Q7Z7M1 (GP144_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable G-protein coupled receptor 144

Alternative name(s):
G-protein coupled receptor PGR24

Gene names

Name:	GPR144
Synonyms:	PGR24

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	963 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Orphan receptor.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily. Contains 1 GPS domain. Contains 1 pentaxin domain.
Sequence caution	The sequence BAC05829.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	neuropeptide signaling pathway Inferred from electronic annotation. Source: InterPro
Cellular_component	integral to membrane Traceable author statement Ref.1. Source: GDB plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	G-protein coupled receptor activity Traceable author statement Ref.1. Source: GDB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 963	963	Probable G-protein coupled receptor 144		PRO_0000070338
Regions
	Topological domain	1 – 662	662	Extracellular Potential
	Transmembrane	663 – 683	21	Helical; Name=1; Potential
	Topological domain	684 – 691	8	Cytoplasmic Potential
	Transmembrane	692 – 712	21	Helical; Name=2; Potential
	Topological domain	713 – 720	8	Extracellular Potential
	Transmembrane	721 – 741	21	Helical; Name=3; Potential
	Topological domain	742 – 762	21	Cytoplasmic Potential
	Transmembrane	763 – 783	21	Helical; Name=4; Potential
	Topological domain	784 – 800	17	Extracellular Potential
	Transmembrane	801 – 821	21	Helical; Name=5; Potential
	Topological domain	822 – 857	36	Cytoplasmic Potential
	Transmembrane	858 – 878	21	Helical; Name=6; Potential
	Topological domain	879 – 880	2	Extracellular Potential
	Transmembrane	881 – 901	21	Helical; Name=7; Potential
	Topological domain	902 – 963	62	Cytoplasmic Potential
	Domain	131 – 311	181	Pentaxin
	Domain	572 – 648	77	GPS
Amino acid modifications
	Glycosylation	271	1	N-linked (GlcNAc...) Potential
	Glycosylation	634	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	Q7Z7M1 [UniParc]. Last modified October 1, 2003. Version 1. Checksum: EA7BEE0663F7A54C	FASTA	963	104,087
	10 20 30 40 50 60 MDAPWGAGER WLHGAAVDRS GVSLGPPPTP QVNQGTLGPQ VAPVAAGEVV KTAGGVCKFS 70 80 90 100 110 120 GQRLSWWQAQ ESCEQQFGHL ALQPPDGVLA SRLRDPVWVG QREAPLRRPP QRRARTTAVL 130 140 150 160 170 180 VFDERTADRA ARLRSPLPEL AALTACTHVQ WDCASPDPAA LFSVAAPALP NALQLRAFAE 190 200 210 220 230 240 PGGVVRAALV VRGQHAPFLA AFRADGRWHH VCATWEQRGG RWALFSDGRR RAGARGLGAG 250 260 270 280 290 300 HPVPSGGILV LGQDQDSLGG GFSVRHALSG NLTDFHLWAR ALSPAQLHRA RACAPPSEGL 310 320 330 340 350 360 LFRWDPGALD VTPSLLPTVW VRLLCPVPSE ECPTWNPGPR SEGSELCLEP QPFLCCYRTE 370 380 390 400 410 420 PYRRLQDAQS WPGQDVISRV NALANDIVLL PDPLSEVHGA LSPAEASSFL GLLEHVLAME 430 440 450 460 470 480 MAPLGPAALL AVVRFLKRVV ALGAGDPELL LTGPWEQLSQ GVVSVASLVL EEQVADTWLS 490 500 510 520 530 540 LREVIGGPMA LVASVQRLAP LLSTSMTSER PRMRIQHRHA GLSGVTVIHS WFTSRVFQHT 550 560 570 580 590 600 LEGPDLEPQA PASSEEANRV QRFLSTQVGS AIISSEVWDV TGEVNVAMTF HLQHRAQSPL 610 620 630 640 650 660 FPPHPPSPYT GGAWATTGCS VAALYLDSTA CFCNHSTSFA ILLQIYEVQR GPEEESLLRT 670 680 690 700 710 720 LSFVGCGVSF CALTTTFLLF LVAGVPKSER TTVHKNLTFS LASAEGFLMT SEWAKANEVA 730 740 750 760 770 780 CVAVTVAMHF LFLVAFSWML VEGLLLWRKV VAVSMHPGPG MRLYHATGWG VPVGIVAVTL 790 800 810 820 830 840 AMLPHDYVAP GHCWLNVHTN AIWAFVGPVL FVLTANTCIL ARVVMITVSS ARRRARMLSP 850 860 870 880 890 900 QPCLQQQIWT QIWATVKPVL VLLPVLGLTW LAGILVHLSP AWAYAAVGLN SIQGLYIFLV 910 920 930 940 950 960 YAACNEEVRS ALQRMAEKKV AEVLRALGVW GGAAKEHSLP FSVLPLFLPP KPSTPRHPLK APA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The human and mouse repertoire of the adhesion family of G-protein-coupled receptors." Bjarnadottir T.K., Fredriksson R., Hoeglund P.J., Gloriam D.E., Lagerstroem M.C., Schioeth H.B. Genomics 84:23-33(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes." Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y. Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"DNA sequence and analysis of human chromosome 9." Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I. Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The G protein-coupled receptor repertoires of human and mouse." Vassilatis D.K., Hohmann J.G., Zeng H., Li F., Ranchalis J.E., Mortrud M.T., Brown A., Rodriguez S.S., Weller J.R., Wright A.C., Bergmann J.E., Gaitanaris G.A. Proc. Natl. Acad. Sci. U.S.A. 100:4903-4908(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 619-897.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY278562 mRNA. Translation: AAP35064.1. AB065601 Genomic DNA. Translation: BAC05829.1. Sequence problems. AL137846 Genomic DNA. Translation: CAI10884.1. AY255620 mRNA. Translation: AAO85132.1.
IPI	IPI00385573.
RefSeq	NP_001155280.1. NM_001161808.1.
UniGene	Hs.454099.
3D structure databases
ProteinModelPortal	Q7Z7M1.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000335156.
Protein family/group databases
MEROPS	S63.018.
GPCRDB	Search...
PTM databases
PhosphoSite	Q7Z7M1.
Polymorphism databases
DMDM	59797942.
Proteomic databases
PaxDb	Q7Z7M1.
PRIDE	Q7Z7M1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000334810; ENSP00000335156; ENSG00000180264.
GeneID	347088.
KEGG	hsa:347088.
UCSC	uc010mwn.3. human.
Organism-specific databases
CTD	347088.
GeneCards	GC09P127213.
HGNC	HGNC:18651. GPR144.
HPA	HPA049597.
neXtProt	NX_Q7Z7M1.
PharmGKB	PA134882616.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG319967.
HOGENOM	HOG000112770.
HOVERGEN	HBG051785.
InParanoid	Q7Z7M1.
KO	K08466.
OMA	VVRGHHA.
OrthoDB	EOG402WRP.
Gene expression databases
Bgee	Q7Z7M1.
CleanEx	HS_GPR144.
Genevestigator	Q7Z7M1.
Family and domain databases
Gene3D	2.60.120.200. 1 hit.
InterPro	IPR008985. ConA-like_lec_gl_sf. IPR013320. ConA-like_subgrp. IPR017981. GPCR_2-like. IPR000832. GPCR_2_secretin-like. IPR000203. GPS_dom. IPR001759. Pentaxin. [Graphical view]
Pfam	PF00002. 7tm_2. 1 hit. PF01825. GPS. 1 hit. PF00354. Pentaxin. 1 hit. [Graphical view]
PRINTS	PR00895. PENTAXIN.
SMART	SM00303. GPS. 1 hit. [Graphical view]
SUPFAM	SSF49899. ConA_like_lec_gl. 1 hit.
PROSITE	PS00649. G_PROTEIN_RECEP_F2_1. False negative. PS00650. G_PROTEIN_RECEP_F2_2. False negative. PS50227. G_PROTEIN_RECEP_F2_3. False negative. PS50261. G_PROTEIN_RECEP_F2_4. 1 hit. PS50221. GPS. 1 hit. PS00289. PENTAXIN. False negative. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	347088.
NextBio	99034.

Entry information

Entry name

GP144_HUMAN

Accession

Primary (citable) accession number: Q7Z7M1
Secondary accession number(s): Q86SL4, Q8NH12

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 15, 2005
Last sequence update:	October 1, 2003
Last modified:	May 1, 2013
This is version 81 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.