Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q7Z7L1 (SLN11_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Schlafen family member 11
Gene names
Name:SLFN11
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length901 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Interferon (IFN)-induced antiviral protein which acts as an inhibitor of retrovirus protein synthesis. Specifically abrogates the production of retroviruses such as human immunodeficiency virus 1 (HIV-1) by acting as a specific inhibitor of the synthesis of retroviruses encoded proteins in a codon-usage-dependent manner. Binds to tRNAs and exploits the unique viral codon bias towards A/T nucleotides. The exact inhibition mechanism is unclear: may either sequesters tRNAs, prevents their maturation via post-transcriptional processing or accelerates their deacylation. Does not inhibit reverse transcription, integration or production and nuclear export of viral RNA. May play a role in cell cycle arrest and/or induction of apoptosis in response to exogenously induced DNA damage. Ref.8 Ref.9

Subcellular location

Nucleus Ref.9.

Tissue specificity

Exhibits a wider expression range in ovarian and colon adenocarcinoma than in their corresponding healthy tissues. Ref.9

Induction

By type I interferons, poly-IC and poly-dAdT. Ref.6 Ref.8

Sequence similarities

Belongs to the Schlafen family.

Sequence caution

The sequence BAB85010.1 differs from that shown. Reason: Frameshift at position 135.

Ontologies

Keywords
   Biological processAntiviral defense
Immunity
   Cellular componentNucleus
   Coding sequence diversityPolymorphism
   LigandATP-binding
Nucleotide-binding
RNA-binding
tRNA-binding
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processdefense response to virus

Inferred from mutant phenotype Ref.8. Source: UniProtKB

negative regulation of G1/S transition of mitotic cell cycle

Inferred from mutant phenotype Ref.9. Source: UniProtKB

   Cellular_componentcytoplasm

Inferred from direct assay. Source: HPA

nucleus

Inferred from direct assay Ref.9. Source: UniProtKB

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

tRNA binding

Inferred from direct assay Ref.8. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 901901Schlafen family member 11
PRO_0000283091

Regions

Nucleotide binding599 – 6068ATP Potential

Natural variations

Natural variant1211V → F. Ref.1
Corresponds to variant rs12453150 [ dbSNP | Ensembl ].
VAR_031492
Natural variant3011N → D. Ref.1 Ref.2 Ref.4 Ref.5
Corresponds to variant rs4796077 [ dbSNP | Ensembl ].
VAR_031493
Natural variant4891R → L.
Corresponds to variant rs9898983 [ dbSNP | Ensembl ].
VAR_062186
Natural variant8221Y → C.
Corresponds to variant rs3803860 [ dbSNP | Ensembl ].
VAR_031494

Experimental info

Sequence conflict201N → S in BAC03835. Ref.1
Sequence conflict1431M → T in BAC03835. Ref.1
Sequence conflict3241V → M in CAD38606. Ref.2
Sequence conflict6651I → V in BAC03835. Ref.1
Sequence conflict6651I → V in CAD38606. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q7Z7L1 [UniParc].

Last modified November 30, 2010. Version 2.
Checksum: 514FD89CB7C12E8D

FASTA901102,836
        10         20         30         40         50         60 
MEANQCPLVV EPSYPDLVIN VGEVTLGEEN RKKLQKIQRD QEKERVMRAA CALLNSGGGV 

        70         80         90        100        110        120 
IRMAKKVEHP VEMGLDLEQS LRELIQSSDL QAFFETKQQG RCFYIFVKSW SSGPFPEDRS 

       130        140        150        160        170        180 
VKPRLCSLSS SLYRRSETSV RSMDSREAFC FLKTKRKPKI LEEGPFHKIH KGVYQELPNS 

       190        200        210        220        230        240 
DPADPNSDPA DLIFQKDYLE YGEILPFPES QLVEFKQFST KHFQEYVKRT IPEYVPAFAN 

       250        260        270        280        290        300 
TGGGYLFIGV DDKSREVLGC AKENVDPDSL RRKIEQAIYK LPCVHFCQPQ RPITFTLKIV 

       310        320        330        340        350        360 
NVLKRGELYG YACMIRVNPF CCAVFSEAPN SWIVEDKYVC SLTTEKWVGM MTDTDPDLLQ 

       370        380        390        400        410        420 
LSEDFECQLS LSSGPPLSRP VYSKKGLEHK KELQQLLFSV PPGYLRYTPE SLWRDLISEH 

       430        440        450        460        470        480 
RGLEELINKQ MQPFFRGILI FSRSWAVDLN LQEKPGVICD ALLIAQNSTP ILYTILREQD 

       490        500        510        520        530        540 
AEGQDYCTRT AFTLKQKLVN MGGYTGKVCV RAKVLCLSPE SSAEALEAAV SPMDYPASYS 

       550        560        570        580        590        600 
LAGTQHMEAL LQSLVIVLLG FRSLLSDQLG CEVLNLLTAQ QYEIFSRSLR KNRELFVHGL 

       610        620        630        640        650        660 
PGSGKTIMAM KIMEKIRNVF HCEAHRILYV CENQPLRNFI SDRNICRAET RKTFLRENFE 

       670        680        690        700        710        720 
HIQHIVIDEA QNFRTEDGDW YGKAKSITRR AKGGPGILWI FLDYFQTSHL DCSGLPPLSD 

       730        740        750        760        770        780 
QYPREELTRI VRNADPIAKY LQKEMQVIRS NPSFNIPTGC LEVFPEAEWS QGVQGTLRIK 

       790        800        810        820        830        840 
KYLTVEQIMT CVADTCRRFF DRGYSPKDVA VLVSTAKEVE HYKYELLKAM RKKRVVQLSD 

       850        860        870        880        890        900 
ACDMLGDHIV LDSVRRFSGL ERSIVFGIHP RTADPAILPN VLICLASRAK QHLYIFPWGG 


H 

« Hide

References

« Hide 'large scale' references
[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS PHE-121 AND ASP-301.
Tissue: Spleen.
[2]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ASP-301.
Tissue: Skeletal muscle.
[3]"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L. expand/collapse author list , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ASP-301.
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ASP-301.
Tissue: Skin.
[6]"Role of interferon {alpha} (IFN{alpha})-inducible Schlafen-5 in regulation of anchorage-independent growth and invasion of malignant melanoma cells."
Katsoulidis E., Mavrommatis E., Woodard J., Shields M.A., Sassano A., Carayol N., Sawicki K.T., Munshi H.G., Platanias L.C.
J. Biol. Chem. 285:40333-40341(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: INDUCTION.
[7]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[8]"Codon-usage-based inhibition of HIV protein synthesis by human schlafen 11."
Li M., Kao E., Gao X., Sandig H., Limmer K., Pavon-Eternod M., Jones T.E., Landry S., Pan T., Weitzman M.D., David M.
Nature 491:125-128(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, TRNA-BINDING, INDUCTION.
[9]"Putative DNA/RNA helicase Schlafen-11 (SLFN11) sensitizes cancer cells to DNA-damaging agents."
Zoppoli G., Regairaz M., Leo E., Reinhold W.C., Varma S., Ballestrero A., Doroshow J.H., Pommier Y.
Proc. Natl. Acad. Sci. U.S.A. 109:15030-15035(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK074184 mRNA. Translation: BAB85010.1. Frameshift.
AK092241 mRNA. Translation: BAC03835.1.
AL831964 mRNA. Translation: CAD38606.2.
AC060766 Genomic DNA. No translation available.
CH471147 Genomic DNA. Translation: EAW80156.1.
CH471147 Genomic DNA. Translation: EAW80157.1.
CH471147 Genomic DNA. Translation: EAW80158.1.
BC052586 mRNA. Translation: AAH52586.1.
CCDSCCDS11294.1.
RefSeqNP_001098057.1. NM_001104587.1.
NP_001098058.1. NM_001104588.1.
NP_001098059.1. NM_001104589.1.
NP_001098060.1. NM_001104590.1.
NP_689483.3. NM_152270.3.
XP_005258125.1. XM_005258068.1.
XP_006722234.1. XM_006722171.1.
UniGeneHs.745059.

3D structure databases

ProteinModelPortalQ7Z7L1.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid124851. 11 interactions.
IntActQ7Z7L1. 1 interaction.
MINTMINT-4720222.
STRING9606.ENSP00000312402.

PTM databases

PhosphoSiteQ7Z7L1.

Polymorphism databases

DMDM313104011.

Proteomic databases

MaxQBQ7Z7L1.
PaxDbQ7Z7L1.
PRIDEQ7Z7L1.

Protocols and materials databases

DNASU91607.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000308377; ENSP00000312402; ENSG00000172716.
ENST00000394566; ENSP00000378067; ENSG00000172716.
GeneID91607.
KEGGhsa:91607.
UCSCuc002hjg.4. human.

Organism-specific databases

CTD91607.
GeneCardsGC17M033677.
H-InvDBHIX0018885.
HGNCHGNC:26633. SLFN11.
HPAHPA023030.
MIM614953. gene.
neXtProtNX_Q7Z7L1.
PharmGKBPA144596358.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG25289.
HOGENOMHOG000049135.
HOVERGENHBG056880.
InParanoidQ7Z7L1.
OMAEAEWSQG.
OrthoDBEOG712TVN.
PhylomeDBQ7Z7L1.
TreeFamTF337168.

Gene expression databases

ArrayExpressQ7Z7L1.
BgeeQ7Z7L1.
CleanExHS_SLFN11.
GenevestigatorQ7Z7L1.

Family and domain databases

Gene3D3.40.50.300. 1 hit.
InterProIPR007421. ATPase_AAA-4.
IPR018647. DUF2075.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF04326. AAA_4. 1 hit.
PF09848. DUF2075. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
ProtoNetSearch...

Other

ChiTaRSSLFN11. human.
GeneWikiSLFN11.
GenomeRNAi91607.
NextBio77319.
PROQ7Z7L1.
SOURCESearch...

Entry information

Entry nameSLN11_HUMAN
AccessionPrimary (citable) accession number: Q7Z7L1
Secondary accession number(s): E1P643 expand/collapse secondary AC list , Q8N3S8, Q8N762, Q8TEE0
Entry history
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: November 30, 2010
Last modified: July 9, 2014
This is version 91 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM