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Q7Z7M1

- GP144_HUMAN

UniProt

Q7Z7M1 - GP144_HUMAN

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Protein
Probable G-protein coupled receptor 144
Gene
GPR144, PGR24
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Orphan receptor.

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: GDB
Complete GO annotation...

GO - Biological processi

  1. G-protein coupled receptor signaling pathway Source: GDB
  2. neuropeptide signaling pathway Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Protein family/group databases

MEROPSiS63.018.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable G-protein coupled receptor 144
Alternative name(s):
G-protein coupled receptor PGR24
Gene namesi
Name:GPR144
Synonyms:PGR24
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 9

Organism-specific databases

HGNCiHGNC:18651. GPR144.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 662662Extracellular Reviewed prediction
Add
BLAST
Transmembranei663 – 68321Helical; Name=1; Reviewed prediction
Add
BLAST
Topological domaini684 – 6918Cytoplasmic Reviewed prediction
Transmembranei692 – 71221Helical; Name=2; Reviewed prediction
Add
BLAST
Topological domaini713 – 7208Extracellular Reviewed prediction
Transmembranei721 – 74121Helical; Name=3; Reviewed prediction
Add
BLAST
Topological domaini742 – 76221Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei763 – 78321Helical; Name=4; Reviewed prediction
Add
BLAST
Topological domaini784 – 80017Extracellular Reviewed prediction
Add
BLAST
Transmembranei801 – 82121Helical; Name=5; Reviewed prediction
Add
BLAST
Topological domaini822 – 85736Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei858 – 87821Helical; Name=6; Reviewed prediction
Add
BLAST
Topological domaini879 – 8802Extracellular Reviewed prediction
Transmembranei881 – 90121Helical; Name=7; Reviewed prediction
Add
BLAST
Topological domaini902 – 96362Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: GDB
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134882616.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 963963Probable G-protein coupled receptor 144
PRO_0000070338Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi271 – 2711N-linked (GlcNAc...) Reviewed prediction
Glycosylationi634 – 6341N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ7Z7M1.
PRIDEiQ7Z7M1.

PTM databases

PhosphoSiteiQ7Z7M1.

Expressioni

Gene expression databases

BgeeiQ7Z7M1.
CleanExiHS_GPR144.
GenevestigatoriQ7Z7M1.

Organism-specific databases

HPAiHPA049597.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000335156.

Structurei

3D structure databases

ProteinModelPortaliQ7Z7M1.
SMRiQ7Z7M1. Positions 120-321, 661-897.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini131 – 311181Pentaxin
Add
BLAST
Domaini572 – 64877GPS
Add
BLAST

Sequence similaritiesi

Contains 1 GPS domain.
Contains 1 pentaxin domain.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG319967.
HOGENOMiHOG000112770.
HOVERGENiHBG051785.
InParanoidiQ7Z7M1.
OMAiCPVPSEE.
OrthoDBiEOG7966G0.
PhylomeDBiQ7Z7M1.
TreeFamiTF351999.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
InterProiIPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR017981. GPCR_2-like.
IPR000832. GPCR_2_secretin-like.
IPR000203. GPS.
IPR001759. Pentaxin.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
PF01825. GPS. 1 hit.
PF00354. Pentaxin. 1 hit.
[Graphical view]
PRINTSiPR00895. PENTAXIN.
SMARTiSM00303. GPS. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7Z7M1-1 [UniParc]FASTAAdd to Basket

« Hide

MDAPWGAGER WLHGAAVDRS GVSLGPPPTP QVNQGTLGPQ VAPVAAGEVV    50
KTAGGVCKFS GQRLSWWQAQ ESCEQQFGHL ALQPPDGVLA SRLRDPVWVG 100
QREAPLRRPP QRRARTTAVL VFDERTADRA ARLRSPLPEL AALTACTHVQ 150
WDCASPDPAA LFSVAAPALP NALQLRAFAE PGGVVRAALV VRGQHAPFLA 200
AFRADGRWHH VCATWEQRGG RWALFSDGRR RAGARGLGAG HPVPSGGILV 250
LGQDQDSLGG GFSVRHALSG NLTDFHLWAR ALSPAQLHRA RACAPPSEGL 300
LFRWDPGALD VTPSLLPTVW VRLLCPVPSE ECPTWNPGPR SEGSELCLEP 350
QPFLCCYRTE PYRRLQDAQS WPGQDVISRV NALANDIVLL PDPLSEVHGA 400
LSPAEASSFL GLLEHVLAME MAPLGPAALL AVVRFLKRVV ALGAGDPELL 450
LTGPWEQLSQ GVVSVASLVL EEQVADTWLS LREVIGGPMA LVASVQRLAP 500
LLSTSMTSER PRMRIQHRHA GLSGVTVIHS WFTSRVFQHT LEGPDLEPQA 550
PASSEEANRV QRFLSTQVGS AIISSEVWDV TGEVNVAMTF HLQHRAQSPL 600
FPPHPPSPYT GGAWATTGCS VAALYLDSTA CFCNHSTSFA ILLQIYEVQR 650
GPEEESLLRT LSFVGCGVSF CALTTTFLLF LVAGVPKSER TTVHKNLTFS 700
LASAEGFLMT SEWAKANEVA CVAVTVAMHF LFLVAFSWML VEGLLLWRKV 750
VAVSMHPGPG MRLYHATGWG VPVGIVAVTL AMLPHDYVAP GHCWLNVHTN 800
AIWAFVGPVL FVLTANTCIL ARVVMITVSS ARRRARMLSP QPCLQQQIWT 850
QIWATVKPVL VLLPVLGLTW LAGILVHLSP AWAYAAVGLN SIQGLYIFLV 900
YAACNEEVRS ALQRMAEKKV AEVLRALGVW GGAAKEHSLP FSVLPLFLPP 950
KPSTPRHPLK APA 963
Length:963
Mass (Da):104,087
Last modified:October 1, 2003 - v1
Checksum:iEA7BEE0663F7A54C
GO

Sequence cautioni

The sequence BAC05829.1 differs from that shown. Reason: Erroneous gene model prediction.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY278562 mRNA. Translation: AAP35064.1.
AB065601 Genomic DNA. Translation: BAC05829.1. Sequence problems.
AL137846 Genomic DNA. Translation: CAI10884.1.
AY255620 mRNA. Translation: AAO85132.1.
RefSeqiXP_006717411.1. XM_006717348.1.
UniGeneiHs.454099.

Genome annotation databases

EnsembliENST00000334810; ENSP00000335156; ENSG00000180264.
GeneIDi347088.
KEGGihsa:347088.
UCSCiuc010mwn.3. human.

Polymorphism databases

DMDMi59797942.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY278562 mRNA. Translation: AAP35064.1 .
AB065601 Genomic DNA. Translation: BAC05829.1 . Sequence problems.
AL137846 Genomic DNA. Translation: CAI10884.1 .
AY255620 mRNA. Translation: AAO85132.1 .
RefSeqi XP_006717411.1. XM_006717348.1.
UniGenei Hs.454099.

3D structure databases

ProteinModelPortali Q7Z7M1.
SMRi Q7Z7M1. Positions 120-321, 661-897.
ModBasei Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000335156.

Protein family/group databases

MEROPSi S63.018.
GPCRDBi Search...

PTM databases

PhosphoSitei Q7Z7M1.

Polymorphism databases

DMDMi 59797942.

Proteomic databases

PaxDbi Q7Z7M1.
PRIDEi Q7Z7M1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000334810 ; ENSP00000335156 ; ENSG00000180264 .
GeneIDi 347088.
KEGGi hsa:347088.
UCSCi uc010mwn.3. human.

Organism-specific databases

CTDi 347088.
GeneCardsi GC09P127213.
HGNCi HGNC:18651. GPR144.
HPAi HPA049597.
neXtProti NX_Q7Z7M1.
PharmGKBi PA134882616.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG319967.
HOGENOMi HOG000112770.
HOVERGENi HBG051785.
InParanoidi Q7Z7M1.
OMAi CPVPSEE.
OrthoDBi EOG7966G0.
PhylomeDBi Q7Z7M1.
TreeFami TF351999.

Miscellaneous databases

GeneWikii GPR144.
NextBioi 99034.
PROi Q7Z7M1.

Gene expression databases

Bgeei Q7Z7M1.
CleanExi HS_GPR144.
Genevestigatori Q7Z7M1.

Family and domain databases

Gene3Di 2.60.120.200. 1 hit.
InterProi IPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR017981. GPCR_2-like.
IPR000832. GPCR_2_secretin-like.
IPR000203. GPS.
IPR001759. Pentaxin.
[Graphical view ]
Pfami PF00002. 7tm_2. 1 hit.
PF01825. GPS. 1 hit.
PF00354. Pentaxin. 1 hit.
[Graphical view ]
PRINTSi PR00895. PENTAXIN.
SMARTi SM00303. GPS. 1 hit.
[Graphical view ]
SUPFAMi SSF49899. SSF49899. 1 hit.
PROSITEi PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The human and mouse repertoire of the adhesion family of G-protein-coupled receptors."
    Bjarnadottir T.K., Fredriksson R., Hoeglund P.J., Gloriam D.E., Lagerstroem M.C., Schioeth H.B.
    Genomics 84:23-33(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 619-897.

Entry informationi

Entry nameiGP144_HUMAN
AccessioniPrimary (citable) accession number: Q7Z7M1
Secondary accession number(s): Q86SL4, Q8NH12
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: October 1, 2003
Last modified: September 3, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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