Q7Z7L8 (CK096_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Uncharacterized protein C11orf96

Alternative name(s):
Protein Ag2 homolog

Gene names

Name:	C11orf96
Synonyms:	AG2

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	435 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Post-translational modification

Phosphorylated upon DNA damage, probably by ATM or ATR. Ref.3

Ontologies

Keywords
Coding sequence diversity	Polymorphism
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 435	435	Uncharacterized protein C11orf96		PRO_0000320641
Regions
	Compositional bias	242 – 307	66	Pro-rich
Amino acid modifications
	Modified residue	368	1	Phosphothreonine Ref.3
	Modified residue	385	1	Phosphoserine Ref.3
	Modified residue	407	1	Phosphothreonine By similarity
Natural variations
	Natural variant	26	1	T → A. Corresponds to variant rs1973717 [ dbSNP | Ensembl ].		VAR_039242
	Natural variant	47	1	S → P. Corresponds to variant rs12797684 [ dbSNP | Ensembl ].		VAR_039243
	Natural variant	110	1	R → S. Corresponds to variant rs12796438 [ dbSNP | Ensembl ].		VAR_039244
	Natural variant	144	1	R → C. Corresponds to variant rs12796667 [ dbSNP | Ensembl ].		VAR_039245
	Natural variant	151	1	F → S. Corresponds to variant rs12798337 [ dbSNP | Ensembl ].		VAR_039246
	Natural variant	352	1	P → S. Corresponds to variant rs2434483 [ dbSNP | Ensembl ].		VAR_039247

Sequences

	Sequence		Length	Mass (Da)
	Q7Z7L8 [UniParc]. Last modified May 5, 2009. Version 3. Checksum: F536980973B14478	FASTA	435	46,114
	10 20 30 40 50 60 MGNKQPQKVT VPTGTALQGV VLIVSTLHQP GGWICGKDPC CSLRPLSNSV QNALACKSKQ 70 80 90 100 110 120 DYQAGILFKT RAFISRDCGS DAAEDSASKG ETYTLTLEHK GAGEGDLRPR GQPGWCRLGD 130 140 150 160 170 180 PRRDSARPVA AIEGPCPGAA RASRVLRGRG FSRNPRGRGL PSGAGWRGAG GAGEGAVTFP 190 200 210 220 230 240 ERRGDVRRKG AGRARFKWHS LSSELRAVWA AAGYISREPG RRGADGDSSG GERLGARRNS 250 260 270 280 290 300 APRAPCPPTG PPARPPSRGA PARAREGRRH PAADLDPPPG EPPAAASRGA PAQRPPSESP 310 320 330 340 350 360 GAPPPGPADA GGAMAAKPGE LMGICSSYQA VMPHFVCLAD EFPQPVRPAK LPKGRGRLRR 370 380 390 400 410 420 PRQSRFKTQP VTFDEIQEVE EEGVSPMEEE KAKKSFLQSL ECLRRSTQSL SLQREQLSSC 430 KLRNSLDSSD SDSAL

References

[1]	"Human chromosome 11 DNA sequence and analysis including novel gene identification." Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y. Nature 440:497-500(2006) [PubMed: 16554811] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 209-435. Tissue: Salivary gland.
[3]	"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage." Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III, Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N., Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J. Science 316:1160-1166(2007) [PubMed: 17525332] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-368 AND SER-385, MASS SPECTROMETRY. Tissue: Embryonic kidney.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC087521 Genomic DNA. No translation available. BC052560 mRNA. Translation: AAH52560.1.
IPI	IPI00398347.
RefSeq	NP_001138505.1. NM_001145033.1.
UniGene	Hs.714890.
3D structure databases
ProteinModelPortal	Q7Z7L8.
ModBase	Search...
PTM databases
PhosphoSite	Q7Z7L8.
Polymorphism databases
DMDM	229463005.
Proteomic databases
PRIDE	Q7Z7L8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000339446; ENSP00000340667; ENSG00000187479.
GeneID	387763.
KEGG	hsa:387763.
Organism-specific databases
CTD	387763.
GeneCards	GC11P043947.
H-InvDB	HIX0035967.
HGNC	HGNC:38675. C11orf96.
HPA	HPA038843.
neXtProt	NX_Q7Z7L8.
PharmGKB	PA165543281.
GenAtlas	Search...
Phylogenomic databases
eggNOG	maNOG22857.
GeneTree	ENSGT00390000016821.
InParanoid	Q7Z7L8.
OMA	GEGAVTF.
OrthoDB	EOG4SJ5FG.
Gene expression databases
ArrayExpress	Q7Z7L8.
Bgee	Q7Z7L8.
Genevestigator	Q7Z7L8.
Family and domain databases
ProtoNet	Search...

Entry information

Entry name

CK096_HUMAN

Accession

Primary (citable) accession number: Q7Z7L8

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	May 5, 2009
Last modified:	January 25, 2012
This is version 47 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.