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Q7Z7L1

- SLN11_HUMAN

UniProt

Q7Z7L1 - SLN11_HUMAN

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Protein
Schlafen family member 11
Gene
SLFN11
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Interferon (IFN)-induced antiviral protein which acts as an inhibitor of retrovirus protein synthesis. Specifically abrogates the production of retroviruses such as human immunodeficiency virus 1 (HIV-1) by acting as a specific inhibitor of the synthesis of retroviruses encoded proteins in a codon-usage-dependent manner. Binds to tRNAs and exploits the unique viral codon bias towards A/T nucleotides. The exact inhibition mechanism is unclear: may either sequesters tRNAs, prevents their maturation via post-transcriptional processing or accelerates their deacylation. Does not inhibit reverse transcription, integration or production and nuclear export of viral RNA. May play a role in cell cycle arrest and/or induction of apoptosis in response to exogenously induced DNA damage.2 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi599 – 6068ATP Reviewed prediction

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. tRNA binding Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  1. defense response to virus Source: UniProtKB
  2. negative regulation of G1/S transition of mitotic cell cycle Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Antiviral defense, Immunity

Keywords - Ligandi

ATP-binding, Nucleotide-binding, RNA-binding, tRNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Schlafen family member 11
Gene namesi
Name:SLFN11
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:26633. SLFN11.

Subcellular locationi

Nucleus 1 Publication

GO - Cellular componenti

  1. cytoplasm Source: HPA
  2. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA144596358.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 901901Schlafen family member 11
PRO_0000283091Add
BLAST

Proteomic databases

MaxQBiQ7Z7L1.
PaxDbiQ7Z7L1.
PRIDEiQ7Z7L1.

PTM databases

PhosphoSiteiQ7Z7L1.

Expressioni

Tissue specificityi

Exhibits a wider expression range in ovarian and colon adenocarcinoma than in their corresponding healthy tissues.1 Publication

Inductioni

By type I interferons, poly-IC and poly-dAdT.2 Publications

Gene expression databases

ArrayExpressiQ7Z7L1.
BgeeiQ7Z7L1.
CleanExiHS_SLFN11.
GenevestigatoriQ7Z7L1.

Organism-specific databases

HPAiHPA023030.

Interactioni

Protein-protein interaction databases

BioGridi124851. 11 interactions.
IntActiQ7Z7L1. 1 interaction.
MINTiMINT-4720222.
STRINGi9606.ENSP00000312402.

Structurei

3D structure databases

ProteinModelPortaliQ7Z7L1.

Family & Domainsi

Sequence similaritiesi

Belongs to the Schlafen family.

Phylogenomic databases

eggNOGiNOG25289.
HOGENOMiHOG000049135.
HOVERGENiHBG056880.
InParanoidiQ7Z7L1.
OMAiEAEWSQG.
OrthoDBiEOG712TVN.
PhylomeDBiQ7Z7L1.
TreeFamiTF337168.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR007421. ATPase_AAA-4.
IPR018647. DUF2075.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF04326. AAA_4. 1 hit.
PF09848. DUF2075. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7Z7L1-1 [UniParc]FASTAAdd to Basket

« Hide

MEANQCPLVV EPSYPDLVIN VGEVTLGEEN RKKLQKIQRD QEKERVMRAA    50
CALLNSGGGV IRMAKKVEHP VEMGLDLEQS LRELIQSSDL QAFFETKQQG 100
RCFYIFVKSW SSGPFPEDRS VKPRLCSLSS SLYRRSETSV RSMDSREAFC 150
FLKTKRKPKI LEEGPFHKIH KGVYQELPNS DPADPNSDPA DLIFQKDYLE 200
YGEILPFPES QLVEFKQFST KHFQEYVKRT IPEYVPAFAN TGGGYLFIGV 250
DDKSREVLGC AKENVDPDSL RRKIEQAIYK LPCVHFCQPQ RPITFTLKIV 300
NVLKRGELYG YACMIRVNPF CCAVFSEAPN SWIVEDKYVC SLTTEKWVGM 350
MTDTDPDLLQ LSEDFECQLS LSSGPPLSRP VYSKKGLEHK KELQQLLFSV 400
PPGYLRYTPE SLWRDLISEH RGLEELINKQ MQPFFRGILI FSRSWAVDLN 450
LQEKPGVICD ALLIAQNSTP ILYTILREQD AEGQDYCTRT AFTLKQKLVN 500
MGGYTGKVCV RAKVLCLSPE SSAEALEAAV SPMDYPASYS LAGTQHMEAL 550
LQSLVIVLLG FRSLLSDQLG CEVLNLLTAQ QYEIFSRSLR KNRELFVHGL 600
PGSGKTIMAM KIMEKIRNVF HCEAHRILYV CENQPLRNFI SDRNICRAET 650
RKTFLRENFE HIQHIVIDEA QNFRTEDGDW YGKAKSITRR AKGGPGILWI 700
FLDYFQTSHL DCSGLPPLSD QYPREELTRI VRNADPIAKY LQKEMQVIRS 750
NPSFNIPTGC LEVFPEAEWS QGVQGTLRIK KYLTVEQIMT CVADTCRRFF 800
DRGYSPKDVA VLVSTAKEVE HYKYELLKAM RKKRVVQLSD ACDMLGDHIV 850
LDSVRRFSGL ERSIVFGIHP RTADPAILPN VLICLASRAK QHLYIFPWGG 900
H 901
Length:901
Mass (Da):102,836
Last modified:November 30, 2010 - v2
Checksum:i514FD89CB7C12E8D
GO

Sequence cautioni

The sequence BAB85010.1 differs from that shown. Reason: Frameshift at position 135.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti121 – 1211V → F.1 Publication
Corresponds to variant rs12453150 [ dbSNP | Ensembl ].
VAR_031492
Natural varianti301 – 3011N → D.4 Publications
Corresponds to variant rs4796077 [ dbSNP | Ensembl ].
VAR_031493
Natural varianti489 – 4891R → L.
Corresponds to variant rs9898983 [ dbSNP | Ensembl ].
VAR_062186
Natural varianti822 – 8221Y → C.
Corresponds to variant rs3803860 [ dbSNP | Ensembl ].
VAR_031494

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti20 – 201N → S in BAC03835. 1 Publication
Sequence conflicti143 – 1431M → T in BAC03835. 1 Publication
Sequence conflicti324 – 3241V → M in CAD38606. 1 Publication
Sequence conflicti665 – 6651I → V in BAC03835. 1 Publication
Sequence conflicti665 – 6651I → V in CAD38606. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK074184 mRNA. Translation: BAB85010.1. Frameshift.
AK092241 mRNA. Translation: BAC03835.1.
AL831964 mRNA. Translation: CAD38606.2.
AC060766 Genomic DNA. No translation available.
CH471147 Genomic DNA. Translation: EAW80156.1.
CH471147 Genomic DNA. Translation: EAW80157.1.
CH471147 Genomic DNA. Translation: EAW80158.1.
BC052586 mRNA. Translation: AAH52586.1.
CCDSiCCDS11294.1.
RefSeqiNP_001098057.1. NM_001104587.1.
NP_001098058.1. NM_001104588.1.
NP_001098059.1. NM_001104589.1.
NP_001098060.1. NM_001104590.1.
NP_689483.3. NM_152270.3.
XP_005258125.1. XM_005258068.1.
XP_006722234.1. XM_006722171.1.
UniGeneiHs.745059.

Genome annotation databases

EnsembliENST00000308377; ENSP00000312402; ENSG00000172716.
ENST00000394566; ENSP00000378067; ENSG00000172716.
GeneIDi91607.
KEGGihsa:91607.
UCSCiuc002hjg.4. human.

Polymorphism databases

DMDMi313104011.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK074184 mRNA. Translation: BAB85010.1 . Frameshift.
AK092241 mRNA. Translation: BAC03835.1 .
AL831964 mRNA. Translation: CAD38606.2 .
AC060766 Genomic DNA. No translation available.
CH471147 Genomic DNA. Translation: EAW80156.1 .
CH471147 Genomic DNA. Translation: EAW80157.1 .
CH471147 Genomic DNA. Translation: EAW80158.1 .
BC052586 mRNA. Translation: AAH52586.1 .
CCDSi CCDS11294.1.
RefSeqi NP_001098057.1. NM_001104587.1.
NP_001098058.1. NM_001104588.1.
NP_001098059.1. NM_001104589.1.
NP_001098060.1. NM_001104590.1.
NP_689483.3. NM_152270.3.
XP_005258125.1. XM_005258068.1.
XP_006722234.1. XM_006722171.1.
UniGenei Hs.745059.

3D structure databases

ProteinModelPortali Q7Z7L1.
ModBasei Search...

Protein-protein interaction databases

BioGridi 124851. 11 interactions.
IntActi Q7Z7L1. 1 interaction.
MINTi MINT-4720222.
STRINGi 9606.ENSP00000312402.

PTM databases

PhosphoSitei Q7Z7L1.

Polymorphism databases

DMDMi 313104011.

Proteomic databases

MaxQBi Q7Z7L1.
PaxDbi Q7Z7L1.
PRIDEi Q7Z7L1.

Protocols and materials databases

DNASUi 91607.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000308377 ; ENSP00000312402 ; ENSG00000172716 .
ENST00000394566 ; ENSP00000378067 ; ENSG00000172716 .
GeneIDi 91607.
KEGGi hsa:91607.
UCSCi uc002hjg.4. human.

Organism-specific databases

CTDi 91607.
GeneCardsi GC17M033677.
H-InvDB HIX0018885.
HGNCi HGNC:26633. SLFN11.
HPAi HPA023030.
MIMi 614953. gene.
neXtProti NX_Q7Z7L1.
PharmGKBi PA144596358.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG25289.
HOGENOMi HOG000049135.
HOVERGENi HBG056880.
InParanoidi Q7Z7L1.
OMAi EAEWSQG.
OrthoDBi EOG712TVN.
PhylomeDBi Q7Z7L1.
TreeFami TF337168.

Miscellaneous databases

ChiTaRSi SLFN11. human.
GeneWikii SLFN11.
GenomeRNAii 91607.
NextBioi 77319.
PROi Q7Z7L1.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q7Z7L1.
Bgeei Q7Z7L1.
CleanExi HS_SLFN11.
Genevestigatori Q7Z7L1.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR007421. ATPase_AAA-4.
IPR018647. DUF2075.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF04326. AAA_4. 1 hit.
PF09848. DUF2075. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS PHE-121 AND ASP-301.
    Tissue: Spleen.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ASP-301.
    Tissue: Skeletal muscle.
  3. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ASP-301.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ASP-301.
    Tissue: Skin.
  6. "Role of interferon {alpha} (IFN{alpha})-inducible Schlafen-5 in regulation of anchorage-independent growth and invasion of malignant melanoma cells."
    Katsoulidis E., Mavrommatis E., Woodard J., Shields M.A., Sassano A., Carayol N., Sawicki K.T., Munshi H.G., Platanias L.C.
    J. Biol. Chem. 285:40333-40341(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. "Codon-usage-based inhibition of HIV protein synthesis by human schlafen 11."
    Li M., Kao E., Gao X., Sandig H., Limmer K., Pavon-Eternod M., Jones T.E., Landry S., Pan T., Weitzman M.D., David M.
    Nature 491:125-128(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TRNA-BINDING, INDUCTION.
  9. "Putative DNA/RNA helicase Schlafen-11 (SLFN11) sensitizes cancer cells to DNA-damaging agents."
    Zoppoli G., Regairaz M., Leo E., Reinhold W.C., Varma S., Ballestrero A., Doroshow J.H., Pommier Y.
    Proc. Natl. Acad. Sci. U.S.A. 109:15030-15035(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiSLN11_HUMAN
AccessioniPrimary (citable) accession number: Q7Z7L1
Secondary accession number(s): E1P643
, Q8N3S8, Q8N762, Q8TEE0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: November 30, 2010
Last modified: July 9, 2014
This is version 91 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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