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Q7Z7M1

- GP144_HUMAN

UniProt

Q7Z7M1 - GP144_HUMAN

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Protein

Probable G-protein coupled receptor 144

Gene

GPR144

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Orphan receptor.

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: GDB

GO - Biological processi

  1. G-protein coupled receptor signaling pathway Source: GDB
  2. neuropeptide signaling pathway Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Protein family/group databases

MEROPSiS63.018.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable G-protein coupled receptor 144
Alternative name(s):
G-protein coupled receptor PGR24
Gene namesi
Name:GPR144
Synonyms:PGR24
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 9

Organism-specific databases

HGNCiHGNC:18651. GPR144.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 662662ExtracellularSequence AnalysisAdd
BLAST
Transmembranei663 – 68321Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini684 – 6918CytoplasmicSequence Analysis
Transmembranei692 – 71221Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini713 – 7208ExtracellularSequence Analysis
Transmembranei721 – 74121Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini742 – 76221CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei763 – 78321Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini784 – 80017ExtracellularSequence AnalysisAdd
BLAST
Transmembranei801 – 82121Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini822 – 85736CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei858 – 87821Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini879 – 8802ExtracellularSequence Analysis
Transmembranei881 – 90121Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini902 – 96362CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: GDB
  2. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134882616.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 963963Probable G-protein coupled receptor 144PRO_0000070338Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi271 – 2711N-linked (GlcNAc...)Sequence Analysis
Glycosylationi634 – 6341N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ7Z7M1.
PRIDEiQ7Z7M1.

PTM databases

PhosphoSiteiQ7Z7M1.

Expressioni

Gene expression databases

BgeeiQ7Z7M1.
CleanExiHS_GPR144.
GenevestigatoriQ7Z7M1.

Organism-specific databases

HPAiHPA049597.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000335156.

Structurei

3D structure databases

ProteinModelPortaliQ7Z7M1.
SMRiQ7Z7M1. Positions 120-321, 661-897.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini131 – 311181PentaxinAdd
BLAST
Domaini572 – 64877GPSPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 GPS domain.PROSITE-ProRule annotation
Contains 1 pentaxin domain.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG319967.
HOGENOMiHOG000112770.
HOVERGENiHBG051785.
InParanoidiQ7Z7M1.
KOiK08466.
OMAiCPVPSEE.
OrthoDBiEOG7966G0.
PhylomeDBiQ7Z7M1.
TreeFamiTF351999.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
InterProiIPR013320. ConA-like_dom.
IPR017981. GPCR_2-like.
IPR000832. GPCR_2_secretin-like.
IPR000203. GPS.
IPR001759. Pentaxin.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
PF01825. GPS. 1 hit.
PF00354. Pentaxin. 1 hit.
[Graphical view]
PRINTSiPR00895. PENTAXIN.
SMARTiSM00303. GPS. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7Z7M1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDAPWGAGER WLHGAAVDRS GVSLGPPPTP QVNQGTLGPQ VAPVAAGEVV
60 70 80 90 100
KTAGGVCKFS GQRLSWWQAQ ESCEQQFGHL ALQPPDGVLA SRLRDPVWVG
110 120 130 140 150
QREAPLRRPP QRRARTTAVL VFDERTADRA ARLRSPLPEL AALTACTHVQ
160 170 180 190 200
WDCASPDPAA LFSVAAPALP NALQLRAFAE PGGVVRAALV VRGQHAPFLA
210 220 230 240 250
AFRADGRWHH VCATWEQRGG RWALFSDGRR RAGARGLGAG HPVPSGGILV
260 270 280 290 300
LGQDQDSLGG GFSVRHALSG NLTDFHLWAR ALSPAQLHRA RACAPPSEGL
310 320 330 340 350
LFRWDPGALD VTPSLLPTVW VRLLCPVPSE ECPTWNPGPR SEGSELCLEP
360 370 380 390 400
QPFLCCYRTE PYRRLQDAQS WPGQDVISRV NALANDIVLL PDPLSEVHGA
410 420 430 440 450
LSPAEASSFL GLLEHVLAME MAPLGPAALL AVVRFLKRVV ALGAGDPELL
460 470 480 490 500
LTGPWEQLSQ GVVSVASLVL EEQVADTWLS LREVIGGPMA LVASVQRLAP
510 520 530 540 550
LLSTSMTSER PRMRIQHRHA GLSGVTVIHS WFTSRVFQHT LEGPDLEPQA
560 570 580 590 600
PASSEEANRV QRFLSTQVGS AIISSEVWDV TGEVNVAMTF HLQHRAQSPL
610 620 630 640 650
FPPHPPSPYT GGAWATTGCS VAALYLDSTA CFCNHSTSFA ILLQIYEVQR
660 670 680 690 700
GPEEESLLRT LSFVGCGVSF CALTTTFLLF LVAGVPKSER TTVHKNLTFS
710 720 730 740 750
LASAEGFLMT SEWAKANEVA CVAVTVAMHF LFLVAFSWML VEGLLLWRKV
760 770 780 790 800
VAVSMHPGPG MRLYHATGWG VPVGIVAVTL AMLPHDYVAP GHCWLNVHTN
810 820 830 840 850
AIWAFVGPVL FVLTANTCIL ARVVMITVSS ARRRARMLSP QPCLQQQIWT
860 870 880 890 900
QIWATVKPVL VLLPVLGLTW LAGILVHLSP AWAYAAVGLN SIQGLYIFLV
910 920 930 940 950
YAACNEEVRS ALQRMAEKKV AEVLRALGVW GGAAKEHSLP FSVLPLFLPP
960
KPSTPRHPLK APA
Length:963
Mass (Da):104,087
Last modified:October 1, 2003 - v1
Checksum:iEA7BEE0663F7A54C
GO

Sequence cautioni

The sequence BAC05829.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY278562 mRNA. Translation: AAP35064.1.
AB065601 Genomic DNA. Translation: BAC05829.1. Sequence problems.
AL137846 Genomic DNA. Translation: CAI10884.1.
AY255620 mRNA. Translation: AAO85132.1.
RefSeqiXP_006717411.1. XM_006717348.1.
UniGeneiHs.454099.

Genome annotation databases

EnsembliENST00000334810; ENSP00000335156; ENSG00000180264.
GeneIDi347088.
KEGGihsa:347088.
UCSCiuc010mwn.3. human.

Polymorphism databases

DMDMi59797942.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY278562 mRNA. Translation: AAP35064.1 .
AB065601 Genomic DNA. Translation: BAC05829.1 . Sequence problems.
AL137846 Genomic DNA. Translation: CAI10884.1 .
AY255620 mRNA. Translation: AAO85132.1 .
RefSeqi XP_006717411.1. XM_006717348.1.
UniGenei Hs.454099.

3D structure databases

ProteinModelPortali Q7Z7M1.
SMRi Q7Z7M1. Positions 120-321, 661-897.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000335156.

Protein family/group databases

MEROPSi S63.018.
GPCRDBi Search...

PTM databases

PhosphoSitei Q7Z7M1.

Polymorphism databases

DMDMi 59797942.

Proteomic databases

PaxDbi Q7Z7M1.
PRIDEi Q7Z7M1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000334810 ; ENSP00000335156 ; ENSG00000180264 .
GeneIDi 347088.
KEGGi hsa:347088.
UCSCi uc010mwn.3. human.

Organism-specific databases

CTDi 347088.
GeneCardsi GC09P127213.
HGNCi HGNC:18651. GPR144.
HPAi HPA049597.
neXtProti NX_Q7Z7M1.
PharmGKBi PA134882616.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG319967.
HOGENOMi HOG000112770.
HOVERGENi HBG051785.
InParanoidi Q7Z7M1.
KOi K08466.
OMAi CPVPSEE.
OrthoDBi EOG7966G0.
PhylomeDBi Q7Z7M1.
TreeFami TF351999.

Miscellaneous databases

GeneWikii GPR144.
GenomeRNAii 347088.
NextBioi 99034.
PROi Q7Z7M1.

Gene expression databases

Bgeei Q7Z7M1.
CleanExi HS_GPR144.
Genevestigatori Q7Z7M1.

Family and domain databases

Gene3Di 2.60.120.200. 1 hit.
InterProi IPR013320. ConA-like_dom.
IPR017981. GPCR_2-like.
IPR000832. GPCR_2_secretin-like.
IPR000203. GPS.
IPR001759. Pentaxin.
[Graphical view ]
Pfami PF00002. 7tm_2. 1 hit.
PF01825. GPS. 1 hit.
PF00354. Pentaxin. 1 hit.
[Graphical view ]
PRINTSi PR00895. PENTAXIN.
SMARTi SM00303. GPS. 1 hit.
[Graphical view ]
SUPFAMi SSF49899. SSF49899. 1 hit.
PROSITEi PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The human and mouse repertoire of the adhesion family of G-protein-coupled receptors."
    Bjarnadottir T.K., Fredriksson R., Hoeglund P.J., Gloriam D.E., Lagerstroem M.C., Schioeth H.B.
    Genomics 84:23-33(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 619-897.

Entry informationi

Entry nameiGP144_HUMAN
AccessioniPrimary (citable) accession number: Q7Z7M1
Secondary accession number(s): Q86SL4, Q8NH12
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: October 1, 2003
Last modified: October 29, 2014
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3