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Protein

Zinc finger and SCAN domain-containing protein 2

Gene

ZSCAN2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation during the post-meiotic stages of spermatogenesis.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri222 – 244C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri250 – 272C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri278 – 300C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri306 – 328C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri334 – 356C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri362 – 384C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri390 – 412C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri418 – 440C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri446 – 468C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri474 – 496C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri502 – 524C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri530 – 552C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri558 – 580C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri586 – 608C2H2-type 14PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Spermatogenesis, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger and SCAN domain-containing protein 2
Alternative name(s):
Zinc finger protein 29 homolog
Short name:
Zfp-29
Zinc finger protein 854
Gene namesi
Name:ZSCAN2
Synonyms:ZFP29, ZNF854
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:20994. ZSCAN2.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000176371.
PharmGKBiPA134941325.

Polymorphism and mutation databases

BioMutaiZSCAN2.
DMDMi296453062.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000477491 – 614Zinc finger and SCAN domain-containing protein 2Add BLAST614

Proteomic databases

EPDiQ7Z7L9.
MaxQBiQ7Z7L9.
PaxDbiQ7Z7L9.
PeptideAtlasiQ7Z7L9.
PRIDEiQ7Z7L9.

PTM databases

iPTMnetiQ7Z7L9.
PhosphoSitePlusiQ7Z7L9.

Expressioni

Gene expression databases

BgeeiENSG00000176371.
CleanExiHS_ZSCAN2.
ExpressionAtlasiQ7Z7L9. baseline and differential.
GenevisibleiQ7Z7L9. HS.

Organism-specific databases

HPAiHPA007296.
HPA024331.

Interactioni

Protein-protein interaction databases

BioGridi120326. 1 interactor.
IntActiQ7Z7L9. 1 interactor.
STRINGi9606.ENSP00000410198.

Structurei

3D structure databases

ProteinModelPortaliQ7Z7L9.
SMRiQ7Z7L9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini59 – 132SCAN boxPROSITE-ProRule annotationAdd BLAST74

Sequence similaritiesi

Contains 14 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 SCAN box domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri222 – 244C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri250 – 272C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri278 – 300C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri306 – 328C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri334 – 356C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri362 – 384C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri390 – 412C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri418 – 440C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri446 – 468C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri474 – 496C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri502 – 524C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri530 – 552C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri558 – 580C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri586 – 608C2H2-type 14PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00860000133674.
HOGENOMiHOG000234619.
HOVERGENiHBG066767.
InParanoidiQ7Z7L9.
KOiK09230.
OMAiHRRTHLV.
OrthoDBiEOG091G02KC.
PhylomeDBiQ7Z7L9.
TreeFamiTF337913.

Family and domain databases

Gene3Di3.30.160.60. 14 hits.
InterProiIPR008916. Retrov_capsid_C.
IPR003309. SCAN_dom.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF02023. SCAN. 1 hit.
PF00096. zf-C2H2. 9 hits.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00431. SCAN. 1 hit.
SM00355. ZnF_C2H2. 14 hits.
[Graphical view]
SUPFAMiSSF47353. SSF47353. 1 hit.
PROSITEiPS50804. SCAN_BOX. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 14 hits.
PS50157. ZINC_FINGER_C2H2_2. 14 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q7Z7L9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMAADIPRVT TPLSSLVQVP QEEDRQEEEV TTMILEDDSW VQEAVLQEDG
60 70 80 90 100
PESEPFPQSA GKGGPQEEVT RGPQGALGRL RELCRRWLRP EVHTKEQMLT
110 120 130 140 150
MLPKEIQAWL QEHRPESSEE AAALVEDLTQ TLQDSDFEIQ SENGENCNQD
160 170 180 190 200
MFENESRKIF SEMPEGESAQ HSDGESDFER DAGIQRLQGH SPGEDHGEVV
210 220 230 240 250
SQDREVGQLI GLQGTYLGEK PYECPQCGKT FSRKSHLITH ERTHTGEKYY
260 270 280 290 300
KCDECGKSFS DGSNFSRHQT THTGEKPYKC RDCGKSFSRS ANLITHQRIH
310 320 330 340 350
TGEKPFQCAE CGKSFSRSPN LIAHQRTHTG EKPYSCPECG KSFGNRSSLN
360 370 380 390 400
THQGIHTGEK PYECKECGES FSYNSNLIRH QRIHTGEKPY KCTDCGQRFS
410 420 430 440 450
QSSALITHRR THTGEKPYQC SECGKSFSRS SNLATHRRTH MVEKPYKCGV
460 470 480 490 500
CGKSFSQSSS LIAHQGMHTG EKPYECLTCG ESFSWSSNLL KHQRIHTGEK
510 520 530 540 550
PYKCSECGKC FSQRSQLVVH QRTHTGEKPY KCLMCGKSFS RGSILVMHQR
560 570 580 590 600
AHLGDKPYRC PECGKGFSWN SVLIIHQRIH TGEKPYKCPE CGKGFSNSSN
610
FITHQRTHMK EKLY
Length:614
Mass (Da):69,547
Last modified:May 18, 2010 - v2
Checksum:iEF36B0199D575D03
GO
Isoform 3 (identifier: Q7Z7L9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     136-150: DFEIQSENGENCNQD → AVAVVASLPVEVTSL
     151-614: Missing.

Show »
Length:150
Mass (Da):16,697
Checksum:iE0EBCB4A7672160D
GO
Isoform 4 (identifier: Q7Z7L9-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     136-146: DFEIQSENGEN → ETASCVHGCPV
     147-614: Missing.

Note: No experimental confirmation available.
Show »
Length:146
Mass (Da):16,344
Checksum:iFEA520C6A210B7A2
GO

Sequence cautioni

The sequence BAC87537 differs from that shown. Reason: Erroneous translation. Aberrant splicing.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti135 – 136SD → N in AAP36989 (Ref. 1) Curated2
Isoform 3 (identifier: Q7Z7L9-3)
Sequence conflicti140V → F in BAA91283 (PubMed:14702039).Curated1
Sequence conflicti140V → F in AAH41620 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_065095191S → T.2 PublicationsCorresponds to variant rs2044502dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_011947136 – 150DFEIQ…NCNQD → AVAVVASLPVEVTSL in isoform 3. 2 PublicationsAdd BLAST15
Alternative sequenceiVSP_040201136 – 146DFEIQSENGEN → ETASCVHGCPV in isoform 4. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_040202147 – 614Missing in isoform 4. 1 PublicationAdd BLAST468
Alternative sequenceiVSP_011948151 – 614Missing in isoform 3. 2 PublicationsAdd BLAST464

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY262259 mRNA. Translation: AAP36989.1.
AK000602 mRNA. Translation: BAA91283.1.
AK128624 mRNA. Translation: BAC87537.1. Sequence problems.
AY279349 mRNA. Translation: AAQ62846.1.
AC048382 Genomic DNA. No translation available.
BC041620 mRNA. Translation: AAH41620.1.
BC136342 mRNA. Translation: AAI36343.1.
CCDSiCCDS10329.2. [Q7Z7L9-1]
CCDS32315.1. [Q7Z7L9-4]
CCDS32316.1. [Q7Z7L9-3]
RefSeqiNP_001007073.1. NM_001007072.1. [Q7Z7L9-4]
NP_060364.4. NM_017894.5. [Q7Z7L9-3]
NP_870992.2. NM_181877.3. [Q7Z7L9-1]
UniGeneiHs.594023.

Genome annotation databases

EnsembliENST00000334141; ENSP00000333895; ENSG00000176371. [Q7Z7L9-3]
ENST00000379358; ENSP00000368663; ENSG00000176371. [Q7Z7L9-4]
ENST00000448803; ENSP00000410198; ENSG00000176371. [Q7Z7L9-1]
ENST00000540894; ENSP00000441855; ENSG00000176371. [Q7Z7L9-1]
ENST00000546148; ENSP00000445451; ENSG00000176371. [Q7Z7L9-1]
GeneIDi54993.
KEGGihsa:54993.
UCSCiuc002bkp.4. human. [Q7Z7L9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY262259 mRNA. Translation: AAP36989.1.
AK000602 mRNA. Translation: BAA91283.1.
AK128624 mRNA. Translation: BAC87537.1. Sequence problems.
AY279349 mRNA. Translation: AAQ62846.1.
AC048382 Genomic DNA. No translation available.
BC041620 mRNA. Translation: AAH41620.1.
BC136342 mRNA. Translation: AAI36343.1.
CCDSiCCDS10329.2. [Q7Z7L9-1]
CCDS32315.1. [Q7Z7L9-4]
CCDS32316.1. [Q7Z7L9-3]
RefSeqiNP_001007073.1. NM_001007072.1. [Q7Z7L9-4]
NP_060364.4. NM_017894.5. [Q7Z7L9-3]
NP_870992.2. NM_181877.3. [Q7Z7L9-1]
UniGeneiHs.594023.

3D structure databases

ProteinModelPortaliQ7Z7L9.
SMRiQ7Z7L9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120326. 1 interactor.
IntActiQ7Z7L9. 1 interactor.
STRINGi9606.ENSP00000410198.

PTM databases

iPTMnetiQ7Z7L9.
PhosphoSitePlusiQ7Z7L9.

Polymorphism and mutation databases

BioMutaiZSCAN2.
DMDMi296453062.

Proteomic databases

EPDiQ7Z7L9.
MaxQBiQ7Z7L9.
PaxDbiQ7Z7L9.
PeptideAtlasiQ7Z7L9.
PRIDEiQ7Z7L9.

Protocols and materials databases

DNASUi54993.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000334141; ENSP00000333895; ENSG00000176371. [Q7Z7L9-3]
ENST00000379358; ENSP00000368663; ENSG00000176371. [Q7Z7L9-4]
ENST00000448803; ENSP00000410198; ENSG00000176371. [Q7Z7L9-1]
ENST00000540894; ENSP00000441855; ENSG00000176371. [Q7Z7L9-1]
ENST00000546148; ENSP00000445451; ENSG00000176371. [Q7Z7L9-1]
GeneIDi54993.
KEGGihsa:54993.
UCSCiuc002bkp.4. human. [Q7Z7L9-1]

Organism-specific databases

CTDi54993.
GeneCardsiZSCAN2.
HGNCiHGNC:20994. ZSCAN2.
HPAiHPA007296.
HPA024331.
neXtProtiNX_Q7Z7L9.
OpenTargetsiENSG00000176371.
PharmGKBiPA134941325.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00860000133674.
HOGENOMiHOG000234619.
HOVERGENiHBG066767.
InParanoidiQ7Z7L9.
KOiK09230.
OMAiHRRTHLV.
OrthoDBiEOG091G02KC.
PhylomeDBiQ7Z7L9.
TreeFamiTF337913.

Miscellaneous databases

GenomeRNAii54993.
PROiQ7Z7L9.

Gene expression databases

BgeeiENSG00000176371.
CleanExiHS_ZSCAN2.
ExpressionAtlasiQ7Z7L9. baseline and differential.
GenevisibleiQ7Z7L9. HS.

Family and domain databases

Gene3Di3.30.160.60. 14 hits.
InterProiIPR008916. Retrov_capsid_C.
IPR003309. SCAN_dom.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF02023. SCAN. 1 hit.
PF00096. zf-C2H2. 9 hits.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00431. SCAN. 1 hit.
SM00355. ZnF_C2H2. 14 hits.
[Graphical view]
SUPFAMiSSF47353. SSF47353. 1 hit.
PROSITEiPS50804. SCAN_BOX. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 14 hits.
PS50157. ZINC_FINGER_C2H2_2. 14 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZSCA2_HUMAN
AccessioniPrimary (citable) accession number: Q7Z7L9
Secondary accession number(s): A6NG83
, B2RMQ9, Q6ZQY9, Q9NWU4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: May 18, 2010
Last modified: November 30, 2016
This is version 125 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.