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Q7Z7M0

- MEGF8_HUMAN

UniProt

Q7Z7M0 - MEGF8_HUMAN

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Protein
Multiple epidermal growth factor-like domains protein 8
Gene
MEGF8, C19orf49, EGFL4, KIAA0817
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. protein binding Source: IntAct
  3. receptor activity Source: InterPro

GO - Biological processi

  1. BMP signaling pathway Source: UniProt
  2. cell migration involved in gastrulation Source: UniProt
  3. craniofacial suture morphogenesis Source: UniProt
  4. determination of digestive tract left/right asymmetry Source: UniProt
  5. determination of heart left/right asymmetry Source: UniProt
  6. embryonic heart tube left/right pattern formation Source: UniProt
  7. embryonic heart tube morphogenesis Source: UniProt
  8. embryonic limb morphogenesis Source: UniProt
  9. embryonic skeletal system morphogenesis Source: UniProt
  10. epiboly involved in gastrulation with mouth forming second Source: UniProt
  11. fasciculation of sensory neuron axon Source: UniProt
  12. left/right pattern formation Source: UniProt
  13. limb morphogenesis Source: UniProt
  14. positive regulation of axon extension involved in axon guidance Source: UniProt
  15. regulation of gene expression Source: UniProt
Complete GO annotation...

Keywords - Ligandi

Calcium

Enzyme and pathway databases

SignaLinkiQ7Z7M0.

Names & Taxonomyi

Protein namesi
Recommended name:
Multiple epidermal growth factor-like domains protein 8
Short name:
Multiple EGF-like domains protein 8
Alternative name(s):
Epidermal growth factor-like protein 4
Short name:
EGF-like protein 4
Gene namesi
Name:MEGF8
Synonyms:C19orf49, EGFL4, KIAA0817
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:3233. MEGF8.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini28 – 26472620Extracellular Reviewed prediction
Add
BLAST
Transmembranei2648 – 266821Helical; Reviewed prediction
Add
BLAST
Topological domaini2669 – 2845177Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. extracellular vesicular exosome Source: UniProt
  2. integral component of membrane Source: UniProtKB-KW
  3. nucleus Source: UniProt
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Involvement in diseasei

Carpenter syndrome 2 (CRPT2) [MIM:614976]: An autosomal recessive multiple congenital malformation disorder characterized by multisuture craniosynostosis and polysyndactyly of the hands and feet, in association with abnormal left-right patterning and other features, most commonly obesity, umbilical hernia, cryptorchidism, and congenital heart disease.
Note: The disease is caused by mutations affecting the gene represented in this entry.1 Publication
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti199 – 1991G → R in CRPT2. 1 Publication
VAR_069305
Natural varianti1566 – 15661R → H in CRPT2. 1 Publication
VAR_069306
Natural varianti2434 – 24341S → G in CRPT2. 1 Publication
VAR_069307

Keywords - Diseasei

Craniosynostosis, Disease mutation

Organism-specific databases

MIMi614976. phenotype.
Orphaneti65759. Carpenter syndrome.
PharmGKBiPA27666.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2727 Reviewed prediction
Add
BLAST
Chaini28 – 28452818Multiple epidermal growth factor-like domains protein 8
PRO_0000055629Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi30 ↔ 57 By similarity
Glycosylationi50 – 501N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi142 ↔ 152 By similarity
Disulfide bondi146 ↔ 158 By similarity
Disulfide bondi174 ↔ 184 By similarity
Disulfide bondi178 ↔ 191 By similarity
Disulfide bondi193 ↔ 202 By similarity
Glycosylationi217 – 2171N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1048 – 10481N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi1078 ↔ 1091 By similarity
Disulfide bondi1085 ↔ 1100 By similarity
Disulfide bondi1102 ↔ 1114 By similarity
Disulfide bondi1163 ↔ 1171 By similarity
Disulfide bondi1165 ↔ 1179 By similarity
Disulfide bondi1182 ↔ 1191 By similarity
Disulfide bondi1194 ↔ 1208 By similarity
Disulfide bondi1211 ↔ 1224 By similarity
Disulfide bondi1213 ↔ 1231 By similarity
Disulfide bondi1233 ↔ 1242 By similarity
Disulfide bondi1245 ↔ 1259 By similarity
Disulfide bondi1263 ↔ 1302 By similarity
Glycosylationi1271 – 12711N-linked (GlcNAc...)1 Publication
Disulfide bondi1336 ↔ 1367 By similarity
Modified residuei1353 – 13531Phosphothreonine By similarity
Disulfide bondi1407 ↔ 1421 By similarity
Disulfide bondi1415 ↔ 1433 By similarity
Disulfide bondi1435 ↔ 1444 By similarity
Glycosylationi2066 – 20661N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi2182 ↔ 2195 By similarity
Disulfide bondi2189 ↔ 2204 By similarity
Glycosylationi2229 – 22291N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi2253 ↔ 2261 By similarity
Disulfide bondi2255 ↔ 2270 By similarity
Disulfide bondi2273 ↔ 2282 By similarity
Disulfide bondi2285 ↔ 2299 By similarity
Disulfide bondi2380 ↔ 2389 By similarity
Disulfide bondi2382 ↔ 2397 By similarity
Disulfide bondi2399 ↔ 2424 By similarity
Disulfide bondi2427 ↔ 2441 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ7Z7M0.
PRIDEiQ7Z7M0.

PTM databases

PhosphoSiteiQ7Z7M0.

Expressioni

Gene expression databases

ArrayExpressiQ7Z7M0.
BgeeiQ7Z7M0.
CleanExiHS_MEGF8.
GenevestigatoriQ7Z7M0.

Organism-specific databases

HPAiHPA049248.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ATXN7O152652EBI-947617,EBI-708350
CACNA1AO005552EBI-947617,EBI-766279

Protein-protein interaction databases

BioGridi108274. 6 interactions.
IntActiQ7Z7M0. 8 interactions.
MINTiMINT-2808456.
STRINGi9606.ENSP00000334219.

Structurei

3D structure databases

ProteinModelPortaliQ7Z7M0.
SMRiQ7Z7M0. Positions 39-203, 211-343, 1084-1259, 1430-1483, 2201-2373.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini30 – 140111CUB 1
Add
BLAST
Domaini138 – 16831EGF-like 1
Add
BLAST
Domaini170 – 20334EGF-like 2
Add
BLAST
Repeati241 – 28747Kelch 1
Add
BLAST
Repeati290 – 33849Kelch 2
Add
BLAST
Repeati346 – 39954Kelch 3
Add
BLAST
Repeati402 – 45352Kelch 4
Add
BLAST
Repeati459 – 51153Kelch 5
Add
BLAST
Repeati525 – 57551Kelch 6
Add
BLAST
Domaini561 – 61353PSI 1
Add
BLAST
Domaini847 – 89953PSI 2
Add
BLAST
Domaini900 – 94748PSI 3
Add
BLAST
Domaini1074 – 111542EGF-like 3; calcium-binding Reviewed prediction
Add
BLAST
Domaini1163 – 121048Laminin EGF-like 1
Add
BLAST
Domaini1211 – 126151Laminin EGF-like 2
Add
BLAST
Domaini1263 – 1405143CUB 2
Add
BLAST
Domaini1403 – 144543EGF-like 4
Add
BLAST
Repeati1522 – 157049Kelch 7
Add
BLAST
Repeati1580 – 162647Kelch 8
Add
BLAST
Repeati1632 – 167948Kelch 9
Add
BLAST
Repeati1685 – 173551Kelch 10
Add
BLAST
Repeati1796 – 184348Kelch 11
Add
BLAST
Repeati1852 – 189847Kelch 12
Add
BLAST
Domaini1876 – 191641PSI 4
Add
BLAST
Domaini1924 – 197956PSI 5
Add
BLAST
Domaini2060 – 211859PSI 6
Add
BLAST
Domaini2120 – 217758PSI 7
Add
BLAST
Domaini2178 – 221639EGF-like 5
Add
BLAST
Domaini2253 – 230149Laminin EGF-like 3
Add
BLAST
Domaini2380 – 244364Laminin EGF-like 4
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi2528 – 256437Pro-rich
Add
BLAST
Compositional biasi2739 – 283395Gly-rich
Add
BLAST

Sequence similaritiesi

Contains 2 CUB domains.
Contains 5 EGF-like domains.
Contains 12 Kelch repeats.
Contains 7 PSI domains.

Keywords - Domaini

EGF-like domain, Kelch repeat, Laminin EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG304142.
HOGENOMiHOG000113554.
HOVERGENiHBG108128.
OMAiGHSMVFH.
OrthoDBiEOG7J9VRK.
PhylomeDBiQ7Z7M0.
TreeFamiTF321873.

Family and domain databases

Gene3Di2.120.10.80. 3 hits.
2.60.120.290. 1 hit.
InterProiIPR000859. CUB_dom.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR002049. EGF_laminin.
IPR015915. Kelch-typ_b-propeller.
IPR016201. Plexin-like_fold.
IPR002165. Plexin_repeat.
[Graphical view]
PfamiPF00431. CUB. 1 hit.
PF07645. EGF_CA. 1 hit.
PF00053. Laminin_EGF. 3 hits.
PF01437. PSI. 1 hit.
[Graphical view]
SMARTiSM00042. CUB. 1 hit.
SM00181. EGF. 6 hits.
SM00179. EGF_CA. 1 hit.
SM00180. EGF_Lam. 1 hit.
SM00423. PSI. 9 hits.
[Graphical view]
SUPFAMiSSF49854. SSF49854. 1 hit.
PROSITEiPS00010. ASX_HYDROXYL. 2 hits.
PS01180. CUB. 2 hits.
PS00022. EGF_1. 6 hits.
PS01186. EGF_2. 7 hits.
PS50026. EGF_3. 4 hits.
PS01187. EGF_CA. 1 hit.
PS01248. EGF_LAM_1. 4 hits.
PS50027. EGF_LAM_2. 4 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q7Z7M0-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MALGKVLAMA LVLALAVLGS LSPGARAGDC KGQRQVLREA PGFVTDGAGN     50
YSVNGNCEWL IEAPSPQHRI LLDFLFLDTE CTYDYLFVYD GDSPRGPLLA 100
SLSGSTRPPP IEASSGKMLL HLFSDANYNL LGFNASFRFS LCPGGCQSHG 150
QCQPPGVCAC EPGWGGPDCG LQECSAYCGS HGTCASPLGP CRCEPGFLGR 200
ACDLHLWENQ GAGWWHNVSA RDPAFSARIG AAGAFLSPPG LLAVFGGQDL 250
NNALGDLVLY NFSANTWESW DLSPAPAARH SHVAVAWAGS LVLMGGELAD 300
GSLTNDVWAF SPLGRGHWEL LAPPASSSSG PPGLAGHAAA LVDDVWLYVS 350
GGRTPHDLFS SGLFRFRLDS TSGGYWEQVI PAGGRPPAAT GHSMVFHAPS 400
RALLVHGGHR PSTARFSVRV NSTELFHVDR HVWTTLKGRD GLQGPRERAF 450
HTASVLGNYM VVYGGNVHTH YQEEKCYEDG IFFYHLGCHQ WVSGAELAPP 500
GTPEGRAAPP SGRYSHVAAV LGGSVLLVAG GYSGRPRGDL MAYKVPPFVF 550
QAPAPDYHLD YCSMYTDHSV CSRDPECSWC QGACQAAPPP GTPLGACPAA 600
SCLGLGRLLG DCQACLAFSS PTAPPRGPGT LGWCVHNESC LPRPEQARCR 650
GEQISGTVGW WGPAPVFVTS LEACVTQSFL PGLHLLTFQQ PPNTSQPDKV 700
SIVRSTTITL TPSAETDVSL VYRGFIYPML PGGPGGPGAE DVAVWTRAQR 750
LHVLARMARG PDTENMEEVG RWVAHQEKET RRLQRPGSAR LFPLPGRDHK 800
YAVEIQGQLN GSAGPGHSEL TLLWDRTGVP GGSEISFFFL EPYRSSSCTS 850
YSSCLGCLAD QGCGWCLTSA TCHLRQGGAH CGDDGAGGSL LVLVPTLCPL 900
CEEHRDCHAC TQDPFCEWHQ STSRKGDAAC SRRGRGRGAL KSPEECPPLC 950
SQRLTCEDCL ANSSQCAWCQ STHTCFLFAA YLARYPHGGC RGWDDSVHSE 1000
PRCRSCDGFL TCHECLQSHE CGWCGNEDNP TLGRCLQGDF SGPLGGGNCS 1050
LWVGEGLGLP VALPARWAYA RCPDVDECRL GLARCHPRAT CLNTPLSYEC 1100
HCQRGYQGDG ISHCNRTCLE DCGHGVCSGP PDFTCVCDLG WTSDLPPPTP 1150
APGPPAPRCS RDCGCSFHSH CRKRGPGFCD ECQDWTWGEH CERCRPGSFG 1200
NATGSRGCRP CQCNGHGDPR RGHCDNLSGL CFCQDHTEGA HCQLCSPGYY 1250
GDPRAGGSCF RECGGRALLT NVSSVALGSR RVGGLLPPGG GAARAGPGLS 1300
YCVWVVSATE ELQPCAPGTL CPPLTLTFSP DSSTPCTLSY VLAFDGFPRF 1350
LDTGVVQSDR SLIAAFCGQR RDRPLTVQAL SGLLVLHWEA NGSSSWGFNA 1400
SVGSARCGSG GPGSCPVPQE CVPQDGAAGA GLCRCPQGWA GPHCRMALCP 1450
ENCNAHTGAG TCNQSLGVCI CAEGFGGPDC ATKLDGGQLV WETLMDSRLS 1500
ADTASRFLHR LGHTMVDGPD ATLWMFGGLG LPQGLLGNLY RYSVSERRWT 1550
QMLAGAEDGG PGPSPRSFHA AAYVPAGRGA MYLLGGLTAG GVTRDFWVLN 1600
LTTLQWRQEK APQTVELPAV AGHTLTARRG LSLLLVGGYS PENGFNQQLL 1650
EYQLATGTWV SGAQSGTPPT GLYGHSAVYH EATDSLYVFG GFRFHVELAA 1700
PSPELYSLHC PDRTWSLLAP SQGAKRDRMR NVRGSSRGLG QVPGEQPGSW 1750
GFREVRKKMA LWAALAGTGG FLEEISPHLK EPRPRLFHAS ALLGDTMVVL 1800
GGRSDPDEFS SDVLLYQVNC NAWLLPDLTR SASVGPPMEE SVAHAVAAVG 1850
SRLYISGGFG GVALGRLLAL TLPPDPCRLL SSPEACNQSG ACTWCHGACL 1900
SGDQAHRLGC GGSPCSPMPR SPEECRRLRT CSECLARHPR TLQPGDGEAS 1950
TPRCKWCTNC PEGACIGRNG SCTSENDCRI NQREVFWAGN CSEAACGAAD 2000
CEQCTREGKC MWTRQFKRTG ETRRILSVQP TYDWTCFSHS LLNVSPMPVE 2050
SSPPLPCPTP CHLLPNCTSC LDSKGADGGW QHCVWSSSLQ QCLSPSYLPL 2100
RCMAGGCGRL LRGPESCSLG CAQATQCALC LRRPHCGWCA WGGQDGGGRC 2150
MEGGLSGPRD GLTCGRPGAS WAFLSCPPED ECANGHHDCN ETQNCHDQPH 2200
GYECSCKTGY TMDNMTGLCR PVCAQGCVNG SCVEPDHCRC HFGFVGRNCS 2250
TECRCNRHSE CAGVGARDHC LLCRNHTKGS HCEQCLPLFV GSAVGGGTCR 2300
PCHAFCRGNS HICISRKELQ MSKGEPKKYS LDPEEIENWV TEGPSEDEAV 2350
CVNCQNNSYG EKCESCLQGY FLLDGKCTKC QCNGHADTCN EQDGTGCPCQ 2400
NNTETGTCQG SSPSDRRDCY KYQCAKCRES FHGSPLGGQQ CYRLISVEQE 2450
CCLDPTSQTN CFHEPKRRAL GPGRTVLFGV QPKFTNVDIR LTLDVTFGAV 2500
DLYVSTSYDT FVVRVAPDTG VHTVHIQPPP APPPPPPPAD GGPRGAGDPG 2550
GAGASSGPGA PAEPRVREVW PRGLITYVTV TEPSAVLVVR GVRDRLVITY 2600
PHEHHALKSS RFYLLLLGVG DPSGPGANGS ADSQGLLFFR QDQAHIDLFV 2650
FFSVFFSCFF LFLSLCVLLW KAKQALDQRQ EQRRHLQEMT KMASRPFAKV 2700
TVCFPPDPTA PASAWKPAGL PPPAFRRSEP FLAPLLLTGA GGPWGPMGGG 2750
CCPPAIPATT AGLRAGPITL EPTEDGMAGV ATLLLQLPGG PHAPNGACLG 2800
SALVTLRHRL HEYCGGGGGA GGSGHGTGAG RKGLLSQDNL TSMSL 2845
Length:2,845
Mass (Da):303,100
Last modified:December 16, 2008 - v2
Checksum:iDDBF0EE07511587D
GO
Isoform 2 (identifier: Q7Z7M0-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     700-766: Missing.

Show »
Length:2,778
Mass (Da):295,934
Checksum:i73F2F7537697D450
GO

Sequence cautioni

The sequence AAP35084.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.
The sequence BAA32469.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti199 – 1991G → R in CRPT2. 1 Publication
VAR_069305
Natural varianti1566 – 15661R → H in CRPT2. 1 Publication
VAR_069306
Natural varianti2434 – 24341S → G in CRPT2. 1 Publication
VAR_069307

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei700 – 76667Missing in isoform 2.
VSP_036067Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB011541 mRNA. Translation: BAA32469.2. Different initiation.
AC011497 Genomic DNA. No translation available.
AC024078 Genomic DNA. No translation available.
BC153880 mRNA. Translation: AAI53881.1.
AY280362 mRNA. Translation: AAP35084.1. Different initiation.
CCDSiCCDS12604.2. [Q7Z7M0-2]
CCDS62693.1. [Q7Z7M0-1]
PIRiT00209.
RefSeqiNP_001258867.1. NM_001271938.1. [Q7Z7M0-1]
NP_001401.2. NM_001410.2. [Q7Z7M0-2]
UniGeneiHs.132483.

Genome annotation databases

EnsembliENST00000251268; ENSP00000251268; ENSG00000105429. [Q7Z7M0-1]
ENST00000334370; ENSP00000334219; ENSG00000105429. [Q7Z7M0-2]
GeneIDi1954.
KEGGihsa:1954.
UCSCiuc002otl.4. human. [Q7Z7M0-2]
uc002otm.5. human. [Q7Z7M0-1]

Polymorphism databases

DMDMi218511690.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB011541 mRNA. Translation: BAA32469.2 . Different initiation.
AC011497 Genomic DNA. No translation available.
AC024078 Genomic DNA. No translation available.
BC153880 mRNA. Translation: AAI53881.1 .
AY280362 mRNA. Translation: AAP35084.1 . Different initiation.
CCDSi CCDS12604.2. [Q7Z7M0-2 ]
CCDS62693.1. [Q7Z7M0-1 ]
PIRi T00209.
RefSeqi NP_001258867.1. NM_001271938.1. [Q7Z7M0-1 ]
NP_001401.2. NM_001410.2. [Q7Z7M0-2 ]
UniGenei Hs.132483.

3D structure databases

ProteinModelPortali Q7Z7M0.
SMRi Q7Z7M0. Positions 39-203, 211-343, 1084-1259, 1430-1483, 2201-2373.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 108274. 6 interactions.
IntActi Q7Z7M0. 8 interactions.
MINTi MINT-2808456.
STRINGi 9606.ENSP00000334219.

PTM databases

PhosphoSitei Q7Z7M0.

Polymorphism databases

DMDMi 218511690.

Proteomic databases

PaxDbi Q7Z7M0.
PRIDEi Q7Z7M0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000251268 ; ENSP00000251268 ; ENSG00000105429 . [Q7Z7M0-1 ]
ENST00000334370 ; ENSP00000334219 ; ENSG00000105429 . [Q7Z7M0-2 ]
GeneIDi 1954.
KEGGi hsa:1954.
UCSCi uc002otl.4. human. [Q7Z7M0-2 ]
uc002otm.5. human. [Q7Z7M0-1 ]

Organism-specific databases

CTDi 1954.
GeneCardsi GC19P042829.
HGNCi HGNC:3233. MEGF8.
HPAi HPA049248.
MIMi 604267. gene.
614976. phenotype.
neXtProti NX_Q7Z7M0.
Orphaneti 65759. Carpenter syndrome.
PharmGKBi PA27666.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG304142.
HOGENOMi HOG000113554.
HOVERGENi HBG108128.
OMAi GHSMVFH.
OrthoDBi EOG7J9VRK.
PhylomeDBi Q7Z7M0.
TreeFami TF321873.

Enzyme and pathway databases

SignaLinki Q7Z7M0.

Miscellaneous databases

ChiTaRSi MEGF8. human.
GenomeRNAii 1954.
NextBioi 7919.
PROi Q7Z7M0.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q7Z7M0.
Bgeei Q7Z7M0.
CleanExi HS_MEGF8.
Genevestigatori Q7Z7M0.

Family and domain databases

Gene3Di 2.120.10.80. 3 hits.
2.60.120.290. 1 hit.
InterProi IPR000859. CUB_dom.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR002049. EGF_laminin.
IPR015915. Kelch-typ_b-propeller.
IPR016201. Plexin-like_fold.
IPR002165. Plexin_repeat.
[Graphical view ]
Pfami PF00431. CUB. 1 hit.
PF07645. EGF_CA. 1 hit.
PF00053. Laminin_EGF. 3 hits.
PF01437. PSI. 1 hit.
[Graphical view ]
SMARTi SM00042. CUB. 1 hit.
SM00181. EGF. 6 hits.
SM00179. EGF_CA. 1 hit.
SM00180. EGF_Lam. 1 hit.
SM00423. PSI. 9 hits.
[Graphical view ]
SUPFAMi SSF49854. SSF49854. 1 hit.
PROSITEi PS00010. ASX_HYDROXYL. 2 hits.
PS01180. CUB. 2 hits.
PS00022. EGF_1. 6 hits.
PS01186. EGF_2. 7 hits.
PS50026. EGF_3. 4 hits.
PS01187. EGF_CA. 1 hit.
PS01248. EGF_LAM_1. 4 hits.
PS50027. EGF_LAM_2. 4 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of high-molecular-weight proteins with multiple EGF-like motifs by motif-trap screening."
    Nakayama M., Nakajima D., Nagase T., Nomura N., Seki N., Ohara O.
    Genomics 51:27-34(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    Tissue: Brain.
  2. Nakayama M., Nakajima D., Nagase T., Nomura N., Seki N., Ohara O.
    Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.
  3. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  5. "Cloning, characterization and location of a novel human gene containing an EGF domain."
    Shan Y.X., Yu L.
    Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 416-2845 (ISOFORM 1).
  6. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
    Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.
    J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-1271.
    Tissue: Plasma.
  7. Cited for: VARIANTS CRPT2 ARG-199; HIS-1566 AND GLY-2434.

Entry informationi

Entry nameiMEGF8_HUMAN
AccessioniPrimary (citable) accession number: Q7Z7M0
Secondary accession number(s): A8KAY0, O75097
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: December 16, 2008
Last modified: July 9, 2014
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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