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Protein

Protein zer-1 homolog

Gene

ZER1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Probably acts as target recruitment subunit in the E3 ubiquitin ligase complex ZER1-CUL2-Elongin BC.1 Publication

GO - Molecular functioni

  • ubiquitin-protein transferase activity Source: UniProtKB

GO - Biological processi

  • protein ubiquitination Source: GOC
  • regulation of ubiquitin-protein transferase activity Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Protein zer-1 homolog
Alternative name(s):
Hzyg
Zyg-11 homolog B-like protein
Gene namesi
Name:ZER1
Synonyms:C9orf60, ZYG, ZYG11BL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:30960. ZER1.

Subcellular locationi

GO - Cellular componenti

  • Cul2-RING ubiquitin ligase complex Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi9 – 91L → S: Abolishes interaction with TCEB1. 1 Publication

Organism-specific databases

PharmGKBiPA162409637.

Polymorphism and mutation databases

DMDMi68566100.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedCombined sources
Chaini2 – 766765Protein zer-1 homologPRO_0000066598Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineCombined sources

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ7Z7L7.
PaxDbiQ7Z7L7.
PRIDEiQ7Z7L7.

PTM databases

iPTMnetiQ7Z7L7.
PhosphoSiteiQ7Z7L7.

Expressioni

Tissue specificityi

Expressed in testis, spermatocytes and spermatids (at protein level). Expressed in spermatocytes, spermatids, prostate, skeletal muscle, ovary, small intestine, heart, brain and pancreas.1 Publication

Gene expression databases

BgeeiQ7Z7L7.
CleanExiHS_ZER1.
ExpressionAtlasiQ7Z7L7. baseline and differential.
GenevisibleiQ7Z7L7. HS.

Organism-specific databases

HPAiHPA044449.
HPA048464.

Interactioni

Subunit structurei

Interacts with the TCEB1-TCEB2/Elongin BC complex. Part of an E3 ubiquitin ligase complex including ZER1, CUL2 and Elongin BC.1 Publication

Protein-protein interaction databases

BioGridi115709. 28 interactions.
IntActiQ7Z7L7. 10 interactions.
MINTiMINT-3034979.
STRINGi9606.ENSP00000291900.

Structurei

3D structure databases

ProteinModelPortaliQ7Z7L7.
SMRiQ7Z7L7. Positions 79-140, 176-291.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati226 – 24520LRR 1Add
BLAST
Repeati246 – 26823LRR 2Add
BLAST
Repeati278 – 30225LRR 3Add
BLAST
Repeati427 – 46741ARM 1Add
BLAST
Repeati511 – 55646ARM 2Add
BLAST
Repeati558 – 60043ARM 3Add
BLAST
Repeati602 – 64342ARM 4Add
BLAST
Repeati714 – 75643ARM 5Add
BLAST

Sequence similaritiesi

Belongs to the zyg-11 family.Curated
Contains 5 ARM repeats.Curated
Contains 3 LRR (leucine-rich) repeats.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiKOG3665. Eukaryota.
ENOG410XPSX. LUCA.
GeneTreeiENSGT00530000063187.
HOGENOMiHOG000232098.
HOVERGENiHBG052709.
InParanoidiQ7Z7L7.
KOiK10350.
OMAiAINCKRF.
OrthoDBiEOG79W94F.
PhylomeDBiQ7Z7L7.
TreeFamiTF313007.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
3.80.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
IPR032675. L_dom-like.
[Graphical view]
SMARTiSM00185. ARM. 4 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7Z7L7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASDTPESLM ALCTDFCLRN LDGTLGYLLD KETLRLHPDI FLPSEICDRL
60 70 80 90 100
VNEYVELVNA ACNFEPHESF FSLFSDPRST RLTRIHLRED LVQDQDLEAI
110 120 130 140 150
RKQDLVELYL TNCEKLSAKS LQTLRSFSHT LVSLSLFGCT NIFYEEENPG
160 170 180 190 200
GCEDEYLVNP TCQVLVKDFT FEGFSRLRFL NLGRMIDWVP VESLLRPLNS
210 220 230 240 250
LAALDLSGIQ TSDAAFLTQW KDSLVSLVLY NMDLSDDHIR VIVQLHKLRH
260 270 280 290 300
LDISRDRLSS YYKFKLTREV LSLFVQKLGN LMSLDISGHM ILENCSISKM
310 320 330 340 350
EEEAGQTSIE PSKSSIIPFR ALKRPLQFLG LFENSLCRLT HIPAYKVSGD
360 370 380 390 400
KNEEQVLNAI EAYTEHRPEI TSRAINLLFD IARIERCNQL LRALKLVITA
410 420 430 440 450
LKCHKYDRNI QVTGSAALFY LTNSEYRSEQ SVKLRRQVIQ VVLNGMESYQ
460 470 480 490 500
EVTVQRNCCL TLCNFSIPEE LEFQYRRVNE LLLSILNPTR QDESIQRIAV
510 520 530 540 550
HLCNALVCQV DNDHKEAVGK MGFVVTMLKL IQKKLLDKTC DQVMEFSWSA
560 570 580 590 600
LWNITDETPD NCEMFLNFNG MKLFLDCLKE FPEKQELHRN MLGLLGNVAE
610 620 630 640 650
VKELRPQLMT SQFISVFSNL LESKADGIEV SYNACGVLSH IMFDGPEAWG
660 670 680 690 700
VCEPQREEVE ERMWAAIQSW DINSRRNINY RSFEPILRLL PQGISPVSQH
710 720 730 740 750
WATWALYNLV SVYPDKYCPL LIKEGGMPLL RDIIKMATAR QETKEMARKV
760
IEHCSNFKEE NMDTSR
Length:766
Mass (Da):88,169
Last modified:October 1, 2003 - v1
Checksum:i0B023E692CDE5520
GO

Sequence cautioni

The sequence CAI15408.1 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence CAI15409.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti249 – 2491R → G in CAA68137 (PubMed:11719588).Curated
Sequence conflicti417 – 4171A → L in CAA68137 (PubMed:11719588).Curated
Sequence conflicti588 – 5881H → I in CAA68137 (PubMed:11719588).Curated
Sequence conflicti653 – 6531E → K in CAA68137 (PubMed:11719588).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti539 – 5391T → I.
Corresponds to variant rs13299702 [ dbSNP | Ensembl ].
VAR_060159

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X99802 mRNA. Translation: CAA68137.1.
AL441992 Genomic DNA. Translation: CAI15407.1.
AL441992 Genomic DNA. Translation: CAI15408.1. Sequence problems.
AL441992 Genomic DNA. Translation: CAI15409.1. Sequence problems.
BC052563 mRNA. Translation: AAH52563.1.
CCDSiCCDS6910.1.
RefSeqiNP_006327.2. NM_006336.3.
XP_005251702.1. XM_005251645.1.
XP_011516424.1. XM_011518122.1.
UniGeneiHs.147950.
Hs.744180.

Genome annotation databases

EnsembliENST00000291900; ENSP00000291900; ENSG00000160445.
GeneIDi10444.
KEGGihsa:10444.
UCSCiuc004bwa.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X99802 mRNA. Translation: CAA68137.1.
AL441992 Genomic DNA. Translation: CAI15407.1.
AL441992 Genomic DNA. Translation: CAI15408.1. Sequence problems.
AL441992 Genomic DNA. Translation: CAI15409.1. Sequence problems.
BC052563 mRNA. Translation: AAH52563.1.
CCDSiCCDS6910.1.
RefSeqiNP_006327.2. NM_006336.3.
XP_005251702.1. XM_005251645.1.
XP_011516424.1. XM_011518122.1.
UniGeneiHs.147950.
Hs.744180.

3D structure databases

ProteinModelPortaliQ7Z7L7.
SMRiQ7Z7L7. Positions 79-140, 176-291.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115709. 28 interactions.
IntActiQ7Z7L7. 10 interactions.
MINTiMINT-3034979.
STRINGi9606.ENSP00000291900.

PTM databases

iPTMnetiQ7Z7L7.
PhosphoSiteiQ7Z7L7.

Polymorphism and mutation databases

DMDMi68566100.

Proteomic databases

MaxQBiQ7Z7L7.
PaxDbiQ7Z7L7.
PRIDEiQ7Z7L7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000291900; ENSP00000291900; ENSG00000160445.
GeneIDi10444.
KEGGihsa:10444.
UCSCiuc004bwa.3. human.

Organism-specific databases

CTDi10444.
GeneCardsiZER1.
HGNCiHGNC:30960. ZER1.
HPAiHPA044449.
HPA048464.
neXtProtiNX_Q7Z7L7.
PharmGKBiPA162409637.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3665. Eukaryota.
ENOG410XPSX. LUCA.
GeneTreeiENSGT00530000063187.
HOGENOMiHOG000232098.
HOVERGENiHBG052709.
InParanoidiQ7Z7L7.
KOiK10350.
OMAiAINCKRF.
OrthoDBiEOG79W94F.
PhylomeDBiQ7Z7L7.
TreeFamiTF313007.

Miscellaneous databases

ChiTaRSiZER1. human.
GenomeRNAii10444.
NextBioi39583.
PROiQ7Z7L7.

Gene expression databases

BgeeiQ7Z7L7.
CleanExiHS_ZER1.
ExpressionAtlasiQ7Z7L7. baseline and differential.
GenevisibleiQ7Z7L7. HS.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
3.80.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
IPR032675. L_dom-like.
[Graphical view]
SMARTiSM00185. ARM. 4 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Meiotic human sperm cells express a leucine-rich homologue of Caenorhabditis elegans early embryogenesis gene, Zyg-11."
    Feral C., Wu Y.-Q., Pawlak A., Guellaen G.
    Mol. Hum. Reprod. 7:1115-1122(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Tissue: Testis.
  2. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lymph.
  4. "The Caenorhabditis elegans cell-cycle regulator ZYG-11 defines a conserved family of CUL-2 complex components."
    Vasudevan S., Starostina N.G., Kipreos E.T.
    EMBO Rep. 8:279-286(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH TCEB1, IDENTIFICATION IN COMPLEX WITH TCEB1; TCEB2 AND CUL2, MUTAGENESIS OF LEU-9.
  5. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS], IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiZER1_HUMAN
AccessioniPrimary (citable) accession number: Q7Z7L7
Secondary accession number(s): O00156, Q5T272, Q5T273
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: October 1, 2003
Last modified: May 11, 2016
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.