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Q7Z7M1 (GP144_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 89. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable G-protein coupled receptor 144
Alternative name(s):
G-protein coupled receptor PGR24
Gene names
Name:GPR144
Synonyms:PGR24
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length963 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Orphan receptor.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.

Contains 1 GPS domain.

Contains 1 pentaxin domain.

Sequence caution

The sequence BAC05829.1 differs from that shown. Reason: Erroneous gene model prediction.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 963963Probable G-protein coupled receptor 144
PRO_0000070338

Regions

Topological domain1 – 662662Extracellular Potential
Transmembrane663 – 68321Helical; Name=1; Potential
Topological domain684 – 6918Cytoplasmic Potential
Transmembrane692 – 71221Helical; Name=2; Potential
Topological domain713 – 7208Extracellular Potential
Transmembrane721 – 74121Helical; Name=3; Potential
Topological domain742 – 76221Cytoplasmic Potential
Transmembrane763 – 78321Helical; Name=4; Potential
Topological domain784 – 80017Extracellular Potential
Transmembrane801 – 82121Helical; Name=5; Potential
Topological domain822 – 85736Cytoplasmic Potential
Transmembrane858 – 87821Helical; Name=6; Potential
Topological domain879 – 8802Extracellular Potential
Transmembrane881 – 90121Helical; Name=7; Potential
Topological domain902 – 96362Cytoplasmic Potential
Domain131 – 311181Pentaxin
Domain572 – 64877GPS

Amino acid modifications

Glycosylation2711N-linked (GlcNAc...) Potential
Glycosylation6341N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q7Z7M1 [UniParc].

Last modified October 1, 2003. Version 1.
Checksum: EA7BEE0663F7A54C

FASTA963104,087
        10         20         30         40         50         60 
MDAPWGAGER WLHGAAVDRS GVSLGPPPTP QVNQGTLGPQ VAPVAAGEVV KTAGGVCKFS 

        70         80         90        100        110        120 
GQRLSWWQAQ ESCEQQFGHL ALQPPDGVLA SRLRDPVWVG QREAPLRRPP QRRARTTAVL 

       130        140        150        160        170        180 
VFDERTADRA ARLRSPLPEL AALTACTHVQ WDCASPDPAA LFSVAAPALP NALQLRAFAE 

       190        200        210        220        230        240 
PGGVVRAALV VRGQHAPFLA AFRADGRWHH VCATWEQRGG RWALFSDGRR RAGARGLGAG 

       250        260        270        280        290        300 
HPVPSGGILV LGQDQDSLGG GFSVRHALSG NLTDFHLWAR ALSPAQLHRA RACAPPSEGL 

       310        320        330        340        350        360 
LFRWDPGALD VTPSLLPTVW VRLLCPVPSE ECPTWNPGPR SEGSELCLEP QPFLCCYRTE 

       370        380        390        400        410        420 
PYRRLQDAQS WPGQDVISRV NALANDIVLL PDPLSEVHGA LSPAEASSFL GLLEHVLAME 

       430        440        450        460        470        480 
MAPLGPAALL AVVRFLKRVV ALGAGDPELL LTGPWEQLSQ GVVSVASLVL EEQVADTWLS 

       490        500        510        520        530        540 
LREVIGGPMA LVASVQRLAP LLSTSMTSER PRMRIQHRHA GLSGVTVIHS WFTSRVFQHT 

       550        560        570        580        590        600 
LEGPDLEPQA PASSEEANRV QRFLSTQVGS AIISSEVWDV TGEVNVAMTF HLQHRAQSPL 

       610        620        630        640        650        660 
FPPHPPSPYT GGAWATTGCS VAALYLDSTA CFCNHSTSFA ILLQIYEVQR GPEEESLLRT 

       670        680        690        700        710        720 
LSFVGCGVSF CALTTTFLLF LVAGVPKSER TTVHKNLTFS LASAEGFLMT SEWAKANEVA 

       730        740        750        760        770        780 
CVAVTVAMHF LFLVAFSWML VEGLLLWRKV VAVSMHPGPG MRLYHATGWG VPVGIVAVTL 

       790        800        810        820        830        840 
AMLPHDYVAP GHCWLNVHTN AIWAFVGPVL FVLTANTCIL ARVVMITVSS ARRRARMLSP 

       850        860        870        880        890        900 
QPCLQQQIWT QIWATVKPVL VLLPVLGLTW LAGILVHLSP AWAYAAVGLN SIQGLYIFLV 

       910        920        930        940        950        960 
YAACNEEVRS ALQRMAEKKV AEVLRALGVW GGAAKEHSLP FSVLPLFLPP KPSTPRHPLK 


APA 

« Hide

References

« Hide 'large scale' references
[1]"The human and mouse repertoire of the adhesion family of G-protein-coupled receptors."
Bjarnadottir T.K., Fredriksson R., Hoeglund P.J., Gloriam D.E., Lagerstroem M.C., Schioeth H.B.
Genomics 84:23-33(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"DNA sequence and analysis of human chromosome 9."
Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. expand/collapse author list , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The G protein-coupled receptor repertoires of human and mouse."
Vassilatis D.K., Hohmann J.G., Zeng H., Li F., Ranchalis J.E., Mortrud M.T., Brown A., Rodriguez S.S., Weller J.R., Wright A.C., Bergmann J.E., Gaitanaris G.A.
Proc. Natl. Acad. Sci. U.S.A. 100:4903-4908(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 619-897.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY278562 mRNA. Translation: AAP35064.1.
AB065601 Genomic DNA. Translation: BAC05829.1. Sequence problems.
AL137846 Genomic DNA. Translation: CAI10884.1.
AY255620 mRNA. Translation: AAO85132.1.
UniGeneHs.454099.

3D structure databases

ProteinModelPortalQ7Z7M1.
SMRQ7Z7M1. Positions 132-321, 661-897.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000335156.

Protein family/group databases

MEROPSS63.018.
GPCRDBSearch...

PTM databases

PhosphoSiteQ7Z7M1.

Polymorphism databases

DMDM59797942.

Proteomic databases

PaxDbQ7Z7M1.
PRIDEQ7Z7M1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000334810; ENSP00000335156; ENSG00000180264.
UCSCuc010mwn.3. human.

Organism-specific databases

GeneCardsGC09P127213.
HGNCHGNC:18651. GPR144.
HPAHPA049597.
neXtProtNX_Q7Z7M1.
PharmGKBPA134882616.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG319967.
HOGENOMHOG000112770.
HOVERGENHBG051785.
InParanoidQ7Z7M1.
OMASEECPTW.
OrthoDBEOG7966G0.
PhylomeDBQ7Z7M1.
TreeFamTF351999.

Gene expression databases

BgeeQ7Z7M1.
CleanExHS_GPR144.
GenevestigatorQ7Z7M1.

Family and domain databases

Gene3D2.60.120.200. 1 hit.
InterProIPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR017981. GPCR_2-like.
IPR000832. GPCR_2_secretin-like.
IPR000203. GPS.
IPR001759. Pentaxin.
[Graphical view]
PfamPF00002. 7tm_2. 1 hit.
PF01825. GPS. 1 hit.
PF00354. Pentaxin. 1 hit.
[Graphical view]
PRINTSPR00895. PENTAXIN.
SMARTSM00303. GPS. 1 hit.
[Graphical view]
SUPFAMSSF49899. SSF49899. 1 hit.
PROSITEPS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio99034.
PROQ7Z7M1.

Entry information

Entry nameGP144_HUMAN
AccessionPrimary (citable) accession number: Q7Z7M1
Secondary accession number(s): Q86SL4, Q8NH12
Entry history
Integrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: October 1, 2003
Last modified: April 16, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 9

Human chromosome 9: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries