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Q7Z7L1

- SLN11_HUMAN

UniProt

Q7Z7L1 - SLN11_HUMAN

Protein

Schlafen family member 11

Gene

SLFN11

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 92 (01 Oct 2014)
      Sequence version 2 (30 Nov 2010)
      Previous versions | rss
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    Functioni

    Interferon (IFN)-induced antiviral protein which acts as an inhibitor of retrovirus protein synthesis. Specifically abrogates the production of retroviruses such as human immunodeficiency virus 1 (HIV-1) by acting as a specific inhibitor of the synthesis of retroviruses encoded proteins in a codon-usage-dependent manner. Binds to tRNAs and exploits the unique viral codon bias towards A/T nucleotides. The exact inhibition mechanism is unclear: may either sequesters tRNAs, prevents their maturation via post-transcriptional processing or accelerates their deacylation. Does not inhibit reverse transcription, integration or production and nuclear export of viral RNA. May play a role in cell cycle arrest and/or induction of apoptosis in response to exogenously induced DNA damage.2 Publications

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi599 – 6068ATPSequence Analysis

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. tRNA binding Source: UniProtKB

    GO - Biological processi

    1. defense response to virus Source: UniProtKB
    2. negative regulation of G1/S transition of mitotic cell cycle Source: UniProtKB

    Keywords - Biological processi

    Antiviral defense, Immunity

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding, RNA-binding, tRNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Schlafen family member 11
    Gene namesi
    Name:SLFN11
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:26633. SLFN11.

    Subcellular locationi

    Nucleus 1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: HPA
    2. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA144596358.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 901901Schlafen family member 11PRO_0000283091Add
    BLAST

    Proteomic databases

    MaxQBiQ7Z7L1.
    PaxDbiQ7Z7L1.
    PRIDEiQ7Z7L1.

    PTM databases

    PhosphoSiteiQ7Z7L1.

    Expressioni

    Tissue specificityi

    Exhibits a wider expression range in ovarian and colon adenocarcinoma than in their corresponding healthy tissues.1 Publication

    Inductioni

    By type I interferons, poly-IC and poly-dAdT.2 Publications

    Gene expression databases

    ArrayExpressiQ7Z7L1.
    BgeeiQ7Z7L1.
    CleanExiHS_SLFN11.
    GenevestigatoriQ7Z7L1.

    Organism-specific databases

    HPAiHPA023030.

    Interactioni

    Protein-protein interaction databases

    BioGridi124851. 11 interactions.
    IntActiQ7Z7L1. 1 interaction.
    MINTiMINT-4720222.
    STRINGi9606.ENSP00000312402.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7Z7L1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the Schlafen family.Curated

    Phylogenomic databases

    eggNOGiNOG25289.
    HOGENOMiHOG000049135.
    HOVERGENiHBG056880.
    InParanoidiQ7Z7L1.
    OMAiEAEWSQG.
    OrthoDBiEOG712TVN.
    PhylomeDBiQ7Z7L1.
    TreeFamiTF337168.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR007421. ATPase_AAA-4.
    IPR018647. DUF2075.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF04326. AAA_4. 1 hit.
    PF09848. DUF2075. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q7Z7L1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEANQCPLVV EPSYPDLVIN VGEVTLGEEN RKKLQKIQRD QEKERVMRAA    50
    CALLNSGGGV IRMAKKVEHP VEMGLDLEQS LRELIQSSDL QAFFETKQQG 100
    RCFYIFVKSW SSGPFPEDRS VKPRLCSLSS SLYRRSETSV RSMDSREAFC 150
    FLKTKRKPKI LEEGPFHKIH KGVYQELPNS DPADPNSDPA DLIFQKDYLE 200
    YGEILPFPES QLVEFKQFST KHFQEYVKRT IPEYVPAFAN TGGGYLFIGV 250
    DDKSREVLGC AKENVDPDSL RRKIEQAIYK LPCVHFCQPQ RPITFTLKIV 300
    NVLKRGELYG YACMIRVNPF CCAVFSEAPN SWIVEDKYVC SLTTEKWVGM 350
    MTDTDPDLLQ LSEDFECQLS LSSGPPLSRP VYSKKGLEHK KELQQLLFSV 400
    PPGYLRYTPE SLWRDLISEH RGLEELINKQ MQPFFRGILI FSRSWAVDLN 450
    LQEKPGVICD ALLIAQNSTP ILYTILREQD AEGQDYCTRT AFTLKQKLVN 500
    MGGYTGKVCV RAKVLCLSPE SSAEALEAAV SPMDYPASYS LAGTQHMEAL 550
    LQSLVIVLLG FRSLLSDQLG CEVLNLLTAQ QYEIFSRSLR KNRELFVHGL 600
    PGSGKTIMAM KIMEKIRNVF HCEAHRILYV CENQPLRNFI SDRNICRAET 650
    RKTFLRENFE HIQHIVIDEA QNFRTEDGDW YGKAKSITRR AKGGPGILWI 700
    FLDYFQTSHL DCSGLPPLSD QYPREELTRI VRNADPIAKY LQKEMQVIRS 750
    NPSFNIPTGC LEVFPEAEWS QGVQGTLRIK KYLTVEQIMT CVADTCRRFF 800
    DRGYSPKDVA VLVSTAKEVE HYKYELLKAM RKKRVVQLSD ACDMLGDHIV 850
    LDSVRRFSGL ERSIVFGIHP RTADPAILPN VLICLASRAK QHLYIFPWGG 900
    H 901
    Length:901
    Mass (Da):102,836
    Last modified:November 30, 2010 - v2
    Checksum:i514FD89CB7C12E8D
    GO

    Sequence cautioni

    The sequence BAB85010.1 differs from that shown. Reason: Frameshift at position 135.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti20 – 201N → S in BAC03835. (PubMed:14702039)Curated
    Sequence conflicti143 – 1431M → T in BAC03835. (PubMed:14702039)Curated
    Sequence conflicti324 – 3241V → M in CAD38606. (PubMed:17974005)Curated
    Sequence conflicti665 – 6651I → V in BAC03835. (PubMed:14702039)Curated
    Sequence conflicti665 – 6651I → V in CAD38606. (PubMed:17974005)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti121 – 1211V → F.1 Publication
    Corresponds to variant rs12453150 [ dbSNP | Ensembl ].
    VAR_031492
    Natural varianti301 – 3011N → D.4 Publications
    Corresponds to variant rs4796077 [ dbSNP | Ensembl ].
    VAR_031493
    Natural varianti489 – 4891R → L.
    Corresponds to variant rs9898983 [ dbSNP | Ensembl ].
    VAR_062186
    Natural varianti822 – 8221Y → C.
    Corresponds to variant rs3803860 [ dbSNP | Ensembl ].
    VAR_031494

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK074184 mRNA. Translation: BAB85010.1. Frameshift.
    AK092241 mRNA. Translation: BAC03835.1.
    AL831964 mRNA. Translation: CAD38606.2.
    AC060766 Genomic DNA. No translation available.
    CH471147 Genomic DNA. Translation: EAW80156.1.
    CH471147 Genomic DNA. Translation: EAW80157.1.
    CH471147 Genomic DNA. Translation: EAW80158.1.
    BC052586 mRNA. Translation: AAH52586.1.
    CCDSiCCDS11294.1.
    RefSeqiNP_001098057.1. NM_001104587.1.
    NP_001098058.1. NM_001104588.1.
    NP_001098059.1. NM_001104589.1.
    NP_001098060.1. NM_001104590.1.
    NP_689483.3. NM_152270.3.
    XP_005258125.1. XM_005258068.1.
    XP_006722234.1. XM_006722171.1.
    UniGeneiHs.745059.

    Genome annotation databases

    EnsembliENST00000308377; ENSP00000312402; ENSG00000172716.
    ENST00000394566; ENSP00000378067; ENSG00000172716.
    GeneIDi91607.
    KEGGihsa:91607.
    UCSCiuc002hjg.4. human.

    Polymorphism databases

    DMDMi313104011.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK074184 mRNA. Translation: BAB85010.1 . Frameshift.
    AK092241 mRNA. Translation: BAC03835.1 .
    AL831964 mRNA. Translation: CAD38606.2 .
    AC060766 Genomic DNA. No translation available.
    CH471147 Genomic DNA. Translation: EAW80156.1 .
    CH471147 Genomic DNA. Translation: EAW80157.1 .
    CH471147 Genomic DNA. Translation: EAW80158.1 .
    BC052586 mRNA. Translation: AAH52586.1 .
    CCDSi CCDS11294.1.
    RefSeqi NP_001098057.1. NM_001104587.1.
    NP_001098058.1. NM_001104588.1.
    NP_001098059.1. NM_001104589.1.
    NP_001098060.1. NM_001104590.1.
    NP_689483.3. NM_152270.3.
    XP_005258125.1. XM_005258068.1.
    XP_006722234.1. XM_006722171.1.
    UniGenei Hs.745059.

    3D structure databases

    ProteinModelPortali Q7Z7L1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 124851. 11 interactions.
    IntActi Q7Z7L1. 1 interaction.
    MINTi MINT-4720222.
    STRINGi 9606.ENSP00000312402.

    PTM databases

    PhosphoSitei Q7Z7L1.

    Polymorphism databases

    DMDMi 313104011.

    Proteomic databases

    MaxQBi Q7Z7L1.
    PaxDbi Q7Z7L1.
    PRIDEi Q7Z7L1.

    Protocols and materials databases

    DNASUi 91607.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000308377 ; ENSP00000312402 ; ENSG00000172716 .
    ENST00000394566 ; ENSP00000378067 ; ENSG00000172716 .
    GeneIDi 91607.
    KEGGi hsa:91607.
    UCSCi uc002hjg.4. human.

    Organism-specific databases

    CTDi 91607.
    GeneCardsi GC17M033677.
    H-InvDB HIX0018885.
    HGNCi HGNC:26633. SLFN11.
    HPAi HPA023030.
    MIMi 614953. gene.
    neXtProti NX_Q7Z7L1.
    PharmGKBi PA144596358.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG25289.
    HOGENOMi HOG000049135.
    HOVERGENi HBG056880.
    InParanoidi Q7Z7L1.
    OMAi EAEWSQG.
    OrthoDBi EOG712TVN.
    PhylomeDBi Q7Z7L1.
    TreeFami TF337168.

    Miscellaneous databases

    ChiTaRSi SLFN11. human.
    GeneWikii SLFN11.
    GenomeRNAii 91607.
    NextBioi 77319.
    PROi Q7Z7L1.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q7Z7L1.
    Bgeei Q7Z7L1.
    CleanExi HS_SLFN11.
    Genevestigatori Q7Z7L1.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR007421. ATPase_AAA-4.
    IPR018647. DUF2075.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF04326. AAA_4. 1 hit.
    PF09848. DUF2075. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS PHE-121 AND ASP-301.
      Tissue: Spleen.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ASP-301.
      Tissue: Skeletal muscle.
    3. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
      Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
      , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
      Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ASP-301.
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ASP-301.
      Tissue: Skin.
    6. "Role of interferon {alpha} (IFN{alpha})-inducible Schlafen-5 in regulation of anchorage-independent growth and invasion of malignant melanoma cells."
      Katsoulidis E., Mavrommatis E., Woodard J., Shields M.A., Sassano A., Carayol N., Sawicki K.T., Munshi H.G., Platanias L.C.
      J. Biol. Chem. 285:40333-40341(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION.
    7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    8. "Codon-usage-based inhibition of HIV protein synthesis by human schlafen 11."
      Li M., Kao E., Gao X., Sandig H., Limmer K., Pavon-Eternod M., Jones T.E., Landry S., Pan T., Weitzman M.D., David M.
      Nature 491:125-128(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, TRNA-BINDING, INDUCTION.
    9. "Putative DNA/RNA helicase Schlafen-11 (SLFN11) sensitizes cancer cells to DNA-damaging agents."
      Zoppoli G., Regairaz M., Leo E., Reinhold W.C., Varma S., Ballestrero A., Doroshow J.H., Pommier Y.
      Proc. Natl. Acad. Sci. U.S.A. 109:15030-15035(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiSLN11_HUMAN
    AccessioniPrimary (citable) accession number: Q7Z7L1
    Secondary accession number(s): E1P643
    , Q8N3S8, Q8N762, Q8TEE0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 3, 2007
    Last sequence update: November 30, 2010
    Last modified: October 1, 2014
    This is version 92 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3