous databases

ChiTaRSiTMEM179B. human.
GenomeRNAii374395.
NextBioi100178.
PROiQ7Z7N9.

Gene expression databases

BgeeiQ7Z7N9.
CleanExiHS_TMEM179B.
ExpressionAtlasiQ7Z7N9. baseline.
GenevestigatoriQ7Z7N9.

Family and domain databases

InterProiIPR029776. TMEM179B.
[Graphical view]
PANTHERiPTHR31056:SF1. PTHR31056:SF1. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Ovary.
  3. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-206, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.

Entry informationi

Entry nameiT179B_HUMAN
AccessioniPrimary (citable) accession number: Q7Z7N9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: October 1, 2003
Last modified: May 27, 2015
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.