Q7Z7L1 (SLN11_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Schlafen family member 11

Gene names

Name:

SLFN11

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	901 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Interferon (IFN)-induced antiviral protein which acts as an inhibitor of retrovirus protein synthesis. Specifically abrogates the production of retroviruses such as human immunodeficiency virus 1 (HIV-1) by acting as a specific inhibitor of the synthesis of retroviruses encoded proteins in a codon-usage-dependent manner. Binds to tRNAs and exploits the unique viral codon bias towards A/T nucleotides. The exact inhibition mechanism is unclear: may either sequesters tRNAs, prevents their maturation via post-transcriptional processing or accelerates their deacylation. Does not inhibit reverse transcription, integration or production and nuclear export of viral RNA. May play a role in cell cycle arrest and/or induction of apoptosis in response to exogenously induced DNA damage. Ref.8 Ref.9
Subcellular location	Nucleus Ref.9.
Tissue specificity	Exhibits a wider expression range in ovarian and colon adenocarcinoma than in their corresponding healthy tissues. Ref.9
Induction	By type I interferons, poly-IC and poly-dAdT. Ref.6 Ref.8
Sequence similarities	Belongs to the Schlafen family.
Sequence caution	The sequence BAB85010.1 differs from that shown. Reason: Frameshift at position 135.

Ontologies

Keywords
Biological process	Antiviral defense Immunity
Cellular component	Nucleus
Coding sequence diversity	Polymorphism
Ligand	ATP-binding Nucleotide-binding RNA-binding tRNA-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	defense response to virus Inferred from mutant phenotype Ref.8. Source: UniProtKB negative regulation of G1/S transition of mitotic cell cycle Inferred from mutant phenotype Ref.9. Source: UniProtKB
Cellular_component	nucleus Inferred from direct assay Ref.9. Source: UniProtKB
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW tRNA binding Inferred from direct assay Ref.8. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 901	901	Schlafen family member 11		PRO_0000283091
Regions
	Nucleotide binding	599 – 606	8	ATP Potential
Natural variations
	Natural variant	121	1	V → F. Ref.1 Corresponds to variant rs12453150 [ dbSNP | Ensembl ].		VAR_031492
	Natural variant	301	1	N → D. Ref.1 Ref.2 Ref.4 Ref.5 Corresponds to variant rs4796077 [ dbSNP | Ensembl ].		VAR_031493
	Natural variant	489	1	R → L. Corresponds to variant rs9898983 [ dbSNP | Ensembl ].		VAR_062186
	Natural variant	822	1	Y → C. Corresponds to variant rs3803860 [ dbSNP | Ensembl ].		VAR_031494
Experimental info
	Sequence conflict	20	1	N → S in BAC03835. Ref.1
	Sequence conflict	143	1	M → T in BAC03835. Ref.1
	Sequence conflict	324	1	V → M in CAD38606. Ref.2
	Sequence conflict	665	1	I → V in BAC03835. Ref.1
	Sequence conflict	665	1	I → V in CAD38606. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q7Z7L1 [UniParc]. Last modified November 30, 2010. Version 2. Checksum: 514FD89CB7C12E8D	FASTA	901	102,836
	10 20 30 40 50 60 MEANQCPLVV EPSYPDLVIN VGEVTLGEEN RKKLQKIQRD QEKERVMRAA CALLNSGGGV 70 80 90 100 110 120 IRMAKKVEHP VEMGLDLEQS LRELIQSSDL QAFFETKQQG RCFYIFVKSW SSGPFPEDRS 130 140 150 160 170 180 VKPRLCSLSS SLYRRSETSV RSMDSREAFC FLKTKRKPKI LEEGPFHKIH KGVYQELPNS 190 200 210 220 230 240 DPADPNSDPA DLIFQKDYLE YGEILPFPES QLVEFKQFST KHFQEYVKRT IPEYVPAFAN 250 260 270 280 290 300 TGGGYLFIGV DDKSREVLGC AKENVDPDSL RRKIEQAIYK LPCVHFCQPQ RPITFTLKIV 310 320 330 340 350 360 NVLKRGELYG YACMIRVNPF CCAVFSEAPN SWIVEDKYVC SLTTEKWVGM MTDTDPDLLQ 370 380 390 400 410 420 LSEDFECQLS LSSGPPLSRP VYSKKGLEHK KELQQLLFSV PPGYLRYTPE SLWRDLISEH 430 440 450 460 470 480 RGLEELINKQ MQPFFRGILI FSRSWAVDLN LQEKPGVICD ALLIAQNSTP ILYTILREQD 490 500 510 520 530 540 AEGQDYCTRT AFTLKQKLVN MGGYTGKVCV RAKVLCLSPE SSAEALEAAV SPMDYPASYS 550 560 570 580 590 600 LAGTQHMEAL LQSLVIVLLG FRSLLSDQLG CEVLNLLTAQ QYEIFSRSLR KNRELFVHGL 610 620 630 640 650 660 PGSGKTIMAM KIMEKIRNVF HCEAHRILYV CENQPLRNFI SDRNICRAET RKTFLRENFE 670 680 690 700 710 720 HIQHIVIDEA QNFRTEDGDW YGKAKSITRR AKGGPGILWI FLDYFQTSHL DCSGLPPLSD 730 740 750 760 770 780 QYPREELTRI VRNADPIAKY LQKEMQVIRS NPSFNIPTGC LEVFPEAEWS QGVQGTLRIK 790 800 810 820 830 840 KYLTVEQIMT CVADTCRRFF DRGYSPKDVA VLVSTAKEVE HYKYELLKAM RKKRVVQLSD 850 860 870 880 890 900 ACDMLGDHIV LDSVRRFSGL ERSIVFGIHP RTADPAILPN VLICLASRAK QHLYIFPWGG H

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS PHE-121 AND ASP-301. Tissue: Spleen.
[2]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ASP-301. Tissue: Skeletal muscle.
[3]	"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L. , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C. Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ASP-301.
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ASP-301. Tissue: Skin.
[6]	"Role of interferon {alpha} (IFN{alpha})-inducible Schlafen-5 in regulation of anchorage-independent growth and invasion of malignant melanoma cells." Katsoulidis E., Mavrommatis E., Woodard J., Shields M.A., Sassano A., Carayol N., Sawicki K.T., Munshi H.G., Platanias L.C. J. Biol. Chem. 285:40333-40341(2010) [PubMed] [Europe PMC] [Abstract] Cited for: INDUCTION.
[7]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[8]	"Codon-usage-based inhibition of HIV protein synthesis by human schlafen 11." Li M., Kao E., Gao X., Sandig H., Limmer K., Pavon-Eternod M., Jones T.E., Landry S., Pan T., Weitzman M.D., David M. Nature 491:125-128(2012) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, TRNA-BINDING, INDUCTION.
[9]	"Putative DNA/RNA helicase Schlafen-11 (SLFN11) sensitizes cancer cells to DNA-damaging agents." Zoppoli G., Regairaz M., Leo E., Reinhold W.C., Varma S., Ballestrero A., Doroshow J.H., Pommier Y. Proc. Natl. Acad. Sci. U.S.A. 109:15030-15035(2012) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK074184 mRNA. Translation: BAB85010.1. Frameshift. AK092241 mRNA. Translation: BAC03835.1. AL831964 mRNA. Translation: CAD38606.2. AC060766 Genomic DNA. No translation available. CH471147 Genomic DNA. Translation: EAW80156.1. CH471147 Genomic DNA. Translation: EAW80157.1. CH471147 Genomic DNA. Translation: EAW80158.1. BC052586 mRNA. Translation: AAH52586.1.
IPI	IPI00171044.
RefSeq	NP_001098057.1. NM_001104587.1. NP_001098058.1. NM_001104588.1. NP_001098059.1. NM_001104589.1. NP_001098060.1. NM_001104590.1. NP_689483.3. NM_152270.3.
UniGene	Hs.462829.
3D structure databases
ProteinModelPortal	Q7Z7L1.
SMR	Q7Z7L1. Positions 574-639.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q7Z7L1. 1 interaction.
STRING	9606.ENSP00000312402.
PTM databases
PhosphoSite	Q7Z7L1.
Polymorphism databases
DMDM	74738896.
Proteomic databases
PaxDb	Q7Z7L1.
PRIDE	Q7Z7L1.
Protocols and materials databases
DNASU	91607.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000308377; ENSP00000312402; ENSG00000172716. ENST00000394566; ENSP00000378067; ENSG00000172716.
GeneID	91607.
KEGG	hsa:91607.
UCSC	uc002hjg.4. human.
Organism-specific databases
CTD	91607.
GeneCards	GC17M033677.
H-InvDB	HIX0018885.
HGNC	HGNC:26633. SLFN11.
HPA	HPA023030.
MIM	614953. gene.
neXtProt	NX_Q7Z7L1.
PharmGKB	PA144596358.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG25289.
HOGENOM	HOG000049135.
HOVERGEN	HBG056880.
InParanoid	Q7Z7L1.
OMA	PNSDPAD.
OrthoDB	EOG4RXXZH.
PhylomeDB	Q7Z7L1.
Gene expression databases
ArrayExpress	Q7Z7L1.
Bgee	Q7Z7L1.
CleanEx	HS_SLFN11.
Genevestigator	Q7Z7L1.
Family and domain databases
InterPro	IPR007421. ATPase_AAA-4. IPR018647. DUF2075. [Graphical view]
Pfam	PF04326. AAA_4. 1 hit. PF09848. DUF2075. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	SLFN11. human.
GenomeRNAi	91607.
NextBio	77319.
SOURCE	Search...

Entry information

Entry name

SLN11_HUMAN

Accession

Primary (citable) accession number: Q7Z7L1
Secondary accession number(s): E1P643 , Q8N3S8, Q8N762, Q8TEE0

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 3, 2007
Last sequence update:	November 30, 2010
Last modified:	May 1, 2013
This is version 79 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.