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Q7Z7M1

- GP144_HUMAN

UniProt

Q7Z7M1 - GP144_HUMAN

Protein

Probable G-protein coupled receptor 144

Gene

GPR144

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 93 (01 Oct 2014)
      Sequence version 1 (01 Oct 2003)
      Previous versions | rss
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    Functioni

    Orphan receptor.

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: GDB

    GO - Biological processi

    1. G-protein coupled receptor signaling pathway Source: GDB
    2. neuropeptide signaling pathway Source: InterPro

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Protein family/group databases

    MEROPSiS63.018.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable G-protein coupled receptor 144
    Alternative name(s):
    G-protein coupled receptor PGR24
    Gene namesi
    Name:GPR144
    Synonyms:PGR24
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 9

    Organism-specific databases

    HGNCiHGNC:18651. GPR144.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: GDB
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134882616.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 963963Probable G-protein coupled receptor 144PRO_0000070338Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi271 – 2711N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi634 – 6341N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ7Z7M1.
    PRIDEiQ7Z7M1.

    PTM databases

    PhosphoSiteiQ7Z7M1.

    Expressioni

    Gene expression databases

    BgeeiQ7Z7M1.
    CleanExiHS_GPR144.
    GenevestigatoriQ7Z7M1.

    Organism-specific databases

    HPAiHPA049597.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000335156.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7Z7M1.
    SMRiQ7Z7M1. Positions 120-321, 661-897.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 662662ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini684 – 6918CytoplasmicSequence Analysis
    Topological domaini713 – 7208ExtracellularSequence Analysis
    Topological domaini742 – 76221CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini784 – 80017ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini822 – 85736CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini879 – 8802ExtracellularSequence Analysis
    Topological domaini902 – 96362CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei663 – 68321Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei692 – 71221Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei721 – 74121Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei763 – 78321Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei801 – 82121Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei858 – 87821Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei881 – 90121Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini131 – 311181PentaxinAdd
    BLAST
    Domaini572 – 64877GPSPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 GPS domain.PROSITE-ProRule annotation
    Contains 1 pentaxin domain.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG319967.
    HOGENOMiHOG000112770.
    HOVERGENiHBG051785.
    InParanoidiQ7Z7M1.
    OMAiCPVPSEE.
    OrthoDBiEOG7966G0.
    PhylomeDBiQ7Z7M1.
    TreeFamiTF351999.

    Family and domain databases

    Gene3Di2.60.120.200. 1 hit.
    InterProiIPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    IPR017981. GPCR_2-like.
    IPR000832. GPCR_2_secretin-like.
    IPR000203. GPS.
    IPR001759. Pentaxin.
    [Graphical view]
    PfamiPF00002. 7tm_2. 1 hit.
    PF01825. GPS. 1 hit.
    PF00354. Pentaxin. 1 hit.
    [Graphical view]
    PRINTSiPR00895. PENTAXIN.
    SMARTiSM00303. GPS. 1 hit.
    [Graphical view]
    SUPFAMiSSF49899. SSF49899. 1 hit.
    PROSITEiPS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
    PS50221. GPS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q7Z7M1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDAPWGAGER WLHGAAVDRS GVSLGPPPTP QVNQGTLGPQ VAPVAAGEVV    50
    KTAGGVCKFS GQRLSWWQAQ ESCEQQFGHL ALQPPDGVLA SRLRDPVWVG 100
    QREAPLRRPP QRRARTTAVL VFDERTADRA ARLRSPLPEL AALTACTHVQ 150
    WDCASPDPAA LFSVAAPALP NALQLRAFAE PGGVVRAALV VRGQHAPFLA 200
    AFRADGRWHH VCATWEQRGG RWALFSDGRR RAGARGLGAG HPVPSGGILV 250
    LGQDQDSLGG GFSVRHALSG NLTDFHLWAR ALSPAQLHRA RACAPPSEGL 300
    LFRWDPGALD VTPSLLPTVW VRLLCPVPSE ECPTWNPGPR SEGSELCLEP 350
    QPFLCCYRTE PYRRLQDAQS WPGQDVISRV NALANDIVLL PDPLSEVHGA 400
    LSPAEASSFL GLLEHVLAME MAPLGPAALL AVVRFLKRVV ALGAGDPELL 450
    LTGPWEQLSQ GVVSVASLVL EEQVADTWLS LREVIGGPMA LVASVQRLAP 500
    LLSTSMTSER PRMRIQHRHA GLSGVTVIHS WFTSRVFQHT LEGPDLEPQA 550
    PASSEEANRV QRFLSTQVGS AIISSEVWDV TGEVNVAMTF HLQHRAQSPL 600
    FPPHPPSPYT GGAWATTGCS VAALYLDSTA CFCNHSTSFA ILLQIYEVQR 650
    GPEEESLLRT LSFVGCGVSF CALTTTFLLF LVAGVPKSER TTVHKNLTFS 700
    LASAEGFLMT SEWAKANEVA CVAVTVAMHF LFLVAFSWML VEGLLLWRKV 750
    VAVSMHPGPG MRLYHATGWG VPVGIVAVTL AMLPHDYVAP GHCWLNVHTN 800
    AIWAFVGPVL FVLTANTCIL ARVVMITVSS ARRRARMLSP QPCLQQQIWT 850
    QIWATVKPVL VLLPVLGLTW LAGILVHLSP AWAYAAVGLN SIQGLYIFLV 900
    YAACNEEVRS ALQRMAEKKV AEVLRALGVW GGAAKEHSLP FSVLPLFLPP 950
    KPSTPRHPLK APA 963
    Length:963
    Mass (Da):104,087
    Last modified:October 1, 2003 - v1
    Checksum:iEA7BEE0663F7A54C
    GO

    Sequence cautioni

    The sequence BAC05829.1 differs from that shown. Reason: Erroneous gene model prediction.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY278562 mRNA. Translation: AAP35064.1.
    AB065601 Genomic DNA. Translation: BAC05829.1. Sequence problems.
    AL137846 Genomic DNA. Translation: CAI10884.1.
    AY255620 mRNA. Translation: AAO85132.1.
    RefSeqiXP_006717411.1. XM_006717348.1.
    UniGeneiHs.454099.

    Genome annotation databases

    EnsembliENST00000334810; ENSP00000335156; ENSG00000180264.
    GeneIDi347088.
    KEGGihsa:347088.
    UCSCiuc010mwn.3. human.

    Polymorphism databases

    DMDMi59797942.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY278562 mRNA. Translation: AAP35064.1 .
    AB065601 Genomic DNA. Translation: BAC05829.1 . Sequence problems.
    AL137846 Genomic DNA. Translation: CAI10884.1 .
    AY255620 mRNA. Translation: AAO85132.1 .
    RefSeqi XP_006717411.1. XM_006717348.1.
    UniGenei Hs.454099.

    3D structure databases

    ProteinModelPortali Q7Z7M1.
    SMRi Q7Z7M1. Positions 120-321, 661-897.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000335156.

    Protein family/group databases

    MEROPSi S63.018.
    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q7Z7M1.

    Polymorphism databases

    DMDMi 59797942.

    Proteomic databases

    PaxDbi Q7Z7M1.
    PRIDEi Q7Z7M1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000334810 ; ENSP00000335156 ; ENSG00000180264 .
    GeneIDi 347088.
    KEGGi hsa:347088.
    UCSCi uc010mwn.3. human.

    Organism-specific databases

    CTDi 347088.
    GeneCardsi GC09P127213.
    HGNCi HGNC:18651. GPR144.
    HPAi HPA049597.
    neXtProti NX_Q7Z7M1.
    PharmGKBi PA134882616.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG319967.
    HOGENOMi HOG000112770.
    HOVERGENi HBG051785.
    InParanoidi Q7Z7M1.
    OMAi CPVPSEE.
    OrthoDBi EOG7966G0.
    PhylomeDBi Q7Z7M1.
    TreeFami TF351999.

    Miscellaneous databases

    GeneWikii GPR144.
    NextBioi 99034.
    PROi Q7Z7M1.

    Gene expression databases

    Bgeei Q7Z7M1.
    CleanExi HS_GPR144.
    Genevestigatori Q7Z7M1.

    Family and domain databases

    Gene3Di 2.60.120.200. 1 hit.
    InterProi IPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    IPR017981. GPCR_2-like.
    IPR000832. GPCR_2_secretin-like.
    IPR000203. GPS.
    IPR001759. Pentaxin.
    [Graphical view ]
    Pfami PF00002. 7tm_2. 1 hit.
    PF01825. GPS. 1 hit.
    PF00354. Pentaxin. 1 hit.
    [Graphical view ]
    PRINTSi PR00895. PENTAXIN.
    SMARTi SM00303. GPS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49899. SSF49899. 1 hit.
    PROSITEi PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
    PS50221. GPS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The human and mouse repertoire of the adhesion family of G-protein-coupled receptors."
      Bjarnadottir T.K., Fredriksson R., Hoeglund P.J., Gloriam D.E., Lagerstroem M.C., Schioeth H.B.
      Genomics 84:23-33(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
      Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "DNA sequence and analysis of human chromosome 9."
      Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
      , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
      Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 619-897.

    Entry informationi

    Entry nameiGP144_HUMAN
    AccessioniPrimary (citable) accession number: Q7Z7M1
    Secondary accession number(s): Q86SL4, Q8NH12
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 15, 2005
    Last sequence update: October 1, 2003
    Last modified: October 1, 2014
    This is version 93 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 9
      Human chromosome 9: entries, gene names and cross-references to MIM
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3