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Protein

Adhesion G-protein coupled receptor D2

Gene

ADGRD2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Orphan receptor.

GO - Molecular functioni

  • G-protein coupled receptor activity Source: GDB

GO - Biological processi

  • G-protein coupled receptor signaling pathway Source: GDB
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Protein family/group databases

MEROPSiS63.018.

Names & Taxonomyi

Protein namesi
Recommended name:
Adhesion G-protein coupled receptor D21 Publication
Alternative name(s):
G-protein coupled receptor 144
G-protein coupled receptor PGR24
Gene namesi
Name:ADGRD2
Synonyms:GPR144, PGR24
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:18651. ADGRD2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 662662ExtracellularCuratedAdd
BLAST
Transmembranei663 – 68321Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini684 – 6918CytoplasmicCurated
Transmembranei692 – 71221Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini713 – 7208ExtracellularCurated
Transmembranei721 – 74121Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini742 – 76221CytoplasmicCuratedAdd
BLAST
Transmembranei763 – 78321Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini784 – 80017ExtracellularCuratedAdd
BLAST
Transmembranei801 – 82121Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini822 – 85736CytoplasmicCuratedAdd
BLAST
Transmembranei858 – 87821Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini879 – 8802ExtracellularCurated
Transmembranei881 – 90121Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini902 – 96362CytoplasmicCuratedAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: GDB
  • plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134882616.

Polymorphism and mutation databases

DMDMi59797942.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 963963Adhesion G-protein coupled receptor D2PRO_0000070338Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi271 – 2711N-linked (GlcNAc...)Sequence Analysis
Glycosylationi634 – 6341N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ7Z7M1.
PRIDEiQ7Z7M1.

PTM databases

PhosphoSiteiQ7Z7M1.

Expressioni

Gene expression databases

BgeeiQ7Z7M1.
CleanExiHS_GPR144.
ExpressionAtlasiQ7Z7M1. baseline.
GenevisibleiQ7Z7M1. HS.

Organism-specific databases

HPAiHPA049597.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000335156.

Structurei

3D structure databases

ProteinModelPortaliQ7Z7M1.
SMRiQ7Z7M1. Positions 120-321, 661-897.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini131 – 311181PentaxinAdd
BLAST
Domaini572 – 64877GPSPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 GPS domain.PROSITE-ProRule annotation
Contains 1 pentaxin domain.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG319967.
HOGENOMiHOG000112770.
HOVERGENiHBG051785.
InParanoidiQ7Z7M1.
KOiK08466.
OMAiALSFTNC.
OrthoDBiEOG7966G0.
PhylomeDBiQ7Z7M1.
TreeFamiTF351999.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
InterProiIPR013320. ConA-like_dom.
IPR017981. GPCR_2-like.
IPR000832. GPCR_2_secretin-like.
IPR000203. GPS.
IPR001759. Pentaxin.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
PF01825. GPS. 1 hit.
PF00354. Pentaxin. 1 hit.
[Graphical view]
PRINTSiPR00895. PENTAXIN.
SMARTiSM00303. GPS. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7Z7M1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDAPWGAGER WLHGAAVDRS GVSLGPPPTP QVNQGTLGPQ VAPVAAGEVV
60 70 80 90 100
KTAGGVCKFS GQRLSWWQAQ ESCEQQFGHL ALQPPDGVLA SRLRDPVWVG
110 120 130 140 150
QREAPLRRPP QRRARTTAVL VFDERTADRA ARLRSPLPEL AALTACTHVQ
160 170 180 190 200
WDCASPDPAA LFSVAAPALP NALQLRAFAE PGGVVRAALV VRGQHAPFLA
210 220 230 240 250
AFRADGRWHH VCATWEQRGG RWALFSDGRR RAGARGLGAG HPVPSGGILV
260 270 280 290 300
LGQDQDSLGG GFSVRHALSG NLTDFHLWAR ALSPAQLHRA RACAPPSEGL
310 320 330 340 350
LFRWDPGALD VTPSLLPTVW VRLLCPVPSE ECPTWNPGPR SEGSELCLEP
360 370 380 390 400
QPFLCCYRTE PYRRLQDAQS WPGQDVISRV NALANDIVLL PDPLSEVHGA
410 420 430 440 450
LSPAEASSFL GLLEHVLAME MAPLGPAALL AVVRFLKRVV ALGAGDPELL
460 470 480 490 500
LTGPWEQLSQ GVVSVASLVL EEQVADTWLS LREVIGGPMA LVASVQRLAP
510 520 530 540 550
LLSTSMTSER PRMRIQHRHA GLSGVTVIHS WFTSRVFQHT LEGPDLEPQA
560 570 580 590 600
PASSEEANRV QRFLSTQVGS AIISSEVWDV TGEVNVAMTF HLQHRAQSPL
610 620 630 640 650
FPPHPPSPYT GGAWATTGCS VAALYLDSTA CFCNHSTSFA ILLQIYEVQR
660 670 680 690 700
GPEEESLLRT LSFVGCGVSF CALTTTFLLF LVAGVPKSER TTVHKNLTFS
710 720 730 740 750
LASAEGFLMT SEWAKANEVA CVAVTVAMHF LFLVAFSWML VEGLLLWRKV
760 770 780 790 800
VAVSMHPGPG MRLYHATGWG VPVGIVAVTL AMLPHDYVAP GHCWLNVHTN
810 820 830 840 850
AIWAFVGPVL FVLTANTCIL ARVVMITVSS ARRRARMLSP QPCLQQQIWT
860 870 880 890 900
QIWATVKPVL VLLPVLGLTW LAGILVHLSP AWAYAAVGLN SIQGLYIFLV
910 920 930 940 950
YAACNEEVRS ALQRMAEKKV AEVLRALGVW GGAAKEHSLP FSVLPLFLPP
960
KPSTPRHPLK APA
Length:963
Mass (Da):104,087
Last modified:October 1, 2003 - v1
Checksum:iEA7BEE0663F7A54C
GO

Sequence cautioni

The sequence BAC05829.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY278562 mRNA. Translation: AAP35064.1.
AB065601 Genomic DNA. Translation: BAC05829.1. Sequence problems.
AL137846 Genomic DNA. Translation: CAI10884.1.
AY255620 mRNA. Translation: AAO85132.1.
UniGeneiHs.454099.

Genome annotation databases

EnsembliENST00000334810; ENSP00000335156; ENSG00000180264.
KEGGihsa:347088.
UCSCiuc010mwn.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY278562 mRNA. Translation: AAP35064.1.
AB065601 Genomic DNA. Translation: BAC05829.1. Sequence problems.
AL137846 Genomic DNA. Translation: CAI10884.1.
AY255620 mRNA. Translation: AAO85132.1.
UniGeneiHs.454099.

3D structure databases

ProteinModelPortaliQ7Z7M1.
SMRiQ7Z7M1. Positions 120-321, 661-897.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000335156.

Protein family/group databases

MEROPSiS63.018.
GPCRDBiSearch...

PTM databases

PhosphoSiteiQ7Z7M1.

Polymorphism and mutation databases

DMDMi59797942.

Proteomic databases

PaxDbiQ7Z7M1.
PRIDEiQ7Z7M1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000334810; ENSP00000335156; ENSG00000180264.
KEGGihsa:347088.
UCSCiuc010mwn.3. human.

Organism-specific databases

CTDi347088.
GeneCardsiGC09P127213.
HGNCiHGNC:18651. ADGRD2.
HPAiHPA049597.
neXtProtiNX_Q7Z7M1.
PharmGKBiPA134882616.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG319967.
HOGENOMiHOG000112770.
HOVERGENiHBG051785.
InParanoidiQ7Z7M1.
KOiK08466.
OMAiALSFTNC.
OrthoDBiEOG7966G0.
PhylomeDBiQ7Z7M1.
TreeFamiTF351999.

Miscellaneous databases

GeneWikiiGPR144.
GenomeRNAii347088.
NextBioi99034.
PROiQ7Z7M1.

Gene expression databases

BgeeiQ7Z7M1.
CleanExiHS_GPR144.
ExpressionAtlasiQ7Z7M1. baseline.
GenevisibleiQ7Z7M1. HS.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
InterProiIPR013320. ConA-like_dom.
IPR017981. GPCR_2-like.
IPR000832. GPCR_2_secretin-like.
IPR000203. GPS.
IPR001759. Pentaxin.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
PF01825. GPS. 1 hit.
PF00354. Pentaxin. 1 hit.
[Graphical view]
PRINTSiPR00895. PENTAXIN.
SMARTiSM00303. GPS. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The human and mouse repertoire of the adhesion family of G-protein-coupled receptors."
    Bjarnadottir T.K., Fredriksson R., Hoeglund P.J., Gloriam D.E., Lagerstroem M.C., Schioeth H.B.
    Genomics 84:23-33(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 619-897.
  5. Cited for: NOMENCLATURE.

Entry informationi

Entry nameiAGRD2_HUMAN
AccessioniPrimary (citable) accession number: Q7Z7M1
Secondary accession number(s): Q86SL4, Q8NH12
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: October 1, 2003
Last modified: June 24, 2015
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.